基本信息
刘思金  男  博导  中国科学院生态环境研究中心
电子邮件: sjliu@rcees.ac.cn
通信地址: 北京市海淀区双清路18号
邮政编码: 100085

研究领域

环境医学与环境毒理学,主要内容包括:(1)环境污染物对血细胞损伤的分子机制;(2)环境肿瘤学及肿瘤进展的机理;(3)人工纳米材料的生物安全性。

招生信息

   
招生专业
083001-环境科学
0703Z1-化学生物学
071009-细胞生物学
招生方向
环境肿瘤学,纳米生物学
环境毒理学,纳米生物学
环境医学与分子毒理学

教育背景

2001-09--2004-07   中科院遗传发育所   博士

工作经历

   
工作简历
2008-02~2009-08,美国塔芙茨大学医学院, 讲师
2007-07~2008-01,美国哈佛大学医学院, 研究助理
2004-08~2007-06,美国麻省理工学院, 博士后
社会兼职
2012-02-27-今,国家环境与健康专家咨询委员会, 委员

教授课程

环境毒理学研究方法
现代生物学技术在环境健康研究中的应用
环境污染与健康危害进展
环境与健康研究系列讲座
环境与健康研究进展

专利与奖励

   
奖励信息
(1) 国家万人计划, 一等奖, 部委级, 2018
(2) 国家青年科技领军人才, 一等奖, 部委级, 2017
(3) 十四届中国青年科技奖, 国家级, 2016
(4) 中国科学院青年科学家奖, 一等奖, 院级, 2015
(5) 中国科学院青年科学家奖, 一等奖, 院级, 2015
(6) 中国科学院青年科学家奖, 一等奖, 院级, 2015
(7) 高登学术会议(Gordon conference)Nature Travel Award, 一等奖, 其他, 2015
(8) 高登学术会议(Gordon conference)Nature Travel Award, 一等奖, 其他, 2015
(9) 中科院2013年度杰出科技成就奖, 一等奖, 院级, 2015
(10) ****终期考评被评选为优秀, 一等奖, 院级, 2014
(11) 第九届PTS青年科学家奖, 一等奖, 国家级, 2012
(12) 美国骨与矿物质学会青年研究者奖, 一等奖, 其他, 2009
专利成果
( 1 ) 一种噻唑烷酮类化合物及其在制备治疗铁紊乱相关疾病药物中的应用, 实用新型, 2014, 第 2 作者, 专利号: 201410698860.7

