实验室主要研究方向为疫苗与大分子药物研发。详细分为传染性疾病的研究，包括HIV、呼吸道病毒、抗体研发等几大方向：

•艾滋病疫苗研究：

Ø发现了通过阻断PD-1 及Tim-3的免疫负调节信号通路可显著提升艾滋病疫苗的CD8+ T细胞免疫应答水平，为HIV疫苗佐剂设计提供了新思路（Hum VaccinImmunother., 2013 Dec 10;10(3).）；

Ø揭示了机体可利用自噬机制对内源性蛋白（包括HIV抗原）进行MHCⅡ类分子的抗原提呈，从而提升了HIV疫苗CD4+T细胞免疫应答，对新型疫苗研发有重要启示意义。（PloS One, 2014, Mar 26;9(3)）；

Ø率先研发了可防治黏膜途径感染猴艾滋病毒（SIV）的新型疫苗，发现其激发的效应记忆性CD8+ T细胞免疫与保护效果呈正相关，相关产品即将进入临床研究（Journal of Virology, 2013, 87:5669）；

Ø以猴艾滋病疫苗为模型，研发了克服抗腺病毒抗体的新技术，提升了相关生物制品的使用效率和范围。（Journal of Virology, 2012， 86:11031）。

Ø发明了矿化HIV疫苗（Adv Mat, 2015 Nov 26. doi: 10.1002/adma.201503740.）

•呼吸道传染病及疫苗研究： 

Ø发现了流感病毒致病新机理（Journal of Virology, 2015 Oct 14. pii: JVI.00576-15.）；

Ø结核疫苗的研究（Hum Vaccine Immunother, 2015 Jul 3;11(7)1803-13）； 

ØH7N9的研究（Antiviral Research, 2014, Apr 16 )；

Ø新示踪流感病毒并可用于活体动物跟踪流感病毒感染（Nature Communications 2013;4:2369）；

Ø抗流感病毒药物筛选（Current Pharmaceutical Design, 2013, 19: 5146）；

Ø提高流感疫苗株的产量（Hum Vaccine Immunother. 2012,1:252）。

•生物药物的研发： 

Ø探究如何快速研发中和抗体。建立并验证了以免疫猕猴的外周血淋巴细胞为来源，建立抗体噬菌体库，筛选针对病原体的高亲和力中和抗体的平台（Scientific Reports, 25856 (2016);One, 2013, June 8:6:e66276）； 

Ø基因敲除小鼠研究基因新功能。发现了sPLA2可调控代谢及炎症及免疫反应（Obesity, 2015 Apr;23(4):760-8. Hepatology, 2011, 53:458-466.）。

​

实验室长期致力于传染性疾病的研究，包括HIV、流感、腺病毒以及生物抗体研发等几大方向。目前各方向均打下了坚实的基础，取得了良好的成果，我们热忱欢迎各位新同学的加入，为在人类攻克各项疾病方向贡献自己的一份力量！    

071010-生物化学与分子生物学
100102-免疫学
100103-病原生物学

HIV疫苗研究
呼吸道传染病及疫苗研究
大分子生物药物研发

1992-01--1994-06 美国哈佛大学 博士后
1985-09--1991-12 美国印第安那大学 博士
1979-09--1985-06 上海第一医学院 医学学士

具有在学术界、工业界双重管理经验。

2014-11--今 中国科学院广州生物医药与健康研究院 高级研究员
2012-08--今 呼吸疾病国家重点实验室 常务副主任
2012-01--2012-08 赛诺菲巴斯德(Sanofi Pasteur) 全球疫苗研发副总裁(Vaccine R&D Vice President）
2008-08--2011-12 葛兰素史克公司(GlaxoSmithKline) 全球研发副总裁(R&D Vice President）
2004-03--2008-06 中国科学院广州生物医药与健康研究院 院长，研究员
2001-07--2004-06 美国Lexicon Genetics Inc 生物制药部主任（Director）
2000-07--2001-06 美国默克制药公司 资深研究员
1997-01--2000-06 美国默克制药公司 研究员
1994-07--1996-12 美国哈佛大学 讲师

