HIV-1致病机制。

硕士研究生

071010-生物化学与分子生物学

HIV的致病机制研究

2005-09--2008-07   中国科学院   博士
2002-09--2005-07   中国协和医科大学   硕士
1998-09--2002-07   云南大学   学士

博士

博士

2012年至今在中国科学院昆明动物所工作。从博士期间近10年来一直从事HIV/AIDS相关的药物筛选、分子生物学、流行病学和动物模型研究。2011年入选昆明市学术与技术带头人后备人选。2013年12月被评为副研究员。

2014-01~2014-07,中国科学院昆明动物研究所, 副研究员
2012-03~2012-12,中国科学院昆明动物研究所, 助理研究员
2010-08~2012-03,昆明市延安医院, 助理研究员
2008-08~2010-08,中国科学院昆明动物研究所, 博士后
2005-09~2008-07,中国科学院, 博士
2002-09~2005-07,中国协和医科大学, 硕士
1998-09~2002-07,云南大学, 学士

2014-10-01-2018-10-01,云南省医学会微生物学与免疫学会, 副主任委员

   

（1） 昆明市学术与技术带头人后备人选, 院级, 2011
（2） 2010 年度云南省科技进步三等奖, 省级, 2010
（3） 第九届云南省优秀科技论文(云锡奖)一等奖, 国家级, 2009
（4） 中国科学院博士后学术年会暨生命科学前沿与发展学术会论文一等奖, 国家级, 2009

