基本信息
李国红 男 博导 生物物理研究所
电子邮件:liguohong@sun5.ibp.ac.cn
通信地址:北京市朝阳区大屯路15号
邮政编码:100101

研究领域

染色质结构和表观遗传调控

招生信息

2012年计划招收2名硕博生
招生专业:生物化学和分子生物学


招生方向
染色质结构和基因表达调控的生物学研究

教育背景

   
学历
1991-1995:武汉大学病毒系,本科
1995-1998:北京医科大学基础医学院生物物理系,硕士研究生
1998-2003:德国马普细胞生物学研究所/海德堡大学,博士研究生
学位
1995:武汉大学病毒系,学士学位
1998:北京医科大学基础医学院生物物理系,硕士学位
2003:德国海德堡大学生物系, 博士学位

工作经历

2003-2006:美国新泽西医科大学生物化学系/霍华德.休斯医学研究院,Danny Reinberg实验室博士后
2006-2009:美国纽约大学医学院生物化学系/霍华德.休斯医学研究院,Danny Reinberg实验室博士后
2009-current:中国科学院生物物理研究所,“****”研究员,博士生导师

专利与奖励

   
专利成果
[1] 李国红, 俞洋, 包新华, 胡明丽, 王胜, 章清萍, 阮海荷. 特异性结合H1.4移码突变蛋白的单克隆抗体制备及其应用. CN113480646B, 2022-03-15.