出版信息

   
发表论文
(1) Antiviral nanoagents: More attention and effort needed?, Nano Today, 2020, 通讯作者
(2) LncRNA UCA1 Antagonizes Arsenic-Induced Cell Cycle Arrest through Destabilizing EZH2 and Facilitating NFATc2 Expression, Advanced Science, 2020, 通讯作者
(3) Bisphenol A and polychlorinated biphenyls enhance the cancer stem cell properties of human ovarian cancer cells by activating the WNT signaling pathway, Chemosphere, 2020, 其他(合作组作者)
(4) Depriving Iron Supply to the Virus Represents a Promising Adjuvant Therapeutic Against Viral Survival, Current Clinical Microbiology Reports, 2020, 通讯作者
(5) Understanding the knowledge gaps between air pollution controls and health impacts including pathogen epidemic, Environmental Research, 2020, 通讯作者
(6) Nanocrystal facet modulation to enhance transferrin binding and cellular delivery, Nature communications, 2020, 其他(合作组作者)
(7) Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting, Theranostics, 2020, 通讯作者
(8) Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver, ACS Nano, 2020, 通讯作者
(9) Graphene Oxide Promotes Cancer Metastasis through Associating with Plasma Membrane To Promote TGF‑β Signaling-Dependent Epithelial−Mesenchymal Transition, ACS Nano, 2020, 通讯作者
(10) New Thiazolidinones Reduce Iron Overload in Mouse Models of Hereditary Hemochromatosis and β-thalassemia., Haematologica, 2019, 通讯作者
(11) Desferrioxamine-caffeine Shows Improved Efficacy in Chelating Iron and Depleting Cancer Stem Cells, Journal of Trace Elements in Medicine and Biology, 2019, 通讯作者
(12) ron Homeostasis in Pregnancy and Spontaneous Abortion., American Journal of Hematology., 2019, 通讯作者
(13) Silver Nanoparticles Compromise Female Embryonic Stem Cell Differentiation through Disturbing X Chromosome Inactivation, ACS Nano., 2019, 通讯作者
(14) Protein target identification and toxicological mechanism investigation of silver nanoparticles-induced hepatotoxicity by integrating proteomic and metallomic strategies., Part Fibre Toxicol., 2019, 通讯作者
(15) Improved Healing of Diabetic Foot Ulcer upon Oxygenation Therapeutics through Oxygen-Loading Nanoperfluorocarbon Triggered by Radial Extracorporeal Shock Wave., Oxid Med Cell Longev, 2019, 通讯作者
(16) Black Phosphorus-Based Multimodal Nanoagent: Showing Targeted Combinatory Therapeutics against Cancer Metastasis., Nano Lett., 2019, 通讯作者
(17) Diagnostic significance of metallothionein members in recognizing cadmium exposure in various organs under low-dose exposure., Chemosphere, 2019, 通讯作者
(18) Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice., Environ Int., 2019, 通讯作者
(19) Carbon black-induced detrimental effect on osteoblasts at low concentrations: Remarkably compromised differentiation without significant cytotoxicity., Ecotoxicol Environ Saf., 2019, 通讯作者
(20) Desferrioxamine-caffeine shows improved efficacy in chelating iron and depleting cancer stem cells., J Trace Elem Med Biol., 2019, 通讯作者
(21) Distinct Iron Deposition Profiles of Liver Zones in Various Models with Iron Homeostasis Disorders., Adv Sci (Weinh)., 2018, 通讯作者
(22) Iron homeostasis in pregnancy and spontaneous abortion., Am J Hematol., 2018, 通讯作者
(23) How Entanglement of Different Physicochemical Properties Complicates the Prediction of in Vitro and in Vivo Interactions of Gold Nanoparticles., ACS Nano, 2018, 通讯作者
(24) Reduction of graphene oxide alters its cyto-compatibility towards primary and immortalized macrophages., Nanoscale, 2018, 通讯作者
(25) LncRNA MT1DP Aggravates Cadmium-Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR-365., Adv Sci (Weinh), 2018, 通讯作者
(26) China's Fight for Clean Air and Human Health., Environ Sci Technol., 2018, 第 2 作者
(27) Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles., J Environ Sci (China)., 2018, 第 10 作者
(28) Bio-transformation of Graphene Oxide in Lung Fluids Significantly Enhances Its Photothermal Efficacy., Nanotheranostics, 2018, 通讯作者
(29) Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with a Pulmonary Surfactant, ACS Appl Mater Interfaces, 2018, 通讯作者
(30) From the lung to the knee joint: Toxicity evaluation of carbon black nanoparticles on macrophages and chondrocytes., J Hazard Mater., 2018, 第 6 作者
(31) Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress., Cell Discov, 2018, 通讯作者
(32) Oxygen content determines the bio-reactivity and toxicity profiles of carbon black particles., Ecotoxicol Environ Saf., 2018, 通讯作者
(33) LncRNA UCA1 attenuates autophagy-dependent cell death through blocking autophagic flux under arsenic stress., Toxicol Lett., 2018, 通讯作者
(34) The Effects and the Potential Mechanism of Environmental Transformation of Metal Nanoparticles on Their Toxicity in Organisms., Environmental Science: Nano, 2018, 通讯作者
(35) Bridge knowledge gaps in environmental health and safety for sustainable development of nano-industries, Nano Today., 2018, 第 1 作者
(36) Distinct Iron Deposition Profiles of Liver Zones in Various Models with Iron Homeostasis Disorders., Advanced Science, 2018, 通讯作者
(37) Carbon nanotubes disrupt iron homeostasis and induce anemia of inflammation through inflammatory pathway as a secondary effect distant to their portal-of-entry, Small, 2017, 通讯作者
(38) Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells, Biomaterials, 2017, 通讯作者
(39) Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents, ACS Nano, 2017, 通讯作者
(40) Determining the Cytotoxicity of Rare Earth Element Nanoparticles in, Environ. Sci. Technol, 2017, 其他(合作组作者)
(41) An Important Function of Petrosiol E in Inducing the Differentiation of Neuronal Progenitors and in Protecting Them against Oxidative Stress, Advanced science, 2017, 通讯作者
(42) Two-Dimensional Nanomaterials for Cancer Nanotheranostics, Small, 2017, 通讯作者
(43) Synthesis of different-sized gold nanostars for Raman bioimaging and photothermal therapy in cancer nanotheranostics, SCIENCE CHINA, 2017, 通讯作者
(44) Molybdenum disulfide/graphene oxide nanocomposites show favorable lung targeting Q1 and enhanced drug loading/tumor-killing efficacy with improved biocompatibility, NPG Asia Materials, 2017, 通讯作者
(45) TiO2 particles in seafood and surimi products: Attention should be paid to their exposure and uptake through foods, Chemosphere, 2017, 通讯作者
(46) Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress, Cell discovery, 2017, 通讯作者
(47) Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment, Adv Mater, 2016, 通讯作者
(48) Carbon nanotubes stimulate synovial inflammation by inducing systemic pro-inflammatory cytokines, Nanoscale, 2016, 通讯作者
(49) Metal-Organic-Framework-Derived Mesoporous Carbon Nanospheres Containing Porphyrin-Like Metal Centers for Conformal Phototherapy, Adv Mater, 2016, 通讯作者
