基本信息
许永  男  博导  中国科学院广州生物医药与健康研究院
电子邮件: xu_yong@gibh.ac.cn
通信地址: 广州市萝岗区开源大道190号
邮政编码:

研究领域

药物化学;计算机辅助药物设计;结构生物学;核受体药物;表观遗传

招生信息

   
招生专业
100701-药物化学
招生方向
药物分子设计与合成

教育背景

2001-09--2004-07   中科院上海药物所   博士
学历

研究生

学位

博士研究生

工作经历

   
工作简历
2011-09~现在, 中科院广州生物医药与健康研究院, 研究员
2006-06~2011-08,美国Van Andel研究所, 博士后
2005-08~2006-05,中科院上海有机所, 博士后

专利与奖励

Prostate Cancer Fundation, 2017 PCF challenge award

专利成果
[1] 许永, 薛晓纤, 张岩, 宋明, 武春, 刘照轩, 吴锡山, 罗小雨, 向秋萍, 张茂风. 一种2-氧代-1,2-二氢苯并cd吲哚类化合物. CN: CN111662226B, 2022-03-18.

[2] 许永, 吴东海, 聂涛, 赵雪梅, 赵世亭, 惠晓艳. 非人哺乳动物模型及其构建方法和应用. CN: CN112126659A, 2020-12-25.

[3] 许永, 薛晓纤, 张茂风, 张岩, 向秋萍, 王超, 宋明. 一种苯并六元氮杂环化合物及其制备方法和应用. CN: CN110092782A, 2019-08-06.

[4] 许永, 张岩, 吴锡山, 薛晓纤, 罗小雨, 师语聃, 王蕊. 一种联苯胺类化合物及其应用. CN: CN109879784A, 2019-06-14.

[5] Xu, Yong, Xue, Xiaoqian, Zhang, Yan, Song, Ming. 2-oxo-1,2-dihydrobenzocdindole compound and use thereof. CN: US10183010(B2), 2019-01-22.

[6] 许永, 罗小雨, 王蕊, 邢艳丽, 吴锡山, 薛晓纤, 张岩. 四氢喹啉相关二环类化合物及其应用. CN: CN107021923A, 2017-08-08.

[7] 许永, 薛晓纤, 张岩, 宋明, 武春, 刘照轩, 吴锡山, 罗小雨, 向秋萍, 张茂风. 一种2-氧代-1,2-二氢苯并cd吲哚类化合物及其应用. CN: CN105985282A, 2016-10-05.

[8] 许永, 罗小雨, 张岩, 薛晓纤, 武春, 宋明, 金翔宇, 宋宇, 周洋. N-苯基酰胺类化合物及其应用. CN: CN105272904A, 2016-01-27.

[9] 许永, 张茂风, 薛晓纤, 张岩, 刘照轩. 一类苯并d异恶唑类化合物及其应用. CN: CN105085427A, 2015-11-25.

[10] 许永, 薛晓纤, 张岩, 李静, 金翔宇, 罗小雨, 宋宇. 2-氧代-1,2-二氢苯并cd吲哚-6-磺酰胺类化合物及其组合物和应用. CN: CN104530014A, 2015-04-22.

[11] 丁克, 徐石林, 常少华, 张连文, 涂正超, 许永, 陆小云. 嘧啶并二氮杂卓类化合物及其药用组合物和应用. CN: CN103374000A, 2013-10-30.

