基本信息
高福 男 博导 微生物研究所
电子邮件:gaof@im.ac.cn
通信地址:北京市朝阳区北辰西路1号院3号
邮政编码:1000101

研究领域

病原微生物与免疫学, 主要研究病原微生物与宿主互作及宿主免疫识别过程中相关的蛋白质结构与功能。
分子免疫学领域:集中研究T细胞免疫中分子识别的蛋白质与蛋白质的相互作用,尤其是细胞界面的表面蛋白质(受体与配体)之间的相互作用。
分子病毒学领域:囊膜病毒侵入的分子机制,尤其是细胞受体与病毒囊膜蛋白相互作用及融合抑制剂的药物设计。
分子流行病学与分子进化:近几年来,联合国内其他优势单位,对野生水禽感染禽流感、人感染2型猪链球菌、猪的无名高热等传染病进行了系统研究。

招生信息

   
招生专业
071010-生物化学与分子生物学
071007-遗传学
招生方向
免疫识别的结构基础与病原微生物跨种间传播的分子机制

教育背景

1991-09--1994-08 英国牛津大学 博士
1983-09--1986-07 北京农业大学(现中国农业大学) 硕士
1979-09--1983-07 山西农业大学 学士
学历
1991 - 1995, 英国牛津大学 (Oxford University),博士,生物化学。
1983 - 1986, 北京农业大学,硕士,微生物学与动物传染病学。
1979 - 1983, 山西农业大学,学士,兽医学。
学位
-- 博士
出国学习工作

1991-1994 年 英国牛津大学 博士 ( DPhil-Oxon )(师从 David H L Bishop, Ernest A Gould )
1994 年(3个月) 加拿大 Calgary University 博士后(师从 Robert Bell )  1995-1998 年 英国牛津大学 博士后(师从 John I bell, Andrew J McMichael, Bent K Jakobsen )
1999-2001 年 美国哈佛大学 / 哈佛医学院 博士后(师从 Don C Wiley, Stephen C Harrison )(工作期间资助:英国 Wellcome Trust International Travelling Fellow )
2001-2004 年 英国牛津大学 讲师、博士生导师、 Group leader

工作经历

1986-1991 年 北京农业大学 助教 / 讲师
1994 年(3个月) 加拿大 Calgary University 博士后(师从 Robert Bell )   
1995-1998 年 英国牛津大学 博士后(师从 John I bell, Andrew J McMichael, Bent K Jakobsen )
1999-2001 年 美国哈佛大学 / 哈佛医学院 博士后(师从 Don C Wiley, Stephen C Harrison )(工作期间资助:英国 Wellcome Trust International Travelling Fellow )
2001-2004 年 英国牛津大学 讲师、博士生导师、 Group leader
2004 -2008年 中国科学院微生物研究所 所长
2004-至今   中国科学院微生物研究所 研究员、博士生导师
2008-至今   中国科学院北京生命科学研究院 副院长,中国科学院病原微生物与免疫学重点实验室 主任  
2010-至今   英国牛津大学 客座教授
2011-至今   中国疾病预防控制中心 副主任
社会兼职
2012-01--今 《Philosophical Transactions of the Royal Society B: Biological Sciences》杂志
2011-10--今 中国微生物学会病毒学专业委员会 ,副主任委员
2011-06--今 中国科学技术协会,第八届常委
2010-12--今 中国生物工程学会,第五届理事会副理事长
2010-10--今 中国免疫学会
2010-01--今 《Protein & Cell》杂志
2010-01--今 牛津大学,客座教授
2009-01--今 《Experimental Biology and Medicine》杂志
2006-06--今 国际抗病毒联盟(ICAV)

出版信息

   
发表论文
[1] Song, Hao, Zhao, Zhennan, Chai, Yan, Jin, Xiyue, Li, Changyao, Yuan, Fei, Liu, Sheng, Gao, Zhengrong, Wang, Haiyuan, Song, Jian, Vazquez, Leonardo, Zhang, Yanfang, Tan, Shuguang, Morel, Carlos M, Yan, Jinghua, Shi, Yi, Qi, Jianxun, Gao, Feng, Gao, George F. Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein. CELL[J]. 2019, 177(7): 1714-+, http://dx.doi.org/10.1016/j.cell.2019.04.008.
[2] Gao Fu. Human neonatal Fc receptor is 1 the cellular uncoating receptor for Enterovirus B.. Cell. 2019, [3] Shang, Zifang, Son, Hao, Shi, Yi, Qi, Jianxun, Gao, George F. Crystal Structure of the Capsid Protein from Zika Virus. JOURNAL OF MOLECULAR BIOLOGY[J]. 2018, 430(7): 948-962, http://dx.doi.org/10.1016/j.jmb.2018.02.006.
[4] Gao, George F. From "A'' IV to "Z''IKV: Attacks from Emerging and Re-emerging Pathogens. CELLnull. 2018, 172(6): 1157-1159, http://dx.doi.org/10.1016/j.cell.2018.02.025.
[5] Wong, Gary, Gao, George F. Did ZIKV evolve to be more dangerous? A new clue towards neurovirulence. NATIONAL SCIENCE REVIEWnull. 2018, 5(2): 120-+, http://lib.cqvip.com/Qikan/Article/Detail?id=675477729.
[6] Yuan Yuan, Duanfang Cao, Yanfang Zhang, Jun Ma, Jianxun Qi, Qihui Wang, Guangwen Lu, Ying Wu, Jinghua Yan, Yi Shi, Xinzheng Zhang, George F Gao. Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/0a48ce79c98942e39775d23cb6720f81.
