基本信息
马小锋  男  博导  中国科学院成都生物研究所
电子邮件: maxf@cib.ac.cn
通信地址: 成都市高新区科园南路93号,中国科学院成都生物研究所
邮政编码: 610041

研究领域

有机化学、药物化学

招生信息

   
招生专业
070303-有机化学
100701-药物化学
招生方向
糖化学
不对称催化
有机合成、药物合成

教育背景

2007-09--2012-07   中国科学院成都生物研究所天然产物研究中心   理学博士
2003-09--2007-07   兰州大学 药学院   医学学士

工作经历

2019-09~现在, 中国科学院成都生物研究所天然产物研究中心, 研究员
2016-03~2019-03,英国布里斯托大学化学系, 博士后
2012-12~2016-03,比利时天主教鲁汶大学化学与药物化学系, 博士后
2012-07~2012-10,中国科学院成都生物研究所天然产物研究中心, 研究助理


工作简历
2019-09~现在, 中国科学院成都生物研究所天然产物研究中心, 研究员
2016-03~2019-03,英国布里斯托大学化学系, 博士后
2012-12~2016-03,比利时天主教鲁汶大学化学与药物化学系, 博士后
2012-07~2012-10,中国科学院成都生物研究所天然产物研究中心, 项目聘用

专利与奖励

   
专利成果
[1] 马小锋, 刘亚洲, 王阿木, 史小可, 王飞. 调节雌激素受体合成活性的吡唑并吡啶衍生物. 2021107866683, 2021-07-12.

[2] 马小锋, 刘亚洲. 一种二苯并c,e1,2氧硫杂环己烷-6-氧化物类化合物的转化方法. CN: CN110683940A, 2020-01-14.

[3] 吴中柳, 张帅兵, 裴小琼, 马小锋, 邵华武. 两个阿魏酸酯酶酶活检测的新化合物及其制备方法. 中国: CN102190586A, 2011.09.21.

[4] 邵华武, 马小锋. 一种立体选择性制备吡喃衍生物的方法. 中国: CN102180923A, 2011-09-14.

[5] 邵华武, 赵晋忠, 魏善巧, 马小锋. 一种制备3,4-二-O-乙酰基-L-鼠李烯糖的方法. 中国: CN101497592, 2009.08.05.