[1] Wei Pang, Yong Shao, Xiao-Lin Zhuang, Ying Lu, Wen-Qiang He, Hong-Yi Zheng, Rong Xin, Ming-Xu Zhang, Xiao-Liang Zhang, Jia-Hao Song, Ren-Rong Tian, Fan Shen, Yi-Hui Li, Zu-Jiang Zhao, Dong-Dong Wu, Yong-Tang Zheng. Genomic evidence for the nonpathogenic state in HIV-1-infected northern pig-tailed macaques. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2023, 40(5): https://academic.oup.com/mbe/article-lookup/doi/10.1093/molbev/msad101.
[2] WenQiang He, XiaoYan He, Ying Lu, Shuai Zhang, MingXu Zhang, YongTang Zheng, Wei Pang. HIV-1 but not SIVmac239 induces higher interferon-α antiviral state in chronic infected northern pig-tailed macaques (Macaca leonina). MICROBES AND INFECTION[J]. 2022, 24(5): http://dx.doi.org/10.1016/j.micinf.2022.104970.
[3] Pang, Wei, Lu, Ying, Zhao, YanBo, Shen, Fan, Fan, ChangFa, Wang, Qian, He, WenQiang, He, XiaoYan, Li, ZeKai, Chen, TaoTao, Yang, CuiXian, Li, YouZhi, Xiao, SiXuan, Zhao, ZuJiang, Huang, XuSheng, Luo, RongHua, Yang, LiuMeng, Zhang, Mi, Dong, XingQi, Li, MingHua, Feng, XiaoLi, Zhou, QingCui, Qu, Wang, Jiang, Shibo, Ouyang, Songying, Zheng, YongTang. A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein. CELL RESEARCH[J]. 2022, 32(12): 1068-1085, [4] Yang, Ruoheng, Liu, Qingwei, Pang, Wei, Gao, Fei, Liang, Huabin, Zhang, Wei, Lin, Yalong, Li, Min, Liu, Zhihua, Gao, George F, Zhang, Linqi, Xiao, Hui, Zheng, Yongtang, Huang, Zhong, Jin, Xia. Two immunogenic recombinant protein vaccine candidates showed disparate protective efficacy against Zika virus infection in rhesus macaques. VACCINE[J]. 2021, 39(6): 915-925, http://dx.doi.org/10.1016/j.vaccine.2020.12.077.
[5] Pang, W, Lin, YL, Xin, R, Chen, XX, Lu, Y, Zheng, CB, Yang, LM, Zheng, YT. Zika virus transmission via breast milk in suckling mice. CLINICAL MICROBIOLOGY AND INFECTION[J]. 2021, 27(3): 469.e1-469.e7, http://dx.doi.org/10.1016/j.cmi.2020.04.021.
[6] 陈秀秀, 罗荣华, 姚债文, 郑昌博, 唐秋菊, 庞伟, 汪芳, 杨柳萌, 熊思东, 郑永唐. FDA已批准上市药物托伐普坦可在体内外抑制寨卡病毒感染. 中国药学：英文版[J]. 2021, 30(3): 218-229, http://lib.cqvip.com/Qikan/Article/Detail?id=7104383827.
[7] Shan, Chao, Yao, YanFeng, Yang, XingLou, Zhou, YiWu, Gao, Ge, Peng, Yun, Yang, Lian, Hu, Xue, Xiong, Jin, Jiang, RenDi, Zhang, HuaJun, Gao, XiaoXiao, Peng, Cheng, Min, Juan, Chen, Ying, Si, HaoRui, Wu, Jia, Zhou, Peng, Wang, YanYi, Wei, HongPing, Pang, Wei, Hu, ZhengFei, Lv, LongBao, Zheng, YongTang, Shi, ZhengLi, Yuan, ZhiMing. Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques. CELL RESEARCH[J]. 2020, 30(8): 670-677, http://lib.cqvip.com/Qikan/Article/Detail?id=7102918057.
[8] Mei Ye, Xin Chen, Yu Wang, YanHeng Zhou, Wei Pang, Chiyu Zhang, YongTang Zheng. HIV-1 Drug Resistance in ART-Naïve Individuals in Myanmar. INFECTION AND DRUG RESISTANCE. 2020, 13: 1123-1132, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182463/.
[9] Zhang, XiaoLiang, Luo, MengTing, Song, JiaHao, Pang, Wei, Zheng, YongTang. An Alu Element Insertion in Intron 1 Results in Aberrant Alternative Splicing of APOBEC3G Pre-mRNA in Northern Pig-Tailed Macaques (Macaca leonina) That May Reduce APOBEC3G-Mediated Hypermutation Pressure on HIV-1. JOURNAL OF VIROLOGY[J]. 2020, 94(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000510867500021.
[10] MingXu Zhang, TianZhang Song, HongYi Zheng, XueHui Wang, Ying Lu, HanDan Zhang, Ting Li, Wei Pang, 郑永唐. Superior intestinal integrity and limited microbial translocation are associated with lower immune activation in SIVmac239-infected northern pig-tailed macaques (Macaca leonina). 动物学研究[J]. 2019, 40(6): 522-531, http://lib.cqvip.com/Qikan/Article/Detail?id=7003048993.
[11] Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina)infected with SIVmac239. 动物学研究[J]. 2018, 39(1): 42-51, http://lib.cqvip.com/Qikan/Article/Detail?id=674503003.