(50) Two-Dimensional Nanomaterials for Cancer Nano theranostics, small, 2016, 通讯作者
(51) Low-Dose Bisphenol A Exposure: A Seemingly Instigating Carcinogenic Effect on Breast Cancer, Adv Sci (Weinh)., 2016, 通讯作者
(52) miR-214protectserythroidcellsagainstoxidativestressbytargeting ATF4andEZH2, FreeRadicalBiologyandMedicine, 2016, 通讯作者
(53) Hepcidin: A Promising Therapeutic Target for Iron Disorders, Medicine, 2016, 通讯作者
(54) Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)- Functionalization is Superior to PEGylation, ACS Nano, 2016, 通讯作者
(55) Bisphenol A and Hormone-Associated Cancers: Current Progress and Perspectives, Medicine, 2015, 通讯作者
(56) CrucialRole of Lateral Size forGraphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals, ACS Nano, 2015, 通讯作者
(57) Silver nanoparticle-induced hemoglobin decrease involves alteration of histone 3 methylation status, Biomaterials, 2015, 通讯作者
(58) Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review, ScienceDirect, 2015, 通讯作者
(59) An important role of the hepcidin–ferroportin signaling in affecting tumor growth and metastasis, Original Article, 2015, 通讯作者
(60) Establishment of a novel orthotopic model of breast cancer metastasis to the lung, ONCOLOGY REPORTS, 2015, 通讯作者
(61) Mechanisms of nanosilver-induced toxicological effects: more attention should be paid to its sublethal effects, Nanoscale, 2015, 通讯作者
(62) Synergistic hepatotoxicity by cadmium and chlorpyrifos: Disordered hepatic lipid homeostasis, MOLECULAR MEDICINE, 2015, 通讯作者
(63) Polychlorinated Biphenyls (PCBs) Inhibit Hepcidin Expression through an Estrogen-Like Effect Associated with Disordered Systemic Iron Homeostasis, chemistry research in toxicology, 2015, 通讯作者
(64) Estrogen contributes to regulating iron metabolism through governing ferroportin signaling via an estrogen response element, Cellular Signalling, 2015, 通讯作者
(65) Disordered signaling governing ferroportin transcription favors breast cancer growth, Cellular Signalling, 2015, 通讯作者
(66) Cadmium depletes cellular iron availability through enhancing ferroportin translation via iron responsive element, MOLECULAR MEDICINE, 2015, 通讯作者
(67) Heme-Regulated eIF2α Kinase Plays a Crucial Role in Protecting Erythroid Cells against Pb-Induced Hemolytic Stress, chemistry research in toxicology, 2015, 通讯作者
(68) Nanosilver Incurs an Adaptive Shunt of Energy Metabolism Mode to Glycolysis in Tumor and Nontumor Cells, ACS Nano, 2014, 通讯作者
(69) Myeloid zinc-finger 1 (MZF-1) suppresses prostate tumor growth through enforcing ferroportin-conducted iron egress, Oncogene, 2014, 通讯作者
(70) HSPC111 Governs Breast Cancer Growth by Regulating Ribosomal Biogenesis, Oncogenes and Tumor Suppressors, 2014, 通讯作者
(71) ROCK has a crucial role in regulating prostate tumor growth through interaction with c-Myc, Oncogene, 2014, 通讯作者
(72) Disordered hepcidin–ferroportin signaling promotes breast cancer growth, Cellular Signalling, 2014, 通讯作者
(73) Hepcidin deficiency undermines bone load-bearing capacity through inducing iron overload, Gene, 2014, 通讯作者
(74) Sublethal exposure of organophosphate pesticide chlorpyrifos alters cellular iron metabolism in hepatocytes and macrophages, MOLECULAR MEDICINE, 2014, 通讯作者
(75) 重金属暴露与前列腺癌发生和进展的关系综述, ENVIRONMENTAL CHEMISTRY, 2014, 通讯作者
(76) Cytotoxicity of quantum dots and graphene oxide to erythroid cells and macrophages, Nanoscale Research Letters, 2013, 通讯作者
(77) Silver nanoparticles induced RNA polymerase-silver binding and RNA transcription inhibition in erythroid progenitor cells, ACS Nano, 2013, 通讯作者
(78) Evaluation of the biological fate and the transport through biological barriers of nanosilver in mice, Current Pharmaceutical Design, 2013, 通讯作者
(79) The capability quantum dots in crossing placental barrier and the potential influence on erythrocytes, Journal of Nanoscience and Nanotechnology, 2013, 通讯作者
(80) Characterization of the interaction between cadmium and chlorpyrifos with integrative techniques in incurring synergistic hepatoxicity, PLoS One, 2013, 通讯作者
(81) Identification of TBBPA MAE and TBBPA MBPE as emerging brominated substances in the ambient environment near a manufacturing site and in mollusks at a coastal region: byproducts or transformation products of other TBBPA derivatives, Environ Sci Technol, 2013, 通讯作者
(82) The ex vivo and in vivo biological performances of graphene oxide and the impact of surfactant on graphene oxide’s biocompatibility, J Environ Sci, 2013, 通讯作者
(83) Quantum dots (QDs) restrain human cervical carcinoma HeLa cell proliferation through inhibition of the ROCK-c-Myc signaling, Integr Biol (Camb), 2013, 通讯作者
(84) Quantum dots impair macrophagic morphology and the ability of phagocytosis by inhibiting the Rho-associated kinase signaling, Nanoscale, 2012, 通讯作者
(85) Downregulation of ubiquitin E3 ligase TNF receptor-associated factor 7 leads to stabilization of p53 in breast cancer, Oncol Rep, 2012, 通讯作者
(86) A microRNA expression signature characterizing the properties of tumor-initiating cells for breast cancer, Oncology Letters, 2012, 通讯作者
(87) Carbon nanotubes provoke inflammation by inducing the pro-inflammatory genes, Gene, 2012, 通讯作者
(88) Subcellular distribution of CdSe quantum dots (QDs) in breast cancer cells., Journal of Nanoscience and Nanotechnology, 2012, 通讯作者
(89) Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element, Gene, 2012, 通讯作者
(90) A lung cancer gene GPC5 could also be crucial in breast cancer, Molecular Genetics and Metabolism, 2011, 通讯作者
(91) AG490: An inhibitor of hepcidin expression in vivo, World J Gastroenterol, 2011, 通讯作者
(92) CdSe Quantum Dot (QD)-Induced Morphological and Functional Impairments to Liver in Mice, Plos One, 2011, 通讯作者
(93) The associations between the environmental exposure to polychlorinated biphenyls (PCBs) and breast cancer risk and progression, SCIENCE CHINA Chemistry, 2010, 第 1 作者
(94) Polychlorinated biphenyls (PCBs) enhance metastatic properties of breast cancer cells by activating Rho-associated kinase (ROCK), Plos One, 2010, 第 1 作者
(95) Inhibition of ROCK signaling prevents breast cancer metastasis to human bone, Cancer Research, 2009, 第 1 作者
(96) Deficiency of Heme-regulated eIF2a decreases hepcidin expression and splenic iron in HFE-/- mice, Haematologica, 2008, 第 1 作者
(97) Heme-regulated eIF2α kinase is necessary for erythropoiesis in the stress of iron deficiency. British Journal of Haematology, British Journal of Haematology, 2008, 第 1 作者
(98) The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation, Journal of Clinical Investigation, 2007, 第 1 作者
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科研活动