出版信息

   
发表论文
[1] Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li, Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu, Donghai Wu, Jinsong Liu, Yong Xu. Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist. J Med Chem[J]. 2021, [2] Liu, Xiaomin, Zhang, Yuwei, Chu, Yi, Zhao, Xuemei, Mao, Liufeng, Zhao, Shiting, Lin, Shaoqiang, Hui, Xiaoyan, Gu, Ping, Xu, Yong, Loomes, Kerry, Tang, Shibing, Nie, Tao, Wu, Donghai. The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 545: 189-194, http://dx.doi.org/10.1016/j.bbrc.2021.01.080.
[3] Huang, Minhao, Huang, Yongjun, Guo, Jing, Yu, Lei, Chang, Yu, Wang, Xiaolu, Luo, Jinfeng, Huang, Yanhui, Tu, Zhengchao, Lu, Xiaoyun, Xu, Yong, Zhang, Zhimin, Zhang, Zhang, Ding, Ke. Pyrido2, 3-dpyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 211: http://dx.doi.org/10.1016/j.ejmech.2020.113023.
[4] Wu, Tianbang, Xiang, Qiuping, Wang, Chao, Wu, Chun, Zhang, Cheng, Zhang, Maofeng, Liu, Zhaoxuan, Zhang, Yan, Xiao, Linjiu, Xu, Yong. Y06014 is a selective BET inhibitor for the treatment of prostate cancer. ACTA PHARMACOLOGICA SINICA[J]. 2021, 42(12): 2120-2131, https://www.webofscience.com/wos/woscc/full-record/WOS:000624397300002.
[5] Zheng, Suqing, Xiong, Jun, Wang, Lei, Zhai, Dong, Xu, Yong, Lin, Fu. e-Graphene: A Computational Platform for the Prediction of Graphene-Based Drug Delivery System by Quantum Genetic Algorithm and Cascade Protocol. FRONTIERS IN CHEMISTRY[J]. 2021, 9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138207/.
[6] Xishan Wu, Hui Shen, Yan Zhang, Chao Wang, Qiu Li, Cheng Zhang, Xiaoxi Zhuang, Chenchang Li, Yudan Shi, Yanli Xing, Qiuping Xiang, Jinxin Xu, Donghai Wu, Jinsong Liu, Yong Xu. Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist. J Med Chem[J]. 2021, [7] Liu, Xiaomin, Zhang, Yuwei, Chu, Yi, Zhao, Xuemei, Mao, Liufeng, Zhao, Shiting, Lin, Shaoqiang, Hui, Xiaoyan, Gu, Ping, Xu, Yong, Loomes, Kerry, Tang, Shibing, Nie, Tao, Wu, Donghai. The natural compound rutaecarpine promotes white adipocyte browning through activation of the AMPK-PRDM16 axis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS[J]. 2021, 545: 189-194, http://dx.doi.org/10.1016/j.bbrc.2021.01.080.
[8] Huang, Minhao, Huang, Yongjun, Guo, Jing, Yu, Lei, Chang, Yu, Wang, Xiaolu, Luo, Jinfeng, Huang, Yanhui, Tu, Zhengchao, Lu, Xiaoyun, Xu, Yong, Zhang, Zhimin, Zhang, Zhang, Ding, Ke. Pyrido2, 3-dpyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2021, 211: http://dx.doi.org/10.1016/j.ejmech.2020.113023.
[9] Wu, Tianbang, Xiang, Qiuping, Wang, Chao, Wu, Chun, Zhang, Cheng, Zhang, Maofeng, Liu, Zhaoxuan, Zhang, Yan, Xiao, Linjiu, Xu, Yong. Y06014 is a selective BET inhibitor for the treatment of prostate cancer. ACTA PHARMACOLOGICA SINICA[J]. 2021, 42(12): 2120-2131, https://www.webofscience.com/wos/woscc/full-record/WOS:000624397300002.
[10] Zheng, Suqing, Xiong, Jun, Wang, Lei, Zhai, Dong, Xu, Yong, Lin, Fu. e-Graphene: A Computational Platform for the Prediction of Graphene-Based Drug Delivery System by Quantum Genetic Algorithm and Cascade Protocol. FRONTIERS IN CHEMISTRY[J]. 2021, 9: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8138207/.
[11] Mo, Cheng, Zhang, Zhang, Li, Yupeng, Huang, Minhao, Zou, Jian, Luo, Jinfeng, Tu, ZhengChao, Xu, Yong, Ren, Xiaomei, Ding, Ke, Lu, Xiaoyun. Design and Optimization of 3 '-(Imidazo1,2-alphapyrazin-3-yl)-1,1 '-biphenyl-3-carboxamides as Selective DDR1 Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2020, 11(3): 379-384, [12] Zheng, Suqing, Xiong, Jun, Wang, Yibing, Liang, Guang, Xu, Yong, Lin, Fu. Quantitative Prediction of Hemolytic Toxicity for Small Molecules and Their Potential Hemolytic Fragments by Machine Learning and Recursive Fragmentation Methods. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2020, 60(6): 3231-3245, https://www.webofscience.com/wos/woscc/full-record/WOS:000543717300051.
[13] Zheng, Suqing, Wang, Yibing, Liu, Wenxin, Chang, Wenping, Liang, Guang, Xu, Yong, Lin, Fu. In Silico Prediction of Hemolytic Toxicity on the Human Erythrocytes for Small Molecules by Machine-Learning and Genetic Algorithm. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 63(12): 6499-6512, https://www.webofscience.com/wos/woscc/full-record/WOS:000545660500014.
[14] Hu, Qingqing, Wang, Chao, Xiang, Qiuping, Wang, Rui, Zhang, Cheng, Zhang, Maofeng, Xue, Xiaoqian, Luo, Guolong, Liu, Xiaomin, Wu, Xishan, Zhang, Yan, Wu, Donghai, Xu, Yong. Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo d isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities. BIOORGANIC CHEMISTRY[J]. 2020, 94: http://dx.doi.org/10.1016/j.bioorg.2019.103424.