出版信息

   
发表论文
[1] 李国红. Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1. Science[J]. 2023, [2] Cuifang Liu, Juan Yu, Aoqun Song, Min Wang, Jiansen Hu, Ping Chen, Jicheng Zhao, Guohong Li. Histone H1 facilitates restoration of H3K27me3 during DNA replication by chromatin compaction. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-17, http://dx.doi.org/10.1038/s41467-023-39846-y.
[3] Anfeng Luo, Jingwei Kong, Jun Chen, Xue Xiao, Jie Lan, Xiaorong Li, Cuifang Liu, PengYe Wang, Guohong Li, Wei Li, Ping Chen. H2B ubiquitination recruits FACT to maintain a stable altered nucleosome state for transcriptional activation. NATURE COMMUNICATIONS[J]. 2023, 14(1): 1-13, https://doaj.org/article/e445c44dde834a22bdbc191f10913242.
[4] Ge, Weiran, Yu, Cong, Li, Jingjing, Yu, Zhenyu, Li, Xiaorong, Zhang, Yan, Liu, ChaoPei, Li, Yingfeng, Tian, Changlin, Zhang, Xinzheng, Li, Guohong, Zhu, Bing, Xu, RuiMing. Basis of the H2AK119 specificity of the Polycomb repressive deubiquitinase. NATURE. 2023, http://dx.doi.org/10.1038/s41586-023-05841-y.
[5] Wang, YiZhou, Liu, Cuifang, Zhao, Jicheng, Yu, Juan, Luo, Anfeng, Xiao, Xue, Dou, ShuoXing, Ma, Lu, Wang, PengYe, Li, Ming, Li, Guohong, Yan, Jianbin, Chen, Ping, Li, Wei. H2A mono-ubiquitination differentiates FACT's functions in nucleosome assembly and disassembly. NUCLEIC ACIDS RESEARCH[J]. 2022, 50(2): 833-846, http://dx.doi.org/10.1093/nar/gkab1271.
[6] Liu, Yuting, Wang, Kehui, Huang, Li, Zhao, Jicheng, Chen, Xinpeng, Wu, Qiang, Yu, Zhouliang, Li, Guohong. Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice. SCIENCE CHINA-LIFE SCIENCES[J]. 2022, 65(9): 1881-1889, http://lib.cqvip.com/Qikan/Article/Detail?id=7107979929.
[7] Shao, Wen, Bi, Xianju, Pan, Yixuan, Gao, Boyang, Wu, Jun, Yin, Yafei, Liu, Zhimin, Peng, Mengyuan, Zhang, Wenhao, Jiang, Xu, Ren, Wenlin, Xu, Yanhui, Wu, Zhongyang, Wang, Kaili, Zhan, Ge, Lu, J Yuyang, Han, Xue, Li, Tong, Wang, Jianlong, Li, Guohong, Deng, Haiteng, Li, Bing, Shen, Xiaohua. Phase separation of RNA-binding protein promotes polymerase binding and transcription. NATURE CHEMICAL BIOLOGY[J]. 2022, 18(1): 70-+, [8] Huo, Dawei, Yu, Zhaowei, Li, Rui, Gong, Meihan, Sidoli, Simone, Lu, Xukun, Hou, Yuying, Dai, Zhongye, Kong, Yu, Liu, Guifen, Jensen, Ole N, Xie, Wei, Helin, Kristian, Xiong, Chaoyang, Li, Guohong, Zhang, Yong, Wu, Xudong. CpG island reconfiguration for the establishment and synchronization of polycomb functions upon exit from naive pluripotency. MOLECULAR CELL[J]. 2022, 82(6): 1169-+, http://dx.doi.org/10.1016/j.molcel.2022.01.027.
[9] Chen, Xinpeng, Lin, Haiyan, Li, Guohong. The influence of high-order chromatin state in the regulation of stem cell fate. BIOCHEMICAL SOCIETY TRANSACTIONSnull. 2022, 50(6): 1809-1822, [10] Liu, ChaoPei, Jin, Wenxing, Hu, Jie, Wang, Mingzhu, Chen, Jingjing, Li, Guohong, Xu, RuiMing. Distinct histone H3-H4 binding modes of sNASP reveal the basis for cooperation and competition of histone chaperones. GENES & DEVELOPMENT[J]. 2021, 35(23-24): 1610-1624, http://dx.doi.org/10.1101/gad.349100.121.
[11] Chen, Ping, Li, Wei, Li, Guohong, Dill, KA. Structures and Functions of Chromatin Fibers. ANNUAL REVIEW OF BIOPHYSICS, VOL 50, 2021null. 2021, 50: 95-116, http://dx.doi.org/10.1146/annurev-biophys-062920-063639.
