100104-病理学与病理生理学
071009-细胞生物学

表观遗传调控与肿瘤
代谢、DNA损伤应答与肿瘤
肿瘤生物治疗

2013-09--2016-07   中国科学院大学   理学博士
2010-09--2013-07   云南大学   理学硕士
2006-09--2010-07   云南大学   理学学士

   

2022-01~现在, 中国科学院昆明动物研究所, 研究员
2017-09~2021-12,中国科学院昆明动物研究所, 副研究员
2016-07~2017-09,中国科学院昆明动物研究所, 助理研究员

2022-10-20-今,云南省细胞学会, 委员
2022-08-01-今,云南省预防医学会肿瘤预防与控制专业委员会, 常务委员
2021-02-01-2026-01-31,中国老年医学学会基础与转化医学分会第二届委员会, 委员
2021-01-01-今,云南省抗癌协会第一届乳腺癌青年专业委员会, 副主任委员
2019-08-09-今,中国抗癌协会第一届肿瘤微环境专业委员会, 委员
2018-06-21-今,云南省抗癌协会第二届乳腺癌专业委员会, 委员

   

[1] Cui, Qiuxia, Sun, Jian, Yuan, Jingping, Li, Juanjuan, Yang, Chuanyu, Du, Guangshi, Zhou, Chengang, Qiu, Pu, Gao, Jidong, Zhang, Yuanqi, Jiang, Dewei, Chen, Ceshi. DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis. GENES & DISEASES[J]. 2024, 第 11 作者  通讯作者  11(1): 91-94, http://dx.doi.org/10.1016/j.gendis.2023.03.028.
[2] Zhao, Ping, Sun, Jian, Huang, Xinwei, Zhang, Xiangwu, Liu, Xin, Liu, Rong, Du, Guangshi, Gan, Wenqiang, Yang, Chuanyu, Tang, Yiyin, Chen, Ceshi, Jiang, Dewei. Targeting the KLF5-EphA2 axis can restrain cancer stemness and overcome chemoresistance in basal-like breast cancer. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES[J]. 2023, 第 12 作者  通讯作者  19(6): 1861-1874, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000981659900004.
[3] Cui, Qiuxia, Jiang, Dewei, Zhang, Yuanqi, Chen, Ceshi. The tumor-nerve circuit in breast cancer. CANCER AND METASTASIS REVIEWS. 2023, 第 2 作者42(2): 543-574, http://dx.doi.org/10.1007/s10555-023-10095-1.
[4] Dewei Jiang, Ting Qiu, Junjiang Peng, Siyuan Li, Tala, Wenlong Ren, Chuanyu Yang, Yi Wen, Chuan-Huizi Chen, Jian Sun, Yingying Wu, Rong Liu, Jun Zhou, Kongming Wu, Wen Liu, Xioayun Mao, Zhongmei Zhou, Ceshi Chen. YB-1 is a positive regulator of KLF5 transcription factor in basal-like breast cancer. Cell Death and Differentiation[J]. 2022, 第 1 作者29(6): 1283-1295, 
[5] Guanghsi Du, Jian Sun, Zhen Li, Qian Zhang, Wenjing Liu, Chuanyu Yang, Ping Zhao, Xingye Wang, Qiyan Yin, Yao Luo, Jinhuan Song, Yi Wen, Haioxia Wang, Chuan-Huizi Chen, Guosheng Hu, Zhongmei Zhou, Xiaoyun Mao, Wen Liu, Zhenzhen Liu, Dewei Jiang, Ceshi Chen. A feedforward circuit between KLF5 and lncRNA KPRT4 contributes to BLBCs. Cancer Letters[J]. 2022, 第 20 作者  通讯作者  534: 215618, 
[6] Liu, Wenjing, Zheng, Min, Zhang, Rou, Jiang, Qiuyun, Du, Guangshi, Wu, Yingying, Yang, Chuanyu, Li, Fubing, Li, Wei, Wang, Luzhen, Wu, Jiao, Shi, Lei, Li, Wenhui, Zhang, Kai, Zhou, Zhongmei, Liu, Rong, Gao, Yingzheng, Huang, Xinwei, Fan, Songqing, Zhi, Xu, Jiang, Dewei, Chen, Ceshi. RNF126-Mediated MRE11 Ubiquitination Activates the DNA Damage Response and Confers Resistance of Triple-Negative Breast Cancer to Radiotherapy. ADVANCED SCIENCE. 2022, 第 21 作者  通讯作者  10(5): http://dx.doi.org/10.1002/advs.202203884.
[7] Wu, Jiao, Yeung, SaiChing Jim, Liu, Sicheng, Qdaisat, Aiham, Jiang, Dewei, Liu, Wenli, Cheng, Zhuo, Liu, Wenjing, Wang, Haixia, Li, Lu, Zhou, Zhongmei, Liu, Rong, Yang, Chuanyu, Chen, Ceshi, Yang, Runxiang. Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2021, 第 5 作者6(1): https://doaj.org/article/c5face3f362d4ad7b194e997084906cd.
[8] Benfu Zhong, Dewei Jiang, Yang Hong, Lifang Li, Li Qiu, Ronghui Yang, Xiaohan Jin, Yawen Song, Ceshi Chen, Binghui Li. Glucose-6-phosphate dehydrogenase neutralizes stresses by supporting reductive glutamine metabolism and AMPK activation. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2021, 第 2 作者6(1): 580-583, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859178/.
[9] Ping Zhao, Dewei Jiang, Yunchao Huang, Cehsi Chen. EphA2: A promising therapeutic target in breast cancer. J Genet Genomics[J]. 2021, 第 2 作者48(4): 261-267, 
[10] Wang, Xinye, Qiu, Ting, Wu, Yingying, Yang, Chuanyu, Li, Yi, Du, Guangshi, He, Yaohui, Liu, Wen, Liu, Rong, Chen, Chuanhuizi, Shi, Yujie, Pan, Jingxuan, Zhou, Jia, Jiang, Dewei, Chen, Ceshi. Arginine methyltransferase PRMT5 methylates and stabilizes KLF5 via decreasing its phosphorylation and ubiquitination to promote basal-like breast cancer. CELL DEATH AND DIFFERENTIATION[J]. 2021, 第 14 作者  通讯作者  28(10): 2931-2945, http://dx.doi.org/10.1038/s41418-021-00793-0.
