070321-化学生物学
070303-有机化学
100705-微生物与生化药学

天然产物生物合成，化学生物学
微生物生理与生化，合成生物学
微生物药物

1994-09--1999-07   中国科学院上海有机化学研究所   硕博联读/博士
1990-09--1994-06   南开大学   本科/学士
1987-09--1990-06   山东省龙口市第一中学   高中

-- 研究生

-- 博士

   

2003-09~现在, 中国科学院上海有机化学研究所, 课题组长
2001-07~2003-08,美国威斯康辛大学药学院, 研究助理
2000-09~2001-06,美国加州大学戴维斯分校化学系, 博士后
1999-08~2000-08,中科院上海有机所, 课题组副组长/助研、副研

2014-06-15-今,沈阳药科大学兼职教授,

天然产物生物合成
核酸化学；天然产物生物合成
核酸与蛋白质；天然产物生物合成
核酸与蛋白质、天然产物生物合成
核酸与蛋白质化
核酸与蛋白质化学概论

   

[1] 唐功利, 张媚, 潘海学. 三欣卡辛的生物合成基因簇及其应用. CN: CN104911196B, 2020-04-28.

[2] 唐功利, 董雷, 侯现锋, 潘海学. 新型LL-D49194al类似物，及其制备方法和应用. ZL 201910156416.5, 2019-03-01.

[3] 唐功利, 胡煜, 张转, 潘海学. 阿克拉霉素类似物及其制法和用途. CN: CN108864221A, 2018-11-23.

[4] 唐功利, 姜浩, 潘海学, 赵娟, 李岩. 一种构建FK520高产工程菌株的方法和吸水链霉菌高产菌株. CN: CN107629994A, 2018-01-26.

[5] 唐功利, 孟松, 潘海学, 赵娟. 双环霉素生物合成中六个氧化酶的功能及其应用. ZL201711184703.4, 2017-11-23.

[6] 唐功利, 马宏敏, 周强, 张转. 越野他汀的生物合成基因簇及其应用. CN: CN103215282B, 2016-08-03.

[7] 唐功利, 李玮涛, 潘海学, 蹇晓红. 金核霉素的生物合成基因簇及其应用. CN: CN103540603B, 2015-10-28.

[8] 唐功利, 黄伟, 李燕, 张凤, 徐慧. 谷田霉素的生物合成基因簇. CN: CN102174531B, 2014-04-09.

[9] 唐功利, 王健博. 一种改造除虫链霉菌产生多拉菌素的方法. CN: CN102093997B, 2013-03-13.

[10] 唐功利, 张凤. FR901464的生物合成基因簇. CN: CN101818158B, 2013-03-13.

[11] 唐功利, 王健博. 利用调控蛋白基因提高阿维菌素的产量. CN: CN101724646B, 2012-07-18.

[12] 唐功利, 王健博. 利用初级糖代谢基因提高阿维菌素的产量. CN: CN101717778B, 2012-06-27.

[13] 唐功利, 刘文, 李磊. 番红霉素的生物合成基因簇. CN: CN101157929B, 2012-05-23.

   