[15] Mo, Cheng, Zhang, Zhang, Li, Yupeng, Huang, Minhao, Zou, Jian, Luo, Jinfeng, Tu, ZhengChao, Xu, Yong, Ren, Xiaomei, Ding, Ke, Lu, Xiaoyun. Design and Optimization of 3 '-(Imidazo1,2-alphapyrazin-3-yl)-1,1 '-biphenyl-3-carboxamides as Selective DDR1 Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2020, 11(3): 379-384, [16] Zheng, Suqing, Xiong, Jun, Wang, Yibing, Liang, Guang, Xu, Yong, Lin, Fu. Quantitative Prediction of Hemolytic Toxicity for Small Molecules and Their Potential Hemolytic Fragments by Machine Learning and Recursive Fragmentation Methods. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2020, 60(6): 3231-3245, https://www.webofscience.com/wos/woscc/full-record/WOS:000543717300051.
[17] Zheng, Suqing, Wang, Yibing, Liu, Wenxin, Chang, Wenping, Liang, Guang, Xu, Yong, Lin, Fu. In Silico Prediction of Hemolytic Toxicity on the Human Erythrocytes for Small Molecules by Machine-Learning and Genetic Algorithm. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2020, 63(12): 6499-6512, https://www.webofscience.com/wos/woscc/full-record/WOS:000545660500014.
[18] Hu, Qingqing, Wang, Chao, Xiang, Qiuping, Wang, Rui, Zhang, Cheng, Zhang, Maofeng, Xue, Xiaoqian, Luo, Guolong, Liu, Xiaomin, Wu, Xishan, Zhang, Yan, Wu, Donghai, Xu, Yong. Discovery and optimization of novel N-benzyl-3,6-dimethylbenzo d isoxazol-5-amine derivatives as potent and selective TRIM24 bromodomain inhibitors with potential anti-cancer activities. BIOORGANIC CHEMISTRY[J]. 2020, 94: http://dx.doi.org/10.1016/j.bioorg.2019.103424.
[19] Zheng, Suqing, Chang, Wenping, Xu, Wenxin, Xu, Yong, Lin, Fu. e-Sweet: A Machine-Learning Based Platform for the Prediction of Sweetener and Its Relative Sweetness. FRONTIERS IN CHEMISTRY[J]. 2019, 7: https://doaj.org/article/963ff945d436441eaf2199df580e0896.
[20] Zheng, Suqing, Wang, Yibing, Liu, Hongmei, Chang, Wenping, Xu, Yong, Lin, Fu. Prediction of Hemolytic Toxicity for Saponins by Machine-Learning Methods. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2019, 32(6): 1014-1026, [21] Zou, Lingjiao, Xiang, Qiuping, Xue, Xiaoqian, Zhang, Cheng, Li, Chenchang, Wang, Chao, Li, Qiu, Wang, Rui, Wu, Shuang, Zhou, Yulai, Zhang, Yan, Xu, Yong. Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer. ACTA PHARMACOLOGICA SINICA[J]. 2019, 40(11): 1436-1447, http://lib.cqvip.com/Qikan/Article/Detail?id=7100537090.
[22] Peng, Lijie, Zhang, Zhensheng, Lei, Chong, Li, Shan, Zhang, Zhang, Ren, Xiaomei, Chang, Yu, Zhang, Yan, Xu, Yong, Ding, Ke. Identification of New Small Molecule Inducers of Estrogen-related Receptor alpha (ERR alpha) Degradation. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2019, 10(5): 767-772, [23] Zheng, Suqing, Chang, Wenping, Liu, Wenxin, Liang, Guang, Xu, Yong, Lin, Fu. Computational Prediction of a New ADMET Endpoint for Small Molecules: Anticommensal Effect on Human Gut Microbiota. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2019, 59(3): 1215-1220, https://www.webofscience.com/wos/woscc/full-record/WOS:000462943700025.
[24] Cui, Shengyang, Wang, Yongjin, Wang, Yuting, Tang, Xia, Ren, Xiaomei, Zhang, Lei, Xu, Yong, Zhang, Zhang, Zhang, ZhiMin, Lu, Xiaoyun, Ding, Ke. Design, synthesis and biological evaluation of 3-(imidazo1,2-a pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 179: 470-482, http://dx.doi.org/10.1016/j.ejmech.2019.06.064.
[25] Zhang, Yan, Wu, Xishan, Xue, Xiaoqian, Li, Chenchang, Wang, Junjian, Wang, Rui, Zhang, Cheng, Wang, Chao, Shi, Yudan, Zou, Lingjiao, Li, Qiu, Huang, Zenghong, Hao, Xiaojuan, Loomes, Kerry, Wu, Donghai, Chen, HongWu, Xu, Jinxin, Xu, Yong. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 62(9): 4716-4730, [26] Wu, Xishan, Zhang, Yan, Xu, Yong. Discovery of the First Low Nanomolar Liver Receptor Homolog-1 (LRH-1) Agonist. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 62(24): 11019-11021, https://www.webofscience.com/wos/woscc/full-record/WOS:000505633400005.
[27] Zheng, Suqing, Chang, Wenping, Xu, Wenxin, Xu, Yong, Lin, Fu. e-Sweet: A Machine-Learning Based Platform for the Prediction of Sweetener and Its Relative Sweetness. FRONTIERS IN CHEMISTRY[J]. 2019, 7: https://doaj.org/article/963ff945d436441eaf2199df580e0896.
[28] Zheng, Suqing, Wang, Yibing, Liu, Hongmei, Chang, Wenping, Xu, Yong, Lin, Fu. Prediction of Hemolytic Toxicity for Saponins by Machine-Learning Methods. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2019, 32(6): 1014-1026, [29] Zou, Lingjiao, Xiang, Qiuping, Xue, Xiaoqian, Zhang, Cheng, Li, Chenchang, Wang, Chao, Li, Qiu, Wang, Rui, Wu, Shuang, Zhou, Yulai, Zhang, Yan, Xu, Yong. Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer. ACTA PHARMACOLOGICA SINICA[J]. 2019, 40(11): 1436-1447, http://lib.cqvip.com/Qikan/Article/Detail?id=7100537090.