[11] Zhao, Lina, Qiu, Ting, Jiang, Dewei, Xu, Haibo, Zou, Li, Yang, Qin, Chen, Ceshi, Jiao, Baowei. SGCE Promotes Breast Cancer Stem Cells by Stabilizing EGFR. ADVANCED SCIENCE[J]. 2020, 第 3 作者7(14): https://doaj.org/article/212269c52e6444efb47c9c20c8dcffd1.
[12] Yu, Le, Zhang, Jun Feng, Li, Mingle, Jiang, Dewei, Zhou, Ying, Verwilst, Peter, Kim, Jong Seung. Combining viscosity-restricted intramolecular motion and mitochondrial targeting leads to selective tumor visualization. CHEMICAL COMMUNICATIONS[J]. 2020, 第 4 作者56(49): 6684-6687, http://dx.doi.org/10.1039/d0cc02943b.
[13] Wenjing Liu, Xiaoqing Lu, Peiguo Shi, Guangxi Yang, Zhongmei Zhou, Wei Li, Xiaoyun Mao, Dewei Jiang, Ceshi Chen. TNF-α increases breast cancer stem-like cells through up-regulating TAZ expression via the non-canonical NF-κB pathway. SCIENTIFIC REPORTS[J]. 2020, 第 8 作者  通讯作者  10(1): 1-11, http://dx.doi.org/10.1038/s41598-020-58642-y.
[14] 蒋德伟, 陈策实. 促癌因子TRIM59不依赖泛素化酶活性促进乳腺癌转移的机制. 中国科学:生命科学[J]. 2019, 第 1 作者191-192, http://lib.cqvip.com/Qikan/Article/Detail?id=74678875504849574850484857.
[15] Jiang, Dewei, Wei, Shu, Chen, Fei, Zhang, Ying, Li, Jiali. TET3-mediated DNA oxidation promotes ATR-dependent DNA damage response. EMBO REPORTS[J]. 2017, 第 1 作者18(5): 781-796, http://159.226.149.26:8080/handle/152453/11033.
[16] Su, Hao, Zhao, Yong, Zhou, Jing, Feng, Huihua, Jiang, Dewei, Zhang, KeQin, Yang, Jinkui. Trapping devices of nematode-trapping fungi: formation, evolution, and genomic perspectives. BIOLOGICAL REVIEWS[J]. 2017, 第 5 作者92(1): 357-368, http://dx.doi.org/10.1111/brv.12233.
[17] Dewei Jiang, Jing Zhou, Guizhen Bai, Xinjing Xing, Liyan Tang, Xuewei Yang, Juan Li, Ke-Qin Zhang, Jinkui Yang. Random mutagenesis analysis and identification of a novel C(2)H(2-)type transcription factor from the nematode-trapping fungus Arthrobotrys oligospora. SCIENTIFIC REPORTS[J]. 2017, 第 1 作者7(1): https://doaj.org/article/53261390eab24483b1f76f3797199cf4.
[18] Jiang, Dewei, Zhang, Ying, Hart, Ronald P, Chen, Jianmin, Herrup, Karl, Li, Jiali. Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. BRAIN[J]. 2015, 第 1 作者138: 3520-3536, http://www.irgrid.ac.cn/handle/1471x/1149220.
[19] Li, Jiali, Jiang, Dewei. The role of epigenomics in the neurodegeneration of ataxia-telangiectasia. EPIGENOMICS. 2015, 第 2 作者7(2): 137-141, https://www.webofscience.com/wos/woscc/full-record/WOS:000354097500002.
[20] 赵勇, 王云川, 蒋德伟, 苏浩, 杨金奎. 真菌G蛋白信号调控蛋白的功能研究进展. 微生物学通报[J]. 2014, 第 3 作者41(4): 712-718, https://wswxtb.ijournals.cn/wswxtbcn/article/abstract/tb14040712?st=article_issue.
[21] Yang, Jinkui, Yu, Yan, Li, Juan, Zhu, Wei, Geng, Zongyi, Jiang, Dewei, Wang, Yunchuan, Zhang, KeQin. Characterization and functional analyses of the chitinase-encoding genes in the nematode-trapping fungus Arthrobotrys oligospora. ARCHIVES OF MICROBIOLOGY[J]. 2013, 第 6 作者195(7): 453-462, http://dx.doi.org/10.1007/s00203-013-0894-6.
[22] Jiang, Dewei, Zhu, Wei, Wang, Yunchuan, Sun, Chang, Zhang, KeQin, Yang, Jinkui. Molecular tools for functional genomics in filamentous fungi: Recent advances and new strategies. BIOTECHNOLOGY ADVANCES. 2013, 第 1 作者31(8): 1562-1574, http://dx.doi.org/10.1016/j.biotechadv.2013.08.005.
[23] Wang, Yunchuan, Geng, Zongyi, Jiang, Dewei, Long, Fangfang, Zhao, Yong, Su, Hao, Zhang, KeQin, Yang, Jinkui. Characterizations and functions of regulator of G protein signaling (RGS) in fungi. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2013, 第 3 作者97(18): 7977-7987, http://dx.doi.org/10.1007/s00253-013-5133-1.
[24] 赵婷, 杨玲玲, 刘姮, 蒋德伟, 王云, 王兴红. 血竭诱导及形成机制的研究进展. 中草药[J]. 2010, 第 4 作者附5-附8, http://lib.cqvip.com/Qikan/Article/Detail?id=33667542.
[25] 薛宝金, 蒋德伟, 刘姮, 马丽波, 黄新伟, 王晓鹏, 王兴红. 一种由白色类诺卡放线菌产生的新的巴卡亭ⅢC—10脱乙酰酶. 天然产物研究与开发[J]. 2010, 第 2 作者22(B08): 1-4, http://lib.cqvip.com/Qikan/Article/Detail?id=36386606.