   
科研项目
( 1 ) 典型有机磷农药和重金属的联合毒性效应与作用机理, 主持, 国家级, 2011-01--2013-12
( 2 ) 持久性有机污染物的分子毒理学研究, 主持, 部委级, 2009-09--2013-12
( 3 ) 多氯联苯(PCBs)暴露对乳腺癌肿瘤转移的影响及相关分子机制的研究, 主持, 国家级, 2011-01--2013-12
( 4 ) 纳米银的胚胎发育毒性机理研究, 主持, 国家级, 2012-01--2015-12
( 5 ) 人工纳米材料环境效应的分子作用机制研究, 主持, 国家级, 2014-01--2018-12
( 6 ) 典型污染物对肿瘤细胞增殖与转移的影响机制, 主持, 部委级, 2014-07--2019-06
( 7 ) 环境污染物的毒理与健康效应, 主持, 国家级, 2015-01--2018-12
( 8 ) 高环境暴露风险金属纳米材料的胚胎发育毒性, 主持, 国家级, 2017-01--2021-12
( 9 ) 大气细颗粒物肺内转化对其毒性的影响机制, 主持, 国家级, 2020-01--2024-12
( 10 ) 大气细颗粒物与肺内生物分子的相互作用及损伤机制, 主持, 部委级, 2020-01--2022-12
参与会议
(1)Biotransformation of graphene oxide in lung fluids significantly alters its inherent properties and in vitro and in vivo bio-interactions    第255届美国化学会年会   2018-08-23
(2)Molybdenum disulfide (MoS2)/graphene oxide (GO) nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with desirable biocompatibility    第255届美国化学会年会   2018-08-22
(3)重金属等污染物的毒性靶点识别与毒性通路    2018环境与健康学术会议   2018-08-14
(4)重金属等污染物的毒性靶点识别与毒性通路    2018环境与健康学术会议   2018-08-14
(5)石墨烯的毒性机制与转化毒理研究    第二届全国环境纳米技术及生物效应学术研讨会(2018)   2018-06-18
(6)石墨烯的毒性机制与转化毒理研究    第二届全国环境纳米技术及生物效应学术研讨会(2018)   2018-06-18
(7)Silver nanoparticles repress hemoglobin transcription through an epigenetic mechanism: altering the methylation status of histone 3   2015-12-15
(8)Environmental pollutants, iron metabolism, and cancer risk   2015-11-15
(9)Silver Nanoparticles Induced RNA Polymerase-Silver Binding and RNA Transcription Inhibition in Erythroid Progenitor Cells   2013-08-12