[30] Peng, Lijie, Zhang, Zhensheng, Lei, Chong, Li, Shan, Zhang, Zhang, Ren, Xiaomei, Chang, Yu, Zhang, Yan, Xu, Yong, Ding, Ke. Identification of New Small Molecule Inducers of Estrogen-related Receptor alpha (ERR alpha) Degradation. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2019, 10(5): 767-772, [31] Zheng, Suqing, Chang, Wenping, Liu, Wenxin, Liang, Guang, Xu, Yong, Lin, Fu. Computational Prediction of a New ADMET Endpoint for Small Molecules: Anticommensal Effect on Human Gut Microbiota. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2019, 59(3): 1215-1220, https://www.webofscience.com/wos/woscc/full-record/WOS:000462943700025.
[32] Cui, Shengyang, Wang, Yongjin, Wang, Yuting, Tang, Xia, Ren, Xiaomei, Zhang, Lei, Xu, Yong, Zhang, Zhang, Zhang, ZhiMin, Lu, Xiaoyun, Ding, Ke. Design, synthesis and biological evaluation of 3-(imidazo1,2-a pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 179: 470-482, http://dx.doi.org/10.1016/j.ejmech.2019.06.064.
[33] Zhang, Yan, Wu, Xishan, Xue, Xiaoqian, Li, Chenchang, Wang, Junjian, Wang, Rui, Zhang, Cheng, Wang, Chao, Shi, Yudan, Zou, Lingjiao, Li, Qiu, Huang, Zenghong, Hao, Xiaojuan, Loomes, Kerry, Wu, Donghai, Chen, HongWu, Xu, Jinxin, Xu, Yong. Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable ROR gamma Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 62(9): 4716-4730, [34] Wu, Xishan, Zhang, Yan, Xu, Yong. Discovery of the First Low Nanomolar Liver Receptor Homolog-1 (LRH-1) Agonist. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2019, 62(24): 11019-11021, https://www.webofscience.com/wos/woscc/full-record/WOS:000505633400005.
[35] Zhu, Dongsheng, Guo, Haijun, Chang, Yu, Ni, Yun, Li, Lin, Zhang, ZhiMin, Hao, Piliang, Xu, Yong, Ding, Ke, Li, Zhengqiu. Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(30): 9284-9289, https://www.webofscience.com/wos/woscc/full-record/WOS:000438712600008.
[36] Zheng, Suqing, Jiang, Mengying, Zhao, Chengwei, Zhu, Rui, Hu, Zhicheng, Xu, Yong, Lin, Fu. e-Bitter: Bitterant Prediction by the Consensus Voting From the Machine-Learning Methods. FRONTIERS IN CHEMISTRY[J]. 2018, 6: https://doaj.org/article/5dc2e3ef6f544f9ca3f692c74c15cb36.
[37] Nie, Tao, Zhao, Shiting, Mao, Liufeng, Yang, Yiting, Sun, Wei, Lin, Xiaoliang, Liu, Shuo, Li, Kuai, Sun, Yirong, Li, Peng, Zhou, Zhiguang, Lin, Shaoqiang, Hui, Xiaoyan, Xu, Aimin, Ma, Chung Wah, Xu, Yong, Wang, Cunchuan, Dunbar, P Rod, Wu, Donghai. The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPAR gamma activity. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2018, 175(9): 1439-1450, https://www.webofscience.com/wos/woscc/full-record/WOS:000430116700004.
[38] Zhang, Maofeng, Zhang, Yan, Song, Ming, Xue, Xiaoqian, Wang, Junjian, Wang, Chao, Zhang, Cheng, Li, Chenchang, Xiang, Qiuping, Zou, Lingjiao, Wu, Xishan, Wu, Chun, Dong, Baijun, Xue, Wei, Zhou, Yulai, Chen, Hongwu, Wu, Donghai, Ding, Ke, Xu, Yong. Structure-Based Discovery and Optimization of Benzo&ITd&ITisoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 61(7): 3037-3058, https://www.webofscience.com/wos/woscc/full-record/WOS:000430256600027.
[39] Yong Xu. Structure-Based Discovery and Optimization of Benzo[d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). Journal of Medicinal Chemistry. 2018, [40] Xiang, Quping, Zhang, Yan, Li, Jiaguo, Xue, Xiaoqian, Wang, Chao, Song, Ming, Zhang, Cheng, Wang, Rui, Li, Chenchang, Wu, Chun, Zhou, Yulai, Yang, Xiaohong, Li, Guohui, Ding, Ke, Xu, Yong. Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2018, 9(3): 262-267, http://cas-ir.dicp.ac.cn/handle/321008/168890.
[41] Li, Hong, Zhao, Lihua, Singh, Rani, Ham, J Nina, Fadoju, Doris O, Bean, Lora J H, Zhang, Yan, Xu, Yong, Xu, H Eric, Gambello, Michael J. The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine. MOLECULAR GENETICS AND METABOLISM REPORTS[J]. 2018, 17: 46-52, http://dx.doi.org/10.1016/j.ymgmr.2018.09.006.
[42] Xun, Qiuju, Zhang, Zhang, Luo, Jinfeng, Tong, Linjiang, Huang, Minhao, Wang, Zhen, Zou, Jian, Liu, Yingqiang, Xu, Yong, Xie, Hua, Tu, ZhengChao, Lu, Xiaoyun, Ding, Ke. Design, Synthesis, and Structure-Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido4,5-dpyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 61(6): 2353-2371, http://www.corc.org.cn/handle/1471x/2172116.
[43] Xiang, Qiuping, Wang, Chao, Zhang, Yan, Xue, Xiaoqian, Song, Ming, Zhang, Cheng, Li, Chenchang, Wu, Chun, Li, Kuai, Hui, Xiaoyan, Zhou, Yulai, Smaill, Jeff B, Patterson, Adam V, Wu, Donghai, Ding, Ke, Xu, Yong. Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 147: 238-252, https://www.webofscience.com/wos/woscc/full-record/WOS:000427217100019.
[44] Xue, Xiaoqian, Zhang, Yan, Wang, Chao, Zhang, Maofeng, Xiang, Qiuping, Wang, Junjian, Wang, Anhui, Li, Chenchang, Zhang, Cheng, Zou, Lingjiao, Wang, Rui, Wu, Shuang, Lu, Yongzhi, Chen, Hongwu, Ding, Ke, Li, Guohui, Xu, Yong. Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 152: 542-559, http://dx.doi.org/10.1016/j.ejmech.2018.04.034.