[12] 陈萍, 李国红, 李伟. 单分子力谱研究组蛋白H2A泛素化修饰调控核小体的分子机制. 医用生物力学[J]. 2021, 36(S01): 69-69, http://lib.cqvip.com/Qikan/Article/Detail?id=00002EKL4J3O7JP0MN508JL0MNR.
[13] Wang, Kehui, Liu, Yuting, Yu, Zhouliang, Gu, Bo, Hu, Jie, Huang, Li, Ge, Xiao, Xu, Lingyi, Zhang, Mengyu, Zhao, Jicheng, Hu, Mingli, Le, Rongrong, Wu, Qiang, Ye, Sheng, Gao, Shaorong, Zhang, Xiaodong, Xu, RuiMing, Li, Guohong. Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle. CELL REPORTS[J]. 2021, 37(6): http://dx.doi.org/10.1016/j.celrep.2021.109987.
[14] Zhang, Shuming, Xiao, Xue, Kong, Jingwei, Lu, Ke, Dou, ShuoXing, Wang, PengYe, Ma, Lu, Liu, Yuru, Li, Guohong, Li, Wei, Zhang, Huidong. DNA polymerase Gp90 activities and regulations on strand displacement DNA synthesis revealed at single-molecule level. FASEB JOURNAL[J]. 2021, 35(5): http://dx.doi.org/10.1096/fj.202100033RR.
[15] Lu, Ke, Liu, Cuifang, Liu, Yinuo, Luo, Anfeng, Chen, Jun, Lei, Zhichao, Kong, Jingwei, Xiao, Xue, Zhang, Shuming, Wang, YiZhou, Ma, Lu, Dou, ShuoXing, Wang, PengYe, Li, Ming, Li, Guohong, Li, Wei, Chen, Ping. Curaxin-Induced DNA Topology Alterations Trigger the Distinct Binding Response of CTCF and FACT at the Single-Molecule Level. BIOCHEMISTRY[J]. 2021, 60(7): 494-499, http://dx.doi.org/10.1021/acs.biochem.1c00014.
[16] Yu, Juan, Xiong, Chaoyang, Zhuo, Baowen, Wen, Zengqi, Shen, Jie, Liu, Cuifang, Chang, Luyuan, Wang, Kehui, Wang, Min, Wu, Chenyi, Wu, Xudong, Xu, Xueqin, Ruan, Haihe, Li, Guohong. Analysis of Local Chromatin States Reveals Gene Transcription Potential during Mouse Neural Progenitor Cell Differentiation. CELL REPORTS[J]. 2020, 32(4): https://doaj.org/article/535649a3840e43bc8bcee137095351da.
[17] Zhao, Jicheng, Wang, Min, Chang, Luyuan, Yu, Juan, Song, Aoqun, Liu, Cuifang, Huang, Wenjun, Zhang, Tiantian, Wu, Xudong, Shen, Xiaohua, Zhu, Bing, Li, Guohong. RYBP/YAF2-PRC1 complexes and histone H1-dependent chromatin compaction mediate propagation of H2AK119ub1 during cell division. NATURE CELL BIOLOGY[J]. 2020, 22(4): http://dx.doi.org/10.1038/s41556-020-0484-1.
[18] Xiao, Xue, Liu, Cuifang, Pei, Yingxin, Wang, YiZhou, Kong, Jingwei, Lu, Ke, Ma, Lu, Dou, ShuoXing, Wang, PengYe, Li, Guohong, Chen, Ping, Li, Wei. Histone H2A Ubiquitination Reinforces Mechanical Stability and Asymmetry at the Single-Nucleosome Level. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(7): 3340-3345, http://dx.doi.org/10.1021/jacs.9b12448.
[19] Li, Guohong. The 3D organization of genome in the nucleus: from the nucleosome to the 4D nucleome. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 63(6): 791-794, https://www.sciengine.com/doi/10.1007/s11427-020-1723-y.
[20] 李国红. Structures and Functions of Chromatin Fibers.. Annu. Rev. Biophys. 2020, [21] Wen, Zengqi, Zhang, Liwei, Ruan, Haihe, Li, Guohong. Histone variant H2A.Z regulates nucleosome unwrapping and CTCF binding in mouse ES cells. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(11): 5939-5952, http://dx.doi.org/10.1093/nar/gkaa360.
[22] Long, Haizhen, Zhang, Liwei, Lv, Mengjie, Wen, Zengqi, Zhang, Wenhao, Chen, Xiulan, Zhang, Peitao, Li, Tongqing, Chang, Luyuan, Jin, Caiwei, Wu, Guozhao, Wang, Xi, Yang, Fuquan, Pei, Jianfeng, Chen, Ping, Margueron, Raphael, Deng, Haiteng, Zhu, Mingzhao, Li, Guohong. H2A.Z facilitates licensing and activation of early replication origins. NATURE[J]. 2020, 577(7791): 576-+, http://dx.doi.org/10.1038/s41586-019-1877-9.
