Jian-Hua Wang, Prof. PhD

Principal Investigator,

The Unit of Virology

Institut Pasteur of Shanghai

Chinese Academy of Sciences

Research Areas

This unit was established since 2009, and the research focuses on the study of the interaction of retrovirus (HIV-1, MuLV) with host cells, in order to better understand the molecular mechanisms of viral replication, persistence, and immunopathogenesis.


 1999.9-2005.7, Kunming Institute of Zoology, CAS, China, Master-PhD;

1995.9-19997, Henan University, bachelor


 2005- 2009, Postdoctoral Fellow, Medical College of Wisconsin, Milwaukee, WI, USA.

Work Experience

 2009 to date, Professor, Principal Investigator of Unit of Viral Immunology, Institute Pasteur of Shanghai, CAS, China.

Teaching Experience

2015, Professor of UCAS


1). Li C, Wang HB, Kuang WD, Ren XX, Song ST, Zhu HZ, Li Q, Xu LR, Guo HJ, Wu L*, Wang JH*. Naf1 regulates HIV-1 latency by suppressing viral promoter-driven gene expression in primary CD4+ T cells. J Virol. 2016, in press.

2). Ren XX, Wang HB, Li C, Jiang JF, Xiong SD, Jin X, Wu L, Wang JH*. HIV-1 Nef-associated factor 1 enhances viral production by interacting with CRM1 to promote nuclear export of unspliced HIV-1 gag mRNA. J Bio. Chem. 2016. PMID:26733199.

3). Qian YW, Li C, Jiang AP, Ge S, Gu P, Fan X, Li TS, Jin X, Wang JH*, Wang ZL*. HIV-1 gp120 glycoprotein interacting with dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) down-regulates tight junction proteins to disrupt the blood retinal barrier and increase its permeability. J Bio. Chem. 2016. [Epub ahead of print]. PMID: 27605665.

4). Qu D, Li C, Sang F, Li Q, Jiang ZQ, Xu LR, Guo HJ, Zhang C, Wang JH*. The variances of Sp1 and NF-κB elements correlate with the greater capacity of Chinese HIV-1 B′-LTR for driving gene expression. Sci Rep, 2016. PMID: 27698388.

5). Li C, Kuang WD, Qu D, Wang JH*. Toll-Interacting Protein Inhibits HIV-1 Infection and Regulates Viral Latency. Biochem Biophys Res Commun; 2016. PMID: 27181351.

6). Jiang AP, Jiang JF, Wei JF, Guo MG, Qin Y, Guo QQ, Ma L, Liu BC, Wang X, Veazey RS, Ding YB, Wang JH. Human mucosal mast cells capture HIV-1 and mediate viral trans-infection of CD4+ T cells. J Virol. 2015. PMID:26719250

7). Jiang AP, Jiang JF, Guo MG, Jin YM, Li YY, Wang JH. Human blood circulating basophils capture HIV-1 and mediate viral trans-infection of CD4+ T cells. J Virol. 2015. PMID:26018157

8). Ren XX, Li C, Xiong SD, Huang Z, Wang JH*, Wang HB*. Antibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated enterovirus 71 transmission and prevent virus-induced cells death. Virulence. 2015.

9). Zhang Y, Li SK, Yi Yang K, Liu M, Lee N, Tang X, Wang H, Liu L, Chen Z, Zhang C, Wang J, Kwok-Wing Tsui S. Whole genome methylation array reveals the down-regulation of IGFBP6 and SATB2 by HIV-1.Sci Rep. 2015. 5:10806. PMID:26039376

10). Yang FC, Kuang WD, Li C, Sun WW, Qu D, Wang JH. Toll-Interacting Protein Suppresses HIV-1 Long-Terminal-Repeat-Driven Gene Expression and Silences the Post-Integrational Transcription of Viral Proviral DNA. PLoS ONE, 2015;  10(4):e0125563. PMID:25915421

11). Ma L, Shen CJ, Cohen E, Xiong SD, Wang J-H. MiRNA-1236 inhibits HIV-1 infection of monocytes by repressing translation of cellular factor VprBP. PLoS ONE, 2014; 9(6): e99535. PMID: 24932481.

12). Zhai RR, Jiang AP, Wang HB, Ma L, Ren XX, Jiang JF, Wu L, Wei JF, Wang JH. Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve T cell differentiation toward regulatory T cells. Virology, 2013; 442,163-172. PMID 23652320.

13). Liu W, Qin Y, Bai L, Lan K, Wang J-H. Kaposi's-sarcoma -associated-herpesvirus -activated dendritic cells promote HIV-1 trans-infection and suppress CD4+ T cell proliferation. Virology, 2013; 440, 150-159. PMID23510674.

14). Shen CJ, Jia YH, Tian RR, Ding M, Zhang C, Wang J-H. Translation of Pur-α is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection. FASEB J, 2012; 26(11): 4755-64. PMID 22835829.

15). Qin Y, Li Y, Liu W, Tian R, Guo Q, Li S, Li H, Zhang D, Zheng Y, Wu L, Lan K, Wang JH . Penicillium marneffei-stimulated dendritic cells enhance HIV-1 trans-infection and promote viral infection by activating primary CD4+ T cells. PLoS One. 2011; 6: e27609. PMID 22110688.

16). Qin Y, Li Y Y, Jiang A P, Jiang J F, Wang J-H. Stimulation of Cryptococcus neoformans isolated from skin lesion of AIDS patient matures dendritic cells and promotes HIV-1 trans-infection. Biochem Biophys Res Commun; 2012; 423, 709-714. PMID 22704932.

17). Tian RR, Guo HX, Wei JF, Yang CK, He SH, Wang J-H. IFN-lambda inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production. Antiviral Res. 2012; 95, 57-65. PMID 22584351.

18). Ren XX, Ma L, Liu QW, Li C, Huang Z, Wu L, Xiong SD, Wang JH, Wang HB.The molecule of DC-SIGN captures enterovirus 71 and confers dendritic cell-mediated viral trans-infection. Virol J. 2014; 11:47. PMID:24620896.

Research Interests

The research of this unit focuses on the study of the interaction of retrovirus (HIV-1, MuLV) with host cells, in order to better understand the molecular mechanisms of viral replication, persistence, and immunopathogenesis: 1) by using primary cells, ex vivo tissue-culture, and MuLV infected mouse model, to explore the host modulation and viral hijacking during viral acute infection; 2) by using Omics methods, to identify host factor modulating HIV-1 replication and latency, and develop novel strategies for HIV/AIDS functional cure. 



杨福春  01  19178  

秦琰  01  19178  

刘婉  02  19606  

李川  01  19178  

江爱平  01  19178  


况文东  01  19182  

孙玮玮  01  19178  

曲迪  01  19178  

Honors & Distinctions

 2015, Professor of UCAS;

2014, Natural Science Award (the 3rd author), Yunnan Provincial Bureau of Health, Yunnan, China

2013, Award for Zhu-Li Yue-Hua Excellent Graduate Supervisor, CAS, China

2011, Shanghai Rising Star Program, Shanghai, China

2010,100 Talent Program of CAS, China

2010, Award of Sanofi-Aventis-SIBS Scholarship Program, China