[45] Zhu, Dongsheng, Guo, Haijun, Chang, Yu, Ni, Yun, Li, Lin, Zhang, ZhiMin, Hao, Piliang, Xu, Yong, Ding, Ke, Li, Zhengqiu. Cell- and Tissue-Based Proteome Profiling and Dual Imaging of Apoptosis Markers with Probes Derived from Venetoclax and Idasanutlin. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(30): 9284-9289, https://www.webofscience.com/wos/woscc/full-record/WOS:000438712600008.
[46] Zheng, Suqing, Jiang, Mengying, Zhao, Chengwei, Zhu, Rui, Hu, Zhicheng, Xu, Yong, Lin, Fu. e-Bitter: Bitterant Prediction by the Consensus Voting From the Machine-Learning Methods. FRONTIERS IN CHEMISTRY[J]. 2018, 6: https://doaj.org/article/5dc2e3ef6f544f9ca3f692c74c15cb36.
[47] Nie, Tao, Zhao, Shiting, Mao, Liufeng, Yang, Yiting, Sun, Wei, Lin, Xiaoliang, Liu, Shuo, Li, Kuai, Sun, Yirong, Li, Peng, Zhou, Zhiguang, Lin, Shaoqiang, Hui, Xiaoyan, Xu, Aimin, Ma, Chung Wah, Xu, Yong, Wang, Cunchuan, Dunbar, P Rod, Wu, Donghai. The natural compound, formononetin, extracted from Astragalus membranaceus increases adipocyte thermogenesis by modulating PPAR gamma activity. BRITISH JOURNAL OF PHARMACOLOGY[J]. 2018, 175(9): 1439-1450, https://www.webofscience.com/wos/woscc/full-record/WOS:000430116700004.
[48] Zhang, Maofeng, Zhang, Yan, Song, Ming, Xue, Xiaoqian, Wang, Junjian, Wang, Chao, Zhang, Cheng, Li, Chenchang, Xiang, Qiuping, Zou, Lingjiao, Wu, Xishan, Wu, Chun, Dong, Baijun, Xue, Wei, Zhou, Yulai, Chen, Hongwu, Wu, Donghai, Ding, Ke, Xu, Yong. Structure-Based Discovery and Optimization of Benzo&ITd&ITisoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 61(7): 3037-3058, https://www.webofscience.com/wos/woscc/full-record/WOS:000430256600027.
[49] Yong Xu. Structure-Based Discovery and Optimization of Benzo[d]isoxazole Derivatives as Potent and Selective BET Inhibitors for Potential Treatment of Castration-Resistant Prostate Cancer (CRPC). Journal of Medicinal Chemistry. 2018, [50] Xiang, Quping, Zhang, Yan, Li, Jiaguo, Xue, Xiaoqian, Wang, Chao, Song, Ming, Zhang, Cheng, Wang, Rui, Li, Chenchang, Wu, Chun, Zhou, Yulai, Yang, Xiaohong, Li, Guohui, Ding, Ke, Xu, Yong. Y08060: A Selective BET Inhibitor for Treatment of Prostate Cancer. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2018, 9(3): 262-267, http://cas-ir.dicp.ac.cn/handle/321008/168890.
[51] Li, Hong, Zhao, Lihua, Singh, Rani, Ham, J Nina, Fadoju, Doris O, Bean, Lora J H, Zhang, Yan, Xu, Yong, Xu, H Eric, Gambello, Michael J. The first pediatric case of glucagon receptor defect due to biallelic mutations in GCGR is identified by newborn screening of elevated arginine. MOLECULAR GENETICS AND METABOLISM REPORTS[J]. 2018, 17: 46-52, http://dx.doi.org/10.1016/j.ymgmr.2018.09.006.
[52] Xun, Qiuju, Zhang, Zhang, Luo, Jinfeng, Tong, Linjiang, Huang, Minhao, Wang, Zhen, Zou, Jian, Liu, Yingqiang, Xu, Yong, Xie, Hua, Tu, ZhengChao, Lu, Xiaoyun, Ding, Ke. Design, Synthesis, and Structure-Activity Relationship Study of 2-Oxo-3,4-dihydropyrimido4,5-dpyrimidines as New Colony Stimulating Factor 1 Receptor (CSF1R) Kinase Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 61(6): 2353-2371, http://www.corc.org.cn/handle/1471x/2172116.
[53] Xiang, Qiuping, Wang, Chao, Zhang, Yan, Xue, Xiaoqian, Song, Ming, Zhang, Cheng, Li, Chenchang, Wu, Chun, Li, Kuai, Hui, Xiaoyan, Zhou, Yulai, Smaill, Jeff B, Patterson, Adam V, Wu, Donghai, Ding, Ke, Xu, Yong. Discovery and optimization of 1-(1H-indol-1-yl)ethanone derivatives as CBP/EP300 bromodomain inhibitors for the treatment of castration-resistant prostate cancer. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 147: 238-252, https://www.webofscience.com/wos/woscc/full-record/WOS:000427217100019.
[54] Xue, Xiaoqian, Zhang, Yan, Wang, Chao, Zhang, Maofeng, Xiang, Qiuping, Wang, Junjian, Wang, Anhui, Li, Chenchang, Zhang, Cheng, Zou, Lingjiao, Wang, Rui, Wu, Shuang, Lu, Yongzhi, Chen, Hongwu, Ding, Ke, Li, Guohui, Xu, Yong. Benzoxazinone-containing 3,5-dimethylisoxazole derivatives as BET bromodomain inhibitors for treatment of castration-resistant prostate cancer. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2018, 152: 542-559, http://dx.doi.org/10.1016/j.ejmech.2018.04.034.
[55] Zheng, Suqing, Xu, Shaofang, Wang, Guitao, Tang, Qing, Jiang, Xiaonan, Li, Zhanting, Xu, Yong, Wang, Renxiao, Lin, Fu. Proposed Hydrogen-Bonding Index of Donor or Acceptor Reflecting Its Intrinsic Contribution to Hydrogen-Bonding Strength. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2017, 57(7): 1535-1547, https://www.webofscience.com/wos/woscc/full-record/WOS:000406435500004.
[56] Yu, Lei, Huang, Minhao, Xu, Tianfeng, Tong, Linjiang, Yan, Xiaoe, Zhang, Zhang, Xu, Yong, Yun, Caihong, Xie, Hua, Ding, Ke, Lu, Xiaoyun. A structure-guided optimization of pyrido2,3-dpyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 126: 1107-1117, http://dx.doi.org/10.1016/j.ejmech.2016.12.006.