[12] Zhang, MingXu, Zheng, HongYi, Jiang, Jin, Song, JiaHao, Chen, Min, Xiao, Yu, Lian, XiaoDong, Song, TianZhang, Tian, RenRong, Pang, Wei, Zheng, YongTang. Northern pig-tailed macaques (Macaca leonina) maintain superior CD4(+) T-cell homeostasis during SIVmac239 infection. EUROPEAN JOURNAL OF IMMUNOLOGY. 2018, 48(2): 384-385, http://www.corc.org.cn/handle/1471x/2157037.
[13] Chen, Xin, Zhou, YanHeng, Ye, Mei, Wang, Yu, Duo, Lin, Pang, Wei, Zhang, Chiyu, Zheng, YongTang. Burmese injecting drug users in Yunnan play a pivotal role in the cross-border transmission of HIV-1 in the China-Myanmar border region. VIRULENCE[J]. 2018, 9(1): 1195-1204, https://doaj.org/article/dfe51713132f4d33859c5666e9437ffc.
[14] Song, TianZhang, Zhang, MingXu, Xia, YuJie, Xiao, Yu, Pang, Wei, Zheng, YongTang. Parasites may exit immunocompromised northern pig-tailed macaques (Macaca leonina) infected with SIVmac239. ZOOLOGICAL RESEARCH[J]. 2018, 39(1): 42-51, http://lib.cqvip.com/Qikan/Article/Detail?id=674503003.
[15] Pang, Wei, Song, JiaHao, Lu, Ying, Zhang, XiaoLiang, Zheng, HongYi, Jiang, Jin, Zheng, YongTang. Host Restriction Factors APOBEC3G/3F and Other Interferon-Related Gene Expressions Affect Early HIV-1 Infection in Northern Pig-Tailed Macaque (Macaca leonina). FRONTIERS IN IMMUNOLOGY[J]. 2018, 9: http://www.corc.org.cn/handle/1471x/2201698.
[16] TianZhang Song PhD, MingXu Zhang PhD, HanDan Zhang MS, Yu Xiao PhD, Wei Pang PhD, YongTang Zheng PhD. Comparison of HIV Status Between Transgender Women and Men Who Have Sex with Men: A Meta-Analysis. JOURNAL OF THE ASSOCIATION OF NURSES IN AIDS CARE. 2018, 29(5): 681-697, http://dx.doi.org/10.1016/j.jana.2018.04.001.
[17] Chen, Xin, Ye, Mei, Duo, Lin, Pang, Wei, Smith, Davey, Zhang, Chiyu, Zheng, YongTang. First description of two new HIV-1 recombinant forms CRF82_cpx and CRF83_cpx among drug users in Northern Myanmar. VIRULENCE. 2017, 8(5): 497-503, http://159.226.149.26:8080/handle/152453/12066.
[18] Wei Pang, Gao-Hong Zhang, Jin Jiang, Hong-Yi Zheng, Lin-Tao Zhang, Xiao-Liang Zhang, Jia-Hao Song, Ming-Xu Zhang, Jia-wu Zhu, Ai-Hua Lei, Ren-Rong Tian, Xiao-Ming Liu, Liguo Zhang, Guangxia Gao, Lishan Su, Yong-Tang Zheng. HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo. 科学通报：英文版[J]. 2017, 62(19): 1315-1324, http://lib.cqvip.com/Qikan/Article/Detail?id=673594778.
[19] Chen, Xin, Ye, Mei, Pang, Wei, Smith, Davey M, Zhang, Chiyu, Zheng, YongTang. First Appearance of HIV-1 CRF07_BC and CRF08_BC Outside China. AIDS RESEARCH AND HUMAN RETROVIRUSES[J]. 2017, 33(1): 74-76, http://www.irgrid.ac.cn/handle/1471x/1151490.
[20] Pang, Wei, Zhang, GaoHong, Jiang, Jin, Zheng, HongYi, Zhang, LinTao, Zhang, XiaoLiang, Song, JiaHao, Zhang, MingXu, Zhu, JiaWu, Lei, AiHua, Tian, RenRong, Liu, XiaoMing, Zhang, Liguo, Gao, Guangxia, Su, Lishan, Zheng, YongTang. HIV-1 can infect northern pig-tailed macaques (Macaca leonina) and form viral reservoirs in vivo. SCIENCE BULLETIN[J]. 2017, 62(19): 1315-1324, http://lib.cqvip.com/Qikan/Article/Detail?id=673594778.
[21] Zhang, XiaoLiang, Song, JiaHao, Pang, Wei, Zheng, YongTang. Molecular cloning and anti-HIV-1 activities of APOBEC3s from northern pig-tailed macaques (Macaca leonina). ZOOLOGICAL RESEARCH[J]. 2016, 37(4): 246-251, http://159.226.149.26:8080/handle/152453/10944.
[22] 叶梅, 陈鑫, 王雨, 庞伟, 郑永唐. HIV-1阳性配偶/固定性伴的分子流行病学研究进展. 传染病信息[J]. 2016, 29(6): 358-363, http://lib.cqvip.com/Qikan/Article/Detail?id=671242142.
[23] Zhang, LinTao, Tian, RenRong, Zheng, HongYi, Pan, GuoQing, Tuo, XiaoYu, Xia, HouJun, Xia, XueShan, Pang, Wei, Zheng, YongTang. Translocation of microbes and changes of immunocytes in the gut of rapid- and slow-progressor Chinese rhesus macaques infected with SIVmac239. IMMUNOLOGY[J]. 2016, 147(4): 443-452, http://www.irgrid.ac.cn/handle/1471x/1151459.
