071006-神经生物学

精神疾病动物模型
高原低氧与脑健康

2017-09--2021-01   中国科学院昆明动物研究所   博士研究生
2012-09--2015-06   昆明理工大学   硕士研究生
2008-09--2012-06   湘南学院   本科

   

2021-04~现在, 中国科学院昆明动物研究所, 副研究员
2021-01~2021-04,中国科学院昆明动物研究所, 助理研究员
2015-09~2017-08,中国科学院昆明动物研究所, 研究实习员

   

（ 1 ） 一种供显微镜观察使用的可拆卸的细胞培养盒, 实用新型, 2022, 第 1 作者, 专利号: CN 218115467 U

   

[1] Wu, Yong, Zhang, Chuyi, Zhang, Yue, Chen, Rui, Wang, Lu, Chang, Hong, Li, Ming, Xiao, Xiao, Li, Shiwu. Genomic landscape and functional characterization of structural variations in schizophrenia and bipolar disorder. Psychiatry Research[J]. 2024, 第 9 作者  通讯作者  337(1): 115929, https://www.sciencedirect.com/science/article/pii/S0165178124002142.
[2] Yin, MeiYu, Guo, Lei, Zhao, LiJuan, Zhang, Chen, Liu, WeiPeng, Zhang, ChuYi, Huo, JinHua, Wang, Lu, Li, ShiWu, Zheng, ChangBo, Xiao, Xiao, Li, Ming, Wang, Chuang, Chang, Hong. Reduced Vrk2 expression is associated with higher risk of depression in humans and mediates depressive-like behaviors in mice. BMC MEDICINE[J]. 2023, 第 9 作者21(1): http://dx.doi.org/10.1186/s12916-023-02945-0.
[3] Yang, ZhiHui, Cai, Xin, Ding, ZhongLi, Li, Wei, Zhang, ChuYi, Huo, JinHua, Zhang, Yue, Wang, Lu, Zhang, LinMing, Li, ShiWu, Li, Ming, Zhang, Chen, Chang, Hong, Xiao, Xiao. Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function. BMC MEDICINE[J]. 2023, 第 10 作者21(1): http://dx.doi.org/10.1186/s12916-023-02931-6.
[4] Li, Shiwu, Ma, Changguo, Li, Yifan, Chen, Rui, Liu, Yixing, Wan, Li Pear, Xiong, Qiuxia, Wang, Chuang, Huo, Yongxia, Dang, Xinglun, Yang, Yongfeng, Lv, Luxian, Chen, Xi, Sheng, Nengyin, Li, Wenqiang, Luo, XiongJian. The schizophrenia-associated missense variant rs13107325 regulates dendritic spine density. TRANSLATIONAL PSYCHIATRY[J]. 2022, 第 1 作者12(1): http://dx.doi.org/10.1038/s41398-022-02137-z.
[5] Li, Shiwu, Li, Jiao, Liu, Jiewei, Wang, Junyang, Li, Xiaoyan, Huo, Yongxia, Li, Yifan, Liu, Yixing, Li, Ming, Xiao, Xiao, Luo, XiongJian. Regulatory variants at 2q33.1 confer schizophrenia risk by modulating distal gene TYW5 expression. BRAIN[J]. 2022, 第 1 作者145(2): 770-786, http://dx.doi.org/10.1093/brain/awab357.
[6] Wang, Junyang, Li, Shiwu, Li, Xiaoyan, Liu, Jiewei, Yang, Jinfeng, Li, Yifan, Li, Wenqiang, Yang, Yongfeng, Li, Jiao, Chen, Rui, Li, Kaiqin, Huang, Di, Liu, Yixing, Lv, Luxian, Li, Ming, Xiao, Xiao, Luo, XiongJian. Functional variant rs2270363 on 16p13.3 confers schizophrenia risk by regulating NMRAL1. BRAIN[J]. 2022, 第 2 作者145(7): 2569-2585, http://dx.doi.org/10.1093/brain/awac020.
