070302-分析化学
071010-生物化学与分子生物学
083100-生物医学工程

单细胞质谱多组学和成像研究
肿瘤代谢
环境毒理

2009-09--2013-06   中科院生态环境研究中心   博士
2006-09--2009-06   大连海事大学   硕士
2002-09--2006-06   沈阳工业大学   学士

   

2019-09~现在, 中国科学院深圳先进技术研究院医工所, 副研究员
2014-12~2019-07,香港浸会大学环境与生物分析国家重点实验室, 博士后
2013-09~2014-11,中科院生态环境研究中心环境化学与生态毒理学国家重点实验室, 博士后

   

（1） 中国分析测试协会科学技术奖 (CAIA奖) (6/10), 特等奖, 国家级, 2020
（2） 深圳市海外高层次人才“孔雀计划”C类, 省级, 2019
（3） 中国科学院深圳先进技术研究“优秀青年创新基金”, 研究所（学校）, 2019
（4） Young Scientist Travel Award-Asia Oceania Mass Spectrometry Conference 2017, 其他, 2017
（5） 中国分析测试协会科学技术奖 (CAIA奖) (4/10), 特等奖, 国家级, 2015
（6） 香江学者奖, 专项, 2014
（7） 中国分析测试协会科学技术奖 (CAIA奖) (7/10), 一等奖, 国家级, 2013

   