[23] Wang, Liang, Hu, Mingli, Zuo, MeiQing, Zhao, Jicheng, Wu, Di, Huang, Li, Wen, Yongxin, Li, Yunfan, Chen, Ping, Bao, Xinhua, Dong, MengQiu, Li, Guohong, Li, Pilong. Rett syndrome-causing mutations compromise MeCP2-mediated liquid-liquid phase separation of chromatin. CELL RESEARCH[J]. 2020, 30(5): 393-407, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196128/.
[24] 李国红. Structure and dynamics of the 30-nm chromatin fiber in gene regulation. 2020, 2-, [[["https://kns.cnki.net/kcms/detail/detail.aspx?dbcode=CPFD&dbname=CPFDTEMP&filename=IGSS202010001052&v=MDQzMjlNT1VLcmlmWmVadUZDampVN3ZNS0Y0WExDcllmYkc0SE5ITnI0OUZaZXNLRGhOS3VoZGhuajk4VG5qcXF4ZEVl"]]].
[25] Wang, Liang, Gao, Yifei, Zheng, Xiangdong, Liu, Cuifang, Dong, Shuangshuang, Li, Ru, Zhang, Guanwei, Wei, Yixuan, Qu, Hongyuan, Li, Yuhan, Allis, C David, Li, Guohong, Li, Haitao, Li, Pilong. Histone Modifications Regulate Chromatin Compartmentalization by Contributing to a Phase Separation Mechanism. MOLECULAR CELL[J]. 2019, 76(4): 646-+, http://dx.doi.org/10.1016/j.molcel.2019.08.019.
[26] Li, Weizhe, Wang, HongYan, Zhao, Xiaolu, Duan, Hongguo, Cheng, Binghua, Liu, Yafei, Zhao, Mengjie, Shu, Wenjie, Mei, Yuchao, Wen, Zengqi, Tang, Mingliang, Guo, Lin, Li, Guohong, Chen, Qiang, Liu, Xiaoqi, Du, HaiNing. A methylation-phosphorylation switch determines Plk1 kinase activity and function in DNA damage repair. SCIENCE ADVANCES[J]. 2019, 5(3): [27] Bi, Xianju, Xu, Yanhui, Li, Tong, Li, Xinmin, Li, Wenzhi, Shao, Wen, Wang, Kaili, Zhan, Ge, Wu, Zhongyang, Liu, Wei, Lu, J Yuyang, Wang, Liang, Zhao, Jicheng, Wu, Jiawei, Na, Jie, Li, Guohong, Li, Pilong, Shen, Xiaohua. RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control. MOLECULAR CELL[J]. 2019, 75(1): 102-+, http://dx.doi.org/10.1016/j.molcel.2019.05.007.
[28] Zheng, Sihao, Li, Dan, Lu, Zhen, Liu, Guangxue, Wang, Meng, Xing, Poyuan, Wang, Min, Dong, Yang, Wang, Xuejie, Li, Jingyao, Zhang, Simin, Peng, Haoyang, Ira, Grzegorz, Li, Guohong, Chen, Xuefeng. Bre1-dependent H2B ubiquitination promotes homologous recombination by stimulating histone eviction at DNA breaks. NUCLEIC ACIDS RESEARCH[J]. 2018, 46(21): 11326-11339, https://www.webofscience.com/wos/woscc/full-record/WOS:000456710000022.
[29] Xiao Xue, Dong Liping, Wang Yizhou, Wang Pengye, Li Ming, Li Guohong, Chen Ping, Li Wei. Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers. 生物物理学报:英文版[J]. 2018, 4(4): 222-232, http://lib.cqvip.com/Qikan/Article/Detail?id=676327040.
[30] Wang, Yan, Long, Haizhen, Yu, Juan, Dong, Liping, Wassef, Michel, Zhuo, Baowen, Li, Xia, Zhao, Jicheng, Wang, Min, Liu, Cuifang, Wen, Zengqi, Chang, Luyuan, Chen, Ping, Wang, Qianfei, Xu, Xueqing, Margueron, Raphael, Li, Guohong. Histone variants H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition and gene expression regulation in mES cells. BMC BIOLOGY[J]. 2018, 16(1): http://dx.doi.org/10.1186/s12915-018-0568-6.
[31] Xiong, Chaoyang, Wen, Zengqi, Yu, Juan, Chen, Jun, Liu, ChaoPei, Zhang, Xiaodong, Chen, Ping, Xu, RuiMing, Li, Guohong. UBN1/2 of HIRA complex is responsible for recognition and deposition of H3.3 at cis- regulatory elements of genes in mouse ES cells. BMC BIOLOGY[J]. 2018, 16(1): http://dx.doi.org/10.1186/s12915-018-0573-9.