[57] Mo, Cheng, Zhang, Zhang, Guise, Christopher P, Li, Xueqiang, Luo, Jinfeng, Tu, Zhengchao, Xu, Yong, Patterson, Adam V, Smaill, Jeff B, Ren, Xiaomei, Lu, Xiaoyun, Ding, Ke. 2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2017, 8(5): 543-548, https://www.webofscience.com/wos/woscc/full-record/WOS:000401402900014.
[58] Hou, Shulin, Xu, Tingting, Xu, Jinxin, Qu, Linbing, Xu, Yong, Chen, Ling, Liu, Jinsong. Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A(2) group IIE. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/b20fd0d4f09a4ae6b3ee5de809b75eaa.
[59] Mao, Liufeng, Nie, Baoming, Nie, Tao, Hui, Xiaoyan, Gao, Xuefei, Lin, Xiaoliang, Liu, Xin, Xu, Yong, Tang, Xiaofeng, Yuan, Ran, Li, Kuai, Li, Peng, Ding, Ke, Wang, Yu, Xu, Aimin, Fei, Jian, Han, Weiping, Liu, Pentao, Madsen, Lise, Kristiansen, Karsten, Zhou, Zhiguang, Ding, Sheng, Wu, Donghai. Visualization and Quantification of Browning Using a Ucp1-2A-Luciferase Knock-in Mouse Model. DIABETES[J]. 2017, 66(2): 407-417, http://dx.doi.org/10.2337/db16-0343.
[60] Chang, Yu, Lu, Xiaoyun, Shibu, Marthandam Asokan, Dai, YiBo, Luo, Jinfeng, Zhang, Yan, Li, Yingjun, Zhao, Peng, Zhang, Zhang, Xu, Yong, Tu, ZhengChao, Zhang, QingWen, Yun, CaiHong, Huang, ChihYang, Ding, Ke. Structure Based Design of N-(3-((1H-Pyrazolo3,4-bpyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 60(13): 5927-5932, https://www.webofscience.com/wos/woscc/full-record/WOS:000405764900044.
[61] Li, Xueqiang, Guise, Christopher P, Taghipouran, Rana, Yosaatmadja, Yuliana, Ashoorzadeh, Amir, Paik, WooKyong, Squire, Christopher J, Jiang, Shuang, Luo, Jinfeng, Xu, Yong, Tu, ZhengChao, Lu, Xiaoyun, Ren, Xiaomei, Patterson, Adam V, Smaill, Jeff B, Ding, Ke. 2-Oxo-3, 4-dihydropyrimido4, 5-dpyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 135: 531-543, http://dx.doi.org/10.1016/j.ejmech.2017.04.049.
[62] Zheng, Suqing, Xu, Shaofang, Wang, Guitao, Tang, Qing, Jiang, Xiaonan, Li, Zhanting, Xu, Yong, Wang, Renxiao, Lin, Fu. Proposed Hydrogen-Bonding Index of Donor or Acceptor Reflecting Its Intrinsic Contribution to Hydrogen-Bonding Strength. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2017, 57(7): 1535-1547, https://www.webofscience.com/wos/woscc/full-record/WOS:000406435500004.
[63] Yu, Lei, Huang, Minhao, Xu, Tianfeng, Tong, Linjiang, Yan, Xiaoe, Zhang, Zhang, Xu, Yong, Yun, Caihong, Xie, Hua, Ding, Ke, Lu, Xiaoyun. A structure-guided optimization of pyrido2,3-dpyrimidin-7-ones as selective inhibitors of EGFR(L858R/T790M) mutant with improved pharmacokinetic properties. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 126: 1107-1117, http://dx.doi.org/10.1016/j.ejmech.2016.12.006.
[64] Mo, Cheng, Zhang, Zhang, Guise, Christopher P, Li, Xueqiang, Luo, Jinfeng, Tu, Zhengchao, Xu, Yong, Patterson, Adam V, Smaill, Jeff B, Ren, Xiaomei, Lu, Xiaoyun, Ding, Ke. 2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2017, 8(5): 543-548, https://www.webofscience.com/wos/woscc/full-record/WOS:000401402900014.
[65] Hou, Shulin, Xu, Tingting, Xu, Jinxin, Qu, Linbing, Xu, Yong, Chen, Ling, Liu, Jinsong. Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A(2) group IIE. SCIENTIFIC REPORTS[J]. 2017, 7(1): https://doaj.org/article/b20fd0d4f09a4ae6b3ee5de809b75eaa.
[66] Mao, Liufeng, Nie, Baoming, Nie, Tao, Hui, Xiaoyan, Gao, Xuefei, Lin, Xiaoliang, Liu, Xin, Xu, Yong, Tang, Xiaofeng, Yuan, Ran, Li, Kuai, Li, Peng, Ding, Ke, Wang, Yu, Xu, Aimin, Fei, Jian, Han, Weiping, Liu, Pentao, Madsen, Lise, Kristiansen, Karsten, Zhou, Zhiguang, Ding, Sheng, Wu, Donghai. Visualization and Quantification of Browning Using a Ucp1-2A-Luciferase Knock-in Mouse Model. DIABETES[J]. 2017, 66(2): 407-417, http://dx.doi.org/10.2337/db16-0343.
[67] Chang, Yu, Lu, Xiaoyun, Shibu, Marthandam Asokan, Dai, YiBo, Luo, Jinfeng, Zhang, Yan, Li, Yingjun, Zhao, Peng, Zhang, Zhang, Xu, Yong, Tu, ZhengChao, Zhang, QingWen, Yun, CaiHong, Huang, ChihYang, Ding, Ke. Structure Based Design of N-(3-((1H-Pyrazolo3,4-bpyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 60(13): 5927-5932, https://www.webofscience.com/wos/woscc/full-record/WOS:000405764900044.
[68] Li, Xueqiang, Guise, Christopher P, Taghipouran, Rana, Yosaatmadja, Yuliana, Ashoorzadeh, Amir, Paik, WooKyong, Squire, Christopher J, Jiang, Shuang, Luo, Jinfeng, Xu, Yong, Tu, ZhengChao, Lu, Xiaoyun, Ren, Xiaomei, Patterson, Adam V, Smaill, Jeff B, Ding, Ke. 2-Oxo-3, 4-dihydropyrimido4, 5-dpyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2017, 135: 531-543, http://dx.doi.org/10.1016/j.ejmech.2017.04.049.