[24] Chen, Xin, Zhu, Lin, Zhou, YanHeng, Liu, FengLiang, Li, Hong, Yao, ZhiHong, Duo, Lin, Pang, Wei, Ye, Mei, Zheng, YongTang. Factors associated with needle sharing among people who inject drugs in Yunnan, China: a combined network and regression analysis. INFECTIOUS DISEASES OF POVERTY[J]. 2016, 5(X): http://www.irgrid.ac.cn/handle/1471x/1151493.
[25] Zhang, MingXu, Zheng, HongYi, Jiang, Jin, Pang, Wei, Zhang, GaoHong, Zheng, YongTang. Viral seroprevalence in northern pig-tailed macaques (Macaca leonina) derived from Ho Chi Minh City, Vietnam. PRIMATES[J]. 2016, 57(3): 413-419, https://www.webofscience.com/wos/woscc/full-record/WOS:000379192900018.
[26] Zhang, GaoHong, Wu, RunDong, Zheng, HongYi, Zhang, XiaoLiang, Zhang, MingXu, Tian, RenRong, Liu, GuangMing, Pang, Wei, Zheng, YongTang. Lipopolysaccharide Increases Immune Activation and Alters T Cell Homeostasis in SHIVB'WHU Chronically Infected Chinese Rhesus Macaque. JOURNAL OF IMMUNOLOGY RESEARCH[J]. 2015, 2015(X): https://doaj.org/article/5649346a964f45b88bf6b5e6e364bdec.
[27] Hu, QiuXiang, Fan, Yu, Xu, Ling, Pang, Wei, Wang, Shuang, Zheng, YongTang, Lv, LongBao, Yao, YongGang. Analysis of the complete mitochondrial genome and characterization of diverse NUMTs of Macaca leonina. GENE[J]. 2015, 571(2): 279-285, http://dx.doi.org/10.1016/j.gene.2015.06.085.
[28] Zhou, YanHeng, Chen, Xin, Liang, YueBo, Pang, Wei, Qin, WeiHong, Zhang, Chiyu, Zheng, YongTang. Near Full-Length Identification of a Novel HIV-1 CRF01_AE/B/C Recombinant in Northern Myanmar. AIDS RESEARCH AND HUMAN RETROVIRUSES[J]. 2015, 31(8): 845-850, https://www.webofscience.com/wos/woscc/full-record/WOS:000359861200014.
[29] Tian, RenRong, Zhang, MingXu, Zhang, LinTao, Zhang, XiaoLiang, Zheng, HongYi, Zhu, Lin, Pang, Wei, Zhang, GaoHong, Zheng, YongTang. High immune activation and abnormal expression of cytokines contribute to death of SHIV89.6-infected Chinese rhesus macaques. ARCHIVES OF VIROLOGY[J]. 2015, 160(8): 1953-1966, https://www.webofscience.com/wos/woscc/full-record/WOS:000359434000008.
[30] Zheng HY, Zhang MX, Zhang LT, Zhang XL, Pang W, Lv LB, Zheng YT. Flow cytometric characterizations of leukocyte subpopulations in the peripheral blood of northern pig-tailed macaques (Macaca leonina). ZOOLOGICAL RESEARCH[J]. 2014, 35(6): 465-473, http://159.226.149.42:8080:8088/handle/152453/8170.
[31] Zheng, HongYi, Zhang, MingXu, Pang, Wei, Zheng, YongTang. Aged Chinese rhesus macaques suffer severe phenotypic T- and B-cell aging accompanied with sex differences. EXPERIMENTAL GERONTOLOGY[J]. 2014, 55(**): 113-119, http://dx.doi.org/10.1016/j.exger.2014.04.004.
[32] Wei, Chuanyu, Wang, Wenju, Pang, Wei, Meng, Mingyao, Jiang, Lihong, Xue, Sha, Xie, Yanhua, Li, Ruhong, Hou, Zongliu. The CIK cells stimulated with combination of IL-2 and IL-15 provide an improved cytotoxic capacity against human lung adenocarcinoma. TUMOR BIOLOGY[J]. 2014, 35(3): 1997-2007, https://www.webofscience.com/wos/woscc/full-record/WOS:000333536300034.
[33] Lei Aihua, Zhang Gaohong, Tian Renrong, Zhu Jiawu, Zheng Hongyi, Pang Wei, Zheng Yongtang. Replication potentials of HIV-1/HSIV in PBMCs from northern pigtailed macaque (Macaca leonina). ZOOLOGICAL RESEARCH[J]. 2014, 35(3): 186−195-, http://www.irgrid.ac.cn/handle/1471x/846365.
[34] 陈鑫, 庞伟, 周衍衡, 郑永唐. 澜沧江-湄公河次区域HIV-1分子流行病学及跨境传播研究进展. 中国国境卫生检疫杂志[J]. 2014, 37(1): 63-67,72, http://www.irgrid.ac.cn/handle/1471x/1151431.
[35] Feng Yue, Zheng Yongtang, Zhang Xiaoliang, Pang Wei, Deng Deyao, Lv Longbao. Analysis of immunoglobulin, complements and CRP levels in serum of captive northern pig-tailed macaques (Macaca leonina). ZOOLOGICAL RESEARCH[J]. 2014, 35(3): 196−203-, http://www.irgrid.ac.cn/handle/1471x/1151441.