[1] Chen, Xiaorong, He, Rui, Sun, Aiai, Pu, Jinyue, Pan, HaiXue, Tang, GongLi. A Secreted BBE-Like Enzyme Acting as a Drug-Binding Efflux Carrier Confers Microbial Self-Resistance to Mitomycin C. ORGANIC LETTERS[J]. 2024, 第 6 作者  通讯作者  26(6): 1233-1237, http://dx.doi.org/10.1021/acs.orglett.4c00042.
[2] Tian, Tian, Ogura, Yusuke, Ise, Yuji, Takikawa, Hirosato, Okada, Shigeru, Matsunaga, Shigeki, Tang, GongLi. Absolute Configuration of 4-Chloroisoleucine in Cyclolithistide A: An Antifungal Peptide Lactone Discovered in Marine Lithistid Sponges. JOURNAL OF ORGANIC CHEMISTRY[J]. 2024, 第 7 作者  通讯作者  89(12): 9135-9138, http://dx.doi.org/10.1021/acs.joc.4c00913.
[3] He, Jun-Bin, Ren, Yichen, Li, Peifeng, Liu, Yi-Pei, Pan, Hai-Xue, Huang, Lin-Juan, Wang, Jiayuan, Fang, Pengfei, Tang, Gong-Li. Crystal Structure and Mutagenesis of an XYP Subfamily Cyclodipeptide Synthase Reveal Key Determinants of Enzyme Activity and Substrate Specificity. Biochemistry[J]. 2024, 第 9 作者  通讯作者  null(null): 
[4] Jonathan DORIVAL, Hua Yuan, Allison S. Walker, Gong-Li Tang, Brandt F. Eichman. Yatakemycin biosynthesis requires two deoxyribonucleases for toxin self-resistance. RSC Chemical Biology[J]. 2024, 第 4 作者  通讯作者  null(null): 
[5] Yu Hu, Shu-Ya Peng, Xueyang Ma, Hongwei Chen, Qiu-Yue Nie, Jun-Bin He, Qianqian Chen, Qiang Zhou, Xin-Hua Lu, Qiang Hua, Donghui Yang, Yong Liang, Ming Ma, Gong-Li Tang. Functional Characterization and Molecular Basis of a Multi-site Halogenase in Naphthacemycin Biosynthesis. Angewandte Chemie International Edition[J]. 2024, 第 14 作者  通讯作者  null(null): 
[6] 冯金, 潘海学, 唐功利. 近十年天然产物药物的生物合成研究进展. 合成生物学[J]. 2024, 第 3 作者  通讯作者  5(3): 408-446, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7762950&detailType=1.
[7] RuoQin Gao, XiaoDong Hu, Qiang Zhou, XianFeng Hou, Chunyang Cao, GongLi Tang. Different DNA Bindingand Damage Mode between AnticancerAntibiotics Trioxacarcin A and LL-D49194a1. JACS AU[J]. 2024, 第 6 作者  通讯作者  4(9): 3641-3648, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11423299/.
[8] Ning Shao, Xueyang Ma, YingYing Zhang, Donghui Yang, Ming Ma, GongLi Tang. Dihydrofolate reductase-like protein inactivates hemiaminal pharmacophore for self-resistance in safracin biosynthesis. ACTA PHARMACEUTICA SINICA B[J]. 2023, 第 6 作者  通讯作者  13(3): 1318-1325, http://dx.doi.org/10.1016/j.apsb.2022.10.005.
[9] He, JunBin, Wu, Lian, Wei, Wanqing, Meng, Song, Liu, ZhengTao, Wu, Xuan, Pan, HaiXue, Yang, Sheng, Liang, Yong, Zhou, Jiahai, Tang, GongLi. Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis. NATURE CATALYSIS. 2023, 第 11 作者  通讯作者  http://dx.doi.org/10.1038/s41929-023-00987-4.
[10] 王飞, 金文兵, 侯现锋, 潘海学, 唐功利. 金核霉素生物合成途径的体内研究和关键代谢物鉴定. 有机化学[J]. 2023, 第 5 作者  通讯作者  43: 2561-2566, 
[11] Chen, Xiaorong, Pan, HaiXue, Tang, GongLi. Newly Discovered Mechanisms of Antibiotic Self-Resistance with Multiple Enzymes Acting at Different Locations and Stages. ANTIBIOTICS-BASEL[J]. 2023, 第 3 作者  通讯作者  12(1): 35, 
[12] Zhang, YingYing, Shao, Ning, Wen, WanHong, Tang, GongLi. A Cryptic Palmitoyl Chain Involved in Safracin Biosynthesis Facilitates Post-NRPS Modifications. ORGANIC LETTERS[J]. 2022, 第 4 作者  通讯作者  24(1): 127-131, http://dx.doi.org/10.1021/acs.orglett.1c03741.
[13] Pei, ZengFei, Yang, MinJie, Zhang, Kai, Jian, XiaoHong, Tang, GongLi. Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs. CELL CHEMICAL BIOLOGY[J]. 2022, 第 5 作者  通讯作者  29(4): 650-+, http://dx.doi.org/10.1016/j.chembiol.2021.08.005.
[14] Nie, QiuYue, Hu, Yu, Hou, XianFeng, Tang, GongLi. Biosynthesis of DNA-Alkylating Antitumor Natural Products. MOLECULES. 2022, 第 4 作者  通讯作者  27(19): http://dx.doi.org/10.3390/molecules27196387.
[15] 唐功利. Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs.. Cell Chem. Biol.[J]. 2022, 第 1 作者  通讯作者  
[16] Han, TingYan, Zhang, Kai, Tang, GongLi, Zhou, Qiang. Characterizing Post-PKS Modifications of 16-Demethyl-rifamycin Revealed Two Dehydrogenases Diverting the Aromatization Mode of Naphthalenic Ring in Ansamycin Biosynthesis. CHINESE JOURNAL OF CHEMISTRY[J]. 2022, 第 3 作者  通讯作者  40(13): 1553-1558, http://dx.doi.org/10.1002/cjoc.202200098.
[17] Zou, ZiRuo, Zhang, Kai, Han, TingYan, Zhou, Qiang, Lin, Shuangjun, Hou, XianFeng, Tang, GongLi. Two-enzyme cascade catalyzed trideuteromethylative modification of natural products. TETRAHEDRON[J]. 2022, 第 7 作者  通讯作者  129: http://dx.doi.org/10.1016/j.tet.2022.133137.
[18] Gao, YuHang, Nie, QiuYue, Hu, Yu, Lu, Xinhua, Xiang, Wensheng, Wang, Xiangjing, Tang, GongLi. Discovery of glycosylated naphthacemycins and elucidation of the glycosylation. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2022, 第 7 作者  通讯作者  622: 122-128, http://dx.doi.org/10.1016/j.bbrc.2022.06.095.
[19] Chen, Xiaorong, Bradley, Noah P, Lu, Wei, Wahl, Katherine L, Zhang, Mei, Yuan, Hua, Hou, XianFeng, Eichman, Brandt F, Tang, GongLi. Base excision repair system targeting DNA adducts of trioxacarcin/LL-D49194 antibiotics for self-resistance. NUCLEIC ACIDS RESEARCH[J]. 2022, 第 9 作者  通讯作者  50(5): 2417-2430, http://dx.doi.org/10.1093/nar/gkac085.
[20] Hu, Yu, Zhou, Qiang, Zhang, Zhuan, Pan, HaiXue, Ilina, Yulia, MetsaKetela, Mikko, Igarashi, Yasuhiro, Tang, GongLi. Deciphering the Origin and Formation of Aminopyrrole Moiety in Kosinostatin Biosynthesis. CHINESE JOURNAL OF CHEMISTRY[J]. 2021, 第 8 作者  通讯作者  39(12): 3329-3333, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7107335&detailType=1.
[21] 李世杰, 聂秋玥, 季珍瑜, 华会明, 唐功利. 组合生物合成介导C-4羟基异构的新型四环素类化合物的发现. 有机化学[J]. 2021, 第 5 作者41(8): 3297-3302, https://sioc-journal.cn/Jwk_yjhx/CN/10.6023/cjoc202103033.
[22] 陈小蓉, 潘海学, 唐功利. 天然产物产生菌自抗性中DNA损伤修复的研究进展. 微生物学通报[J]. 2021, 第 3 作者48(7): 2454-2466, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb21072454?st=article_issue.
[23] Nie, QiuYue, Ji, ZhenYu, Hu, Yu, Tang, GongLi. Characterization of Highly Reductive Modification of Tetracycline D-Ring Reveals Enzymatic Conversion of Enone to Alkane. ACS CATALYSIS[J]. 2021, 第 4 作者  通讯作者  11(14): 8399-8406, http://dx.doi.org/10.1021/acscatal.1c01226.
[24] Zhang, WenHe, Wang, Fei, Wang, YiLin, You, Song, Pan, HaiXue, Tang, GongLi. Identification and Characterization of Enzymes Catalyzing Early Steps in Miharamycin and Amipurimycin Biosynthesis. ORGANIC LETTERS[J]. 2021, 第 6 作者  通讯作者  23(22): 8761-8765, http://dx.doi.org/10.1021/acs.orglett.1c03254.