[1] JACS Au. 2024,   通讯作者  
[2] Analytical chemistry. 2023,   通讯作者  
[3] Star Protocols. 2023,   通讯作者  
[4] Reviews of Environmental Contamination and Toxicology. 2023, 第 1 作者
[5] iScience. 2022,   通讯作者  
[6] Current Opinion in Chemical Biology. 2022, 第 1 作者
[7] Guo, Lei, Hu, Zhenxing, Zhao, Chao, Xu, Xiangnan, Wang, Shujuan, Xu, Jingjing, Dong, Jiyang, Cai, Zongwei. Data Filtering and Its Prioritization in Pipelines for Spatial Segmentation of Mass Spectrometry Imaging. ANALYTICAL CHEMISTRY[J]. 2021, 第 3 作者  通讯作者  93(11): 4788-4793, 
[8] Zhao, Chao, Yong, Ting, Zhang, Yinbin, Xiao, Yu, Jin, Yaofeng, Zheng, Chang, Nirasawa, Takashi, Cai, Zongwei. Breast cancer proliferation and deterioration-associated metabolic heterogeneity changes induced by exposure of bisphenol S, a widespread replacement of bisphenol A. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 第 1 作者414: 
[9] 赵超, 蔡宗苇. 基于质谱成像和组学分析的环境毒理研究. 化学进展[J]. 2021, 第 1 作者
[10] Zhao, Chao, Xie, Peisi, Yong, Ting, Huang, Wei, Liu, Jianjun, Wu, Desheng, Ji, Fenfen, Li, Min, Zhang, Doudou, Li, Ruijin, Dong, Chuan, Ma, Juan, Dong, Zheng, Liu, Sijin, Cai, Zongwei. Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy. SCIENCE BULLETIN[J]. 2021, 第 1 作者66(6): 578-591, 
[11] The Innovation. 2021, 第 1 作者
[12] Zhao, Chao, Cai, Zongwei. Three-dimensional quantitative mass spectrometry imaging in complex system: From subcellular to whole organism. MASS SPECTROMETRY REVIEWS[J]. 2020, 第 1 作者41(3): 469-487, 
[13] 蔡宗苇, 赵超. 孕鼠PM2.5暴露如何影响后代行为变化？. 科学通报[J]. 2020, 第 2 作者65(34): 3849-3850, 
[14] Zhao, Chao, Yong, Ting, Zhang, Yinbin, Jin, Yaofeng, Xiao, Yu, Wang, Hailin, Zhao, Bin, Cai, Zongwei. Evaluation of the splenic injury following exposure of mice to bisphenol S: A mass spectrometry-based lipidomics and imaging analysis. ENVIRONMENT INTERNATIONAL[J]. 2020, 第 1 作者135: 
[15] Xie, Peisi, Zhao, Chao, Liang, Xiaoping, Huang, Wei, Chen, Yanyan, Cai, Zongwei. Preparation of Frozen Sections of Multicellular Tumor Spheroids Coated with Ice for Mass Spectrometry Imaging. ANALYTICAL CHEMISTRY[J]. 2020, 第 2 作者92(11): 7413-7418, 
[16] Zhao, Chao, Tang, Zhi, Chung, Arthur Chi Kong, Wang, Hailin, Cai, Zongwei. Metabolic perturbation, proliferation and reactive oxygen species jointly contribute to cytotoxicity of human breast cancer cell induced by tetrabromo and tetrachloro bisphenol A. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY[J]. 2019, 第 1 作者170: 495-501, 
[17] Huang, Wei, Zhao, Chao, Zhong, Huan, Zhang, Shoudong, Xia, Yiji, Cai, Zongwei. Bisphenol S induced epigenetic and transcriptional changes in human breast cancer cell line MCF-7. ENVIRONMENTAL POLLUTION[J]. 2019, 第 2 作者246: 697-703, http://dx.doi.org/10.1016/j.envpol.2018.12.084.
[18] Zhao Chao, Tang Zhi, Xie, Peisi, Lin Kaili, Arthur Chi Kong Chung, Cai Zongwei. Immunotoxic Potentials of Bisphenol F Mediated through Lipid Signaling Pathways on Macrophages. Environmental Science & Technology[J]. 2019, 第 1 作者
[19] Zhao, Chao, Zhu, Lin, Li, Ruijin, Wang, Hailin, Cai, Zongwei. Omics approach reveals metabolic disorders associated with the cytotoxicity of airborne particulate matter in human lung carcinoma cells. ENVIRONMENTAL POLLUTION[J]. 2019, 第 1 作者246: 45-52, http://dx.doi.org/10.1016/j.envpol.2018.11.108.
[20] Zhao, Chao, Xie, Peisi, Yang, Ti, Wang, Hailin, Chung, Arthur Chi Kong, Cai, Zongwei. Identification of glycerophospholipid fatty acid remodeling by using mass spectrometry imaging in bisphenol S induced mouse liver. CHINESE CHEMICAL LETTERS[J]. 2018, 第 1 作者29(8): 1281-1283, http://lib.cqvip.com/Qikan/Article/Detail?id=676285936.
[21] Zhao, Chao, Xie, Peisi, Yong, Ting, Wang, Hailin, Chung, Arthur Chi Kong, Cai, Zongwei. MALDI-MS Imaging Reveals Asymmetric Spatial Distribution of Lipid Metabolites from Bisphenol S-Induced Nephrotoxicity. ANALYTICAL CHEMISTRY[J]. 2018, 第 1 作者90(5): 3196-3204, http://ir.rcees.ac.cn/handle/311016/40978.
[22] Zhao, Chao, Xie, Peisi, Wang, Hailin, Cai, Zongwei. Liquid chromatography-mass spectrometry-based metabolomics and lipidomics reveal toxicological mechanisms of bisphenol F in breast cancer xenografts. JOURNAL OF HAZARDOUS MATERIALS[J]. 2018, 第 1 作者358: 503-507, http://dx.doi.org/10.1016/j.jhazmat.2018.05.010.
[23] Zhao, Chao, Tang, Zhi, Yan, Jiacheng, Fang, Jing, Wang, Hailin, Cai, Zongwei. Bisphenol S exposure modulate macrophage phenotype as defined by cytokines profiling, global metabolomics and lipidomics analysis. SCIENCE OF THE TOTAL ENVIRONMENT[J]. 2017, 第 1 作者592: 357-365, http://dx.doi.org/10.1016/j.scitotenv.2017.03.035.
[24] Zhao, Chao, Wang, Hailin, Zhao, Bailin, Li, Cuiping, Yin, Ruichuan, Song, Maoyong, Liu, Baodong, Liu, Zhen, Jiang, Guibin. Boronic acid-mediated polymerase chain reaction for gene- and fragment-specific detection of 5-hydroxymethylcytosine. NUCLEIC ACIDS RESEARCH[J]. 2014, 第 1 作者42(9): http://www.irgrid.ac.cn/handle/1471x/936401.
[25] Zhao Chao. Capillary Monolithic Bioreactor of Immobilizing Snake Venom Phosphodiesterase for Mass Spectrometry Based Oligodeoxynucleotide Sequencing. Analytical Chemistry. 2012, 第 1 作者