[32] 李国红. H2A.Z and H3.3 coordinately regulate PRC2-dependent H3K27me3 deposition in mES cells.. BMC. 2018, [33] Chen, Ping, Dong, Liping, Hu, Mingli, Wang, YiZhou, Xiao, Xue, Zhao, Zhongliang, Yan, Jie, Wang, PengYe, Reinberg, Danny, Li, Ming, Li, Wei, Li, Guohong. Functions of FACT in Breaking the Nucleosome and Maintaining Its Integrity at the Single-Nucleosome Level. MOLECULAR CELL[J]. 2018, 71(2): 284-+, http://dx.doi.org/10.1016/j.molcel.2018.06.020.
[34] Xue Xiao, Liping Dong, Yi-Zhou Wang, Peng-Ye Wang, Ming Li, Guohong Li, Ping Chen, Wei Li. Dissection of structural dynamics of chromatin fibers by single-molecule magnetic tweezers. 生物物理学报:英文版[J]. 2018, 4(4): 222-232, http://lib.cqvip.com/Qikan/Article/Detail?id=676327040.
[35] 李国红, 翁杰敏, 吴强, 俞洋. 染色质可塑性动态调控的蛋白质机器及其作用机理. 中国基础科学[J]. 2018, 20(1): 53-57, http://lib.cqvip.com/Qikan/Article/Detail?id=675432596.
[36] 胡杰, 李国红. 染色质的高级结构与调控. 生命科学[J]. 2017, 29(10): 955-967, http://lib.cqvip.com/Qikan/Article/Detail?id=674160592.
[37] Takada, Mamoru, Zhang, Weiguo, Suzuki, Aussie, Kuroda, Taruho S, Yu, Zhouliang, Inuzuka, Hiroyuki, Gao, Daming, Wan, Lixin, Zhuang, Ming, Hu, Lianxin, Zhai, Bo, Fry, Christopher J, Bloom, Kerry, Li, Guohong, Karpen, Gary H, Wei, Wenyi, Zhang, Qing. FBW7 Loss Promotes Chromosomal Instability and Tumorigenesis via Cyclin E1/CDK2-Mediated Phosphorylation of CENP-A. CANCER RESEARCH[J]. 2017, 77(18): 4881-4893, https://www.webofscience.com/wos/woscc/full-record/WOS:000410945700014.
[38] Wang, Kehui, Yu, Zhouliang, Liu, Yuting, Li, Guohong. Ser68 Phosphorylation Ensures Accurate Cell-Cycle-Dependent CENP-A Deposition at Centromeres. DEVELOPMENTAL CELLnull. 2017, 40(1): 5-6, http://dx.doi.org/10.1016/j.devcel.2016.12.015.
[39] Li, Wei, Chen, Ping, Yu, Juan, Dong, Liping, Liang, Dan, Feng, Jianxun, Yan, Jie, Wang, PengYe, Li, Qing, Zhang, Zhiguo, Li, Ming, Li, Guohong. FACT Remodels the Tetranucleosomal Unit of Chromatin Fibers for Gene Transcription. MOLECULAR CELL[J]. 2016, 64(1): 120-133, http://dx.doi.org/10.1016/j.molcel.2016.08.024.
[40] Fang, Qianglin, Chen, Ping, Wang, Mingzhu, Fang, Junnan, Yang, Na, Li, Guohong, Xu, RuiMing. Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. ELIFE[J]. 2016, 5: https://doaj.org/article/d5ccb8aae2824d78a5f7299303ab4d35.
[41] Liang, Xiaoping, Shan, Shan, Pan, Lu, Zhao, Jicheng, Ranjan, Anand, Wang, Feng, Zhang, Zhuqiang, Huang, Yingzi, Feng, Hanqiao, Wei, Debbie, Huang, Li, Liu, Xuehui, Zhong, Qiang, Lou, Jizhong, Li, Guohong, Wu, Carl, Zhou, Zheng. Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2016, 23(4): 317-323, http://dx.doi.org/10.1038/nsmb.3190.
[42] Zhu, Ping, Li, Guohong. Higher-Order Structure of the 30-nm Chromatin Fiber Revealed by Cryo-EM. IUBMB LIFEnull. 2016, 68(11): 873-878, http://dx.doi.org/10.1002/iub.1568.
[43] Qian Zhao, Jiqin Zhang, Ruoyu Chen, Lina Wang, Bo Li, Hao Cheng, Xiaoya Duan, Haijun Zhu, Wei Wei, Jiwen Li, Qihan Wu, JingDong J Han, Wenqiang Yu, Shaorong Gao, Guohong Li, Jiemin Wong. Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals. NATURE COMMUNICATIONS[J]. 2016, 7(1): https://doaj.org/article/eaa46b60799b4bfabd64eeb76e38f5dd.
[44] 李国红. Dissecting the precise role of histone H3 K9 methylation in crosstalk with DNA maintenance methylation in mammalian cells.. Nature Communications. 2016, [45] Xiong, Chaoyang, Wen, Zengqi, Li, Guohong. Histone Variant H3.3: A versatile H3 variant in health and in disease. SCIENCE CHINA-LIFE SCIENCES[J]. 2016, 59(3): 245-256, http://dx.doi.org/10.1007/s11427-016-5006-9.