[25] Zhou, Qiang, Peng, ShuYa, Zhang, Kai, Luo, GuangCai, Han, Li, He, QingLi, Tang, GongLi. A Flavin-Dependent Monooxygenase Mediates Divergent Oxidation of Rifamycin. ORGANIC LETTERS[J]. 2021, 第 7 作者  通讯作者  23(6): 2342-2346, http://dx.doi.org/10.1021/acs.orglett.1c00485.
[26] WanHong Wen, Yue Zhang, YingYing Zhang, Qian Yu, ChuChu Jiang, ManCheng Tang, JinYue Pu, Lian Wu, YiLei Zhao, Ting Shi, Jiahai Zhou, GongLi Tang. Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics. NATURE COMMUNICATIONS[J]. 2021, 第 12 作者  通讯作者  12: 7085, 
[27] 范震, 潘海学, 唐功利. 工程酵母助力真菌嵌合萜类合酶的快速系统挖掘. 合成生物学[J]. 2021, 第 3 作者2(5): 666-673, http://lib.cqvip.com/Qikan/Article/Detail?id=7106018939.
[28] Zheng, XiaoFu, Liu, XinQiang, Peng, ShuYa, Zhou, Qiang, Xu, Bin, Yuan, Hua, Tang, GongLi. Characterization of the Rifamycin-Degrading Monooxygenase From Rifamycin Producers Implicating Its Involvement in Saliniketal Biosynthesis. FRONTIERS IN MICROBIOLOGY[J]. 2020, 第 7 作者11: https://doaj.org/article/2b837c1d51b44db99a28da55179e1862.
[29] 聂秋玥, 季珍瑜, 唐功利. 金色链霉菌SP-371中新型螺-萘醌结构化合物的发现. 有机化学[J]. 2020, 第 3 作者40(10): 3467-3470, https://sioc-journal.cn/Jwk_yjhx/CN/10.6023/cjoc202005091.
[30] Yin, Yue, Shen, Yi, Meng, Song, Zhang, Mei, Pan, HaiXue, Tang, GongLi. Characterization of aMembrane-BoundO-AcetyltransferaseInvolved in Trioxacarcin Biosynthesis Offers Insights into Its Catalytic Mechanism. CHINESE JOURNAL OF CHEMISTRY[J]. 2020, 第 6 作者  通讯作者  38(12): 1607-1611, http://lib.cqvip.com/Qikan/Article/Detail?id=7103704685.
[31] Wang, Fei, Zhang, WenHe, Zhao, Juan, Kang, WenJia, Wang, Shengyang, Yu, Biao, Pan, HaiXue, Tang, GongLi. Characterization of Miharamycin Biosynthesis Reveals a Hybrid NRPS-PKS to Synthesize High-Carbon Sugar from a Complex Nucleoside. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 第 8 作者  通讯作者  142(13): 5996-6000, https://www.webofscience.com/wos/woscc/full-record/WOS:000526393700017.
[32] Jin, WenBing, Wu, Sheng, Xu, YiFan, Yuan, Hua, Tang, GongLi. Recent advances in HemN-like radical S-adenosyl-l-methionine enzyme-catalyzed reactions. NATURAL PRODUCT REPORTS. 2020, 第 5 作者  通讯作者  37(1): 17-28, https://www.webofscience.com/wos/woscc/full-record/WOS:000509966800002.
[33] 贺俊斌, 孟松, 潘海学, 唐功利. 多酶催化串联策略在复杂天然产物合成中的应用. 合成生物学[J]. 2020, 第 4 作者1(2): 226-246, http://lib.cqvip.com/Qikan/Article/Detail?id=7102383137.
[34] Hu, Yu, Zhang, Zhuan, Yin, Yue, Tang, GongLi. Directed Biosynthesis of Iso-aclacinomycins with Improved Anticancer Activity. ORGANIC LETTERS[J]. 2020, 第 4 作者  通讯作者  22(1): 150-154, http://dx.doi.org/10.1021/acs.orglett.9b04069.
[35] Nie, Qiuyue, Ji, Zhenyu, Tang, Gongli. Discovery a Novel Spiro-Naphthoquinone Compound in Streptomyces aureus SP-371. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2020, 第 3 作者  通讯作者  40(10): 3467-3470, http://dx.doi.org/10.6023/cjoc202005091.
[36] Wang, Shengyang, Zhang, Qingju, Zhao, Yachen, Sun, Jiansong, Kang, Wenjia, Wang, Fei, Pan, Haixue, Tang, Gongli, Yu, Biao. The Miharamycins and Amipurimycin: their Structural Revision and the Total Synthesis of the Latter. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 第 8 作者58(31): 10558-10562, https://www.doi.org/10.1002/anie.201905723.
[37] Zhou, Qiang, Luo, GuangCai, Zhang, Huizhan, Tang, GongLi. 34a-Hydroxylation in Rifamycin Biosynthesis Catalyzed by Cytochrome P450 Encoded by rif-orf13. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 第 4 作者  通讯作者  39(4): 1169-1174, http://dx.doi.org/10.6023/cjoc201811018.
[38] Zhou Qiang, Luo GuangCai, Zhang Huizhan, Tang GongLi. 34a-Hydroxylation in Rifamycin Biosynthesis Catalyzed by Cytochrome P450 Encoded by rif-orf13. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2019, 第 4 作者  通讯作者  39(4): 1169-1174, https://www.webofscience.com/wos/woscc/full-record/WOS:000466156500031.
[39] Yi Shen, QiuYue Nie, Yue Yin, HaiXue Pan, Bin Xu, GongLi Tang. Production of a trioxacarcin analog by introducing a C-3 dehydratase into deoxysugar biosynthesis. Acta Biochimica et Biophysica Sinica[J]. 2019, 第 6 作者  通讯作者  51(5): 539-541, https://www.sciengine.com/doi/10.1093/abbs/gmz024.
[40] 周强, 罗光彩, 张惠展, 唐功利. Rif-orf13编码的细胞色素P450催化利福霉素生物合成过程中C34a位的羟化反应. 有机化学[J]. 2019, 第 4 作者39(4): 1169-1174, https://sioc-journal.cn/Jwk_yjhx/CN/10.6023/cjoc201811018.
[41] Dong, Lei, Shen, Yi, Hou, XianFeng, Li, WenJun, Tang, GongLi. Discovery of Druggability-Improved Analogues by Investigation of the LL-D49194 alpha 1 Biosynthetic Pathway. ORGANIC LETTERS[J]. 2019, 第 5 作者  通讯作者  21(7): 2322-2325, https://www.webofscience.com/wos/woscc/full-record/WOS:000464247500083.
[42] Pan, HaiXue, Chen, Zhang, Zeng, Tianfang, Jin, WenBing, Geng, Yujie, Lin, GengMin, Zhao, Juan, Li, WeiTao, Xiong, Zijun, Huang, ShengXiong, Zhai, Xin, Liu, Hungwen, Tang, GongLi. Elucidation of the Herbicidin Tailoring Pathway Offers Insights into Its Structural Diversity. ORGANIC LETTERS[J]. 2019, 第 13 作者  通讯作者  21(5): 1374-1378, https://www.webofscience.com/wos/woscc/full-record/WOS:000460491700028.
[43] Kang, WenJia, Pan, HaiXue, Wang, Shengyang, Yu, Biao, Hua, Huiming, Tang, GongLi. Identification of the Amipurimycin Gene Cluster Yields Insight into the Biosynthesis of C9 Sugar Nucleoside Antibiotics. ORGANIC LETTERS[J]. 2019, 第 6 作者  通讯作者  21(9): 3148-3152, 
[44] Ji, ZhenYu, Nie, QiuYue, Yin, Yue, Zhang, Mei, Pan, HaiXue, Hou, XianFeng, Tang, GongLi. Activation and Characterization of Cryptic Gene Cluster: Two Series of Aromatic Polyketides Biosynthesized by Divergent Pathways. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 第 7 作者  通讯作者  58(50): 18046-18054, https://www.webofscience.com/wos/woscc/full-record/WOS:000492069300001.
[45] Feifei Qi, Chao Lei, Fengwei Li, Xingwang Zhang, Jin Wang, Wei Zhang, Zhen Fan, Weichao Li, GongLi Tang, Youli Xiao, Guoping Zhao, Shengying Li. Deciphering the late steps of rifamycin biosynthesis. NATURE COMMUNICATIONS[J]. 2018, 第 9 作者9(1): http://www.irgrid.ac.cn/handle/1471x/1782302.
[46] Meng Song, Han Wei, Zhao Juan, Jian XiaoHong, Pan HaiXue, Tang GongLi. y A Six-Oxidase Cascade for Tandem C-H Bond Activation Revealed by Reconstitution of Bicyclomycin Biosynthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 第 6 作者  通讯作者  57(3): 719-723, 
[47] Pei, ZengFei, Yang, MinJie, Li, Lei, Jian, XiaoHong, Yin, Yue, Li, Dehai, Pan, HaiXue, Lu, Yinhua, Jiang, Weihong, Tang, GongLi. Directed production of aurantizolicin and new members based on a YM-216391 biosynthetic system. ORGANICBIOMOLECULARCHEMISTRY[J]. 2018, 第 10 作者  通讯作者  16(48): 9373-9376, https://www.webofscience.com/wos/woscc/full-record/WOS:000453230000008.
