基本信息
房丽晶  女  博导  中国科学院深圳先进技术研究院
电子邮件: lj.fang@siat.ac.cn
通信地址: 深圳市南山区西丽大学城学苑大道1068号
邮政编码:

研究领域

1)多肽药物设计与合成

2)生物活性有机分子的合成与构效关系研究

招生信息

招收有机化学、药物化学以及化学生物学相关专业背景的本科以及硕士毕业生。

招生专业
0703Z1-化学生物学
071010-生物化学与分子生物学
083100-生物医学工程
招生方向
化学生物学
有机化学
药物化学

教育背景

2002-09--2007-06   兰州大学化学化工学院   博士
1998-09--2002-06   兰州大学化学化工学院   学士
学历

博士研究生

学位
博士

工作经历

   
工作简历
2021-01~现在, 中国科学院深圳先进技术研究院, 研究员
2016-01~2020-12,中国科学院深圳先进技术研究院, 副研究员
2011-10~2015-12,中国科学院深圳先进技术研究院, 助理研究员
2010-04~2011-10,陶氏化学(中国)有限公司, 高级研究员
2007-09~2010-02,Texas A&M University, 博士后

教授课程

化学生物学进展

专利与奖励

   
专利成果
[1] 粟武, 王蒲, 王伟, 成哲弘, 房丽晶, 武春雷. 用于抑制EB病毒相关肿瘤的化合物及其制备方法和用途. CN: CN109912577A, 2019-06-21.

[2] 鹏越峰, 张璇, 蔡青青, 房丽晶, 余再丹, 尚鹏. 一种非病毒基因载体材料及其制备方法和应用、脑靶向基因传输系统及其制备方法和应用. 中国: CN103435814A, 2013-12-11.

[3] 鹏越峰, 房丽晶, 蔡青青, 余再丹, 尚鹏, 张璇. 一种还原氰基制备整数代聚丙烯亚胺树形分子的方法. 中国: CN102786421A, 2012.11.21.

出版信息

   
发表论文
[1] 房丽晶. Cell-penetrating riboflavin conjugate for antitumor photodynamic therapy. Chinese Chemical Letters[J]. 2022, [2] Wang, Pengxin, Cheng, Yulian, Wu, Chunlei, Zhou, Yimin, Cheng, Zhehong, Li, Hongchang, Wang, Rui, Su, Wu, Fang, Lijing. Tyrosine-Specific Modification via a Dearomatization-Rearomatization Strategy: Access to Azobenzene Functionalized Peptides. ORGANIC LETTERS[J]. 2021, 23(11): 4137-4141, http://dx.doi.org/10.1021/acs.orglett.1c01013.
[3] Wang, Pengxin, Cheng, Yulian, Wu, Chunlei, Luo, Ruixiang, Ma, Caibing, Zhou, Yimin, Ma, Zhilong, Wang, Rui, Su, Wu, Fang, Lijing. Dearomatization-rearomatization strategy of tyrosine for peptide/protein modification through thiol-addition reactions. CHEMICAL COMMUNICATIONS[J]. 2021, 57(96): 12968-12971, http://dx.doi.org/10.1039/d1cc04191f.
[4] 房丽晶. A Novel N-methylated Cyclodepsipeptide Prodrug for Targeted Cancer Therapy. Journal of Medicinal Chemistry. 2021, [5] Shi, Wenli, Lu, Danyi, Wu, Chunlei, Li, Meiqing, Ding, Zhihao, Li, Yanyan, Chen, Binghua, Lin, Xian, Su, Wu, Shao, Ximing, Xia, Zhihui, Fang, Lijing, Liu, Ke, Li, Hongchang. Coibamide A kills cancer cells through inhibiting autophagy. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 547: 52-58, http://dx.doi.org/10.1016/j.bbrc.2021.01.112.
[6] Li, Meiqing, Lu, Danyi, Cheng, Yulian, Wu, Chunlei, Zhang, Jianchao, Shi, Wenli, Ding, Zhihao, Li, Yanyan, Cheng, Binghua, Lin, Xian, Shao, Ximing, Li, Hongchang, Fang, Lijing, Liu, Ke, Su, Wu. A novel pyrrole-imidazole polyamide targets Aurora kinase A and suppresses tumor growth in vivo. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 571: 167-173, http://dx.doi.org/10.1016/j.bbrc.2021.07.077.
[7] Wu, Chunlei, Cheng, Zhehong, Lu, Danyi, Liu, Ke, Cheng, Yulian, Wang, Pengxin, Zhou, Yimin, Li, Meiqing, Shao, Ximing, Li, Hongchang, Su, Wu, Fang, Lijing. Novel N-Methylated Cyclodepsipeptide Prodrugs for Targeted Cancer Therapy. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 64(2): 991-1000, https://www.webofscience.com/wos/woscc/full-record/WOS:000614306000007.
[8] Li, Meiqing, Shao, Ximing, Wu, Chunlei, Lu, Danyi, Liu, Ke, Wang, Wei, Liu, Jiakai, Li, Hongchang, Su, Wu, Fang, Lijing. Chlorotoxin-derived bicyclic peptides for targeted imaging of glioblastomas. CHEMICAL COMMUNICATIONS[J]. 2020, 56(66): 9537-9540, http://dx.doi.org/10.1039/d0cc01089h.
[9] Wu, Chunlei, Wang, Wei, Fang, Lijing, Su, Wu. Programmable pyrrole-imidazole polyamides: A potent tool for DNA targeting. CHINESE CHEMICAL LETTERS[J]. 2018, 29(7): 1105-1112, http://lib.cqvip.com/Qikan/Article/Detail?id=675580219.
[10] Yao, Guiyang, Wang, Wei, Ao, Lijiao, Cheng, Zhehong, Wu, Chunlei, Pang, Zhengyin, Liu, Ke, Li, Hongchang, Su, Wu, Fang, Lijing. Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 61(19): 8908-8916, http://ir.siat.ac.cn:8080/handle/172644/14615.
[11] Liu, Ke, Fang, Lijing, Sun, Haiyan, Pan, Zhengyin, Zhang, Jianchao, Chen, Juntao, Shao, Ximing, Wang, Wei, Tan, Yuanyan, Ding, Zhihao, Ao, Lijiao, Wu, Chunlei, Liu, Xiaoqi, Li, Huashun, Wang, Rui, Su, Wu, Li, Hongchang. Targeting Polo-like Kinase 1 by a Novel Pyrrole-Imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth In Vivo. MOLECULAR CANCER THERAPEUTICS[J]. 2018, 17(5): 988-1002, http://ir.siat.ac.cn:8080/handle/172644/14593.
[12] Hayatigolkhatmi, Kourosh, Padroni, Giacomo, Su, Wu, Fang, Lijing, GomezCastaneda, Eduardo, Hsieh, YaChing, Jackson, Lorna, Holyoake, Tessa L, Pellicano, Francesca, Burley, Glenn A, Jorgensen, Heather G. Investigation of a minor groove-binding polyamide targeted to E2F1 transcription factor in chronic myeloid leukaemia (CML) cells. BLOOD CELLS MOLECULES AND DISEASESnull. 2018, 69: 119-122, http://ir.siat.ac.cn:8080/handle/172644/14590.
[13] Cheng, Zhehong, Wang, Wei, Wu, Chunlei, Zou, Xiaohua, Fang, Lijing, Su, Wu, Wang, Pu. Novel Pyrrole-Imidazole Polyamide Hoechst Conjugate Suppresses Epstein-Barr Virus Replication and Virus-Positive Tumor Growth. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 61(15): 6674-6684, http://ir.siat.ac.cn:8080/handle/172644/14618.
[14] Yao, Guiyang, Wang, Wei, Ao, Lijiao, Cheng, Zhehong, Wu, Chunlei, Pang, Zhengyin, Liu, Ke, Li, Hongchang, Su, Wu, Fang, Lijing. Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 61(19): 8908-8916, http://ir.siat.ac.cn:8080/handle/172644/14615.
[15] Wu, Chunlei, Pan, Zhengyin, Yao, Guiyang, Wang, Wei, Fang, Lijing, Su, Wu. Synthesis and structure-activity relationship studies of teixobactin analogues. RSC ADVANCES[J]. 2017, 7(4): 1923-1926, [16] Pan, Zhengyin, Wu, Chunlei, Wang, Wei, Cheng, Zhehong, Yao, Guiyang, Liu, Ke, Li, Hongchang, Fang, Lijing, Su, Wu. Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B. ORGANIC LETTERS[J]. 2017, 19(17): 4420-4423, https://www.webofscience.com/wos/woscc/full-record/WOS:000409566400003.
[17] Tan, Yuanyan, Wang, Wei, Wu, Chunlei, Pan, Zhengyin, Yao, Guiyang, Fang, Lijing, Su, Wu. Myristic acid-modified thymopentin for enhanced plasma stability and immune-modulating activity. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2017, 47: 88-94, http://dx.doi.org/10.1016/j.intimp.2017.03.025.
[18] Zhang, Jianchao, Shao, Ximing, Sun, Haiyan, Liu, Ke, Ding, Zhihao, Chen, Juntao, Fang, Lijing, Su, Wu, Hong, Yang, Li, Huashun, Li, Hongchang. NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling. ONCOTARGET[J]. 2016, 7(38): 61036-61053, https://www.webofscience.com/wos/woscc/full-record/WOS:000387164700019.
[19] Fang, Lijing, Yao, Guiyang, Pan, Zhengyin, Wu, Chunlei, Wang, HengShan, Burley, Glenn A, Su, Wu. Fully Automated Synthesis of DNA-Binding Py-lm Polyamides Using a Triphosgene Coupling. ORGANIC LETTERS[J]. 2015, 17(1): 158-161, https://www.webofscience.com/wos/woscc/full-record/WOS:000347506200041.
[20] 姚贵阳, 房丽晶, 潘正银, 王恒山, 粟武. 化学修饰的环孢菌素类非免疫抑制性亲环素抑制剂进展. 集成技术. 2015, 28-44, http://lib.cqvip.com/Qikan/Article/Detail?id=665556346.
[21] Yao, Guiyang, Pan, Zhengyin, Wu, Chunlei, Wang, Wei, Fang, Lijing, Su, Wu. Efficient Synthesis and Stereochemical Revision of Coibamide A. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2015, 137(42): 13488-13491, https://www.webofscience.com/wos/woscc/full-record/WOS:000363916600013.
[22] Fang, Lijing, Wu, Chunlei, Yu, Zaidan, Shang, Peng, Cheng, Yongxian, Peng, Yuefeng, Su, Wu. Triphosgene-Mediated Couplings in the Solid Phase: Total Synthesis of Brachystemin A. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2014, 2014(34): 7572-7576, http://www.irgrid.ac.cn/handle/1471x/929649.
[23] []. Fully Automated Synthesis of DNA-Binding Py-Im Polyamides Using a Triphosgene Coupling Strategy. http://ir.siat.ac.cn:8080/handle/172644/7340.

指导学生

已指导学生

敖丽娇  博士研究生  071010-生物化学与分子生物学  

成哲弘  硕士研究生  085238-生物工程