   

（ 1 ） 西部之光人才计划, 负责人, 中国科学院计划, 2017-01--2019-12
（ 2 ） SGC-X通过激活AP-1促进三阴性乳腺癌干细胞的机制研究, 负责人, 国家任务, 2019-01--2022-12
（ 3 ） 炎症因子TNFα调控TAZ诱导乳腺癌干细胞的机制研究, 负责人, 国家任务, 2019-01--2021-12
（ 4 ） RNF165的甲基化调控及其抑癌机制研究（云南省优秀青年基金）, 负责人, 地方任务, 2020-06--2023-05
（ 5 ） 肿瘤干细胞研究-云南省创新团队, 负责人, 地方任务, 2018-08--2021-07
（ 6 ） 组织器官生长和尺寸控制的信号基础与感知调控 (项目骨干), 负责人, 国家任务, 2020-07--2025-06
（ 7 ） 上皮间质相互转换在乳腺（癌）干细胞中的功能、分子机制和应用研究 (项目骨干), 负责人, 国家任务, 2020-10--2024-12
（ 8 ） 云南省高层次人才培养计划“青年拔尖人才”, 负责人, 地方任务, 2021-01--2025-12
（ 9 ） 西部青年学者, 负责人, 中国科学院计划, 2021-01--2023-12
（ 10 ） 基于类器官模型研究协同BRCA2突变导致乳腺癌发生的遗传与环境因素, 负责人, 国家任务, 2022-01--2025-12
（ 11 ） 乳腺癌类器官库及靶向示踪诊疗技术平台建设和运用-课题1基于乳腺癌患者的肿瘤调控新分子靶标挖掘和机制研究, 负责人, 地方任务, 2023-06--2026-05