（1） Air Pollution, Climate, and Health: An Integrated Perspective on Their Interactions, Chapter 9: Airborne particulate matter and its organic components: Complex triggers of human disease, Elsevier, 2021-05, 第 1 作者

   

（ 1 ） 实时在线微流控芯片质谱技术用于乳腺肿瘤代谢分型的研究, 负责人, 研究所自主部署, 2020-01--2022-01
（ 2 ） 双酚A类似物在人乳腺癌裸鼠模型中的代谢活化途径和毒理效应研究, 负责人, 国家任务, 2016-01--2018-12
（ 3 ） 太原和广州市大气细颗粒物诱导呼吸系统疾病的质谱代谢组学研究, 参与, 国家任务, 2016-01--2019-12
（ 4 ） 毛细管电泳-双光子荧光偏振单分子检测装置, 参与, 国家任务, 2014-01--2017-12
（ 5 ） 基于多重分子相互作用的纳米材料生物效应的研究, 参与, 国家任务, 2011-01--2013-12
（ 6 ） 基于 3D 细胞微球的质谱组学和成像新方法及其在 酚类污染物毒性评价中的应用, 负责人, 地方任务, 2021-01--2023-12
（ 7 ） PM2.5跨代际暴露诱导神经退行性疾病作用机制研究, 负责人, 地方任务, 2021-01--2023-12
（ 8 ） 基于多维度便携式微芯片分析传感系 统的环境污染物检测技术研发及应用示范, 参与, 地方任务, 2020-01--2022-12
（ 9 ） 低剂量双酚A替代物影响乳腺癌肿瘤形成及其诱导脏器损伤的机制研究, 负责人, 国家任务, 2022-01--2025-12

（1）Multiple Imaging Mass Spectrometry Analysis Reveals the Evolution of Tumor Metabolic Heterogeneity    中国质谱学术大会   2018-11-24
（2）Ceramide Accumulation and Altered RNA Splicing Contributing to Cytotoxicity of Human Lung Epithelial Cells Induced by Airborne Particulate Matter: Integrative Analysis of Metabolomics, Lipidomics and Proteomics   The international conference on environmental pollution and Health   2018-05-19
（3）MALDI-TOF MS Imaging for Environmental Toxicology   Clinical & Pharmaceutical Solutions through Analysis (CPSA)   2018-04-18
（4）Multi-omics and Spatial Imaging Analysis Reveal Toxicological Mechanisms of Bisphenol F in Breast Cancer Xenografts   7th Asia Oceania Mass Spectrometry Conference 2017   2017-12-12
（5）Reactive Oxygen Species and Nucleotide Metabolism Jointly Contribute to HepG2 Cytotoxicity Induced by Tetrabromobisphenol A   15th International Conference on Environmental Science and Technology   2017-09-01
（6）Liquid Chromatography-Mass Spectrometry-based Metabolomics and Lipidomics Reveal Toxicological Mechanisms of Bisphenol F in Breast Cancer Xenografts   HKSMS Symposium 2017 & 19th Annual General Meeting   2017-06-24

西安交通大学第二附属医院

复旦大学肿瘤医院