[69] Nie, Tao, Hui, Xiaoyan, Mao, Liufeng, Nie, Baoming, Li, Kuai, Sun, Wei, Gao, Xuefei, Tang, Xiaofeng, Xu, Yong, Jiang, Baishan, Tu, Zhengcao, Li, Peng, Ding, Ke, Han, Weiping, Zhang, Shaoping, Xu, Aimin, Ding, Sheng, Liu, Pentao, Patterson, Adam, Cooper, Garth, Wu, Donghai. Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis. SCIENTIFIC REPORTS[J]. 2016, 6: http://ir.foo.ac.cn/handle/2SETSVCV/422.
[70] Song, Yu, Xue, Xiaoqian, Wu, Xishan, Wang, Rui, Xing, Yanli, Yan, Weiqun, Zhou, Yulai, Qian, ChaoNan, Zhang, Yan, Xu, Yong. Identification of N-phenyl-2-(N-phenylphenylsulfonamido) acetamides as new ROR gamma inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2016, 116: 13-26, http://ir.foo.ac.cn/handle/2SETSVCV/371.
[71] Wang, Zhen, Bian, Huan, Bartual, Sergio G, Du, Wenting, Luo, Jinfeng, Zhao, Hu, Zhang, Shasha, Mo, Cheng, Zhou, Yang, Xu, Yong, Tu, Zhengchao, Ren, Xiaomei, Lu, Xiaoyun, Brekken, Rolf A, Yao, Libo, Bullock, Alex N, Su, Jin, Ding, Ke. Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2016, 59(12): 5911-5916, http://dx.doi.org/10.1021/acs.jmedchem.6b00140.
[72] Junjian Wang, June X Zou, Xiaoqian Xue, Demin Cai, Yan Zhang, Zhijian Duan, Qiuping Xiang, Joy C Yang, Maggie C Louie, Alexander D Borowsky, Allen C Gao, Christopher P Evans, Kit S Lam, Jianzhen Xu, HsingJien Kung, Ronald M Evans, Yong Xu, HongWu Chen. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nature medicine. 2016, 22(5): 488-496, [73] Wang, Junjian, Zou, June X, Xue, Xiaoqian, Cai, Demin, Zhang, Yan, Duan, Zhijian, Xiang, Qiuping, Yang, Joy C, Louie, Maggie C, Borowsky, Alexander D, Gao, Allen C, Evans, Christopher P, Lam, Kit S, Xu, Jianzhen, Kung, HsingJien, Evans, Ronald M, Xu, Yong, Chen, HongWu. ROR-gamma drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. NATURE MEDICINE[J]. 2016, 22(5): 488-496, http://dx.doi.org/10.1038/nm.4070.
[74] Xue, Xiaoqian, Zhang, Yan, Liu, Zhaoxuan, Song, Ming, Xing, Yanli, Xiang, Qiuping, Wang, Zhen, Tu, Zhengchao, Zhou, Yulai, Ding, Ke, Xu, Yong. Discovery of Benzocdindol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2016, 59(4): 1565-1579, http://ir.gibh.ac.cn/handle/344009/886.
[75] Zhou, Yang, Nie, Tao, Zhang, Yan, Song, Ming, Li, Kuai, Ding, Mengxiao, Ding, Ke, Wu, Donghai, Xu, Yong. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2016, 24(18): 4310-4317, http://dx.doi.org/10.1016/j.bmc.2016.07.022.
[76] Yu Song, Xiaoqian Xue, Xishan Wu, Rui Wang, Yanli Xing, Weiqun Yan, Yulai Zhou, Chao-Nan Qian, Yan Zhang, Yong Xu. Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. European Journal of Medicinal Chemistry. 2016, 116: 13-26, http://dx.doi.org/10.1016/j.ejmech.2016.03.052.
[77] Wu, Xishan, Wang, Rui, Xing, Yanli, Xue, Xiaoqian, Zhang, Yan, Lu, Yongzhi, Song, Yu, Luo, Xiaoyu, Wu, Chun, Zhou, Yulai, Jiang, Jianqin, Xu, Yong. Discovery and structural optimization of 4-(4-(benzyloxy) phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists. ACTA PHARMACOLOGICA SINICA[J]. 2016, 37(11): 1516-1524, https://www.webofscience.com/wos/woscc/full-record/WOS:000387755900014.
[78] Zheng, Suqing, Tang, Qing, He, Jian, Du, Shiyu, Xu, Shaofang, Wang, Chaojie, Xu, Yong, Lin, Fu. VFFDT: A New Software for Preparing AMBER Force Field Parameters for Metal-Containing Molecular Systems. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2016, 56(4): 811-818, http://ir.nimte.ac.cn/handle/174433/13037.
[79] Nie, Tao, Hui, Xiaoyan, Mao, Liufeng, Nie, Baoming, Li, Kuai, Sun, Wei, Gao, Xuefei, Tang, Xiaofeng, Xu, Yong, Jiang, Baishan, Tu, Zhengcao, Li, Peng, Ding, Ke, Han, Weiping, Zhang, Shaoping, Xu, Aimin, Ding, Sheng, Liu, Pentao, Patterson, Adam, Cooper, Garth, Wu, Donghai. Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis. SCIENTIFIC REPORTS[J]. 2016, 6: http://ir.foo.ac.cn/handle/2SETSVCV/422.
[80] Song, Yu, Xue, Xiaoqian, Wu, Xishan, Wang, Rui, Xing, Yanli, Yan, Weiqun, Zhou, Yulai, Qian, ChaoNan, Zhang, Yan, Xu, Yong. Identification of N-phenyl-2-(N-phenylphenylsulfonamido) acetamides as new ROR gamma inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2016, 116: 13-26, http://ir.foo.ac.cn/handle/2SETSVCV/371.
[81] Wang, Zhen, Bian, Huan, Bartual, Sergio G, Du, Wenting, Luo, Jinfeng, Zhao, Hu, Zhang, Shasha, Mo, Cheng, Zhou, Yang, Xu, Yong, Tu, Zhengchao, Ren, Xiaomei, Lu, Xiaoyun, Brekken, Rolf A, Yao, Libo, Bullock, Alex N, Su, Jin, Ding, Ke. Structure-Based Design of Tetrahydroisoquinoline-7-carboxamides as Selective Discoidin Domain Receptor 1 (DDR1) Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2016, 59(12): 5911-5916, http://dx.doi.org/10.1021/acs.jmedchem.6b00140.