[36] Zhou, YanHeng, Liang, YueBo, Pang, Wei, Qin, WeiHong, Yao, ZhiHong, Chen, Xin, Zhang, Chiyu, Zheng, YongTang. Diverse forms of HIV-1 among Burmese long-distance truck drivers imply their contribution to HIV-1 cross-border transmission. BMC INFECTIOUS DISEASES[J]. 2014, 14(X): http://www.irgrid.ac.cn/handle/1471x/861366.
[37] YongTang Zheng, Chiyu Zhang, Xin Chen, ZhiHong Yao, WeiHong Qin, Wei Pang, YueBo Liang, YanHeng Zhou. Diverse forms of HIV-1 among Burmese long-distance truck drivers imply their contribution to HIV-1 cross-border transmission. 2014, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201706291925678ZK.
[38] Zhang XL, Pang W, Hu XT, Li JL, Yao YG, Zheng YT. Experimental primates and non-human primate (NHP) models of human diseases in China: current status and progress. ZOOLOGICAL RESEARCH[J]. 2014, 35(6): 447-464, http://www.irgrid.ac.cn/handle/1471x/1149215.
[39] 吴润东, 刘光明, 庞伟. HIV潜伏感染激活剂研究进展. 中国药理学通报[J]. 2014, 30(1): 1-6, http://lib.cqvip.com/Qikan/Article/Detail?id=48334839.
[40] 庞伟, 吕龙宝, 王芸, 李贵, 黄东体, 雷爱华, 张高红, 郑永唐. 北平顶猴（Macaca leonina）血液学和血液生化指标参考值的测定与分析. 动物学研究[J]. 2013, 34(2): 89−96-, http://www.irgrid.ac.cn/handle/1471x/648620.
[41] 雷爱华, 庞伟, 张高红, 郑永唐. 平顶猴在HIV/AIDS 动物模型中的应用及研究进展. 动物学研究[J]. 2013, 34(2): 77−88-, http://www.irgrid.ac.cn/handle/1471x/648619.
[42] Meng, MingYao, Pang, Wei, Jiang, LiHong, Liu, YunHong, Wei, ChuanYu, Xie, YanHua, Yu, HaiDong, Hou, ZongLiu. Stemness gene expression profile analysis in human umbilical cord mesenchymal stem cells. EXPERIMENTAL BIOLOGY AND MEDICINE[J]. 2012, 237(6): 709-719, https://www.webofscience.com/wos/woscc/full-record/WOS:000307146200014.
[43] Kuang, YiQun, Pang, Wei, Zheng, YongTang, Dupre, Denis J. NHERF1 regulates gp120-induced internalization and signaling by CCR5, and HIV-1 production. EUROPEAN JOURNAL OF IMMUNOLOGY[J]. 2012, 42(2): 299-310, https://www.webofscience.com/wos/woscc/full-record/WOS:000299337800006.
[44] Pang, Wei, Zhang, Chiyu, Duo, Lin, Zhou, YanHeng, Yao, ZhiHong, Liu, FengLiang, Li, Hong, Tu, YuanQuan, Zheng, YongTang. Extensive and complex HIV-1 recombination between B ', C and CRF01_AE among IDUs in south-east Asia. AIDS[J]. 2012, 26(9): 1121-1129, http://dx.doi.org/10.1097/QAD.0b013e3283522c97.
[45] Pang, W, Wang, R R, Gao, Y D, Yang, L M, Sun, Y, Huang, J F, Tien, P, Zheng, Y T. A Novel Enzyme-Linked Immunosorbent Assay for Screening HIV-1 Fusion Inhibitors Targeting HIV-1 Gp41 Core Structure (vol 16, pg 221, 2011). JOURNAL OF BIOMOLECULAR SCREENINGnull. 2011, 16(4): 464-464, https://www.webofscience.com/wos/woscc/full-record/WOS:000289199600010.
[46] 孙鹥, 庞伟, 欧阳东云, 郑永唐. Syncytin蛋白的原核表达及其多克隆抗体的制备和鉴定. 免疫学杂志[J]. 2010, 124-127, http://lib.cqvip.com/Qikan/Article/Detail?id=33513493.
[47] Sun, Yi, Ouyang, DongYun, Pang, Wei, Tu, YuanQuan, Li, YuYe, Shen, XiaoMei, Tam, SiuCheung, Yang, HongYing, Zheng, YongTang. Expression of syncytin in leukemia and lymphoma cells. LEUKEMIA RESEARCH[J]. 2010, 34(9): 1195-1202, http://dx.doi.org/10.1016/j.leukres.2010.03.016.
[48] Wei Pang, SiuCheung Tam, YongTang Zheng. Review Current peptide HIV type-1 fusion inhibitors. ANTIVIRAL CHEMISTRY & CHEMOTHERAPY[J]. 2009, 20(20): 1-18, http://www.irgrid.ac.cn/handle/1471x/1151313.
[49] 白雪, 庞伟, 王路, 张高红, 郑永唐. HIV-1 C亚型密码子优化gp120基因重组腺病毒载体的构建及表达. 医学分子生物学杂志[J]. 2009, 397-400, http://lib.cqvip.com/Qikan/Article/Detail?id=32067034.
[50] Pang, Wei, Wang, RuiRui, Yang, LiuMeng, Liu, ChangMei, Tien, Po, Zheng, YongTang. Recombinant protein of heptad-repeat HR212, a stable fusion inhibitor with potent anti-HIV action in vitro. VIROLOGY[J]. 2008, 377(1): 80-87, http://dx.doi.org/10.1016/j.virol.2008.04.013.