[7] Wang, Junyang, Liu, Jiewei, Li, Shiwu, Li, Xiaoyan, Yang, Jinfeng, Dang, Xinglun, Mu, Changgai, Li, Yifan, Li, Kaiqin, Li, Jiao, Chen, Rui, Liu, Yixing, Huang, Di, Zhang, Zhijun, Luo, XiongJian. Genetic regulatory and biological implications of the 10q24.32 schizophrenia risk locus. BRAIN[J]. 2022, 第 3 作者
[8] Zhang, Yan, Zhang, ChuYi, Li, ShiWu, Yuan, Jing, Xu, Li, Wei, Yu Jun, Zhou, Fang, Wang, JunYang, Huo, JinHua, Wang, Lu, Feng, LiMei, Kang, ChuanYuan, Yang, JianZhong. A functional population-specific variant rs77416373 in the Ca(V)2.1 gene is associated with antidepressant treatment response in Han Chinese subjects with major depressive disorder. ASIAN JOURNAL OF PSYCHIATRY[J]. 2022, 第 3 作者77: http://dx.doi.org/10.1016/j.ajp.2022.103272.
[9] Chen, Rui, Liu, Jiewei, Li, Shiwu, Li, Xiaoyan, Huo, Yongxia, Yao, YongGang, Xiao, Xiao, Li, Ming, Luo, XiongJian. Functional genomics elucidates regulatory mechanisms of Parkinson's disease-associated variants. BMC MEDICINE[J]. 2022, 第 3 作者20(1): http://dx.doi.org/10.1186/s12916-022-02264-w.
[10] Li, Yifan, Ma, Changguo, Li, Shiwu, Wang, Junyang, Li, Wenqiang, Yang, Yongfeng, Li, Xiaoyan, Liu, Jiewei, Yang, Jinfeng, Liu, Yixing, Li, Kaiqin, Li, Jiao, Huang, Di, Chen, Rui, Lv, Luxian, Xiao, Xiao, Li, Ming, Luo, XiongJian. Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia Risk By Regulating CTCF Binding and SFMBT1 Expression. ADVANCED SCIENCE[J]. 2022, 第 3 作者9(6): https://doaj.org/article/62b5235d18a44da7a3e4343db9726f6d.
[11] Li, Yifan, Ma, Changguo, Li, Wenqiang, Yang, Yongfeng, Li, Xiaoyan, Liu, Jiewei, Wang, Junyang, Li, Shiwu, Liu, Yixing, Li, Kaiqin, Li, Jiao, Huang, Di, Chen, Rui, Lv, Luxian, Li, Ming, Luo, XiongJian. A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression. MOLECULAR PSYCHIATRY[J]. 2021, 第 8 作者26(11): 6896-6911, http://dx.doi.org/10.1038/s41380-021-01125-x.
[12] Li, Shiwu, Li, Xiaoyan, Liu, Jiewei, Huo, Yongxia, Li, Long, Wang, Junyang, Luo, XiongJian. Functional variants fine-mapping and gene function characterization provide insights into the role of ZNF323 in schizophrenia pathogenesis. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS[J]. 2021, 第 1 作者186(1): 28-39, http://dx.doi.org/10.1002/ajmg.b.32835.
[13] Liu, Jiewei, Li, Shiwu, Li, Xiaoyan, Li, Wenqiang, Yang, Yongfeng, Guo, Suqin, Lv, Luxian, Xiao, Xiao, Yao, YongGang, Guan, Fanglin, Li, Ming, Luo, XiongJian. Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia. BMC MEDICINE[J]. 2021, 第 2 作者19(1): http://dx.doi.org/10.1186/s12916-021-02039-9.
