General
罗晓东 男 汉族 博导 昆明植物研究所
Email: xdluo@mail.kib.ac.cn
Telephone: 0871-5223188
Mobile phone:
Address: 昆明市金牛小区
Postcode: 999999

Research Areas

 Major research interests include 1) bioactive indole alkaloids and their application in medicine, with emphasis on novel indole alkaloids, Antitumor indole alkaloids, Investigational new drug of indole alkaloids; 2) limonoid from Meliaceae and their application in agriculture.

Education

1994-09--1999-06    中国科学院昆明植物研究所   理学博士学位
1987-09--1991-06    华东理工大学化学系   工学学士学位

Experience

1991--1994 云南白药实业股份有限公司,任助理工程师。主要从事药品检验,制药生产工艺及新药开发工作。
1999--2000 中国科学院昆明植物研究所, 植物化学开放室,理学博士,副研究员。
2002-- 中国科学院昆明植物研究所, 植物化学与西部资源持续利用国家重点实验室,资源植物化学研究组组长。

Honors & Distinctions

(1) 中国科学院优秀研究生指导奖, , 院级, 2011
(2) 云南省自然科学奖, 二等奖, 省级, 2010
(3) 中国科学院西部学者突出贡献奖, , 院级, 2009
(4) 中组部、中科院“西部之光”优秀, , 院级, 2006
(5) 云南省中青年学术、技术带头人, , 省级, 2005
(6) 云南省第三届青年科技奖, , 省级, 2003