[82] Junjian Wang, June X Zou, Xiaoqian Xue, Demin Cai, Yan Zhang, Zhijian Duan, Qiuping Xiang, Joy C Yang, Maggie C Louie, Alexander D Borowsky, Allen C Gao, Christopher P Evans, Kit S Lam, Jianzhen Xu, HsingJien Kung, Ronald M Evans, Yong Xu, HongWu Chen. ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nature medicine. 2016, 22(5): 488-496, [83] Wang, Junjian, Zou, June X, Xue, Xiaoqian, Cai, Demin, Zhang, Yan, Duan, Zhijian, Xiang, Qiuping, Yang, Joy C, Louie, Maggie C, Borowsky, Alexander D, Gao, Allen C, Evans, Christopher P, Lam, Kit S, Xu, Jianzhen, Kung, HsingJien, Evans, Ronald M, Xu, Yong, Chen, HongWu. ROR-gamma drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. NATURE MEDICINE[J]. 2016, 22(5): 488-496, http://dx.doi.org/10.1038/nm.4070.
[84] Xue, Xiaoqian, Zhang, Yan, Liu, Zhaoxuan, Song, Ming, Xing, Yanli, Xiang, Qiuping, Wang, Zhen, Tu, Zhengchao, Zhou, Yulai, Ding, Ke, Xu, Yong. Discovery of Benzocdindol-2(1H)-ones as Potent and Specific BET Bromodomain Inhibitors: Structure-Based Virtual Screening, Optimization, and Biological Evaluation. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2016, 59(4): 1565-1579, http://ir.gibh.ac.cn/handle/344009/886.
[85] Zhou, Yang, Nie, Tao, Zhang, Yan, Song, Ming, Li, Kuai, Ding, Mengxiao, Ding, Ke, Wu, Donghai, Xu, Yong. The discovery of novel and selective fatty acid binding protein 4 inhibitors by virtual screening and biological evaluation. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2016, 24(18): 4310-4317, http://dx.doi.org/10.1016/j.bmc.2016.07.022.
[86] Yu Song, Xiaoqian Xue, Xishan Wu, Rui Wang, Yanli Xing, Weiqun Yan, Yulai Zhou, Chao-Nan Qian, Yan Zhang, Yong Xu. Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. European Journal of Medicinal Chemistry. 2016, 116: 13-26, http://dx.doi.org/10.1016/j.ejmech.2016.03.052.
[87] Wu, Xishan, Wang, Rui, Xing, Yanli, Xue, Xiaoqian, Zhang, Yan, Lu, Yongzhi, Song, Yu, Luo, Xiaoyu, Wu, Chun, Zhou, Yulai, Jiang, Jianqin, Xu, Yong. Discovery and structural optimization of 4-(4-(benzyloxy) phenyl)-3,4-dihydropyrimidin-2(1H)-ones as RORc inverse agonists. ACTA PHARMACOLOGICA SINICA[J]. 2016, 37(11): 1516-1524, https://www.webofscience.com/wos/woscc/full-record/WOS:000387755900014.
[88] Zheng, Suqing, Tang, Qing, He, Jian, Du, Shiyu, Xu, Shaofang, Wang, Chaojie, Xu, Yong, Lin, Fu. VFFDT: A New Software for Preparing AMBER Force Field Parameters for Metal-Containing Molecular Systems. JOURNAL OF CHEMICAL INFORMATION AND MODELING[J]. 2016, 56(4): 811-818, http://ir.nimte.ac.cn/handle/174433/13037.
[89] Yan ZHANG, Xiao-yu LUO, Dong-hai WU, Yong XU. ROR nuclear receptors: structures, related diseases, and drug discovery. 中国药理学报:英文版. 2015, 71-87, http://lib.cqvip.com/Qikan/Article/Detail?id=663907404.
[90] Wu, Xue, Xu, Peijun, Wang, Jinguang, Xu, Yong, Fu, Ting, Zhao, Meixia, Zhang, Depeng, Liu, Jiahui, Shen, Hujun, Xiu, Zhilong, Li, Guohui, Wei, D, Xu, Q, Zhao, T, Dai, H. Theoretical Studies on the Folding Mechanisms for Different DNA G-quadruplexes. ADVANCE IN STRUCTURAL BIOINFORMATICS[J]. 2015, 827: 123-141, http://cas-ir.dicp.ac.cn/handle/321008/146027.
[91] Liu, Tianzhou, Wang, Bangxing, Guo, Jintao, Zhou, Yang, Julius, Mugweru, Njire, Moses, Cao, Yuanyuan, Wu, Tian, Liu, Zhiyong, Wang, Changwei, Xu, Yong, Zhang, Tianyu. Role of folP1 and folP2 Genes in the Action of Sulfamethoxazole and Trimethoprim Against Mycobacteria. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2015, 25(9): 1559-1567, http://ir.foo.ac.cn/handle/2SETSVCV/609.
[92] Zhang, Yan, Luo, Xiaoyu, Wu, Donghai, Xu, Yong. ROR nuclear receptors: structures, related diseases, and drug discovery. ACTA PHARMACOLOGICA SINICAnull. 2015, 36(1): 71-87, http://lib.cqvip.com/Qikan/Article/Detail?id=663907404.
[93] Xu, Peijun, Wang, Jinguang, Xu, Yong, Chu, Huiying, Shen, Hujun, Zhang, Depeng, Zhao, Meixia, Liu, Jiahui, Li, Guohui, Wei, D, Xu, Q, Zhao, T, Dai, H. Binding Modes and Interaction Mechanism Between Different Base Pairs and Methylene Blue Trihydrate: A Quantum Mechanics Study. ADVANCE IN STRUCTURAL BIOINFORMATICS[J]. 2015, 827: 187-203, http://cas-ir.dicp.ac.cn/handle/321008/146040.
[94] Wu, Xue, Xu, Peijun, Wang, Jinguang, Xu, Yong, Fu, Ting, Zhang, Depeng, Zhao, Meixia, Liu, Jiahui, Shen, Hujun, Xiu, Zhilong, Li, Guohui, Wei, D, Xu, Q, Zhao, T, Dai, H. Folding Mechanisms of Trefoil Knot Proteins Studied by Molecular Dynamics Simulations and Go-model. ADVANCE IN STRUCTURAL BIOINFORMATICS[J]. 2015, 827: 93-110, http://cas-ir.dicp.ac.cn/handle/321008/146034.
[95] Li, Yingjun, Cheng, Huimin, Zhang, Zhang, Zhuang, Xiaoxi, Luo, Jinfeng, Long, Huoyou, Zhou, Yang, Xu, Yong, Taghipouran, Rana, Li, Dan, Patterson, Adam, Smaill, Jeff, Tu, Zhengchao, Wu, Donghai, Ren, Xiaomei, Ding, Ke. N-(3-Ethynyl-2,4-difluorophenyl)sulfonamide Derivatives as Selective Raf Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2015, 6(5): 543-547, http://ir.gibh.ac.cn/handle/344009/549.
[96] Zhao, Xin, Zhang, ZhenWei, Cui, Wei, Chen, Shengwei, Zhou, Yang, Dong, Jianghong, Jie, Yanling, Wan, Junting, Xu, Yong, Hu, