Dr. Xiaozhong Qu
College of Materials Science and Opto-Electronic Technology
The University of Chinese Academy of Sciences
Address: 19A Yuquan Road, Shijingshan District, Beijing, P. R. China
Postcode: 100049

Research Areas

1. Polymer physics, stimuli resposive polymers
2. Polymeric drug delivery systems


Ph. D., 2001, Institute of Chemistry, Chinese Academy of Sciences 
M. Sc. 1998, Institute of Chemistry, Chinese Academy of Sciences 
B. Sc., 1995, Department of Chemistry, Tsinghua University


Work Experience

2015.12-date, Professor, College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences

2013.7-2015.11, Associate professor, College of Materials Science and Opto-Electronic Technology, University of Chinese Academy of Sciences

2006.1-2013.6, Associate professor, Institute of Chemistry, Chinese Academy of Sciences 

2005.9-2005.12, Assistant professor, Institute of Chemistry, Chinese Academy of Sciences 

2003.1-2005.8, Research associate, Department of Pharmaceutical Sciences, University of Strathclyde, Scotland.



[1] Zhao, L.; Zhu, L.; Chen, Y.; Wang, Q.; Li, J.; Zhang, C.; Liang, F.*; Qu, X.*; Yang, Z.* Janus Micro-Reactors, Chem. Comm. 2013, 49, 6161-6163.
[2] Zhu, L.; Huo, P.; Wang, Q.; Liang, F.; Zhang, C.; Li, J.; Qu, X.*; Wang, G.*; Yang, Z.* Photoluminescent poly(ether ether ketone)/quantum dot composite films, Chem. Comm. 2013, 49, 5283-5285.
[3] Chooi, C.; Hou, X.; Qu, X.; Soundararajan, R.; Uchegbu, I. F. Claw Amphiphiles with a Dendrimer Core: Nanoparticle Stability and Drug Encapsulation Are Directly Proportional to the Number of Digits. Langmuir 2013, 29, 4214-4224.
[4] Zhu, L.; Zhao, L.; Qu, X.*; Yang, Z.* pH-Sensitive polymeric vesicles from coassembly of amphiphilic cholate grafted poly(L-lysine) and acid-cleavable polymer-drug conjugate, Langmuir 2012, 28, 11988-11996.
[5] Jin, H.; Tan, H.; Zhao, L.; Sun, W.; Zhu, L.; Sun, Y.; Hao, H.; Xing, H.; Liu, L.; Qu, X.*; Huang, Y.*; Yang, Z.* Ultrasound-triggered thrombolysis using urokinase-loaded nanogels, Int. J. Pharm. 2012, 434, 384-390.
[6] Tan, H.; Jin, H.; Mei, H.; Zhu, L.; Wei, W.; Wang, Q.; Liang, F.; Zhang, C.; Li, J.; Qu, X.*; Shangguan, D.; Huang, Y.; Yang, Z.* PEG-urokinase nanogels with enhanced stability and controllable bioactivity. Soft Matter 2012, 8, 2644-2650.
[7]  Guo, J.; Cheng, W. P.; Gu, J.; Ding, C.; Qu, X.; Yang, Z.; O’Driscoll, C.* Systemic delivery of therapeutic small interfering RNA using a pH-triggered amphiphilic poly-l-lysine nanocarrier to suppress prostate cancer growth in mice. Eur. J. Pharm. Sci. 2012, 45, 521-532.
[8] Gu, J.; Cheng, W. P.*; Hoskins, C.; Lin, P. K. T.; Zhao, L.; Zhu, L.; Qu, X.*; Yang, Z. Nano self-assemblies based on cholate grafted poly-l-lysine enhanced the solubility of sterol-like drugs. J. Microencapsul. 2011, 28, 752-762.
[9] Zhao, L.; Zhu, L.; Wang, Q.; Li, J.; Zhang, C.; Liu, J.; Qu, X.*; He, G.; Lu, Y.; Yang, Z.* Synthesis of composite microgel capsules by ultrasonic spray combined with in situ crosslinking. Soft Matter 2011, 7, 6144-6150.
[10] Zhao, L.; Zhu, L.; Liu, F.; Liu, C.; Shan-Dan; Wang, Q.; Zhang, C.; Li, J.; Liu, J.; Qu, X.*; Yang, Z.* pH triggered injectable amphiphilic hydrogel containing doxorubicin and paclitaxel. Int. J. Pharm. 2011, 410, 83-91. 
[11] Qu, X.; Yang, Z.* Synthesis of pH responsible drug delivery systems by the inclusion of a dynamic covalent bond, benzoic-imine. Acta Polymerica Sinica (Chinese) 2011, (10), 1118-1124.
[12] Ding, C.; Zhao, L.; Liu, F.; Cheng, J.; Gu, J.; Shan-Dan; Liu, C.; Qu, X.*; Yang, Z.* Dually Responsive Injectable Hydrogel Prepared by In Situ Cross-Linking of Glycol Chitosan and Benzaldehyde-Capped PEO-PPO-PEO. Biomacromolecules 2010, 11, 1043-1051. 
[13] Ding, C.; Gu, J.; Qu, X.*; Yang, Z.* Preparation of Multifunctional Drug Carrier for Tumor-Specific Uptake and Enhanced Intracellular Delivery through the Conjugation of Weak Acid Labile Linker. Bioconjugate Chem. 2009, 20, 1163-1170.  
[14]  Gu, J.; Cheng, W. P.; Liu, J.; Lo, S. Y.; Smith, D.; Qu, X.*; Yang, Z.* pH-triggered reversible “stealth” polycationic micelles. Biomacromolecules 2008, 9, 255-262. 
[15] Qu, X.; Omar, L.; Le, T. B. H.; Tetley, L.; Bolton, K.; Chooi, K. W.; Wang, W.; Uchegbu, I. F.* Polymeric amphiphile branching leads to rare nanodisc shaped planar self-assemblies. Langmuir 2008, 24, 9997-10004.
[16] Thompson, C. J.; Ding, C.; Qu, X.; Yang, Z.; Uchegbu, I. F.; Tetley, L.; Cheng, W. P.* The effect of polymer architecture on the nano self-assemblies based on novel comb-shaped amphiphilic poly(allylamine). Colloid Polym. Sci. 2008, 286, 1511-1526. 
[17] Gu, J.; Xia, F.; Wu, Y.*; Qu, X.*; Yang, Z.; Jiang, L. Programmable delivery of hydrophilic drug using dually responsive hydrogel cages. J. Controlled Rel. 2007, 117, 396-402. 
[18] Qu, X.; Khutoryanskiy, V. V.; Stewart, A.; Rahman, S.; Papahadjopoulos-Sternberg, B.; Dufes, C.; McCarthy, D.; Wilson, C. G.; Lyons, R.; Carter, K. C.; Schatzlein, A.; Uchegbu, I. F.* Carbohydrate-based micelle clusters which enhance hydrophobic drug bioavailability by up to 1 order of magnitude. Biomacromolecules 2006, 7, 3452-3459.

1. 超支化壳聚糖或超支化乙二醇壳聚糖及其制备方法 200610011756.1
2. 二乙三胺五乙酸羧基活化酯或类似物及合成方法和用途200710099349.5

Research Interests

1. Synthesis and self-assembly of amphiphilic polymers
2. Multifunctional polymeric drug delivery systems
3. Polymer composites for diagnosis
4. Smart hydrogel systems for drug delivery and tissue engineering 


CAS, Beijing Obstetrics and Gynecology Hospital, etc.