Publications

   
Papers

(1) Non-alkaloid constituents of Vinca major, Chinese Journal of Natural Medicines, 2016, 通讯作者
(2) Effect of total alkaloids from Alstonia scholaris on airway inflammation in rats, Journal of Ethnopharmacology, 2016, 通讯作者
(3) Potent anti-inflammatory and analgesic steroidal alkaloid sfrom Veratrum taliense, Journal of Ethnopharmacology, 2016, 通讯作者
(4) Alstoscholarisines H−J, Indole Alkaloids from Alstonia scholaris:Structural Evaluation and Bioinspired Synthesis of Alstoscholarisine H, Organic Letters., 2016, 通讯作者
(5) Alstorisine A, a nor-monoterpenoid indole alkaloid from cecidogenous leaves of Alstonia scholaris, Tetrahedron Letters, 2016, 通讯作者
(6) New Cytotoxic Tigliane Diterpenoids from Croton caudatus., Planta Medica, 2016, 通讯作者
(7) A potent antibacterial indole alkaloid from Psychotria pilifera, Journal of Asian Natural Products Research, 2016, 通讯作者
(8) Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling, Oncotarget, 2016, 通讯作者
(9) Alkaloids from Veratrum taliense exert cardiovascular toxic effects via cardiac sodium channel subtype 1.5, Toxins, 2016, 通讯作者
(10) Antibacterial monoterpenoid indole alkaloids from Alstonia scholaris cultivated in temperate zone, Fitoterapia, 2015, 通讯作者
(11) Monoterpenoid Indole Alkaloids from Inadequately Dried Leaves of Alstonia scholaris, Natural Products and Bioprospecting, 2015, 通讯作者
(12) Alstoscholarisines F and G, two unusual monoterpenoid indole alkaloids from the leaves of Alstonia scholaris, Tetrahedron Letters, 2015, 通讯作者
(13) Monoterpenoid Indole Alkaloids from Catharanthus roseus Cultivated in Yunnan, Natural Product Communications, 2015, 通讯作者
(14) Characterization of chemical constituents and rats metabolitesof an alkaloidal extract of Alstonia scholaris leaves by liquidchromatography coupled with mass spectrometry., Journal of Chromatography B, 2015, 通讯作者
(15) Antibacterial constituents from Melodinus suaveolens,  Chinese Journal of Natural Medicines , 2015, 通讯作者
(16) Scholarisines H–O, novel indole alkaloid derivatives from long-term stored Alstonia scholaris, Tetrahedron , 2015, 通讯作者
(17) Indole alkaloids with antibacterial bioactivity from aqueous fraction of Alstonia scholaris,  Tetrahedron, 2015, 通讯作者
(18) Alstolactines A–C, novel monoterpenoid indole alkaloids from Alstonia scholaris , Tetrahedron Letters , 2014, 通讯作者
(19) Dysoxydensins A-G, Seven New Clerodane Diterpenoids from Dysoxylum densiflorum, Planta Medica, 2014, 通讯作者
(20) Indole alkaloids from cultivated Vinca major, Tetrahedron, 2014, 通讯作者
(21) New antimicrobial pregnane glycosides from the stem of Ecdysanthera rosea, Fitoterapia , 2014, 通讯作者
(22) Indole Alkaloids with New Skeleton Activating Neural Stem Cells , Organic Letters, 2014, 通讯作者
(23) Chemical Constituents from the Stems of Ecdysanthera rosea, Natural Products and Bioprospecting , 2014, 通讯作者
(24) Limonoid and Steroidal Saponin from Azadirachta indica, Natural Products and Bioprospecting , 2014, 通讯作者
(25) Prenyleudesmanes, Rare Natural Diterpenoids from Dysoxylum densiflorum , Tetrahedron, 2014, 通讯作者
(26) Cinchona Alkaloids from Cinchona succirubra and Cinchona ledgeriana. , Planta Medica, 2014, 通讯作者
(27) Antibacterial Prenylbenzoic Acid Derivatives from Anodendron formicinum.,  Fitoterapia , 2014, 通讯作者
(28) Chemical Components of Dysoxylum densiflorum, Natural Products and Bioprospecting, 2013, 通讯作者
(29) Induced Furoeudesmanes: A Defense Mechanism Against Stress in Laggera pterodonta, a Chinese Herbal Plant,  Organic Letters, 2013, 通讯作者
(30) Melosuavines A?H, Cytotoxic Bisindole Alkaloid Derivatives from Melodinus suaveolens. , Journal of Natural Products, 2013, 通讯作者
(31) Cytotoxic Indole Alkaloids from Tabernaemontana divaricata. , Journal of Natural Products, 2013, 通讯作者
(32) Gardovatine, a novel Strychnos–Strychnos bisindole alkaloid with cytotoxicity from Gardneria ovata.,  Bioorganic and Medicinal Chemistry Letters, 2013, 通讯作者
(33) Cincholenines A and B, two unprecedented quinoline alkaloids from Cinchona ledgeriana. , Tetrahedron Letters, 2013, 通讯作者
(34) Alkaloids from Melodinus yunnanensis. , Phytochemistry, 2012, 通讯作者
(35) Chemical constituents of Allophylus longipes. , Chinese Journal of Natural Medicines., 2012, 通讯作者
(36) Microfractionation bioactivity-based ultra performance liquidchromatography/quadrupole time-of-flight mass spectrometry for the identification of nuclear factor-κB inhibitors and β2 adrenergic receptor, Journal of Chromatography B, 2012, 通讯作者
(37) Melodinines M-U, Cytotoxic Alkaloids from Melodinus suaveolens, Journal of Natural Products, 2012, 通讯作者
(38) Bioactivity-based liquid chromatography-coupled electrospray ionization tandem ion trap/time of flight mass spectrometry for β2AR agonist identification in alkaloidal extract of Alstonia scholaris,  Journal of Chromatography A, 2012, 通讯作者