出版信息

   
发表论文
[1] Zhang Guoqing, Tang Senling, Yang Chunmei, Cheng Yongjie, Xiang Ling, Shao Huawu, Ma Xiaofeng, Zhang Fan, Jiao Wei. Synthesis of 2,2-Disubstituted Perhydrofuro[2,3-b]-pyran Derivatives containing Indole catalyzed by BF3.Et2O. ASIAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2022, [2] Shi Hailong, Yang Jian, Cheng Yao, Lu Xiaoxia, Ma Xiaofeng. 1, 2‐trans‐Stereoselective 7‐O‐Glycosylation of Flavonoids with Unprotected Pyranoses by Mitsunobu Reaction. Chemistry – An Asian Journal[J]. 2022, https://onlinelibrary.wiley.com/doi/10.1002/asia.202200120.
[3] Wang Amu, Liu Ya-Zhou, Shen Zhongke, Qiao Zeen, Ma Xiaofeng. Regioselective Synthesis of Pyrazolo[1,5-a]pyridine via TEMPO Mediated [3+2] Annulation-Aromatization of N-Aminopyridines and α,β-Unsaturated Compounds. Organic Letters[J]. 2022, https://pubs.acs.org/doi/10.1021/acs.orglett.2c00035.
[4] Damseaux, Caroline, Scholl, Georges, Damblon, Christian, Dejeaifve, Alain, Dobson, Rowan, Ma, Xiaofeng, Marko, Istvan, Monbaliu, JeanChristophe M, De Pauw, Edwin, Eppe, Gauthier. Identification of the Degradation Products from alpha-Ionone Used as Stabiliser in "Green" Propellants through its Lifetime. PROPELLANTS EXPLOSIVES PYROTECHNICS[J]. 2021, 46(11): 1653-1661, http://dx.doi.org/10.1002/prep.202100191.
[5] Zhang, Xiaoke, Pan, Yang, Wang, Haibo, Liang, Chong, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. Strategy to Construct 1,2,3-Triazoles by K2CO3-Mediated 4+1 Annulation Reactions of N-Acetyl Hydrazones with Bifunctional Amino Reagents. ADVANCED SYNTHESIS & CATALYSIS[J]. 2021, 363(2): 459-463, https://www.webofscience.com/wos/woscc/full-record/WOS:000596586300001.
[6] Liang, Peng, Zhao, Hang, Zhou, Tingting, Zeng, Kaiyun, Jiao, Wei, Pan, Yang, Liu, Yazhou, Fang, Dongmei, Ma, Xiaofeng, Shao, Huawu. Rapid Oxidation Indoles into 2-Oxindoles Mediated by PIFA in Combination with n-Bu4NCl center dot H2O. ADVANCED SYNTHESIS & CATALYSIS[J]. 2021, 363(14): 3532-3538, http://dx.doi.org/10.1002/adsc.202100234.
[7] Xiaofeng Ma, Yazhou Liu, Le Du, Jingwei Zhou, Istvn E Mark. Post-functionalization of dibenzothiophene to functionalized biphenyls via a photoinduced thia-Baeyer-Villiger oxidation. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-14522-7.
[8] Pan, Yang, Li, Jiangtao, Li, Zhefeng, Huang, Feng, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. An efficient and facile strategy for trifluoromethylation and perfluoroalkylation of isoquinolines and heteroarenes. CHEMICAL COMMUNICATIONS[J]. 2020, 56(56): 7813-7816, https://www.webofscience.com/wos/woscc/full-record/WOS:000548421300028.
[9] Ma, Xiaofeng, Hazelden, Ian R, Langer, Thomas, Munday, Rachel H, Bower, John F. Enantioselective Aza-Heck Cyclizations of N-(Tosyloxy)carbamates: Synthesis of Pyrrolidines and Piperidines. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 141(8): 3356-3360, http://dx.doi.org/10.1021/jacs.8b12689.
[10] Zhang, Xiaoke, Pan, Yang, Liang, Peng, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. An Effective Method for the Synthesis of 1,3-Dihydro-2H-indazoles via N-N Bond Formation. ADVANCED SYNTHESIS & CATALYSIS[J]. 2019, 361(24): 5552-5557, [11] Ma, Xiaofeng, Dewez, Damien F, Du, Le, Luo, Xiya, Marko, Istvan E, Lam, Kevin. Synthesis of Diketones, Ketoesters, and Tetraketones by Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: Application to the Synthesis of cis-Jasmone. JOURNAL OF ORGANIC CHEMISTRY[J]. 2018, 83(19): 12044-12055, https://www.webofscience.com/wos/woscc/full-record/WOS:000447118100054.