[7] Li, An, Lu, Guangwen, Qi, Jianxun, Wu, Lili, Tian, Kegong, Luo, Tingrong, Shi, Yi, Yan, Jinghua, Gao, George F. Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D. PLOS PATHOGENS[J]. 2017, 13(5): https://doaj.org/article/801e9b0257cb4b6fab1c35d2ee201758.
[8] Peng, Ruchao, Zhang, Shuijun, Cui, Yingzi, Shi, Yi, Gao, George F, Qi, Jianxun. Structures of human-infecting Thogotovirus fusogens support a common ancestor with insect baculovirus. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(42): E8905-E8912, https://www.webofscience.com/wos/woscc/full-record/WOS:000413237900017.
[9] Shi, Yi, Gao, George F. Structural Biology of the Zika Virus. TRENDS IN BIOCHEMICAL SCIENCESnull. 2017, 42(6): 443-456, http://dx.doi.org/10.1016/j.tibs.2017.02.009.
[10] Wu, Yan, Zhu, Yaohua, Gao, Feng, Jiao, Yongjun, Oladejo, Babayemi O, Chai, Yan, Bi, Yuhai, Lu, Shan, Dong, Mengqiu, Zhang, Chang, Huang, Guangmei, Wong, Gary, Li, Na, Zhang, Yanfang, Li, Yan, Feng, Wenhai, Shi, Yi, Liang, Mifang, Zhang, Rongguang, Qi, Jianxun, Gao, George F. Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2017, 114(36): E7564-E7573, https://www.webofscience.com/wos/woscc/full-record/WOS:000409182200018.
[11] Shuguang Tan, Hao Zhang, Yan Chai, Hao Song, Zhou Tong, Qihui Wang, Jianxun Qi, Gary Wong, Xiaodong Zhu, William J Liu, Shan Gao, Zhongfu Wang, Yi Shi, Fuquan Yang, George F Gao, Jinghua Yan. An unexpected N-terminal loop in PD-1 dominates binding by nivolumab. NATURE COMMUNICATIONS[J]. 2017, 8(1): http://www.corc.org.cn/handle/1471x/2201087.
[12] Duan, Wenqian, Song, Hao, Wang, Haiyuan, Chai, Yan, Su, Chao, Qi, Jianxun, Shi, Yi, Gao, George F. The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO JOURNAL[J]. 2017, 36(7): 919-933, https://www.webofscience.com/wos/woscc/full-record/WOS:000398156000009.
[13] Song, Hao, Qi, Jianxun, Xiao, Haixia, Bi, Yuhai, Zhang, Wei, Xu, Ying, Wang, Fei, Shi, Yi, Gao, George F. Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4. CELL REPORTS[J]. 2017, 20(5): 1201-1214, http://dx.doi.org/10.1016/j.celrep.2017.07.028.
[14] Haywood, Joel, Qi, Jianxun, Chen, ChunChi, Lu, Guangwen, Liu, Yingxia, Yan, Jinghua, Shi, Yi, Gao, George F. Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2016, 113(4): 1038-1043, https://www.webofscience.com/wos/woscc/full-record/WOS:000368617900057.
[15] Gao Fu. Intra-host variations of Ebola virus during 2014. Nature Microbiology. 2016, [16] Xu, Xiaoying, Song, Hao, Qi, Jianxun, Liu, Yuqian, Wang, Haiyuan, Su, Chao, Shi, Yi, Gao, George F. Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure. EMBO JOURNAL[J]. 2016, 35(20): 2170-2178, http://www.corc.org.cn/handle/1471x/2374878.
[17] Musyoki, Abednego Moki, Shi, Zhongyu, Xuan, Chunling, Lu, Guangwen, Qi, Jianxun, Gao, Feng, Zheng, Beiwen, Zhang, Qiangmin, Li, Yan, Haywood, Joel, Liu, Cuihua, Yan, Jinghua, Shi, Yi, Gao, George F. Structural and functional analysis of an anchorless fibronectin-binding protein FBPS from Gram-positive bacterium Streptococcus suis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2016, 113(48): 13869-13874, https://www.webofscience.com/wos/woscc/full-record/WOS:000388835700087.
[18] Wang, Han, Shi, Yi, Song, Jian, Qi, Jianxun, Lu, Guangwen, Yan, Jinghua, Gao, George F. Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1. CELL[J]. 2016, 164(1-2): 258-268, http://dx.doi.org/10.1016/j.cell.2015.12.044.
[19] Dai, Lianpan, Song, Jian, Lu, Xishan, Deng, YongQiang, Musyoki, Abednego Moki, Cheng, Huijun, Zhang, Yanfang, Yuan, Yuan, Song, Hao, Haywood, Joel, Xiao, Haixia, Yan, Jinghua, Shi, Yi, Qin, ChengFeng, Qi, Jianxun, Gao, George F. Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody. CELL HOST & MICROBE[J]. 2016, 19(5): 696-704, http://124.16.173.210/handle/834782/2259.
[20] Wang, Qihui, Yang, Huabing, Liu, Xiaoqing, Dai, Lianpan, Ma, Tong, Qi, Jianxun, Wong, Gary, Peng, Ruchao, Liu, Sheng, Li, Junfu, Li, Shihua, Song, Jian, Liu, Jianying, He, Jianhua, Yuan, Hui, Xiong, Ying, Liao, Yong, Li, Jianhua, Yang, Jianping, Tong, Zhou, Griffin, Bryan D, Bi, Yuhai, Liang, Mifang, Xu, Xiaoning, Qin, Chuan, Cheng, Gong, Zhang, Xinzheng, Wang, Peiyi, Qiu, Xiangguo, Kobinger, Gary, Shi, Yi, Yan, Jinghua, Gao, George F. Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus. SCIENCE TRANSLATIONAL MEDICINE[J]. 2016, 8(369): http://ir.sinap.ac.cn/handle/331007/26577.