（ 1 ） 艾滋病实验室检测技术与质量保证, Detection technology and quality guarantee of AIDS laboratory, 科学出版社, 2009-07, 第 3 作者
（ 2 ） 免疫学前沿进展, Advances in immunology, 人民卫生出版社, 2009-09, 第 5 作者
（ 3 ） 艾滋病病毒的潜伏与治疗, 科学出版社, 2015-06, 第 5 作者

   

（ 1 ） 共感染/超感染在中缅边境注射吸毒人群HIV-1高度重组中的作用和机制研究, 主持, 国家级, 2013-01--2016-12
（ 2 ） 中缅越老边境地区高危人群HIV-1分子流行病学、病毒进化及跨境传播动力学研究, 主持, 国家级, 2014-01--2017-12
（ 3 ） JQ1和prostratin激活HIV-1感染北平顶猴模型中潜伏病毒的作用及其机制研究, 主持, 省级, 2014-10--2016-12
（ 4 ） SIVmac239感染中国猕猴艾滋病潜伏模型的创建及潜伏激活剂对体内病毒库的作用和机制研究, 主持, 国家级, 2016-01--2019-12
（ 5 ） 潜伏激活剂的联用对猕猴艾滋病模型体内病毒潜伏库的作用和机制研究, 主持, 省级, 2016-10--2019-09

（1）平顶猴AIDS动物模型建立   第一届非人灵长类动物模型学术论坛   庞伟   2014-11-06
（2）HIV-1感染北平顶猴模型的创建及研究   疾病动物模型学术及战略研讨会暨第二届灵长类动物模型学术论坛   庞伟   2013-11-25
（3）AIDS灵长类动物模型   第五届灵长类生物医学研讨会   庞伟   2012-08-19