   

（1） The Lilly Asian Scientific Excellence Award，一等奖，其他级，2007
（2） 广东省人民政府授予“南粤友谊奖”，一等奖，省级，2005
（3） 默克公司艾滋病疫苗化合物研究杰出贡献奖，一等奖，专项级，2001
（4） 默克公司工作成果和领导才能最高评分，一等奖，其他级，1998
（5） 美国癌症研究学会颁授的葛兰素-威尔康癌症临床研究学者奖，一等奖，其他级，1996
（6） 美国胃肠道疾病学会颁发的优秀学生奖，一等奖，其他级，1992
（7） 西格玛Xi的研究竞赛奖，一等奖，专项级，1991
（8） 美国印第安那大学医学院奖学金，一等奖，研究所（学校）级，1986
（9） 考取CUSBEA奖学金赴美留学，一等奖，专项级，1985

[1] 陈凌, 王龙雨, 冯立强, 冯玉鹏. 一种抗丝状病毒GP蛋白的单克隆抗体及其应用. CN: CN110655572A, 2020-01-07.

[2] 孙彩军, 陈凌, 潘恩祥, 闫洪滨. PD-1信号通路拮抗剂与艾滋病疫苗的联合应用. CN: CN110624106A, 2019-12-31.

[3] 陈凌, 冯玉鹏, 冯立强, 王龙雨. 抗丝状病毒单克隆中和抗体及其制备方法和应用. CN: CN110551213A, 2019-12-10.

[4] 孙彩军, 陈凌, 冯凤玲. 一种增强腺病毒载体生物制品感染靶细胞的方法. CN: CN109735566A, 2019-05-10.

[5] 罗佳, 陈凌, 牛学锋, 李正锋. 一种抗H7N9抗体及其制备方法和应用. CN: CN108752472A, 2018-11-06.

[6] 张天宇, 刘燕, 孙彩军, 潘恩祥, 王邦兴, 郭玲敏, 陈凌, 刘志永. 一种艾滋病疫苗及其制备方法. CN201810359440.4, 2018-04-20.

[7] 孙彩军, 赵军岭, 陈凌, 杨晴, 丁宇洋. 一种吡喃并吲哚类化合物及其制备方法和在制备抗艾滋病的药物中的应用. CN: CN107286170A, 2017-10-24.

[8] 孙彩军, 陈凌, 杨晴. 一种抗艾滋病毒的药物组合物及其应用. CN: CN107096033A, 2017-08-29.

[9] 陈凌, 冯立强, 孙彩军, 秦成峰. 复制型重组人55型腺病毒载体及其制备方法和应用. CN: CN105274142A, 2016-01-27.

[10] 孙彩军, 陈凌, 吴同金. CH25H与25-OHC在免疫应答中的作用及其作为免疫调节剂在疫苗中的应用. CN: CN104998275A, 2015-10-28.

[11] 孙彩军, 陈凌, 靳怡. 一种引发强效CD4+ T细胞免疫反应的新型HIV疫苗. CN: CN103480003A, 2014-01-01.

[12] 周国春, 陈凌, 李志远, 陈绪林, 徐静, 刘劲松. 具有抑制和阻断M2离子通道活性的化合物及其应用. CN: CN101531637B, 2011-07-13.

[13] 胡文辉, 曾少高, 李楚芳, 陈凌. 作为M2抑制剂的环烷胺类化合物及其应用. CN: CN101906056A, 2010-12-08.

[14] 裴端卿, 陈凌, 李锋, 米盖尔·埃斯特班, 冯立强, 谢海军, 陈捷凯, 秦大江. 优化的串连细胞因子及其在诱导多能性干细胞中的应用. CN: CN101709084A, 2010-05-19.

[15] 张健存, 仪明君, 刘燕, 赵宇, 陈凌. 唾液酸类似物及其在制备抗流感病毒药物中的应用. CN: CN101362744A, 2009-02-11.