(39) A New Type of Monoterpenoid Indole Alkaloid Precursor from Alstonia rostrata, Organic Letters , 2011, 通讯作者
(40) New Phenylphenalene Derivatives from Water Hyacinth (Eichhornia crassipes), Helvetica Chimica Acta, 2011, 通讯作者
(41) Amaryllidaceae Alkaloids from Lycoris radiata, Helvetica Chimica Acta  , 2011, 通讯作者
(42) Psychotripine: A New Trimeric Pyrroloindoline Derivative from Psychotria pilifera.,  Organic Letters, 2011, 通讯作者
(43) Inhibition of enterovirus 71 replication by chrysosplenetin and penduletin,  European Journal of Pharmaceutical Sciences, 2011, 通讯作者
(44) Meliaceous Limonoids: Chemistry and Biological Activities, Chemical Reviews, 2011, 通讯作者
(45) Four new isoflavanones from Tadehagi triquetrum. , Natural Products and Bioprospecting, 2011, 通讯作者
(46) Triterpene and Sterol Derivatives from the Roots of Breynia fruticosa, Journal of Natural Products, 2011, 通讯作者
(47) Novel indole and quinoline alkaloids from Melodinus yunnanensis, Natural Products and Bioprospecting, 2011, 通讯作者
(48) Monoterpenoid Indole Alkaloids from Gardneria ovata, Journal of Natural Products  , 2011, 通讯作者
(49) Melotenine A, an Cytotoxic Monoterpenoid Indole Alkaloid from Melodinus tenuicaudatus, Organic Letters   , 2010, 通讯作者
(50) Melodinines A-G, Monoterpenoid Indole Alkaloids from Melodinus henryi, Journal of Natural Products  , 2010, 通讯作者
(51)  Cytotoxic Indole Alkaloids from Melodinus tenuicaudatus, Journal of Natural Products   , 2010, 通讯作者
(52) Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliate,  Chem. Pharm. Bull., 2010, 通讯作者
(53) Abietane Diterpenoids and a Lignan from Pinus yunnanensis,  Zeitschrift für Naturforschung B, A Journal of Chemical Sciences, 2010, 通讯作者
(54) Sterols and Terpenoids from Melia azedarach, Journal of Natural Products, 2010, 通讯作者
(55) Tirucallane-Type Alkaloids from the Bark of Dysoxylum laxiracemosum , Journal of Natural Products, 2010, 通讯作者
(56) Two New Compounds from the Bark of Dysoxylum hainanense, Zeitschrift für Naturforschung B, A Journal of Chemical Sciences, 2010, 通讯作者
(57) Dolabellane diterpenoids from Aglaia odorata,  Phytochemistry, 2010, 通讯作者
(58) Monoterpenoid Indole Alkaloids from Alstonia mairei , Helvetica Chimica Acta, 2010, 通讯作者
(59) Novel Alkaloids from Alstonia scholaris, Zeitschrift für Naturforschung B, A Journal of Chemical Sciences, 2010, 通讯作者
(60) Pharmacological evaluation of Alstonia scholaris: Anti-inflammatory and analgesic effects. , Journal of Ethnopharmacology, 2010, 通讯作者
(61) Pharmacological evaluation of Alstonia scholaris: Anti-tussive, anti-asthmatic and expectorant activities. , Journal of Ethnopharmacology, 2010, 通讯作者
(62) A New Flavone C-Glycoside from Clematis rehderiana.,  Molecules, 2010, 通讯作者
(63) Melohenines A and B, Two Unprecedented Alkaloids from Melodinus henryi , Organic Letters , 2009, 通讯作者
(64) Monoterpenoid Indole Alkaloids from Alstonia yunnanensis, Journal of Natural Products, 2009, 通讯作者
(65) Monoterpenoid Indole Alkaloids from the Bark of Alstonia scholaris, Planta Med, 2009, 通讯作者
(66) Antimicrobially Active Isoquinoline Alkaloids from Litsea cubeba, Planta Med, 2009, 通讯作者
(67) Two New Isoquinoline Alkaloids from Litsea cubeba , Zeitschrift für Naturforschung B, A Journal of Chemical Sciences, 2009, 通讯作者
(68) A New Cyclooxygenase Inhibitor from Incarvillea arguta, Zeitschrift für Naturforschung B, A Journal of Chemical Sciences, 2009, 通讯作者
(69) Three Terpenoids and a Tocopherol-Related Compound from Ricinus communis , Helvetica Chimica Acta, 2009, 通讯作者
(70) Two New Clerodane-type Diterpenoids from Gomphostemma microdon , Zeitschrift für Naturforschung B, A Journal of Chemical Sciences, 2009, 通讯作者
(71) A Cage-monoterpene Indole Alkaloid from Alstonia scholaris, Organic letter, 2008, 通讯作者
(72) Two New Oleanane-type Triterpenoids from Buddleja asiatica, Zeitschrift für Naturforschung B, A Journal of Chemical Sciences, 2008, 通讯作者
(73) Phenylpropanoid Esters of Rhamnose from Buddleja asiatica, Helvetica Chimica Acta, 2008, 通讯作者
(74) Iridoids from the Bark of Alstonia scholaris, Helvetica Chimica Acta, 2008, 通讯作者
(75) Study of solvents effect on distribution of configurational and conformational isomers of apo-tirucallol theoretically and experimentally, Journal of Molecular Structure: THEOCHEM, 2008, 通讯作者
(76) Unique Monoterpenoid Indole Alkaloids from Alstonia scholaris, Organic letter, 2007, 通讯作者
(77)  Alkaloids from Stemona mairei, Planta Med, 2007, 通讯作者
(78) Tirucallane Triterpenoid Saponins from Munronia delavayi , Helvetica Chimica Acta, 2007, 通讯作者
(79) A new Tetranortriterpenoid from Munronia delavayi,  Chinese Journal of Chemistry, 2007, 通讯作者
(80)  A Novel Norditerpene from Eupatorium adenophorum, Zeitschrift für Naturforschung B, A Journal of Chemical Sciences, 2007, 通讯作者