[14] Zhang, Yan, Li, Shiwu, Li, Xiaoyan, Yang, Yongfeng, Li, Wenqiang, Xiao, Xiao, Li, Ming, Lv, Luxian, Luo, XiongJian. Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene. JOURNAL OF MEDICAL GENETICS[J]. 2021, 第 2 作者58(10): 666-678, http://dx.doi.org/10.1136/jmedgenet-2020-106830.
[15] Li, Yifan, Li, Shiwu, Liu, Jiewei, Huo, Yongxia, Luo, XiongJian. The schizophrenia susceptibility gene NAGA regulates dendritic spine density: further evidence for the dendritic spine pathology of schizophrenia. MOLECULAR PSYCHIATRY[J]. 2021, 第 2 作者26(12): 7102-7104, http://dx.doi.org/10.1038/s41380-021-01261-4.
[16] Li, Kaiqin, Li, Yifan, Wang, Junyang, Huo, Yongxia, Huang, Di, Li, Shiwu, Liu, Jiewei, Li, Xiaoyan, Liu, Rong, Chen, Xiaogang, Yao, YongGang, Chen, Ceshi, Xiao, Xiao, Li, Ming, Luo, XiongJian. A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population. JOURNAL OF GENETICS AND GENOMICS[J]. 2020, 第 6 作者47(5): 233-248, http://lib.cqvip.com/Qikan/Article/Detail?id=7102981360.
[17] Li, Shiwu, Li, Yifan, Li, Xiaoyan, Liu, Jiewei, Huo, Yongxia, Wang, Junyang, Liu, Zhongchun, Li, Ming, Luo, XiongJian. Regulatory mechanisms of major depressive disorder risk variants. MOLECULAR PSYCHIATRY[J]. 2020, 第 1 作者25(9): 1926-1945, http://dx.doi.org/10.1038/s41380-020-0715-7.
[18] Liu, Weipeng, Yan, Hao, Zhou, Danyang, Cai, Xin, Zhang, Yuyanan, Li, Shiyi, Li, Huijuan, Li, Shiwu, Zhou, DongSheng, Li, Xingxing, Zhang, Chen, Sun, Yan, Dai, JiaPei, Zhong, Jingmei, Yao, YongGang, Luo, XiongJian, Fang, Yiru, Zhang, Dai, Ma, Yina, Yue, Weihua, Li, Ming, Xiao, Xiao. The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population. TRANSLATIONAL PSYCHIATRY[J]. 2019, 第 8 作者9(1): http://dx.doi.org/10.1038/s41398-019-0675-3.
[19] Zhong, Jingmei, Li, Shiwu, Zeng, Wanli, Li, Xiaoyan, Gu, Chunjie, Liu, Jiewei, Luo, XiongJian. Integration of GWAS and brain eQTL identifies FLOT1 as a risk gene for major depressive disorder. NEUROPSYCHOPHARMACOLOGY[J]. 2019, 第 2 作者44(9): 1542-1551, http://dx.doi.org/10.1038/s41386-019-0345-4.
[20] Yongxia Huo, Shiwu Li, Jiewei Liu, Xiaoyan Li, XiongJian Luo. Functional genomics reveal gene regulatory mechanisms underlying schizophrenia risk. NATURE COMMUNICATIONS[J]. 2019, 第 2 作者10(1): 1-19, https://doaj.org/article/84007106e80b429e9d5b74bc356226ca.

   

（ 1 ） NEGR1基因影响抑郁症的发病机制研究, 负责人, 地方任务, 2023-06--2026-05
（ 2 ） 精神分裂症风险区域2q33.1在疾病中遗传机制及致病机理研究, 负责人, 国家任务, 2022-01--2025-12
（ 3 ） 基于精神分裂症临床队列的免疫组学异常特征及其生物标记物的研究, 参与, 国家任务, 2023-01--2026-12
（ 4 ） 精神分裂风险基因TYW5在疾病中潜在致病机制及药物靶点研究, 负责人, 中国科学院计划, 2022-01--2023-12
（ 5 ） TYW5基因介导精神分裂症易感的生物学机制研究, 负责人, 地方任务, 2024-01--2028-12