[21] Gao Fu. Genesis, evolution and prevalence of H5N6 avian influenza viruses causing sporadic human infections. Cell Host and Microbe. 2016, [22] Song, Hao, Qi, Jianxun, Haywood, Joel, Shi, Yi, Gao, George F. Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2016, 23(5): 456-458, http://dx.doi.org/10.1038/nsmb.3213.
[23] Ma, Wenqiang, Li, Shihua, Ma, Shuoqian, Jia, Lina, Zhang, Fuchun, Zhang, Yong, Zhang, Jingyuan, Wong, Gary, Zhang, Shanshan, Lu, Xuancheng, Liu, Mei, Yan, Jinghua, Li, Wei, Qin, Chuan, Han, Daishu, Qin, Chengfeng, Wang, Na, Li, Xiangdong, Gao, George Fu. Zika Virus Causes Testis Damage and Leads to Male Infertility in Mice. CELL[J]. 2016, 167(6): 1511-+, http://dx.doi.org/10.1016/j.cell.2016.11.016.
[24] Song, Hao, Qi, Jianxun, Khedri, Zahra, Diaz, Sandra, Yu, Hai, Chen, Xi, Varki, Ajit, Shi, Yi, Gao, George F. An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. PLOS PATHOGENS[J]. 2016, 12(1): https://doaj.org/article/cb9b7b9c8938494cb05775cd4e44d294.
[25] Wu, Ying, Cho, MyungSam, Shore, David, Song, Manki, Choi, JungAh, Jiang, Tao, Deng, YongQiang, Bourgeois, Melissa, Almli, Lynn, Yang, Hua, Chen, LiMei, Shi, Yi, Qi, Jianxu, Li, An, Yi, Kye Sook, Chang, MinSeok, Bae, Jin Soo, Lee, HyunJoo, Shin, JiYoung, Stevens, James, Hong, SeoungSuh, Qin, ChengFeng, Gao, George F, Chang, Shin Jae, Donis, Ruben O. A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus. NATURE COMMUNICATIONS[J]. 2015, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000358858500014.
[26] Li, Yan, Wan, Yuhua, Liu, Peipei, Zhao, Jincun, Lu, Guangwen, Qi, Jianxun, Wang, Qihui, Lu, Xuancheng, Wu, Ying, Liu, Wenjun, Zhang, Buchang, Yuen, KwokYung, Perlman, Stanley, Gao, George F, Yan, Jinghua. A humanized neutralizing antibody against MERS-CoV targeting the receptor-binding domain of the spike protein. CELL RESEARCH[J]. 2015, 25(11): 1237-1249, http://www.corc.org.cn/handle/1471x/2159718.
[27] Wang, Min, Zhang, Wei, Qi, Jianxun, Wang, Fei, Zhou, Jianfang, Bi, Yuhai, Wu, Ying, Sun, Honglei, Liu, Jinhua, Huang, Chaobin, Li, Xiangdong, Yan, Jinghua, Shu, Yuelong, Shi, Yi, Gao, George F. Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus. NATURE COMMUNICATIONS[J]. 2015, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000348643700001.
[28] Tong, YiGang, Shi, WeiFeng, Liu, Di, Qian, Jun, Liang, Long, Bo, XiaoChen, Liu, Jun, Ren, HongGuang, Fan, Hang, Ni, Ming, Sun, Yang, Jin, Yuan, Teng, Yue, Li, Zhen, Kargbo, David, Dafae, Foday, Kanu, Alex, Chen, ChengChao, Lan, ZhiHeng, Jiang, Hui, Luo, Yang, Lu, HuiJun, Zhang, XiaoGuang, Yang, Fan, Hu, Yi, Cao, YuXi, Deng, YongQiang, Su, HaoXiang, Sun, Yu, Liu, WenSen, Wang, Zhuang, Wang, ChengYu, Bu, ZhaoYang, Guo, ZhenDong, Zhang, LiuBo, Nie, WeiMin, Bai, ChangQing, Sun, ChunHua, An, XiaoPing, Xu, PeiSong, Zhang, XiangLiLan, Huang, Yong, Mi, ZhiQiang, Yu, Dong, Yao, HongWu, Feng, Yong, Xia, ZhiPing, Zheng, XueXing, Yang, SongTao, Lu, Bing, Jiang, JiaFu, Kargbo, Brima, He, FuChu, Gao, George F, Cao, WuChun, China Mobile Lab Testing Team. Genetic diversity and evolutionary dynamics of Ebola virus in Sierra Leone. NATURE[J]. 2015, 524(7563): 93-U191, https://www.webofscience.com/wos/woscc/full-record/WOS:000359002300038.
[29] Wong, Gary, Liu, Wenjun, Liu, Yingxia, Zhou, Boping, Bi, Yuhai, Gao, George F. MERS, SARS, and Ebola: The Role of Super-Spreaders in Infectious Disease. CELL HOST & MICROBEnull. 2015, 18(4): 398-401, https://www.webofscience.com/wos/woscc/full-record/WOS:000365111600007.