[46] Zhu, Ping, Li, Guohong. Structural insights of nucleosome and the 30-nm chromatin fiber. CURRENT OPINION IN STRUCTURAL BIOLOGY[J]. 2016, 36: 106-115, http://dx.doi.org/10.1016/j.sbi.2016.01.013.
[47] Qianglin Fang. Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome. ELIFE SCIENCES PUBLICATIONS, LTD. 2016, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201904022729925ZK.
[48] 钟琛, 汤富酬, 李国红, 丁建平. 干细胞编程与重编程中表观遗传调控的分子机制和结构基础. 中国基础科学[J]. 2015, 17(4): 24-29, http://lib.cqvip.com/Qikan/Article/Detail?id=666410235.
[49] Liang Dan, Chen Ping, Li GuoHong. The Structure of 30 nm Chromatin Fiber and Its Regulation. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2015, 42(11): 1009-1014, https://www.webofscience.com/wos/woscc/full-record/WOS:000365558600005.
[50] Fang, Junnan, Liu, Yuting, Wei, Yun, Deng, Wenqiang, Yu, Zhouliang, Huang, Li, Teng, Yan, Yao, Ting, You, Qinglong, Ruan, Haihe, Chen, Ping, Xu, RuiMing, Li, Guohong. Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-N. GENES & DEVELOPMENT[J]. 2015, 29(10): 1058-1073, http://www.corc.org.cn/handle/1471x/2376555.
[51] 李国红. Structural Transitions of Centromeric Chromatin Coordinate the Cell Cycle-dependent Recruitment of CENP-N.. Genes and Development. 2015, [52] Yu, Zhouliang, Zhou, Xiang, Wang, Wenjing, Deng, Wenqiang, Fang, Junnan, Hu, Hao, Wang, Zichen, Li, Shangze, Cui, Lei, Shen, Jing, Zhai, Linhui, Peng, Shengyi, Wong, Jiemin, Dong, Shuo, Yuan, Zengqiang, Ou, Guangshuo, Zhang, Xiaodong, Xu, Ping, Lou, Jizhong, Yang, Na, Chen, Ping, Xu, RuiMing, Li, Guohong. Dynamic Phosphorylation of CENP-A at Ser68 Orchestrates Its Cell-Cycle-Dependent Deposition at Centromeres. DEVELOPMENTAL CELL[J]. 2015, 32(1): 68-81, http://dx.doi.org/10.1016/j.devcel.2014.11.030.
[53] Li, Guohong, Zhu, Ping. Structure and organization of chromatin fiber in the nucleus. FEBS LETTERS[J]. 2015, 589(20): 2893-2904, http://dx.doi.org/10.1016/j.febslet.2015.04.023.
[54] Zhao, Hongyu, Xing, Yongqiang, Liu, Guoqing, Chen, Ping, Zhao, Xiujuan, Li, Guohong, Cai, Lu. GAA triplet-repeats cause nucleosome depletion in the human genome. GENOMICS[J]. 2015, 106(2): 88-95, http://dx.doi.org/10.1016/j.ygeno.2015.06.010.
[55] Guo, Xue, Wang, Ling, Li, Jie, Ding, Zhanyu, Xiao, Jianxiong, Yin, Xiaotong, He, Shuang, Shi, Pan, Dong, Liping, Li, Guohong, Tian, Changlin, Wang, Jiawei, Cong, Yao, Xu, Yanhui. Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. NATURE[J]. 2015, 517(7536): 640-U281, http://dx.doi.org/10.1038/nature13899.
[56] Liang Dan, Chen Ping, Li GuoHong. The Structure of 30 nm Chromatin Fiber and Its Regulation. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS[J]. 2015, 42(11): 1009-1014, https://www.webofscience.com/wos/woscc/full-record/WOS:000365558600005.
[57] Chen, Ping, Zhu, Ping, Li, Guohong. New insights into the helical structure of 30-nm chromatin fibers. PROTEIN & CELL[J]. 2014, 5(7): 489-491, https://www.webofscience.com/wos/woscc/full-record/WOS:000339333400001.
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指导学生

现指导学生

房俊男  硕士研究生  071009-细胞生物学  

邓文强  硕士研究生  071009-细胞生物学  

龙海珍  硕士研究生  071010-生物化学与分子生物学  

温增麒  硕士研究生  071010-生物化学与分子生物学  

王岩  博士研究生  071010-生物化学与分子生物学