Patents

( 1 ) 治疗呼吸道相关疾病的药物及其制备方法和应用, 发明, 2011, 第 1 作者, 专利号:  ZL200610010940.4
( 2 ) 薄叶山橙素甲,其药物组合及其制备方法和用途, 发明, 2011, 第 1 作者, 专利号: ZL201010104016.9
( 3 ) 山橙素类双吲哚化合物,其药物组合及其制备方法和用途, 发明, 2015, 第 1 作者, 专利号: ZL201010182905.7
( 4 ) 熊果酸的制备方法, 发明, 2009, 第 1 作者, 专利号: ZL200610048656.6
( 5 ) 双吲哚生物碱类化合物,其药物组合及其制备方法和用途, 发明, 2012, 第 1 作者, 专利号: ZL201010101733.6
( 6 ) 治疗呼吸道相关疾病的药物及其应用, 发明, 2011, 第 1 作者, 专利号: ZL200610010941.9
( 7 ) 抗EV71的黄酮类化合物及其在制药中的应用, 发明, 2013, 第 1 作者, 专利号: ZL201110055201.8
( 8 ) 印楝素的提取工艺, 发明, 1999, 第 2 作者, 专利号: ZL96112529.2
( 9 ) 一种氮硫杂环化合物及其制备方法和用途, 发明, 2012, 第 2 作者, 专利号: ZL 201010583504.2
( 10 ) 海兔烷dolabellane二萜类化合物、其药物组合物及其制备方法和用途, 发明, 2013, 第 3 作者, 专利号: ZL 201110349537.5
( 11 ) 水甘草碱(tabersonine)衍生物其药物组合物及其制备方法和用途, 发明, 2015, 第 1 作者, 专利号: ZL 201210004425.0
( 12 ) 印楝原药及含其的杀虫剂和其制备方法与应用, 发明, 2015, 第 1 作者, 专利号: ZL201310386410.X
( 13 ) Melonine bisindole compounds, pharmaceutical compositions, preparation method and use thereof., 发明, 2015, 第 1 作者, 专利号: US 9163035B2
( 14 ) 银杏内酯B在制备抗烟草花叶病毒药物中的应用, 发明, 2013, 第 2 作者, 专利号: ZL201010291033.8
( 15 ) 6-O-咖啡酰基飞蓬苷在制备抗烟草花叶病毒药物中的应用, 发明, 2012, 第 2 作者, 专利号: ZL 201010291012.6
( 16 ) 柴胡皂苷A在制备抗烟草花叶病毒药物中的应用, 发明, 2013, 第 2 作者, 专利号: ZL201010291073.2

Research Interests

( 1 ) 天然药物化学, 主持, 国家级, 2013-01--2016-12
( 2 ) 灯台叶总生物碱胶囊I期、II期临床研究, 主持, 国家级, 2014-01--2017-12

( 3 ) 灯台叶总生物碱胶囊I期、II期临床研究, 主持, 国家级, 2015-01--2017-12

Conferences

(1)吲哚生物碱--实验室到病房   中德天然产物双边研讨会   罗晓东   2015-10-01
(2)吲哚生物碱新型结构、生物活性及临床前研究   第15届国际植物天然产物科学大会   罗晓东   2015-04-15
(3)吲哚生物碱结构与功能   上海中医药与天然药物国际大会   罗晓东   2012-10-10
(4)植物吲哚的新化合物、活性与新药   2012 IOCD 天然功能分子国际研讨会   罗晓东   2012-09-20

Students

已指导学生

蔡祥海  01  19174  

王明忠  02  19174  

刘亚平  02  19494  

谭钦刚  01  19174  

张蓉婷  02  19494  

张向云  02  52361  

冯涛  01  19494  

李晓宁  02  52361  

钱声艳  02  52361  

刘亚平  01  19494  

保梅芬  02  52361  

古吉  02  52361  

程桂广  01  19494  

李江玲  02  52361  

宋长伟  01  19494  

杨兴伟  01  19494  

李琼  02  67127  

秦徐杰  01  19494  

李丹  02  67128  

刘录  01  19494  

陈莹莹  01  19494  

现指导学生

朱培凤  02  67128  

王蓓  01  19494  

杨雄武  02  67128  

闫自如  02  67128  

魏鑫  01  19494  

于浩飞  01  19494  

丁彩凤  01  19494