[30] Gao Fu. Poultry carrying H9N2 act as incubators for novel human-infecting avian influenza viruses, (Correspondence). The Lancet. 2014, [31] Gao Fu. Crystal structure of HSV-2 gD bound to nectin-1 reveals a conserved mode of receptor recognition. Journal of Virology. 2014, [32] Gao Fu. PILRα and PILAβ have a siglec fold and provide the basis of binding to sialic acid. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2014, [33] Shi, Yi, Wu, Ying, Zhang, Wei, Qi, Jianxun, Gao, George F. Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses. NATURE REVIEWS MICROBIOLOGYnull. 2014, 12(12): 822-831, https://www.webofscience.com/wos/woscc/full-record/WOS:000345220700009.
[34] Wu, Ying, Wu, Yan, Tefsen, Boris, Shi, Yi, Gao, George F. Bat-derived influenza-like viruses H17N10 and H18N11. TRENDS IN MICROBIOLOGYnull. 2014, 22(4): 183-191, http://dx.doi.org/10.1016/j.tim.2014.01.010.
[35] Gao Fu. Influenza and the live poultry trade, (Editorial). Science. 2014, [36] Tefsen, Boris, Lu, Guangwen, Zhu, Yaohua, Haywood, Joel, Zhao, Lili, Deng, Tao, Qi, Jianxun, Gao, George F. The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity. JOURNAL OF VIROLOGY[J]. 2014, 88(4): 1935-1941, https://www.webofscience.com/wos/woscc/full-record/WOS:000331125500008.
[37] Sun, Xiaoman, Li, Qing, Wu, Yan, Wang, Mingyang, Liu, Yue, Qi, Jianxun, Vavricka, Christopher J, Gao, George F. Structure of Influenza Virus N7: the Last Piece of the Neuraminidase "Jigsaw" Puzzle. JOURNAL OF VIROLOGY[J]. 2014, 88(16): 9197-9207, https://www.webofscience.com/wos/woscc/full-record/WOS:000340036800039.
[38] Gao Fu. On the ground in Sierra Leone, (Working Life). Science. 2014, [39] Wang, Qihui, Qi, Jianxun, Yuan, Yuan, Xuan, Yifang, Han, Pengcheng, Wan, Yuhua, Ji, Wei, Li, Yan, Wu, Ying, Wang, Jianwei, Iwamoto, Aikichi, Woo, Patrick C Y, Yuen, KwokYung, Yan, Jinghua, Lu, Guangwen, Gao, George F. Bat Origins of MERS-CoV Supported by Bat Coronavirus HKU4 Usage of Human Receptor CD26. CELL HOST & MICROBE[J]. 2014, 16(3): 328-337, http://www.corc.org.cn/handle/1471x/2157676.
[40] 高福. Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus. Nature communications[J]. 2014, 5: 3142-, https://www.webofscience.com/wos/woscc/full-record/WOS:000331097100006.
[41] Sun, Mingwei, Liu, Jun, Qi, Jianxun, Tefsen, Boris, Shi, Yi, Yan, Jinghua, Gao, George F. N-alpha-Terminal Acetylation for T Cell Recognition: Molecular Basis of MHC Class I-Restricted N-alpha-Acetylpeptide Presentation. JOURNAL OF IMMUNOLOGY[J]. 2014, 192(12): 5509-5519, https://www.webofscience.com/wos/woscc/full-record/WOS:000337172100010.
[42] Gao Fu. Structure of the fusion core and inhibition of fusion by a heptad-repeat peptide derived from the S protein of MERS-CoV. Journal of Virology. 2013, [43] Sun, Xiaoman, Shi, Yi, Lu, Xishan, He, Jianhua, Gao, Feng, Yan, Jinghua, Qi, Jianxun, Gao, George F. Bat-Derived Influenza Hemagglutinin H17 Does Not Bind Canonical Avian or Human Receptors and Most Likely Uses a Unique Entry Mechanism. CELL REPORTS[J]. 2013, 3(3): 769-778, http://dx.doi.org/10.1016/j.celrep.2013.01.025.
[44] 高福. Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors. NATURE COMMUNICATIONS[J]. 2013, 4: 1491-, [45] Zhang, Wei, Shi, Yi, Qi, Jianxun, Gao, Feng, Li, Qing, Fan, Zheng, Yan, Jinghua, Gao, George F. Molecular Basis of the Receptor Binding Specificity Switch of the Hemagglutinins from both the 1918 and 2009 Pandemic Influenza A Viruses by a D225G Substitution. JOURNAL OF VIROLOGY[J]. 2013, 87(10): 5949-5958, http://www.irgrid.ac.cn/handle/1471x/756483.
[46] 高福. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature[J]. 2013, 500(7461): 227-+, http://124.16.173.210/handle/834782/1294.
[47] Gao Fu. Functional and structural analysis of influenza neuraminidase N3 offers further insight into the mechanisms of oseltamivir-resistance. Journal of Virology. 2013, [48] 高福. Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2013, 20(1): 67-U86, https://www.webofscience.com/wos/woscc/full-record/WOS:000313072400012.
[49] 高福. Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses. Cell Research[J]. 2013, 23(12): 1347-1355, http://124.16.173.210/handle/834782/1226.
[50] Gao Fu. Origin and diversity of novel H7N9 avian influenza viruses causing human infecions. The Lancet. 2013, [51] Lu, Xishan, Qi, Jianxun, Shi, Yi, Wang, Ming, Smith, David F, HeimburgMolinaro, Jamie, Zhang, Yanfang, Paulson, James C, Xiao, Haixia, Gao, George F. Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6. JOURNAL OF VIROLOGY[J]. 2013, 87(16): 9077-9085, http://124.16.173.210/handle/834782/1267.
[52] Zhang, Shuijun, Lu, Guangwen, Qi, Jianxun, Li, Yan, Zhang, Zhiyang, Zhang, Buchang, Fan, Zheng, Yan, Jinghua, Gao, George F. Competition of Cell Adhesion and Immune Recognition: Insights into the Interaction between CRTAM and Nectin-like 2. STRUCTURE[J]. 2013, 21(8): 1430-1439, http://www.corc.org.cn/handle/1471x/2157443.
[53] 高福. Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses. Science[J]. 2013, 342(6155): 243-247, http://124.16.173.210/handle/834782/1268.
[54] 高福. An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level. Science[J]. 2013, 340(6139): 1463-1467, https://www.webofscience.com/wos/woscc/full-record/WOS:000320647000045.
[55] Li, Bin, Yi, Yong, Wang, Qi, Woo, Patrick C Y, Tan, Lin, Jing, Hua, Gao, George F, Liu, Cui Hua. Analysis of Drug Resistance Determinants in Klebsiella pneumoniae Isolates from a Tertiary-Care Hospital in Beijing, China. PLOS ONE[J]. 2012, 7(7): http://dx.doi.org/10.1371/journal.pone.0042280.
[56] Gao Fu. Reply to Nuclear export signal and immunodominant CD8+ T cell epitope in influenza A virus matrix protein 1--Sequence sharing between viral nuclear export signals (NES) and CD8+ T cell epitopes. Journal of Virology. 2012, [57] Zhang, Wen, Rong, Chengbo, Chen, Chen, Gao, George F. Type-IVC Secretion System: A Novel Subclass of Type IV Secretion System (T4SS) Common Existing in Gram-Positive Genus Streptococcus. PLOS ONE[J]. 2012, 7(10): https://doaj.org/article/42f5a2bd08c24361a2ad7af76d2f2004.
[58] Han, Huiming, Liu, Cuihua, Wang, Quanhui, Xuan, Chunling, Zheng, Beiwen, Tang, Jiaqi, Yan, Jinghua, Zhang, Jingren, Li, Ming, Cheng, Hao, Lu, Guangwen, Gao, George F. The two-component system Ihk/Irr contributes to the virulence of Streptococcus suis serotype 2 strain 05ZYH33 through alteration of the bacterial cell metabolism. MICROBIOLOGY-SGM[J]. 2012, 158: 1852-1866, http://dx.doi.org/10.1099/mic.0.057448-0.
[59] 高福. Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus. Proceedings of the National Academy of Sciences of the United States of America[J]. 2012, 109(46): 18897-18902, [60] Liu, Jun, Zhang, Shihong, Tan, Shuguang, Yi, Yong, Wu, Bin, Cao, Bin, Zhu, Fengcai, Wang, Chen, Wang, Hua, Qi, Jianxun, Gao, George F. Cross-Allele Cytotoxic T Lymphocyte Responses against 2009 Pandemic H1N1 Influenza A Virus among HLA-A24 and HLA-A3 Supertype-Positive Individuals. JOURNAL OF VIROLOGY[J]. 2012, 86(24): 13281-13294, https://www.webofscience.com/wos/woscc/full-record/WOS:000311299600013.
[61] Liu, Jun, Qian, Xiaomin, Chen, Zhujun, Xu, Xiang, Gao, Feng, Zhang, Shuijun, Zhang, Rongguang, Qi, Jianxun, Gao, George F, Yan, Jinghua. Crystal Structure of Cell Adhesion Molecule Nectin-2/CD112 and Its Binding to Immune Receptor DNAM-1/CD226. JOURNAL OF IMMUNOLOGY[J]. 2012, 188(11): 5511-5520, http://www.irgrid.ac.cn/handle/1471x/756751.
[62] Gao Fu. Insights into avian influenza virus pathogenicity: the hemagglutinin precursor HA0 of H16 subtype has an a-helix structure in its cleavage site with an inefficient HA1/HA2 cleavage. Journal of Virology. 2012, [63] Lu, Qiong, Lu, Hao, Qi, Jianxun, Lu, Guangwen, Gao, George F. An octamer of enolase from Streptococcus suis. PROTEIN & CELL[J]. 2012, 3(10): 769-780, http://124.16.173.210/handle/834782/1302.
[64] Liu, Peipei, Lu, Hao, Li, Shuang, Moureau, Gregory, Deng, YongQiang, Wang, Yongyue, Zhang, Lijiao, Jiang, Tao, de Lamballerie, Xavier, Qin, ChengFeng, Gould, Ernest A, Su, Jingliang, Gao, George F. Genomic and antigenic characterization of the newly emerging Chinese duck egg-drop syndrome flavivirus: genomic comparison with Tembusu and Sitiawan viruses. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 93: 2158-2170, http://dx.doi.org/10.1099/vir.0.043554-0.
[65] Zhang, Jianhua, Chen, Yong, Qi, Jianxun, Gao, Feng, Liu, Yanjie, Liu, Jun, Zhou, Xuyu, Kaufman, Jim, Xia, Chun, Gao, George F. Narrow Groove and Restricted Anchors of MHC Class I Molecule BF2*0401 Plus Peptide Transporter Restriction Can Explain Disease Susceptibility of B4 Chickens. JOURNAL OF IMMUNOLOGY[J]. 2012, 189(9): 4478-4487, http://www.irgrid.ac.cn/handle/1471x/756866.