[12] Zhang, Xiaoke, Pan, Yang, Liang, Peng, Pang, Lu, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. Oxadiazepine Synthesis by Formal 4+3 Cycloaddition of o-Chloromethyl Arylsulfonamides with Nitrones Promoted by NaHCO3. ADVANCED SYNTHESIS & CATALYSIS[J]. 2018, 360(16): 3015-3019, https://www.webofscience.com/wos/woscc/full-record/WOS:000441874400004.
[13] Liang, Peng, Pan, Yang, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. A facile method for the synthesis of fused perhydropyrano2,3-bpyrans promoted by Yb(OTf)(3). JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(14): 3763-3766, [14] Luo, Xiya, Ma, Xiaofeng, Lebreux, Frederic, Marko, Istvan E, Lam, Kevin. Electrochemical methoxymethylation of alcohols - a new, green and safe approach for the preparation of MOM ethers and other acetals. CHEMICAL COMMUNICATIONS[J]. 2018, 54(71): 9969-9972, https://www.webofscience.com/wos/woscc/full-record/WOS:000443170200022.
[15] Farndon, Joshua J, Ma, Xiaofeng, Bower, John F. Transition Metal Free C-N Bond Forming Dearomatizations and Aryl C-H Aminations by in Situ Release of a Hydroxylamine-Based Aminating Agent. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 139(40): 14005-14008, http://dx.doi.org/10.1021/jacs.7b07830.
[16] Ma, Xiaofeng, Farndon, Joshua J, Young, Tom A, Fey, Natalie, Bower, John F. A Simple and Broadly Applicable C-N Bond Forming Dearomatization Protocol Enabled by Bifunctional Amino Reagents. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(46): 14531-14535, http://dx.doi.org/10.1002/anie.201708176.
[17] Ian R. Hazelden, Ma Xiaofeng, Thomas Langer, Bower John F.. Diverse N-Heterocyclic Ring Systems via Aza-Heck Cyclizations of N-(Pentafluorobenzoyloxy)sulfonamides.. Angewandte Chemie (International ed. in English)[J]. 2016, 55(37): 11198-11202, https://doi.org/10.1002/anie.201605152.
[18] Xiaofeng Ma, Hodney Lubin, Enikő Ioja, Orsolya Kékesi, Ágnes Simon, Ágota Apáti, Tamás I. Orbán, László Héja, Julianna Kardos, István E. Markó. Straightforward and effective synthesis of γ-aminobutyric acid transporter subtype 2-selective acyl-substituted azaspiro4.5decanes. Bioorganic & Medicinal Chemistry Letters[J]. 2016, 26(2): 417-423, http://dx.doi.org/10.1016/j.bmcl.2015.11.100.
[19] Shen, Xudong, Xia, Jianhui, Liang, Peng, Ma, Xiaofeng, Jiao, Wei, Shao, Huawu. Zn(OTf)(2) promoted rearrangement of 1,2-cyclopropanated sugars with amines: a convenient method for the synthesis of 3-polyhydroxyalkyl-substituted pyrrole derivatives. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2015, 13(44): 10865-10873, http://210.75.237.14/handle/351003/27600.
[20] Ma, Xiaofeng, Luo, Xiya, Dochain, Simon, Mathot, Charlotte, Marko, Istvan E. Electrochemical Oxidative Decarboxylation of Malonic Acid Derivatives: A Method for the Synthesis of Ketals and Ketones. ORGANIC LETTERS[J]. 2015, 17(19): 4690-4693, https://www.webofscience.com/wos/woscc/full-record/WOS:000362384700011.
[21] Wang, Cong, Ma, Xiaofeng, Zhang, Jichao, Tang, Qin, Jiao, Wei, Shao, Huawu. Methanesulfonic-Acid-Catalysed Ring Opening and Glycosylation of 1,2-(Acetylcyclopropane)-Annulated D-Lyxofuranose. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 2014(21): 4592-4599, http://210.75.237.14/handle/351003/26675.
[22] Ma, Xiaofeng, Tang, Qin, Ke, Jun, Zhang, Jichao, Yang, Xinglong, Shen, Xudong, Shao, Huawu. A neighboring group participation strategy: direct and highly diastereoselective synthesis of 2-substituted and 2,2-bisubstituted perhydrofuro2,3-b pyran derivatives. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2014, 12(37): 7381-7388, http://210.75.237.14/handle/351003/26699.
[23] Ma, Xiaofeng, Zhang, Jichao, Tang, Qin, Ke, Jun, Zou, Wei, Shao, Huawu. Stereospecific 3+2 cycloaddition of 1,2-cyclopropanated sugars and ketones catalyzed by SnCl4: an efficient synthesis of multi-substituted perhydrofuro2,3-bfurans and perhydrofuro2,3-bpyrans. CHEMICAL COMMUNICATIONS[J]. 2014, 50(26): 3505-3508, http://210.75.237.14/handle/351003/26709.
[24] Zhang, Jichao, Yuan, Wen, Ma, Xiaofeng, Wang, Haibo, Shao, Huawu. An Efficient and Simple Method for Stereoselective Synthesis of N-Substituted Iminosugars from D-Xylose Derivative. CHINESE JOURNAL OF CHEMISTRY[J]. 2014, 32(4): 361-364, http://210.75.237.14/handle/351003/26690.
[25] Ma, Xiaofeng, Tang, Qin, Ke, Jun, Zhang, Jichao, Wang, Cong, Wang, Haibo, Li, Yuxue, Shao, Huawu. Straightforward and highly diastereoselective synthesis of 2,2-di-substituted perhydrofuro2,3-bpyran (and furan) derivatives promoted by BiCl3. CHEMICAL COMMUNICATIONS[J]. 2013, 49(63): 7085-7087, http://www.irgrid.ac.cn/handle/1471x/900508.
[26] Ma, Xiaofeng, Tang, Qin, Ke, Jun, Wang, Haibo, Zou, Wei, Shao, Huawu. A convenient and highly stereoselective method for synthesis of octahydropyrano3,2-bpyrrole derivatives. CARBOHYDRATE RESEARCH[J]. 2013, 366: 55-62, http://dx.doi.org/10.1016/j.carres.2012.11.016.
[27] Ma, Xiaofeng, Tang, Qin, Ke, Jun, Yang, Xinglong, Zhang, Jichao, Shao, Huawu. InCl3 Catalyzed Highly Diastereoselective 3+2 Cycloaddition of 1,2-Cyclopropanated Sugars with Aldehydes: A Straightforward Synthesis of Persubstituted Bis-Tetrahydrofurans and Perhydrofuro2,3-bpyrans. ORGANIC LETTERS[J]. 2013, 15(20): 5170-5173, http://www.irgrid.ac.cn/handle/1471x/900532.
[28] Zhang, ShuaiBing, Ma, XiaoFeng, Pei, XiaoQiong, Liu, JingYuan, Shao, HuaWu, Wu, ZhongLiu. A practical high-throughput screening system for feruloyl esterases: Substrate design and evaluation. JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC[J]. 2012, 74(1-2): 36-40, http://dx.doi.org/10.1016/j.molcatb.2011.08.011.
[29] Wang, Haibo, Luo, Hairong, Ma, Xiaofeng, Zou, Wei, Shao, Huawu. Stereoselective Synthesis of a Series of New N-Alkyl-3-hydroxypiperidine Derivatives Containing a Hemiketal. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2011, 2011(25): 4834-4840, http://www.irgrid.ac.cn/handle/1471x/517870.
[30] Tian, Qiang, Dong, Liang, Ma, Xiaofeng, Xu, Liyan, Hu, Changwei, Zou, Wei, Shao, Huawu. Stereoselective Synthesis of 2-C-Branched (Acetylmethyl) Oligosaccharides and Glycoconjugates: Lewis Acid-Catalyzed Glycosylation from 1,2-Cyclopropaneacetylated Sugars. JOURNAL OF ORGANIC CHEMISTRY[J]. 2011, 76(4): 1045-1053, http://www.irgrid.ac.cn/handle/1471x/517898.
[31] Ma, Xiaofeng, Tian, Qiang, Tang, Qin, Zhao, Jinzhong, Shao, Huawu. A Novel and Highly Stereoselective Synthesis of 2-Substituted Perhydrofuro2,3-bpyran Derivatives. ORGANIC LETTERS[J]. 2011, 13(16): 4276-4279, http://www.irgrid.ac.cn/handle/1471x/517871.
[32] Zhao, Jinzhong, Wei, Shanqiao, Ma, Xiaofeng, Shao, Huawu. A simple and convenient method for the synthesis of pyranoid glycals. CARBOHYDRATE RESEARCH[J]. 2010, 345(1): 168-171, http://dx.doi.org/10.1016/j.carres.2009.10.003.
[33] Tian, Qiang, Xu, Liyan, Ma, Xiaofeng, Zou, Wei, Shao, Huawu. Stereoselective Synthesis of 2-C-Acetonyl-2-Deoxy-D-Galactosides using 1,2-Cyclopropaneacetylated Sugar as Novel Glycosyl Donor. ORGANIC LETTERS[J]. 2010, 12(3): 540-543, http://www.chinair.org.cn/handle/1471x/1748698.
[34] Zhao, Jinzhong, Wei, Shanqiao, Ma, Xiaofeng, Shao, Huawu. A mild and environmentally benign method for the synthesis of glycals in PEG-600/H2O. GREEN CHEMISTRY[J]. 2009, 11(8): 1124-1127, http://www.irgrid.ac.cn/handle/1471x/256535.

科研活动

   

指导学生

现指导学生

申忠珂  硕士研究生  078001-药物化学  

张力  博士研究生  100701-药物化学  

李江涛  博士研究生  100701-药物化学  

王阿木  硕士研究生  078001-药物化学  

李小燕  硕士研究生  086000-生物与医药  

杨建  博士研究生  100701-药物化学