General

宋冰  男  博导  中国科学院深圳先进技术研究院
电子邮件： bing.song@siat.ac.cn
通信地址： 广东省深圳市南山区西丽大学城学苑大道1068号
邮政编码： 518055


Education

July 1995, M.D., China Medical University, Shenyang, China.

July 1998, M.Sc., Department of Ophthalmology, China Medical University, Shenyang, China.

August 2004,Ph.D., School of Medical Sciences, University of Aberdeen, UK.


Experience

   
Work Experience

07/2019 – date      Professor of Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences

08/2017 – date      Vice Dean, School of Dentistry, Cardiff University, UK.

10/2009 – date      Professor of Regenerative Dentistry, School of Dentistry, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, UK.

10/2005 – date      Royal Society University Research Fellow, The Royal Society, UK.

10/2007 – 09/2009    Senior Lecturer, University of Aberdeen, UK.

03/2009 – 08/2009    Visiting faculty, University of California, Davis, USA.

10/2005 – 10/2010    Clinical specialist registrar, Aberdeen Royal Infirmary, NHS Grampian, UK.

12/2004 – 01/2005    Visiting faculty, Peter Devreotes lab, Department of Cell Biology,Johns Hopkins University, USA.

03/2003 – 06/2003    Visiting research fellow, Josef Penninger lab, University of Toronto, Canada.

04/1999 – 09/2005    Postdoc research fellow, Department of Biomedical Sciences, University of Aberdeen, UK.

01/1997 – 03/1999    Visiting Research Scholar, Hamamatsu University School of Medicine, Japan.


Publications

   
Papers


  1. Hu Y,      Zhang T, Chen J, Cheng W, Chen J, Zheng Z, Lin J, Zhu G, Zhang Y, Bai X,      Wang Y, Song B, Wang Q, Qin L,      Zhang P (2020). Downregulation of hypoxia-inducible factor-1α by RNA      interference alleviates the development of collagen-induced arthritis in      rats. Molecular Therapy - Nucleic Acids. 19: 1330-1342. Doi:      10.1016/j.omtn.2020.01.014
  2. Liu P,      Kong L, Liang K, Wu Y, Jin H, Song      B, Tan X (2020). Identification of dissociation factors in pancreatic      Cancer using a mass spectrometry-based proteomic approach. BMC      Cancer 20:1. Doi: 10.1186/s12885-020-6522-3
  3. Cheng      WX, Huang H, Chen JH, Zhang TT, Zhu GY, Zheng ZT, Lin JT, Hu YP, Zhang Y,      Bai XL, Wang Y, Xu ZW, Song B,      Mao YY, Yang F, Zhang P (2019). Genistein inhibits      angiogenesis developed during rheumatoid arthritis through the      IL-6/JAK2/STAT3/VEGF signalling pathway. J Orthop Translat. https://doi.org/10.1016/j.jot.2019.07.007.
  4. Liu XM, Liu Y, Yu S, Lei S, Song B, Chen X (2019). Potential immunomodulatory effects of SCAP on Treg conversion in tissue regeneration for regenerative endodontic treatment. Int Endod J. https://doi.org/10.1111/iej.13197.
  5. Jiang W, Wang D, Alraies A, Liu Q, Zhu B, Sloan AJ, Ni L, Song B* (2019). Wnt-GSK3ß/ß-catenin regulates the differentiation of dental pulp stem cells into bladder smooth muscle cells. Stem Cells Int. 2019:8907570. doi: 10.1155/2019/8907570.
  6. Ferguson E, Naseer S, Powell L, Hardwicke J, Young F, Zhu B, Liu Q, Song B, Thomas D (2018). Controlled release of dextrin-conjugated growth factors to support growth and differentiation of neural stem cells. Stem Cell Res. Pub Date : 2018-10-06 , DOI: 10.1016/j.scr.2018.10.008 
  7. Li Y, Gu Y, Wang H, Liu Z, Song B*, Yin T* (2018). Electric pulses can influence galvanotaxis of Dictyostelium discoideum. BioMed Research International. Volume 2018, Article ID 2534625, https://doi.org/10.1155/2018/2534625

  1. Qiao S, Liu Y, Han F, Guo M, Hou X, Ye K, Deng S, Shen Y, Zhao Y, Wei H, Song B, Yao L, Tian W (2018). An intelligent      neural stem cell delivery system for neurodegenerative diseases treatment.      Adv      Healthc Mater. 2018 May 2:e1800080. doi: 10.1002/adhm.201800080.
  2. Liang X, Li X, Duan J, Chen Y, Wang X, Pang L, Kong      D, Song B, Li C, Yang J (2018). Nanoparticles      with CD44 Targeting and ROS Triggering Properties as Effective in Vivo      Antigen Delivery System. Mol Pharm. 2018 Feb      5;15(2):508-518. doi: 10.1021/acs.molpharmaceut.7b00890. Epub 2018 Jan 25.
  3. Hidalgo      San Jose L, Stephens P, Song B, Barrow D (2018). Microfluidic      Encapsulation Supports Stem Cell Viability, Proliferation, and Neuronal      Differentiation.Tissue Eng Part C Methods. 2018      Feb 1. doi: 10.1089/ten.TEC.2017.0368.
  4. Li      M, Ma L, Song B, Yu D, Xiao M, Mei X, Guo H, Yu Q (2018). Cdc42 is      essential for the polarized movement and adhesion of human dental pulp      stem cells. Arch Oral Biol. 2018      Jan;85:104-112. doi: 10.1016/j.archoralbio.2017.09.036.
  5. Mu      XP, Wang HB, Cheng X, Yang L, Sun XY, Qu HL, Zhao SS, Zhou ZK, Liu TT,      Xiao T, Song B, Jolkkonen J, Zhao CS (2017). Inhibition of      Nkcc1 promotes axonal growth and motor recovery in ischemic rats.      Neuroscience. 2017 Dec      4;365:83-93. doi: 10.1016/j.neuroscience.2017.09.036. Epub 2017 Sep 28.
  6. Liu      X, Jiang H, Chen J, Zhou Y, Huang Z, Song B (2017). Gadoxetic      acid disodium-enhanced magnetic resonance imaging outperformed      multidetector computed tomography in diagnosing small hepatocellular      carcinoma: A meta-analysis. Liver Transpl. 2017      Dec;23(12):1505-1518. doi: 10.1002/lt.24867.
  7. An      Q, Sun M, Qi RQ, Zhang L, Zhai JL, Hong YX, Song B, Chen HD, Gao XH      (2017). High Staphylococcus      epidermidis Colonization and Impaired Permeability Barrier in Facial      Seborrheic Dermatitis. Chin Med J (Engl). 2017 Jul      20;130(14):1662-1669. doi: 10.4103/0366-6999.209895.
  8. Yang Y, Wang HX, Huo W, Qi R, Gao Y,      Zhang G, Song B, Chen H and Gao X (2017). Heat increased the editing      efficiency of human papillomavirus E2 gene by inducing upregulation of      APOBEC3A and 3G. J Invest Dermatol. 137(4):      810-18.
  9. Gao YL, Gao XH, Qi RQ, Xu JL, Huo W,      Tang J, Ren Y, Zheng S, Hong YX, Song      B, Chen HD (2017). Br J Dermatol. 176(3):809-812.      Clinical evaluation of local hyperthermia at 44 °C for molluscum      contagiosum: pilot study with 21 patients.
  10. Zhu B, Nicholls M, Gu Y, Zhang G, Zhao C, Franklin      RJ, Song B (2017). Electric      Signals Regulate the Directional Migration of Oligodendrocyte Progenitor      Cells (OPCs) via β1 Integrin. Int J Mol Sci. 2016      Nov 22;17(11). pii: E1948.
  11. Liu Q, Li Y, Jiang W, Li Y, Zhou L, Song B*, Liu X* (2016). Inhibition of HSP90 Promotes Neural Stem Cell Survival from Oxidative Stress through Attenuating NF-κB/p65 Activation. Oxidative Medicine and Cellular Longevity 2016 in press. Doi: 10.1155/2016/3507290
  12. Li P, Asokanathan C, Liu F, Khaing KK, Kmiec D, Wei X, Song B, Xing D, Kong D. (2016). PLGA nano/micro particles encapsulated with pertussis toxoid (PTd) enhances Th1/Th17 immune response in a murine model. Int J Pharm. 2016 Aug 29;513(1-2):183-190. doi: 10.1016/j.ijpharm.2016.08.059.  
  13. Zhang G, Gu Y, Begum R, Chen H, Gao X,  McGrath JA, Parsons M, Song B* (2016). Kindlin-1 regulates keratinocyte electrotaxis.  J Invest Dermatol. 2016 Nov;136 (11):2229-2239. doi: 10.1016/j.jid.2016.05.129.
  14. Yang Y, Wang HX, Huo W, Qi R, Gao Y, Zhang G, Song B, Chen H and Gao X (2017). Heat increased the editing efficiency of human papillomavirus E2 gene by inducing upregulation of APOBEC3A and 3G. J Invest Dermatol. 2017 Apr;137(4):810-818.
  15. Binley KE, Ng WS, Barde YA, Song B, Morgan JE (2016). Brain-derived neurotrophic factor prevents dendritic retraction of adult mouse retinal ganglion cells. Eur J Neurosci. 2016 Aug; 44(3): 2028-39. doi: 10.1111/ejn.13295.
  16. Young FI, Telezhkin V, Youde SJ, Langley MS, Stack M, Kemp PJ, Waddington RJ, Sloan AJ, Song B* (2016). Clonal Heterogeneity in the Neuronal and Glial Differentiation of Dental Pulp Stem/Progenitor Cells. Stem Cells Int. 2016:1290561.  doi: 10.1155/2016/1290561. In press.
  17. Hughes D, Song B* (2016). Dental and Nondental Stem Cell Based Regeneration of the Craniofacial Region: A Tissue Based Approach. Stem Cells Int. 2016:8307195. doi: 10.1155/2016/8307195.
  18.  Morgan AJ, Hidalgo San Jose L, Jamieson WD, Wymant JM, Song B, Stephens P, Barrow DA, Castell OK (2016). Simple and Versatile 3D Printed Microfluidics Using Fused Filament Fabrication. PLoS One. 2016 Apr 6;11(4):e0152023. doi: 10.1371/journal.pone.0152023. In press.
  19. Xue Q, Liu L, Wang Y, Fang C, Zhang K, Liu F, Yu C, Bian G, Song B, Yang A, Ju G, and Wang J (2016). miR-9 and miR-124 synergistically affect regulation of dendritic branching via the AKT/GSK3β pathway by targeting Rap2a. Scientific Reports. 25;6:26781. doi: 10.1038/srep26781.
  1. Song      B*, Jiang W, Alraies A, Liu Q, Gudla V, Oni J, Wei      X, Sloan AJ, Ni L and Agarwal M* (2016). Bladder smooth muscle cells      differentiation from dental pulp stem cells – future potential for bladder      tissue engineering. Stem Cell Int. 2016:6979368. doi:      10.1155/2016/6979368.
  2. Zhu B, Caldwell      M and Song B (2016).      Development of stem cell-based therapies for Parkinson’s disease. Int J Neurosci. 2016 Nov;126(11):955-62
  3. Zhang G, Edmundson M, Telezhkin V, Gu      Y, Wei X, Kemp PJ and Song B      (2016). The role of Kv1.2 channel in electrotaxis cell migration. J      Cell Physiol. 231(6):1375-84.      doi: 10.1002/jcp.25259.
  4. Haan N, Zhu B, Wang J, Wei X, Song B (2015). Crosstalk between macrophages and astrocytes affects proliferation, reactive phenotype and inflammatory response, suggesting a role during reactive gliosis following spinal cord injury. J Neuroinflam. May 30;12:109. doi: 10.1186/s12974-015-0327-3.
  5. Siene Ng W, Binley K, Song B*, Morgan JE* (2015). Lancet. Use of magnetic nanoparticles and oscillating magnetic field for non-viral gene transfer into mouse cornea. 385 Suppl 1:S75.
  6. Jiang W, Ni L, Sloan A, Song B (2015). Tissue Engineering and regenerative medicine, from and beyond the Dentistry. Dentistry. 5:306. doi: 10.4172/2161-1122.1000306
  7. Mehrban N, Zhu B, Tamagnini F, Young F, Wasmuth A, Hudson K, Thomson A, Birchall M, Randall A, Song B*, Woolfson DN* (2015). Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering. ACS Biomaterials Science & Engineering. ACS Biomater. Sci. Eng., 1 (6): 431–439.
  8. Wang J, Zhang K, Zheng J, Bian G, Liu L, Xue Q, Liu F, Yu C, zhang H, Song B, Chung SK, and Ju G (2015). Polarized macrophages have distinct effects on embryonic spinal-cord-derived neural stem cells after grafting to injured sites of spinal cord. Mol Ther. 23(6): 1077-91. doi: 10.1038/mt.2015.46.
  9. Jiang W, Lv H, Wang H, Wang D, Sun S, Jia Q, Wang P, Song B*, Ni L* (2015). Activation of the NLRP3 / caspase -1 inflammasome in human dental pulp tissue and human dental fibroblasts. Cell  Tissue Res. 361(2):541-55. doi: 10.1007/s00441-015-2118-7. 
  1. Liu J, Zhu      B, Zhang G, Wang J, Tian W, Ju G, Wei      X, Song B (2015). Electric signals regulate directional migration of ventral midbrain      derived dopaminergic neural progenitor cells via Wnt/GSK3β signaling.      Exp Neurol. 263:113-21.
  2. Zhang Q, Bian G, Chen P, Liu L, Yu C, Liu F, Xue Q, Chung SK, Song B, Ju G, Wang J. (2015). Aldose Reductase Regulates Microglia/Macrophages Polarization Through the cAMP Response Element-Binding Protein After Spinal Cord Injury in Mice. Mol Neurobiol. 53(1):662-76. doi: 10.1007/s12035-014-9035-8
  1. Liu Y, Song B, Chen X, Cai      Q, Tian W.      (2014). Alginate-based hydrogels      encapsulated TWS119 for inducing neuronal      differentiation of neural stem cells. Journal      of Biomaterials and Tissue Engineering. 2014. Volume 4, Number 12, December 2014, pp. 1087-1092(6)
  2. Xu R, Sun HF, Williams DW, Jones AV, Al-HussainiA, Song B, Wei XQ. (2015). IL-34 suppresses 'Candida albicans' induced TNFα      production in M1 macrophages by downregulating expression of Dectin-1 and      TLR2. Journal of Immunology Research 2015 , 328146. 10.1155/2015/328146
  3. Liu Q, Song B. Electric field regulated signaling pathways. Int J Biochem Cell Biol. 2014 Sep 22;55C:264-268. doi: 10.1016
  4. Zhu B, Zhao C, Young F, Franklin RJM, Song B (2014 In press). Isolation and Long-Term Expansion of Functional, Myelinating Oligodendrocyte Precursor Cells from Neonatal Rat Brain. Curr Protoc Stem Cell Biol. 2014 Nov 3;31:2D.17.1-2D.17.15. PMID: 25366898
  5. Liu J, Zhu B, Zhang G, Wang J, Tian W, Ju G, Wei X, Song B. Electric signals regulate directional migration of ventral midbrain derived dopaminergic neural progenitor cells via Wnt/GSK3β signaling. Exp Neurol. 2014 Sep 28. pii: S0014-4886(14)00297-0. doi: 10.1016
  6. Özkucur N*, Song B*, Bola S, Zhang L, Reid B, Fu G, Funk R,  Zhao M. (2014 May 1st). NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells. Cell Mol Life Sci. In press. *: Co 1st author. PMID: 24788043.
  7. Haan N, Song B (2014). Therapeutic application of electric fields in the injured nervous system. Advances in Wound Care. 3(2): 156-165.
  8. Young F, Sloan A, Song B (2013). Dental pulp stem cells and their potential roles in central nervous system regeneration and repair. J Neurosci Res. 91(11):1383-93.
  9. Li P, Xue Y, Zhang W, Teng F, Sun Y, Qu T, Chen X, Cheng X, Song B, Luo W, Yu Q (2013). Sodium fluoride induces apoptosis in odontoblasts via a JNK-dependent mechanism. Toxicology 308:138-45.
  10. Edmundson M, Thanh NTK, Song B (2013). Nanoparticles based stem cell tracking in regenerative medicine. Theranostics; doi:10.7150/thno.5477.
  11. Zheng XF, Hong YX, Feng GJ, Zhang GF, Rogers H, Lewis MA, Williams DW, Xia ZF, Song B, Wei XQ (2013). Lipopolysaccharide-nduced M2 to M1 macrophage transformation for IL-12p70 production is blocked by Candida albicans mediated up-regulation of EBI3 expression. PloS One. 2013 May 27;8(5):e63967. doi: 10.1371/journal.pone.0063967.
  12. Meng X, Li W, Young F, Gao R, Chalmers L, Zhao M, Song B (2012). Electric field-controlled directed migration of neural progenitor cells in 2D and 3D environment. J Vis. Exp. e3453, DOI: 10. 3791/3453.
  13. Meng X, Arocena M, Penninger J, Gage FH, Zhao M, Song B (2011). PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors. Exp Neurol. 227(1): 210-7.
  14. Meng X, Seton H, Lu L, Prior I, Thanh N and Song B (2011). Magnetic CoPt nanoparticles as MRI contrast agent for transplanted neural stem cells detection. Nanoscale. 3: 977-84. (Cover article, featured inside this issue and Journal Cover Image).