[66] Liu, Cui Hua, Li, Hong Min, Lu, Na, Wang, Qi, Hu, Yong Liang, Yang, Xi, Hu, Yong Fei, Woo, Patrick C Y, Gao, George F, Zhu, Baoli. Genomic sequence based scanning for drug resistance-associated mutations and evolutionary analysis of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. JOURNAL OF INFECTION[J]. 2012, 65(5): 412-422, http://dx.doi.org/10.1016/j.jinf.2012.06.007.
[67] Liu. Membrane Protein of SARS-CoV Acts as a Dominant Immunogen Revealed by a Clustering Region of Novel Functional and Structural Defined CTL Epitopes (vol 202, pg 1171, 2010). JOURNAL OF INFECTIOUS DISEASESnull. 2011, 203(11): 1699-1699, https://www.webofscience.com/wos/woscc/full-record/WOS:000290858800031.
[68] Lu, Guangwen, Qi, Jianxun, Gao, Feng, Yan, Jinghua, Tang, Jiaqi, Gao, George F. A novel "open-form" structure of sortaseC from Streptococcus suis. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS[J]. 2011, 79(9): 2764-2769, http://www.irgrid.ac.cn/handle/1471x/757501.
[69] Shi, Yi, Qi, Jianxun, Iwamoto, Aikichi, Gao, George F. Plasticity of human CD8 alpha alpha binding to peptide-HLA-A*2402. MOLECULAR IMMUNOLOGY[J]. 2011, 48(15-16): 2198-2202, https://www.webofscience.com/wos/woscc/full-record/WOS:000295395300054.
[70] Liu, Jun, Zhang, Shihong, Tan, Shuguang, Zheng, Beiwen, Gao, George F. Revival of the identification of cytotoxic T-lymphocyte epitopes for immunological diagnosis, therapy and vaccine development. EXPERIMENTAL BIOLOGY AND MEDICINEnull. 2011, 236(3): 253-267, https://www.webofscience.com/wos/woscc/full-record/WOS:000295201200002.
[71] Li, Ming, Shen, Xiaodong, Yan, Jinghua, Han, Huiming, Zheng, Beiwen, Liu, Di, Cheng, Hao, Zhao, Yan, Rao, Xiancai, Wang, Changjun, Tang, Jiaqi, Hu, Fuquan, Gao, George F. GI-type T4SS-mediated horizontal transfer of the 89K pathogenicity island in epidemic Streptococcus suis serotype 2. MOLECULAR MICROBIOLOGY[J]. 2011, 79(6): 1670-1683, https://www.webofscience.com/wos/woscc/full-record/WOS:000288164900020.
[72] Wang, Mingyang, Qi, Jianxun, Liu, Yue, Vavricka, Christopher J, Wu, Yan, Li, Qing, Gao, George F. Influenza A Virus N5 Neuraminidase Has an Extended 150-Cavity. JOURNAL OF VIROLOGY[J]. 2011, 85(16): 8431-8435, https://www.webofscience.com/wos/woscc/full-record/WOS:000292923100047.
[73] Hu, Xudong, Liu, Di, Wang, Mingyang, Yang, Le, Wang, Ming, Zhu, Qingyu, Li, Laixing, Gao, George F. Clade 2.3.2 Avian Influenza Virus (H5N1), Qinghai Lake Region, China, 2009-2010. EMERGING INFECTIOUS DISEASESnull. 2011, 17(3): 560-562, http://ir.nwipb.ac.cn/handle/363003/1579.
[74] 孙明伟, 路希山, 高福. 合成病毒:对流感病毒研究的贡献. 生命科学[J]. 2011, 23(9): 921-930, http://lib.cqvip.com/Qikan/Article/Detail?id=39442219.
[75] Cheng, Hao, Mohammed, Fiyaz, Nam, Gol, Chen, Yong, Qi, Jianxun, Garner, Lee I, Allen, Rachel L, Yan, Jinghua, Willcox, Benjamin E, Gao, George F. Crystal Structure of Leukocyte Ig-like Receptor LILRB4 (ILT3/LIR-5/CD85k) A MYELOID INHIBITORY RECEPTOR INVOLVED IN IMMUNE TOLERANCE. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(20): 18013-18025, http://dx.doi.org/10.1074/jbc.M111.221028.
[76] Gao Fu. An infectious clone of the highly pathogenic porcine reproductive and respiratory syndrome virus: topology of glycoprotein 3 (GP3) addressing the intrachain disulfide bonds; PRRSV infectious clone and GP3 topology. Chinese Science Bulletin. 2011, [77] Lu, Guangwen, Qi, Jianxun, Chen, Zhujun, Xu, Xiang, Gao, Feng, Lin, Daizong, Qian, Wangke, Liu, Hong, Jiang, Hualiang, Yan, Jinghua, Gao, George F. Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design. JOURNAL OF VIROLOGY[J]. 2011, 85(19): 10319-10331, http://www.irgrid.ac.cn/handle/1471x/757510.
[78] Zhang Yudan, Cao Sheng, Meng Songdong, Gao, George Fu. A strategy to produce monoclonal antibodies against gp96 by prime-boost regimen using endogenous protein and E. coli heterologously-expressed fragment. JOURNAL OF CENTRAL SOUTH UNIVERSITY OF TECHNOLOGY[J]. 2011, 18(6): 1857-1864, http://lib.cqvip.com/Qikan/Article/Detail?id=40231943.
[79] Liao Hui, Liu Cuihua, Yang Ruifu, Jiang Yongqiang, Zhang Ruifen, Lu Na, Li Jing, Wang Changjun, Li Ming, Wu Zuowei, Gao George F, Tang Jiaqi, Zhu Baoli. Probing genomic diversity and evolution of Streptococcus suis serotype 2 by NimbleGen tiling arrays. BMC Genomics[J]. 2011, 12(1): https://doaj.org/article/438bb56fefb742c4b5b9b0bd68efbd8f.
[80] Feng ChunYan, Gao Feng, Liu YiWei, Wang GuiHua, Peng Hao, Ma YanHe, Yan JingHua, Gao George Fu. Crystal structure of histidine-containing phosphocarrier protein from Thermoanaerobacter tengcongensis MB4 and the implications for thermostability. SCIENCE CHINA-LIFE SCIENCES[J]. 2011, 54(6): 513-519, http://www.irgrid.ac.cn/handle/1471x/757390.
[81] Gao Fu. Two distinct conformations of a CTL epitope from rinderpest virus presented by cattle MHC class I molecule N*01801: a host strategy for presentation of a featured peptide. Journal of Virology. 2011, [82] Du, Pengcheng, Yang, Yinxue, Wang, Haiying, Liu, Di, Gao, George F, Chen, Chen. A large scale comparative genomic analysis reveals insertion sites for newly acquired genomic islands in bacterial genomes. BMC MICROBIOLOGY[J]. 2011, 11(1): 135-135, http://www.corc.org.cn/handle/1471x/2374138.
[83] Gao Fu. Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase (invited review). Chinese Science Bulletin. 2011, [84] Zhang, Nianzhi, Qi, Jianxun, Feng, Sijia, Gao, Feng, Liu, Jun, Pan, Xiaocheng, Chen, Rong, Li, Qirun, Chen, Zhaosan, Li, Xiaoying, Xia, Chun, Gao, George F. Crystal Structure of Swine Major Histocompatibility Complex Class I SLA-1*0401 and Identification of 2009 Pandemic Swine-Origin Influenza A H1N1 Virus Cytotoxic T Lymphocyte Epitope Peptides. JOURNAL OF VIROLOGY[J]. 2011, 85(22): 11709-11724, http://www.irgrid.ac.cn/handle/1471x/757514.
[85] Myongchol Ryu, Yong Chen, Jianxun Qi, Jun Liu, Zheng Fan, Gol Nam, Yi Shi, Hao Cheng, George F Gao. LILRA3 Binds Both Classical and Non-Classical HLA Class I Molecules but with Reduced Affinities Compared to LILRB1/LILRB2: Structural Evidence. PLOS ONE[J]. 2011, 6(4): https://doaj.org/article/771283f228424e01bb492484c8ea81d9.
[86] Su, Jingliang, Li, Shuang, Hu, Xudong, Yu, Xiuling, Wang, Yongyue, Liu, Peipei, Lu, Xishan, Zhang, Guozhong, Hu, Xueying, Liu, Di, Li, Xiaoxia, Su, Wenliang, Lu, Hao, Mok, Ngai Shing, Wang, Peiyi, Wang, Ming, Tian, Kegong, Gao, George F. Duck Egg-Drop Syndrome Caused by BYD Virus, a New Tembusu-Related Flavivirus. PLOS ONE[J]. 2011, 6(3): http://124.16.144.217/handle/311023/2381.
[87] Zhang, Shihong, Liu, Jun, Cheng, Hao, Tan, Shuguang, Qi, Jianxun, Yan, Jinghua, Gao, George F. Structural basis of cross-allele presentation by HLA-A*0301 and HLA-A*1101 revealed by two HIV-derived peptide complexes. MOLECULAR IMMUNOLOGY[J]. 2011, 49(1-2): 395-401, http://dx.doi.org/10.1016/j.molimm.2011.08.015.
[88] Zheng, Beiwen, Zhang, Qiangmin, Gao, Jia, Han, Huiming, Li, Ming, Zhang, Jingren, Qi, Jianxun, Yan, Jinghua, Gao, George F. Insight into the Interaction of Metal Ions with TroA from Streptococcus suis. PLOS ONE[J]. 2011, 6(5): http://124.16.144.217/handle/311023/2389.
[89] 高福. Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nature Communications[J]. 2011, 2: 577-, http://www.corc.org.cn/handle/1471x/2200832.
[90] Yueju Zhao, Yunhua Zhang, Yang Cao, Jianxun Qi, Liangwei Mao, Yanfen Xue, Feng Gao, Hao Peng, Xiaowei Wang, George F Gao, Yanhe Ma. Structural analysis of alkaline β-mannanase from alkaliphilic Bacillus sp. N16-5: implications for adaptation to alkaline conditions.. PLoS ONE[J]. 2011, 6(1): https://doaj.org/article/35b533dcd489420b977445527f302821.
[91] 胡旭东, 路浩, 刘培培, 遇秀玲, 李爽, 王勇月, 莫毅诚, 张国中, 田克恭, 高福, 苏敬良. 我国发现的一种引起鸭产蛋下降综合征的新型黄病毒. 中国兽医杂志. 2011, 47(7): 43-47, http://lib.cqvip.com/Qikan/Article/Detail?id=38801996.
[92] 高福. Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathogens[J]. 2011, 7(10): e1002249-, https://doaj.org/article/1bd4e20a804a463294452adbc0e5ae5e.
[93] Wu, Yan, Gao, Feng, Liu, Jun, Qi, Jianxun, Gostick, Emma, Price, David A, Gao, George F. Structural Basis of Diverse Peptide Accommodation by the Rhesus Macaque MHC Class I Molecule Mamu-B*17: Insights into Immune Protection from Simian Immunodeficiency Virus. JOURNAL OF IMMUNOLOGY[J]. 2011, 187(12): 6382-6392, http://www.irgrid.ac.cn/handle/1471x/757303.
[94] Zengfu Wang, Xiaoling Liu, Zhendong Zhao, Chongfeng Xu, Ke Zhang, Caiwei Chen, Lei Sun, George F Gao, Xin Ye, Wenjun Liu. Cyclophilin E Functions as a Negative Regulator to Influenza Virus Replication by Impairing the Formation of the Viral Ribonucleoprotein Complex. PLOS ONE[J]. 2011, 6(8): https://doaj.org/article/5b052dc924e54ad580b675f6edbe0ffe.
[95] 孙明伟, 高福. 小议2010国内外生命科学重要进展. 遗传[J]. 2011, 33(2): 97-99, http://lib.cqvip.com/Qikan/Article/Detail?id=37086293.
[96] Liu, Jun, Dai, Lianpan, Qi, Jianxun, Gao, Feng, Feng, Youjun, Liu, Wenjun, Yan, Jinghua, Gao, George F. Diverse Peptide Presentation of Rhesus Macaque Major Histocompatibility Complex Class I Mamu-A*02 Revealed by Two Peptide Complex Structures and Insights into Immune Escape of Simian Immunodeficiency Virus. JOURNAL OF VIROLOGY[J]. 2011, 85(14): 7372-7383, https://www.webofscience.com/wos/woscc/full-record/WOS:000291932400052.
[97] 刘军, 齐建勋, 高峰, 严景华, 高福. T细胞功能学与结构免疫学结合方法鉴定HLA-A2限制性的细胞毒性T淋巴细胞表位富集区. 科技导报. 2011, 29(27): 19-26, http://lib.cqvip.com/Qikan/Article/Detail?id=39427917.
[98] 孙业平, 高福. 天然免疫抗病毒效应分子Mx蛋白的结构与功能研究进展. 生物化学与生物物理进展[J]. 2010, 37(7): 699-706, http://lib.cqvip.com/Qikan/Article/Detail?id=34772339.
[99] Gao Fu. Novel immunodominant peptide presentation strategy: a featured HLA-A*2402 restricted CTL-epitope stabilized by intra-chain hydrogen-bonds from SARS-CoV N protein. Journal of Virology. 2010, [100] Wang Fei, Qi Jianxun, Bi Yuhai, Zhang Wei, Wang Min, Zhang Baorong, Wang Ming, Liu Jinhua, Yan Jinghua, Shi Yi, Gao George F. Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference. The EMBO Journal. 34(12): 1661-1673, 
发表著作
(1) 免疫学前沿进展 (第二版) 第七章: 结构免疫学研究进展: 主要组织相容性复合物的分子识别,Frontier Progress of Immunology (Edition 2) Chapter 7 Research Progress of Sructural Immunology: Molecular Recognition of Major Histocompatibility Complex ,人民卫生出版社,2011-12,第3作者
(2) 主要组织相容性复合物与多肽的相互作用,Major Histocompatibility Complex: Interaction with Peptides,John Wiley and Sons, Ltd,2011-08,第2作者
(3) 应用于健康、环境及生物安全的生物传感器 第七章:应用于人类健康的无标记生物传感器,Biosensors for Health, Environment and Biosecurity Chapter 7: Label-free Biosensors for Health Applications,InTech,2011-07,第1作者
(4) 免疫学前沿进展(第一版) 第六章: 结构免疫学研究进展: 主要组织相容性复合物的分子识别,Frontier Progress of Immunology (Edition 1) Chapter 6 Research Progress of Sructural Immunology: Molecular Recognition of Major Histocompatibility Complex ,人民卫生出版社,2009-12,第3作者

科研活动

   
科研项目
(1) Follow-up of Surveillance of the Wild Birds and Pl,主持,其他级,2011-12--2012-11
(2) 新型免疫细胞δβ T细胞识别配体的功能和结构基础,主持,部委级,2011-01--2014-12
(3) 重要病毒跨种间感染与传播致病的分子机制研究,主持,部委级,2011-01--2015-12
(4) 病原微生物与宿主互作的分子机制,主持,部委级,2011-01--2013-12
(5) 获得性免疫的起源与演化,参与,部委级,2011-01--2013-12
参与会议
(1) Special characteristics of the 2009-pandemic H1N1 influenza A virus hemagglutinin and neuraminidase,2012-04,高福
(2) Nectin and nectin-like molecules: Adhesion, immune,2012-04,高福
(3) 2009 Pandemic influenza virus: what special for its HA and NA,2012-01,高福
(4) Making the CTL-epitopes featured for T cell recognition,2011国际免疫暨肿瘤研讨会,2011-12,高福
(5) 创新:永远的追求——我所认识的田波院士,第九届全国病毒学学术研讨会,2011-09,高福
(6) 分会主席,2011-09,分会主席
(7) ILT: Differential Binding to HLA,第二届海峡两岸四地免疫学研讨会,2011-08,高福
(8) T-cell-based immunotherapy,第五届中国生物产业大会,2011-06,高福
(9) 2009 Pandemic influenza virus: what special for its HA and NA,2011-06,高福
(10) Study of CTL-based cellular immunity against severe acute respiratory syndrome coronavirus,2011-06,高福
(11) 2009 Pandemic influenza virus: what special for its HA and NA,2011-01,高福