[48] Jin Wenbing, Yuan Hua, Tang Gongli. Strategies for Construction of Cyclopropanes in Natural Products. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 第 3 作者  通讯作者  38(9): 2324-2334, http://doi.org/10.6023/cjoc201805059.
[49] Jin, Wenbing, Yuan, Hua, Tang, Gongli. Strategies for Construction of Cyclopropanes in Natural Products. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 第 3 作者  通讯作者  38(9): 2324-2334, http://dx.doi.org/10.6023/cjoc201805059.
[50] Wang, Shengyang, Sun, Jiansong, Zhang, Qingju, Cao, Xin, Zhao, Yachen, Tang, Gongli, Yu, Biao. Amipurimycin: Total Synthesis of the Proposed Structures and Diastereoisomers. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 第 6 作者57(11): 2884-2888, https://www.webofscience.com/wos/woscc/full-record/WOS:000426490700021.
[51] Meng, Song, Tang, GongLi, Pan, HaiXue. Enzymatic Formation of Oxygen-Containing Heterocycles in Natural Product Biosynthesis. CHEMBIOCHEM. 2018, 第 2 作者  通讯作者  19(19): 2002-2022, https://www.webofscience.com/wos/woscc/full-record/WOS:000446429400001.
[52] 唐功利. Directed production of aurantizolicin and new members based on YM-216391 biosynthetic system.. Org. Biomol. Chem.[J]. 2018, 第 1 作者  通讯作者  
[53] Zhang, Yue, Wen, WanHong, Pu, JinYue, Tang, ManCheng, Zhang, Liwen, Peng, Chao, Xu, Yuquan, Tang, GongLi. Extracellularly oxidative activation and inactivation of matured prodrug for cryptic self-resistance in naphthyridinomycin biosynthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 第 8 作者  通讯作者  115(44): 11232-11237, https://www.webofscience.com/wos/woscc/full-record/WOS:000448713200049.
[54] Meng, Song, Han, Wei, Zhao, Juan, Jian, XiaoHong, Pan, HaiXue, Tang, GongLi. A Six-Oxidase Cascade for Tandem C-H Bond Activation Revealed by Reconstitution of Bicyclomycin Biosynthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 第 6 作者  通讯作者  57(3): 719-723, https://www.webofscience.com/wos/woscc/full-record/WOS:000419594700017.
[55] Chen Xinya, Yin Yue, Xi Jie, Yuan Yi, Li Yan, Li Qing, Wang Renxiao, Yao Zhujun, Tang Gongli. 11-Aza-artemisinin Derivatives Exhibit Anticancer Activities by Targeting the Fatty Acid Binding Protein 6 (FABP6). CHINESE JOURNAL OF CHEMISTRY[J]. 2018, 第 9 作者  通讯作者  36(12): 1197-1201, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6389303&detailType=1.
[56] Xu Wang, Sheng Wu, Wenbing Jin, Bin Xu, Gongli Tang, Hua Yuan. Bioinformatics-guided connection of a biosynthetic gene cluster to the antitumor antibiotic gilvusmycin. Acta Biochimica et Biophysica Sinica[J]. 2018, 第 5 作者  通讯作者  50(5): 516-518, https://www.sciengine.com/doi/10.1093/abbs/gmy030.
[57] 唐功利. Enzymology of anthraquinone--pyrone ring formation in complex aromatic polyketide biosynthesis.. Angew. Chem. Int. Ed.. 2018, 第 1 作者  通讯作者  
[58] WenBing Jin, Sheng Wu, XiaoHong Jian, Hua Yuan, GongLi Tang. A radical S-adenosyl-L-methionine enzyme and a methyltransferase catalyze cyclopropane formation in natural product biosynthesis. NATURE COMMUNICATIONS[J]. 2018, 第 5 作者  通讯作者  9(1): https://doaj.org/article/363ff5321e1e41c99aac34d9167b5d26.
[59] Hou, XianFeng, Song, YuJiao, Zhang, Mei, Lan, Wenxian, Meng, Song, Wang, Chunxi, Pan, HaiXue, Cao, Chunyang, Tang, GongLi. Enzymology of Anthraquinone-gamma-Pyrone Ring Formation in Complex Aromatic Polyketide Biosynthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 第 9 作者  通讯作者  57(41): 13475-13479, https://www.webofscience.com/wos/woscc/full-record/WOS:000446306600015.
[60] Zhou Hongyang, Luo Guangcai, Zhang Zhuan, Zhou Qiang, Zhai Xin, Tang GongLi. Cooperation of Two Biosynthetic Gene Clusters in the Biosynthesis of New Anthracycline Polyketide. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 第 6 作者  通讯作者  37(12): 3262-3266, https://www.webofscience.com/wos/woscc/full-record/WOS:000424747900024.
[61] He, Nisha, Wu, Pan, Lei, Yongxing, Xu, Baofu, Zhu, Xiaochen, Xu, Gudan, Gao, Yaojie, Qi, Jianzhao, Deng, Zixin, Tang, Gongli, Chen, Wenqing, Xiao, Youli. Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics. CHEMICAL SCIENCE[J]. 2017, 第 10 作者8(1): 444-451, https://www.webofscience.com/wos/woscc/full-record/WOS:000391454500051.
[62] Zhang, Zhuan, Gong, YuKang, Zhou, Qiang, Hu, Yu, Ma, HongMin, Chen, YongSheng, Igarashi, Yasuhiro, Pan, Lifeng, Tang, GongLi. Hydroxyl regioisomerization of anthracycline catalyzed by a four-enzyme cascade. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 第 9 作者  通讯作者  114(7): 1554-1559, http://dx.doi.org/10.1073/pnas.1610097114.
[63] Wu, Sheng, Jiang, XiaoHong, Yuan, Hua, Jin, WenBing, Yin, Yue, Wang, LingYun, Zhao, Juan, Tang, GongLi. Unified Biosynthetic Origin of the Benzodipyrrole Subunits in CC-1065. ACS CHEMICAL BIOLOGY[J]. 2017, 第 8 作者  通讯作者  12(6): 1603-1610, https://www.webofscience.com/wos/woscc/full-record/WOS:000403854000021.
[64] Zhou, Hongyang, Luo, Guangcai, Zhang, Zhuan, Zhou, Qiang, Zhai, Xin, Tang, GongLi. Cooperation of Two Biosynthetic Gene Clusters in the Biosynthesis of New Anthracycline Polyketide. CHINESEJOURNALOFORGANICCHEMISTRY[J]. 2017, 第 6 作者  通讯作者  37(12): 3262-3266, http://dx.doi.org/10.6023/cjoc201708007.
[65] Song, LiQiang, Zhang, YingYing, Pu, JinYue, Tang, ManCheng, Peng, Chao, Tang, GongLi. Catalysis of Extracellular Deamination by a FAD-Linked Oxidoreductase after Prodrug Maturation in the Biosynthesis of Saframycin A. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 第 6 作者  通讯作者  56(31): 9116-9120, https://www.webofscience.com/wos/woscc/full-record/WOS:000424260200032.
[66] 唐功利. A FAD-linked oxidoreductase enables an extracellular deamination after saframycin A maturation.. Angew. Chem. Int. Ed.. 2017, 第 1 作者  通讯作者  
[67] Zhuan Zhang, HaiXue Pan, GongLi Tang. New insights into bacterial type II polyketide biosynthesis. F1000RESEARCH. 2017, 第 3 作者6: http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=15&recid=&FileName=SJRX9AE4E4C38426AD5B6278B5E314C9421F&DbName=WWMERGEJLAST&DbCode=WWME&yx=&pr=&URLID=&bsm=.
[68] Yuan, Hua, Zhang, Jinru, Cai, Yujuan, Wu, Sheng, Yang, Kui, Chan, H C Stephen, Huang, Wei, Jin, WenBing, Li, Yan, Yin, Yue, Igarashi, Yasuhiro, Yuan, Shuguang, Zhou, Jiahai, Tang, GongLi. Gyrl-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. NATURE COMMUNICATIONS[J]. 2017, 第 14 作者  通讯作者  8: http://dx.doi.org/10.1038/s41467-017-01508-1.
[69] Hua Yuan, Jinru Zhang, Yujuan Cai, Sheng Wu, Kui Yang, H C Stephen Chan, Wei Huang, WenBing Jin, Yan Li, Yue Yin, Yasuhiro Igarashi, Shuguang Yuan, Jiahai Zhou, GongLi Tang. GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. NATURE COMMUNICATIONS[J]. 2017, 第 14 作者8(1): 1-8, https://doaj.org/article/266a1355c538408382157a4388d51a1c.
[70] Wu, LongFei, Meng, Song, Tang, GongLi. Ferrous iron and alpha-ketoglutarate-dependent dioxygenases in the biosynthesis of microbial natural products. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. 2016, 第 3 作者  通讯作者  1864(5): 453-470, https://www.webofscience.com/wos/woscc/full-record/WOS:000373538300004.
[71] Kang, WenJia, Wu, Sheng, Hua, Huiming, Pan, HaiXue, Tang, GongLi. Discovery of a New Pyrazinone Natural Product by Genome Mining. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2016, 第 5 作者36(7): 1696-1699, http://dx.doi.org/10.6023/cjoc201602016.
[72] Huang, Yong, Yang, Dong, Pan, Guohui, Tang, GongLi, Shen, Ben. Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2016, 第 4 作者100(24): 10555-10562, http://dx.doi.org/10.1007/s00253-016-7864-2.
[73] Tang, GongLi, Tang, ManCheng, Song, LiQiang, Zhang, Yue. Biosynthesis of Tetrahydroisoquinoline Antibiotics. CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2016, 第 1 作者  通讯作者  16(15): 1717-1726, http://dx.doi.org/10.2174/1568026616666151012112329.
[74] Wu LongFei, Meng Song, Tang GongLi. Ferrous iron and α-ketoglutarate-dependent dioxygenases in the biosynthesis of microbial natural products. BBA - PROTEINS AND PROTEOMICS[J]. 2016, 第 3 作者1864(5): 453-470, http://dx.doi.org/10.1016/j.bbapap.2016.01.012.
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[76] Huang, Yong, Tang, GongLi, Pan, Guohui, Chang, ChinYuan, Shen, Ben. Characterization of the Ketosynthase and Acyl Carrier Protein Domains at the LnmI Nonribosomal Peptide Synthetase-Polyketide Synthase Interface for Leinamycin Biosynthesis. ORGANIC LETTERS[J]. 2016, 第 2 作者18(17): 4288-4291, https://www.webofscience.com/wos/woscc/full-record/WOS:000382711200036.
[77] Yang, Kui, Qi, LiHua, Zhang, Mei, Hou, XianFeng, Pan, HaiXue, Tang, GongLi, Wang, Wei, Yuan, Hua. The SARP Family Regulator Txn9 and Two-Component Response Regulator Txn11 are Key Activators for Trioxacarcin Biosynthesis in Streptomyces bottropensis. CURRENT MICROBIOLOGY[J]. 2015, 第 6 作者71(4): 458-464, http://dx.doi.org/10.1007/s00284-015-0868-9.
[78] Zhang, Mei, Hou, XianFeng, Qi, LiHua, Yin, Yue, Li, Qing, Pan, HaiXue, Chen, XinYa, Tang, GongLi. Biosynthesis of trioxacarcin revealing a different starter unit and complex tailoring steps for type II polyketide synthase. CHEMICAL SCIENCE[J]. 2015, 第 8 作者  通讯作者  6(6): 3440-3447, https://www.webofscience.com/wos/woscc/full-record/WOS:000354815600022.
[79] 潘海学, 袁华, 蹇晓红, 唐功利. 天然产物生物合成与抗肿瘤药物合成生物学研究. 中国科学（生命科学）[J]. 2015, 第 4 作者45(10): 1027-1039, https://d.wanfangdata.com.cn/periodical/zgkx-cc201510014.
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[82] Wu, LongFei, He, HaiYan, Pan, HaiXue, Han, Li, Wang, Renxiao, Tang, GongLi. Characterization of QmnD3/QmnD4 for Double Bond Formation in Quartromicin Biosynthesis. ORGANIC LETTERS[J]. 2014, 第 6 作者  通讯作者  16(6): 1578-1581, https://www.webofscience.com/wos/woscc/full-record/WOS:000333477400011.
[83] 邱海波, 陈新雅, 李晴, 钱文建, 于顺明, 唐功利, 姚祝军. Unified flexible total synthesis of chlorofusin and artificial Click mimics as antagonists against p53-HDM2 interactions. TETRAHEDRON LETT.[J]. 2014, 第 6 作者55(44): 6055-6059, http://ir.sioc.ac.cn/handle/331003/38958.
[84] Qi, LiHua, Zhang, Mei, Pan, HaiXue, Chen, XiaoDong, Tang, GongLi. Production of a Trioxacarcin Analogue by Engineering of Its Biosynthetic Pathway. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 第 5 作者34(7): 1376-1381, http://dx.doi.org/10.6023/cjoc201403032.
[85] Wang Jianbo, Zhang Feng, Pu Jinyue, Zhao Juan, Zhao Qunfei, Tang Gongli. Characterization of AvaR1, an autoregulator receptor that negatively controls avermectins production in a high avermectin-producing strain. BIOTECHNOL. LETT.[J]. 2014, 第 6 作者36(4): 813-819, http://ir.sioc.ac.cn/handle/331003/38936.
[86] He, HaiYan, Yuan, Hua, Tang, ManCheng, Tang, GongLi. An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing alpha-Ketone in Polyketide Starter Unit Biosynthesis. ANGEWANDTECHEMIEINTERNATIONALEDITION[J]. 2014, 第 4 作者  通讯作者  53(42): 11315-11319, https://www.webofscience.com/wos/woscc/full-record/WOS:000343751100038.
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[88] 贺海燕, 袁华, 唐满成, 唐功利. An Unusual Dehydratase Acting on Glycerate and a Ketoreducatse Stereoselectively Reducing alpha-Ketone in Polyketide Starter Unit Biosynthesis. ANGEW. CHEM.-INT. EDIT.[J]. 2014, 第 4 作者53(42): 11315-11319, http://ir.sioc.ac.cn/handle/331003/38960.
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[91] He, HaiYan, Tang, ManCheng, Zhang, Feng, Tang, GongLi. Cis-Double Bond Formation by Thioesterase and Transfer by Ketosynthase in FR901464 Biosynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2014, 第 4 作者  通讯作者  136(12): 4488-4491, https://www.webofscience.com/wos/woscc/full-record/WOS:000333551800011.
[92] Qi, LiHua, Zhang, Mei, Pan, HaiXue, Chen, XiaoDong, Tang, GongLi. Production of a Trioxacarcin Analogue by Engineering of Its Biosynthetic Pathway. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 第 5 作者34(7): 1376-1381, https://www.webofscience.com/wos/woscc/full-record/WOS:000340703200013.
[93] Pan Haixue, Chen Zhouzhou, Li Jian, Zhu Chunbao, Tang Gongli, Chen Daijie. Production of ramoplanin analogues by genetic engineering of Actinoplanes sp.. BIOTECHNOL. LETT.[J]. 2013, 第 5 作者35(10): 1685-1692, http://www.irgrid.ac.cn/handle/1471x/870634.
[94] Pan Haixue, Li Jian, Shao Lei, Zhu Chunbao, Tang Gongli, Chen Daijie. Genetic manipulation revealing an unusual N-terminal region in a stand-alone non-ribosomal peptide synthetase involved in the biosynthesis of ramoplanins. BIOTECHNOL. LETT.[J]. 2013, 第 5 作者35(1): 107-114, http://www.irgrid.ac.cn/handle/1471x/870690.
[95] Li Jine, GUO ZHENGYAN, HUANG WEI, MENG XIANGXI, AI GUOMIN, Tang Gongli, Chen Yihua. Mining of a streptothricin gene cluster from Streptomyces sp TP-A0356 genome via heterologous expression. SCI. CHINA-LIFE SCI.[J]. 2013, 第 6 作者56(7): 619-627, http://www.irgrid.ac.cn/handle/1471x/870665.
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[102] 唐功利. Unprecedented hybrid system for construction of pyrrolopyrrole moiety in kosinostatin biosynthesis.. Chem Biology. 2013, 第 1 作者  通讯作者  
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[112] Li JinE, Guo ZhengYan, Huang Wei, Meng XiangXi, Ai GuoMin, Tang GongLi, Chen YiHua. Mining of a streptothricin gene cluster from Streptomyces sp TP-A0356 genome via heterologous expression. SCIENCE CHINA-LIFE SCIENCES[J]. 2013, 第 6 作者  通讯作者  56(7): 619-627, http://dx.doi.org/10.1007/s11427-013-4504-2.
[113] 唐功利. Self-resistance to antitumor antibiotic: a DNA glycosylase triggers the base excision repair system in yatakemycin biosynthesis.. 2012, 第 1 作者  通讯作者  
[114] 唐满成, 唐功利. 抗肿瘤活性四氢异喹啉抗生素的生物合成研究进展. 有机化学[J]. 2012, 第 2 作者32(9): 1568-1576, http://ir.sioc.ac.cn/handle/331003/28569.
[115] He Haiyan, Pan Haixue, Wu Longfei, Zhang Beibei, Chai Hanbo, Liu Wen, Tang Gongli. Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line. CHEM. BIOL.[J]. 2012, 第 7 作者19(10): 1313-1323, http://dx.doi.org/10.1016/j.chembiol.2012.07.024.
[116] Jian, XiaoHong, Pan, HaiXue, Nin, TingTing, Shi, YuanYuan, Chen, YongSheng, Li, Yan, Zeng, XiaoWei, Xu, Jian, Tang, GongLi. Analysis of YM-216391 Biosynthetic Gene Cluster and Improvement of the Cyclopeptide Production in a Heterologous Host. ACS CHEMICAL BIOLOGY[J]. 2012, 第 9 作者  通讯作者  7(4): 646-651, http://www.irgrid.ac.cn/handle/1471x/681928.
[117] Huang, Wei, Xu, Hui, Li, Yan, Zhang, Feng, Chen, XinYa, He, QingLi, Igarashi, Yasuhiro, Tang, GongLi. Characterization of Yatakemycin Gene Cluster Revealing a Radical S-Adenosylmethionine Dependent Methyltransferase and Highlighting Spirocyclopropane Biosynthesis. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2012, 第 8 作者  通讯作者  134(21): 8831-8840, http://www.irgrid.ac.cn/handle/1471x/681921.
[118] Tang, ManCheng, Tang, GongLi. Biosynthetic Progress of the Tetrahydroisoquinoline Antitumor Antibiotics. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2012, 第 2 作者32(9): 1568-1576, http://dx.doi.org/10.6023/cjoc201207006.
[119] Peng, Chao, Pu, JinYue, Song, LiQiang, Jian, XiaoHong, Tang, ManCheng, Tang, GongLi. Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly line. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2012, 第 6 作者  通讯作者  109(22): 8540-8545, https://www.webofscience.com/wos/woscc/full-record/WOS:000304881700042.
[120] Peng Chao, Tang YuMin, Li Lei, Ding Wei, Deng Wei, Pu JinYue, Liu Wen, Tang GongLi. In vivo investigation of the role of SfmO2 in saframycin A biosynthesis by structural characterization of the analogue saframycin O. SCIENCE CHINA-CHEMISTRY[J]. 2012, 第 8 作者  通讯作者  55(1): 90-97, http://lib.cqvip.com/Qikan/Article/Detail?id=40705761.
[121] Tang Mancheng, Fu Chengyu, Tang Gongli. Characterization of SfmD as a Heme Peroxidase That Catalyzes the Regioselective Hydroxylation of 3-Methyltyrosine to 3-Hydroxy-5-methyltyrosine in Saframycin A Biosynthesis. J. BIOL. CHEM.[J]. 2012, 第 3 作者287(7): 5112-5121, http://dx.doi.org/10.1074/jbc.M111.306316.
[122] 彭超, 蒲津越, 宋立强, 蹇晓红, 唐满成, 唐功利. Hijacking a hydroxyethyl unit from a central metabolic ketose into a nonribosomal peptide assembly line AMERICA. PROC. NATL. ACAD. SCI. U. S. A.[J]. 2012, 第 6 作者109(22): 8540-8545, http://ir.sioc.ac.cn/handle/331003/28525.
[123] Peng Chao, Tang Yumin, Li Lei, Ding Wei, Deng Wei, Pu Jinyue, Liu Wen, Tang Gongli. In vivo investigation of the role of SfmO2 in saframycin A biosynthesis by structural characterization of the analogue saframycin O. SCI. CHINA-CHEM.[J]. 2012, 第 8 作者55(1): 90-97, http://lib.cqvip.com/Qikan/Article/Detail?id=40705761.
[124] Tang ManCheng, Tang GongLi. Biosynthetic Progress of the Tetrahydroisoquinoline Antitumor Antibiotics. CHINESE JOURNAL OF ORGANIC CHEMISTRY[J]. 2012, 第 2 作者32(9): 1568-1576, http://ir.sioc.ac.cn/handle/331003/28569.
[125] He, HaiYan, Pan, HaiXue, Wu, LongFei, Zhang, BeiBei, Chai, HanBo, Liu, Wen, Tang, GongLi. Quartromicin Biosynthesis: Two Alternative Polyketide Chains Produced by One Polyketide Synthase Assembly Line. CHEMISTRY & BIOLOGY[J]. 2012, 第 7 作者  通讯作者  19(10): 1313-1323, http://dx.doi.org/10.1016/j.chembiol.2012.07.024.
[126] Chen, YunLiang, Zhao, Juan, Liu, Wei, Gao, JuFang, Tao, LiMing, Pan, HaiXue, Tang, GongLi. Identification of phoslactomycin biosynthetic gene clusters from Streptomyces platensis SAM-0654 and characterization of PnR1 and PnR2 as positive transcriptional regulators. GENE[J]. 2012, 第 7 作者509(2): 195-200, http://dx.doi.org/10.1016/j.gene.2012.08.030.
[127] Tang, ManCheng, Fu, ChengYu, Tang, GongLi. Characterization of SfmD as a Heme Peroxidase That Catalyzes the Regioselective Hydroxylation of 3-Methyltyrosine to 3-Hydroxy-5-methyltyrosine in Saframycin A Biosynthesis. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2012, 第 3 作者  通讯作者  287(7): 5112-5121, http://dx.doi.org/10.1074/jbc.M111.306316.
[128] Wang, JianBo, Pan, HaiXue, Tang, GongLi. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2011, 第 3 作者  通讯作者  21(11): 3320-3323, http://dx.doi.org/10.1016/j.bmcl.2011.04.008.
[129] Wang Jianbo, Pan Haixue, Tang Gongli. Production of doramectin by rational engineering of the avermectin biosynthetic pathway. BIOORG. MED. CHEM. LETT.[J]. 2011, 第 3 作者21(11): 3320-3323, http://dx.doi.org/10.1016/j.bmcl.2011.04.008.
[130] 黄伟, 王健博, 唐功利. 天然产物类药物的合成生物学研究. 生命科学[J]. 2011, 第 3 作者23(9): 891-899, http://ir.sioc.ac.cn/handle/331003/28483.
[131] Zhang, Feng, He, HaiYan, Tang, ManCheng, Tang, YuMin, Zhou, Qiang, Tang, GongLi. Cloning and Elucidation of the FR901464 Gene Cluster Revealing a Complex Acyltransferase-less Polyketide Synthase Using Glycerate as Starter Units. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2011, 第 6 作者  通讯作者  133(8): 2452-2462, http://www.irgrid.ac.cn/handle/1471x/681894.
[132] 黄伟, 王健博, 唐功利. 天然产物类药物的合成生物学研究. 生命科学[J]. 2011, 第 3 作者23(9): 891-899, http://ir.sioc.ac.cn/handle/331003/28483.
[133] Qu, Xudong, Jiang, Nan, Xu, Fei, Shao, Lei, Tang, Gongli, Wilkinson, Barrie, Liu, Wen. Cloning, sequencing and characterization of the biosynthetic gene cluster of sanglifehrin A, a potent cyclophilin inhibitor. MOLECULAR BIOSYSTEMS[J]. 2011, 第 5 作者7(3): 852-861, http://www.irgrid.ac.cn/handle/1471x/681895.
[134] Ding, Wei, Deng, Wei, Tang, Mancheng, Zhang, Qi, Tang, Gongli, Bi, Yurong, Liu, Wen. Biosynthesis of 3-methoxy-5-methyl naphthoic acid and its incorporation into the antitumor antibiotic azinomycin B. MOLECULAR BIOSYSTEMS[J]. 2010, 第 5 作者6(6): 1071-1081, http://dx.doi.org/10.1039/b926358f.
[135] Fu ChengYu, Tang, ManCheng, Peng, Chao, Li, Lei, He, YanLing, Liu, Wen, Tang, GongLi. Biosynthesis of 3-Hydroxy-5-Methyl-O-Methyltyrosine in the Saframycin/Safracin Biosynthetic Pathway. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2009, 第 7 作者  通讯作者  19(5): 439-446, http://www.irgrid.ac.cn/handle/1471x/681885.
[136] He, QingLi, Jia, XinYing, Tang, ManCheng, Tian, ZhenHua, Tang, GongLi, Liu, Wen. Dissection of Two Acyl-Transfer Reactions Centered on Acyl-S-Carrier Protein Intermediates for Incorporating 5-Chloro-6-methyl-O-methylsalicyclic Acid into Chlorothricin. CHEMBIOCHEM[J]. 2009, 第 5 作者  通讯作者  10(5): 813-819, http://dx.doi.org/10.1002/cbic.200800714.
[137] FU CHENGYU, Tang Mancheng, Peng Chao, Li Lei, HE YANLING, Liu Wen, Tang Gongli. Biosynthesis of 3-Hydroxy-5-Methyl-O-Methyltyrosine in the Saframycin/Safracin Biosynthetic Pathway. J. MICROBIOL. BIOTECHNOL.[J]. 2009, 第 7 作者19(5): 439-446, http://www.irgrid.ac.cn/handle/1471x/681885.
[138] 唐功利. 天然产物的代谢工程与菌种改良. 上海化工[J]. 2009, 第 1 作者16-22, http://lib.cqvip.com/Qikan/Article/Detail?id=31862106.
[139] 宁婷婷, 唐功利, 陶黎明. 两种外源二型硫酯酶TEII对链霉菌NRRL8165产生阿维菌素的影响. 农药学学报[J]. 2009, 第 2 作者11(3): 323-328, http://lib.cqvip.com/Qikan/Article/Detail?id=31852283.
[140] 陶黎明, 宁婷婷, 唐功利. 两种外源二型硫酯酶TEⅡ链霉菌NRRL8165产生阿维菌素的影响. 农药学学报[J]. 2009, 第 3 作者11(3): 323-328,  http://dx.doi.org/10.3969/j.issn.1008-7303.2009.03.007.
[141] Yu, Yi, Duan, Lian, Zhang, Qi, Liao, Rijing, Ding, Ying, Pan, Haixue, WendtPienkowski, Evelyn, Tang, Gongli, Shen, Ben, Liu, Wen. Nosiheptide Biosynthesis Featuring a Unique Indole Side Ring Formation on the Characteristic Thiopeptide Framework. ACS CHEMICAL BIOLOGY[J]. 2009, 第 8 作者4(10): 855-864, http://dx.doi.org/10.1021/cb900133x.
[142] Wen Liu. Characterization of the saframycin A gene cluster from Streptomyces lavendulae NRRL 11002 revealing a NRPS system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. J. Bacteriol.. 2008, 
[143] Zhao, Qunfei, He, Qingli, Ding, Wei, Tang, Mancheng, Kang, Qianjin, Yu, Yi, Deng, Wei, Zhang, Qi, Fang, Jie, Tang, Gongli, Liu, Wen. Characterization of the azinomycin B biosynthetic gene cluster revealing a different iterative type I polyketide synthase for naphthoate biosynthesis. CHEMISTRY & BIOLOGY[J]. 2008, 第 10 作者15(7): 693-705, http://dx.doi.org/10.1016/j.chembiol.2008.05.021.
[144] He, QingLi, Jiang, Hui, Zhang, Feng, Chen, HaiBao, Tang, GongLi. Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloning. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2008, 第 5 作者  通讯作者  18(14): 3995-3998, http://dx.doi.org/10.1016/j.bmcl.2008.06.006.
[145] He Qingli, Jiang Hui, Zhang Feng, Chen Haibao, Tang Gongli. Simultaneous identification of multiple receptors of natural product using an optimized cDNA phage display cloning. BIOORG. MED. CHEM. LETT.[J]. 2008, 第 5 作者18(14): 3995-3998, http://dx.doi.org/10.1016/j.bmcl.2008.06.006.
[146] Li, Lei, Deng, Wei, Song, Jie, Ding, Wei, Zhao, QunFei, Peng, Chao, Song, WeiWen, Tang, GongLi, Liu, Wen. Characterization of the saframycin a gene cluster from Streptomyces lavendulae NRRL 11002 revealing a nonribosomal peptide synthetase system for assembling the unusual tetrapeptidyl skeleton in an iterative manner. JOURNAL OF BACTERIOLOGY[J]. 2008, 第 8 作者  通讯作者  190(1): 251-263, http://www.irgrid.ac.cn/handle/1471x/670683.
[147] Fang, Jie, Zhang, Yiping, Huang, Lijuan, Jia, Xinying, Zhang, Qi, Zhang, Xu, Tang, Gongli, Liu, Wen. Cloning and characterization of the tetrocarcin a gene cluster from Micromonospora chalcea NRRL 11289 reveals a highly conserved strategy for tetronate biosynthesis in spirotetronate antibiotics. JOURNAL OF BACTERIOLOGY[J]. 2008, 第 7 作者190(17): 6014-6025, http://dx.doi.org/10.1128/JB.00533-08.
[148] 唐功利. Chain initiation in the leinamycin-producing hybrid nonribosomal peptide/polyketide synthetase from Streptomyces atroolivaceus S-140.. J. Biol. Chem.. 2007, 第 1 作者
[149] Tang, GL, Cheng, YQ, Shen, B. Polyketide chain skipping mechanism in the biosynthesis of the hybrid nonribosomal peptide-polyketide antitumor antibiotic leinamycin in Streptomyces atroolivaceus S-140. JOURNAL OF NATURAL PRODUCTS[J]. 2006, 69(3): 387-393, https://www.webofscience.com/wos/woscc/full-record/WOS:000236497400018.
[150] 邵雷, 瞿旭东, 贾新颖, 赵群飞, 田振华, 王闵, 唐功利, 刘文. Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase 6-methylsalicyclic acid; biosynthesis. BIOCHEM. BIOPHYS. RES. COMMUN.[J]. 2006, 第 7 作者345(1): 133-139, http://ir.sioc.ac.cn/handle/331003/27641.
[151] 唐功利. Characterization of the Chlorothricin Biosynthetic Gene Cluster as a model for Spirotetronate Antibiotic Biosynthesis.. Chem. Biol.. 2006, 第 1 作者  通讯作者  
[152] Shao, Lei, Qu, XuDong, Jia, XinYing, Zhao, QunFei, Tian, ZhenHua, Wang, Min, Tang, GongLi, Liu, Wen. Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2006, 第 7 作者  通讯作者  345(1): 133-139, https://www.webofscience.com/wos/woscc/full-record/WOS:000237877700019.
[153] 刘文, 唐功利. 以生物合成为基础的代谢工程和组合生物合成. 中国生物工程杂志[J]. 2005, 第 2 作者25(1): 1-5, https://manu60.magtech.com.cn/biotech/CN/Y2005/V25/I01/1.
[154] 唐功利. The biosynthetic gene cluster of the antitumor antibiotic leinamycin from streptomycus atroolivaceus S-140 revealing unprecedented architectural complexity for a hybrid non-ribosomal peptide and polyketide synthetase.. Chm. Biol.. 2004, 第 1 作者
[155] Cheng, YQ, Tang, GL, Shen, B. Type I polyketide synthase requiring a discrete acyltransferase for polyketide biosynthesis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2003, 100(6): 3149-3154, https://www.webofscience.com/wos/woscc/full-record/WOS:000181675200033.
[156] 陈海宝, 唐功利. 基因工程制备菠菜叶绿体三糖磷酸酯异构化酶. 科技开发动态[J]. 2001, 第 2 作者38-38, http://lib.cqvip.com/Qikan/Article/Detail?id=10123370.
[157] 唐功利, 杨春松, 鲍建绍, 王燕芳, 陈海宝. 丙糖磷酸异构酶、果糖-1，6-二磷酸醛缩酶及果糖-1，6-二磷酸酶的共表达、. 生物化学与生物物理学报[J]. 2001, 第 1 作者33(1): 131-136, http://ir.sioc.ac.cn/handle/331003/25745.
[158] 唐功利, 王燕芳, 鲍建绍, 陈海宝. Two-cistron system overexpression of chloroplastglyceraldehyde-3-phosphate dehydrogenase subunit B and B-derivatives from spinach in escherichia coli. PROTEIN EXPR. PURIF.[J]. 2001, 第 1 作者22(1): 31-37, http://ir.sioc.ac.cn/handle/331003/25747.
[159] 陈海宝, 唐功利. 代谢工程研究进展. 有机化学[J]. 2000, 第 2 作者20(5): 634-640, http://ir.sioc.ac.cn/handle/331003/25737.
[160] 唐功利, 麻锦彪, 吴厚铭, 陈海宝. 生物活性小分子与靶点相互作用研究中的新方法和新技术. 科学通报[J]. 2000, 第 1 作者45(13): 1345-1357, http://ir.sioc.ac.cn/handle/331003/17255.
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[163] 唐功利, 王燕芳, 鲍建绍, 陈海宝. Overexpression in escherichia coli and characterization of the chloroplast fructose-1,6-bisphosphatase from wheat.. PROTEIN EXPR. PURIF.[J]. 2000, 第 1 作者19(3): 411-418, http://ir.sioc.ac.cn/handle/331003/25739.

   

（ 1 ） 两类高活性抗肿瘤天然产物靶蛋白的筛选及作用机制研究, 主持, 国家级, 2010-01--2012-12
（ 2 ） 复杂天然产物中Diels-Alder酶催化反应研究, 主持, 国家级, 2011-01--2013-12
（ 3 ） 农业生防微生物制剂的合成与作用机理及定向改造, 参与, 国家级, 2009-01--2013-12
（ 4 ） 具有重要生物活性的天然产物的化学合成, 参与, 国家级, 2010-01--2014-12
（ 5 ） 链霉菌源四氢异喹啉生物碱的生物合成与抗癌新药合成生物学研究, 主持, 国家级, 2014-01--2018-12
（ 6 ） 越野他汀生物合成与抗肿瘤蒽环抗生素组合生物合成研究, 主持, 国家级, 2014-01--2017-12
（ 7 ） 抗肿瘤多环天然产物的生物合成与调控研究, 参与, 国家级, 2017-01--2021-12
（ 8 ） 两类特殊大环天然产物的生物合成、途径再造与分子创新, 主持, 国家级, 2018-01--2020-12

已指导学生

瞿旭东  博士研究生  070303-有机化学  

贺庆利  博士研究生  070303-有机化学  

田振华  博士研究生  070303-有机化学  

马宏敏  博士研究生  070303-有机化学  

唐满成  博士研究生  070303-有机化学  

彭超  博士研究生  070303-有机化学  

黄伟  博士研究生  070303-有机化学  

王健博  博士研究生  070303-有机化学  

李玮涛  博士研究生  070303-有机化学  

蒲津越  博士研究生  070303-有机化学  

贺海燕  博士研究生  070303-有机化学  

张转  博士研究生  070303-有机化学  

宋立强  博士研究生  070303-有机化学  

张媚  博士研究生  070303-有机化学  

张玥  博士研究生  070303-有机化学  

殷乐  博士研究生  070303-有机化学  

吴龙飞  博士研究生  070303-有机化学  

季珍瑜  博士研究生  070303-有机化学  

裴增飞  博士研究生  070303-有机化学  

孟松  博士研究生  070303-有机化学  

现指导学生

董超  硕士研究生  0703Z1-化学生物学  

章盈盈  博士研究生  070303-有机化学  

胡煜  博士研究生  0703Z1-化学生物学  

杨敏杰  博士研究生  0703Z1-化学生物学  

刘正涛  硕士研究生  085238-生物工程  

温万红  博士研究生  070303-有机化学  

金文兵  博士研究生  0703Z1-化学生物学  

邵宁  硕士研究生  070303-有机化学  

徐一帆  硕士研究生  070303-有机化学  

张凯  硕士研究生  085238-生物工程  

聂秋玥  博士研究生  0703Z1-化学生物学