指导学生

已指导学生

张书平  博士研究生  083001-环境科学  

王立新  博士研究生  083001-环境科学  

王哲  博士研究生  083001-环境科学  

王雷  硕士研究生  430130-环境工程  

王小岩  博士研究生  083001-环境科学  

郭文丽  博士研究生  083001-环境科学  

刘静  博士研究生  083001-环境科学  

张洁  博士研究生  083001-环境科学  

高婕  硕士研究生  083001-环境科学  

马娟  博士研究生  083001-环境科学  

吴亚坤  博士研究生  083001-环境科学  

陈禹男  硕士研究生  077601-环境科学  

尹春阳  博士研究生  070303-有机化学  

陈永久  博士研究生  083001-环境科学  

汪顺浩  博士研究生  070303-有机化学  

申心铭  硕士研究生  085238-生物工程  

任泉仲  硕士研究生  077601-环境科学  

现指导学生

杨秋源  博士研究生  083001-环境科学  

刘伟  博士研究生  083001-环境科学  

闫旭  博士研究生  083001-环境科学  

冯文雅  博士研究生  070303-有机化学  

王瑞霞  博士研究生  083001-环境科学  

丘嘉煌  博士研究生  083001-环境科学  

徐立宁  博士研究生  083001-环境科学  

陈誉才  硕士研究生  086000-生物与医药  

董政  博士研究生  083001-环境科学