  15. Arocena M, Zhao M, Collinson J, Song B (2010). A time-lapse and quantitative modelling analysis of neural stem cell motion in the absence of directional cues and in electric fields. J Neurosci Res. 88(15):3267-74.
  16. Guo A, Song B, Reid B, Gu Y, Forrester JV, Jahoda CA, Zhao M (2010). Effects of physiological electric fields on migration of human dermal fibroblasts. J Invest Dermatol.130(9):2320-7.
  17. Hardwicke J, Song B, Moseley R, Thomas DW (2010). Investigation of the potential of polymer therapeutics in corneal re-epithelialisation. B J Ophthalmol. 94(12):1566-70.
  18. Lois N, Reid B, Song B, Zhao M, Forrester J, McCaig C (2010). Electric currents and lens regeneration in the rat. Exp Eye Res. 90(2):316-23.
  19. McCaig CD, Song B, Rajnicek AM (2009). Electrical dimensions in cell science. J Cell Sci. 122:4267-76.
  20. Reid B, Song B, Zhao M. (2009). Electric currents in Xenopus tadpole tail regeneration. Dev Biol. 335: 198-207.
  21. Sun H, Song B, Dong H, Reid B, Player MA, Watson J, Zhao M. (2008). Visualization of fast-moving cells in vivo using digital holographic video microscopy. J Biomed Opt.13(1):014007.
  22. Song B, Gu Y, Pu J, Reid B, Zhao Z, Zhao M. (2007). Application of direct current electric fields to cells and tissues in vitro and modulating wound electric field in vivo. Nature Protoc. 2(6):1479-89.
  23. Zhao M, Song B, Pu J, Wada T, Reid B, Tai G, Wang F, Guo A, Walczysko P, Gu Y, Sasaki T, Suzuki A, Forrester J, Bourne H, Devreotes P, McCaig C, Penninger J. (2006). Electrical signals control wound healing via phosphatidylinositol-3 kinase g and PTEN. Nature 442: 457-60. (Featured inside this issue).
  24. Pullar CE, Zhao M, Song B, Pu J, Reid B, Ghoghawala S, McCaig C, Isseroff R. (2007). Beta-adrenergic receptor agonists delay while antagonists accelerate epithelial wound healing: Evidence of an endogenous adrenergic network within the corneal epithelium. J Cell Physiol. 211(1):261-72.
  25. Lang B, Song B, Davidson W, MacKenzie A, Smith N, McCaig CD, Harmar AJ and Shen S. (2006). Expression of the human PAC1 receptor leads to dosage-dependent hydrocephalus-related abnormalities in mice. J. Clin. Invest. 116: 1924-34.
  26. McCaig CD, Rajnicek AN, Song B & Zhao M. (2005). Controlling cell behaviour electrically: Current views and future potential. Physiol Rev. 85(3):943-78.
  27. Reid B, Song B, McCaig CD, Zhao M. (2005). Wound healing in rat cornea: the role of electric currents. FASEB J. 19(3):379-86.
  28. Song B, Zhao M, Forrester J, McCaig CD. (2004). Nerve regeneration and wound healing are stimulated and directed by an endogenous electrical field in vivo. J Cell Sci. 117(20): 4681-90. (Journal Cover Image and Featured Inside this Issue).
  29. Song B, Zhao M, Pu J, Forrester JV, McCaig CD. (2003). Direct visualization of a stratified epithelium reveals that wounds heal by unified sliding of cell sheets. FASEB J. 17(3):397-406. Co 1st author with Zhao M.
  30. Song B, Zhao M, Forrester JV, McCaig CD. (2002). Electrical cues regulate the orientation and frequency of cell division and the rate of wound healing in vivo. Proc Natl Acad Sci U S A. 99(21):13577-82. (Featured inside this issue).
  31. McCaig CD, Rajnicek AM, Song B, Zhao M. (2002). Has electrical growth cone guidance found its potential? Trends Neurosci. 25(7):354-9.
  32. Song B, Zhao M, Forrester JV, McCaig CD. (2001). A physiological electric field directs nerve growth, cell migration and cell division in vivo. Mol. Biol. Cell, Vol.12 (suppl): 233.

*: Co-corresponding author.