   

[1] Wang, Jinlin, Shu, Tao, Deng, Weiqi, Zheng, Yali, Liao, Min, Ye, Xianmiao, Han, Lujie, He, Ping, Zheng, Xuehua, Li, Ting, Feng, Ying, Hu, Fengyu, Li, Pingchao, Sun, Caijun, Chen, Ling, Li, Feng, Feng, Liqiang. Mucosal Priming with a Recombinant Influenza A Virus-Vectored Vaccine Elicits T-Cell and Antibody Responses to HIV-1 in Mice. JOURNAL OF VIROLOGY[J]. 2021, 95(12): http://dx.doi.org/10.1128/JVI.00059-21.
[2] Yan, Qihong, Li, Pingchao, Ye, Xianmiao, Huang, Xiaohan, Feng, Bo, Ji, Tianxing, Chen, Zhilong, Li, Feng, Zhang, Yudi, Luo, Kun, Chen, Fengjuan, Mo, Xiaoneng, Wang, Jianhua, Feng, Liqiang, Hu, Fengyu, Lei, Chunliang, Qu, Linbing, Chen, Ling. Longitudinal Peripheral Blood Transcriptional Analysis Reveals Molecular Signatures of Disease Progression in COVID-19 Patients. JOURNAL OF IMMUNOLOGY[J]. 2021, 206(9): 2146-2159, http://dx.doi.org/10.4049/jimmunol.2001325.
[3] Wu, Chunxiu, Zhao, Jin, Li, Ruiting, Feng, Fengling, He, Yizi, Li, Yanjun, Huang, Runhan, Li, Guangye, Yang, Heng, Cheng, Genhong, Chen, Ling, Ma, Feng, Li, Pingchao, Sun, Caijun. Modulation of Antiviral Immunity and Therapeutic Efficacy by 25-Hydroxycholesterol in Chronically SIV-Infected, ART-Treated Rhesus Macaques. VIROLOGICA SINICA. 2021, 36(5): 1197-1209, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8165512/.
[4] 陈凌. Monoclonal antibodies against Zika virus NS1 protein confer protection via Fcg receptor-dependent and -independent pathways. mbio. 2021, [5] Yan, Qihong, He, Ping, Huang, Xiaohan, Luo, Kun, Zhang, Yudi, Yi, Haisu, Wang, Qian, Li, Feng, Hou, Ruitian, Fan, Xiaodi, Li, Pingchao, Liu, Xinglong, Liang, Huan, Deng, Yijun, Chen, Zhaoming, Chen, Yunfei, Mo, Xiaoneng, Feng, Liqiang, Xiong, Xiaoli, Li, Song, Han, Jian, Qu, Linbing, Niu, Xuefeng, Chen, Ling. Germline IGHV3-53-encoded RBD-targeting neutralizing antibodies are commonly present in the antibody repertoires of COVID-19 patients. EMERGING MICROBES & INFECTIONS[J]. 2021, 10(1): 1097-1111, http://dx.doi.org/10.1080/22221751.2021.1925594.
[6] Peng, Jiaojiao, Ran, Yeqian, Xie, Haojun, Deng, Ling, Li, Chufang, Ling, Chen. Sarco/Endoplasmic Reticulum Ca2+-Transporting ATPase (SERCA) Modulates Autophagic, Inflammatory, and Mitochondrial Responses during Influenza A Virus Infection in Human Lung Cells. JOURNAL OF VIROLOGY[J]. 2021, 95(10): http://dx.doi.org/10.1128/JVI.00217-21.
[7] Chen, Musha, Li, Yanjun, Chen, Jiaoshan, Wen, Ziyu, Feng, Fengling, Zou, Huachun, Fu, Chuanxi, Chen, Ling, Shu, Yuelong, Sun, Caijun. An online survey of the attitude and willingness of Chinese adults to receive COVID-19 vaccination. HUMAN VACCINES & IMMUNOTHERAPEUTICS[J]. 2021, 17(7): 2279-2288, http://dx.doi.org/10.1080/21645515.2020.1853449.
[8] Yu, Lei, Liu, Xinglong, Ye, Xianmiao, Su, Wan, Zhang, Xiaoyan, Deng, Weiqi, Luo, Jia, Xiang, Mengrong, Guo, Wenjing, Zhang, Shengnan, Xu, Wei, Yan, Qihong, Wang, Qian, Cui, Yilan, Wu, Caixia, Niu, Xuefeng, Zhang, Fuchun, Lei, Chunliang, Qu, Linbing, Chen, Ling, Feng, Liqiang. Monoclonal Antibodies against Zika Virus NS1 Protein Confer Protection via Fc gamma Receptor-Dependent and -Independent Pathways. MBIO[J]. 2021, 12(1): http://dx.doi.org/10.1128/mBio.03179-20.
[9] Feng, Ying, Yi, Changhua, Liu, Xinglong, Qu, Linbing, Su, Wan, Shu, Tao, Zheng, Xuehua, Ye, Xianmiao, Luo, Jia, Hao, Mingli, Sun, Xikui, Li, Liang, Liu, Xiaolin, Yang, Chenchen, Guan, Suhua, Chen, Ling, Feng, Liqiang. Human Desmoglein-2 and Human CD46 Mediate Human Adenovirus Type 55 Infection, but Human Desmoglein-2 Plays the Major Roles. JOURNAL OF VIROLOGY[J]. 2020, 94(17): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7431812/.
[10] Wang, Yanqun, Sun, Jing, Li, Xiaobo, Zhu, Airu, Guan, Wenda, Sun, DeQiang, Gan, Mian, Niu, Xuefeng, Dai, Jun, Zhang, Lu, Zhang, Zhaoyong, Shi, Yongxia, Huang, Shuxiang, Mok, Chris Ka Pun, Yang, Zifeng, Wang, Zhongfang, Tan, Wenjie, Li, Yimin, Chen, Ling, Chen, Rongchang, Peiris, Malik, Zhong, Nanshan, Zhao, Jingxian, Huang, Jicheng, Zhao, Jincun. Increased Pathogenicity and Virulence of Middle East Respiratory Syndrome Coronavirus Clade B In Vitro and In Vivo. JOURNAL OF VIROLOGY[J]. 2020, 94(15): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375386/.
[11] Ji, Tianxing, Liu, Ying, Li, Yaqing, Khan, Shahzad Akbar, Zhou, Qiang, Chen, Bo, Lin, Zhen, Wang, Xingchen, Ye, Xianmiao, Zheng, Xuehua, Chen, Ling, Feng, Liqiang. Molecular typing and genomic characteristic of human adenoviruses in Datong, Northern China. JOURNAL OF MEDICAL VIROLOGY[J]. 2020, 92(12): 3111-3118, https://www.webofscience.com/wos/woscc/full-record/WOS:000547182500001.
[12] Yang, Meng, Liu, Qingli, Huang, Tongling, Tan, Wenjuan, Qu, Linbing, Chen, Tianke, Pan, Haobo, Chen, Ling, Liu, Jinsong, Wong, ChiWai, Lu, William W, Guan, Min. Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development. THERANOSTICS[J]. 2020, 10(24): 10874-10891, https://www.webofscience.com/wos/woscc/full-record/WOS:000573667200003.
[13] Sun, Baoqing, Feng, Ying, Mo, Xiaoneng, Zheng, Peiyan, Wang, Qian, Li, Pingchao, Peng, Ping, Liu, Xiaoqing, Chen, Zhilong, Huang, Huimin, Zhang, Fan, Luo, Wenting, Niu, Xuefeng, Hu, Peiyu, Wan, Longyu, Peng, Hui, Huang, Zhifeng, Feng, Liqiang, Li, Feng, Zhang, Fuchun, Li, Fang, Zhong, Nanshan, Chen, Ling. Kinetics of SARS-CoV-2 specific IgM and IgG responses in COVID-19 patients. EMERGING MICROBES & INFECTIONS[J]. 2020, 9(1): 940-948, http://dx.doi.org/10.1080/22221751.2020.1762515.
[14] Niu, Xuefeng, Yan, Qihong, Yao, Zhipeng, Zhang, Fan, Qu, Linbing, Wang, Chunlin, Wang, Chengrui, Lei, Hui, Chen, Chaoming, Liang, Renshan, Luo, Jia, Wang, Qian, Zhaog, Lingzhai, Zhang, Yudi, Luo, Kun, Wang, Longyu, Wu, Hongkai, Liu, Tingting, Li, Pingchao, Zheng, Zhiqiang, Tan, Yee Joo, Feng, Liqiang, Zhang, Zhenhai, Han, Jian, Zhang, Fuchun, Chen, Ling. Longitudinal analysis of the antibody repertoire of a Zika virus-infected patient revealed dynamic changes in antibody response. EMERGING MICROBES & INFECTIONS[J]. 2020, 9(1): 111-123, http://dx.doi.org/10.1080/22221751.2019.1701953.
[15] Feng, Liqiang, Wang, Qian, Shan, Chao, Yang, Chenchen, Feng, Ying, Wu, Jia, Liu, Xiaolin, Zhou, Yiwu, Jiang, Rendi, Hu, Peiyu, Liu, Xinglong, Zhang, Fan, Li, Pingchao, Niu, Xuefeng, Liu, Yichu, Zheng, Xuehua, Luo, Jia, Sun, Jing, Gu, Yingying, Liu, Bo, Xu, Yongcun, Li, Chufang, Pan, Weiqi, Zhao, Jincun, Ke, Changwen, Chen, Xinwen, Xu, Tao, Zhong, Nanshan, Guan, Suhua, Yuan, Zhiming, Chen, Ling. An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques. NATURE COMMUNICATIONS[J]. 2020, 11(1): https://doaj.org/article/30d2b47ccb1d4b11a9dcc003e80a75d7.
[16] 陈凌. Human desmoglein-2 and human CD46 mediate Ad55 infection but human desmoglein-2 plays the major roles.. Journal of virology. 2020, [17] Yang, Xinzhe, Wang, Qian, Hu, Peiyu, Xu, Chao, Guo, Wenjing, Wang, Zhi, Mao, Zhu, Yang, Zhan, Liu, Cong, Shi, Guang, Chen, Ling, Xu, Bingjia, Chi, Zhenguo. Achieving remarkable and reversible mechanochromism from a bright ionic AIEgen with high specificity for mitochondrial imaging and secondary aggregation emission enhancement for long-term tracking of tumors. MATERIALS CHEMISTRY FRONTIERS[J]. 2020, 4(3): 941-949, https://www.webofscience.com/wos/woscc/full-record/WOS:000519639900021.
[18] Niu, Xuefeng, Li, Song, Li, Pingchao, Pan, Wenjing, Wang, Qian, Feng, Ying, Mo, Xiaoneng, Yan, Qihong, Ye, Xianmiao, Luo, Jia, Qu, Linbing, Weber, Daniel, ByrneSteele, Miranda L, Wang, Zhe, Yu, Fengjia, Li, Fang, Myers, Richard M, Lotze, Michael T, Zhong, Nanshan, Han, Jian, Chen, Ling. Longitudinal Analysis of T and B Cell Receptor Repertoire Transcripts Reveal Dynamic Immune Response in COVID-19 Patients (vol 11, 582010, 2020). FRONTIERS IN IMMUNOLOGYnull. 2020, 11: https://www.webofscience.com/wos/woscc/full-record/WOS:000604588600001.
[19] Zhang, Shengnan, Yi, Changhua, Li, Chufang, Zhang, Fan, Peng, Jiaojiao, Wang, Qian, Liu, Xinglong, Ye, Xianmiao, Li, Pingchao, Wu, Min, Yan, Qihong, Guo, Wenjing, Niu, Xuefeng, Feng, Liqiang, Pan, Weiqi, Chen, Ling, Qu, Linbing. Chloroquine inhibits endosomal viral RNA release and autophagy-dependent viral replication and effectively prevents maternal to fetal transmission of Zika virus. ANTIVIRAL RESEARCH[J]. 2019, 169: 104547-, http://dx.doi.org/10.1016/j.antiviral.2019.104547.
[20] Zhang, Fan, Wang, Longyu, Niu, Xuefeng, Li, Jiashun, Luo, Jia, Feng, Yupeng, Yang, Yanjia, He, Ping, Fan, Wenxia, Liang, Renshan, Zheng, Zhiqiang, Pan, Weiqi, Li, Chufang, Tan, Yee Joo, Yu, Haijian, Chen, Ling, Li, Pingchao. Phenotypic Characterization of Chinese Rhesus Macaque Plasmablasts for Cloning Antigen-Specific Monoclonal Antibodies. FRONTIERS IN IMMUNOLOGY[J]. 2019, 10: https://doaj.org/article/a1416e00b925401ba1a9af8b049f778a.
[21] Feng, Fengling, Zhao, Jin, Li, Pingchao, Li, Ruiting, Chen, Ling, Sun, Caijun. Preexisting Virus-Specific T Lymphocytes-Mediated Enhancement of Adenovirus Infections to Human Blood CD14+Cells. VIRUSES-BASEL[J]. 2019, 11(2): https://doaj.org/article/64ffbb4552d94417992384cc86702b5c.
[22] Yang, Qing, Feng, Fengling, Li, Pingchao, Pan, Enxiang, Wu, Chunxiu, He, Yizi, Zhang, Fan, Zhao, Jin, Li, Ruiting, Feng, Liqiang, Hu, Fengyu, Li, Linghua, Zou, Huachun, Cai, Weiping, Lehner, Thomas, Sun, Caijun, Chen, Ling. Arsenic Trioxide Impacts Viral Latency and Delays Viral Rebound after Termination of ART in Chronically SIV-Infected Macaques. ADVANCED SCIENCE[J]. 2019, 6(13): https://doaj.org/article/b884d10eedfd4e2a9eb2ad8286d392e6.
[23] Niu, Xuefeng, Zhao, Lingzhai, Qu, Linbing, Yao, Zhipeng, Zhan, Fan, Yan, Qihong, Zhang, Shengnan, Liang, Renshan, Chen, Peihai, Luo, Jia, Xu, Wei, Lv, Huibin, Liu, Xinglong, Lei, Hui, Yi, Changhua, Li, Pingchao, Wang, Qian, Wang, Yang, Yu, Lei, Zhang, Xiaoyan, Bryan, L Aubrey, Davidson, Edgar, Doranz, J Benjamin, Feng, Liqiang, Pan, Weiqi, Zhang, Fuchun, Chen, Ling. Convalescent patient-derived monoclonal antibodies targeting different epitopes of E protein confer protection against Zika virus in a neonatal mouse model. EMERGING MICROBES & INFECTIONS[J]. 2019, 8(1): 749-759, http://dx.doi.org/10.1080/22221751.2019.1614885.
[24] Chen, Longhui, Wu, Min, Zhang, Shengnan, Tan, Wenjuan, Guan, Min, Feng, Liqiang, Chen, Chen, Tao, Jun, Chen, Ling, Qu, Linbing. Estrogen-related receptor gamma regulates hepatic triglyceride metabolism through phospholipase A2 G12B. FASEB JOURNAL[J]. 2019, 33(7): 7942-7952, https://www.webofscience.com/wos/woscc/full-record/WOS:000476234700012.
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自2004年归国以来，先后承担国家自然基金委杰青、重大培育、面上等项目，中国科学院知识创新工程重要方向项目，科技部重大专项子课题、卫计委应急专项以及省市等项目，并出任广州市协同创新重大专项子专题“呼吸道新发突发及重大传染病综合防诊治”首席科学家，并传染性疾病的防治上取得了不俗的成果。

（1） 肺巨噬细胞在流感病毒感染后继发革兰氏阴性菌感染的作用与机制研究，主持，国家级，2015-01--2017-12
（2） 磷脂酶sPLA2G2E缺失导致动脉粥样硬化新机制的研究，主持，国家级，2015-01--2018-12
（3） 应对新发/突发呼吸系统病毒传染性疾病，主持，市地级，2014-01--2016-12
（4） 广州市协同创新重大专项子专题“呼吸道新发突发及重大传染病综合防诊治”，主持，市地级，2014-01--2017-12
（5） H7N9猴血清制备和猴抗体研发，参与，专项级，2013-07--2016-12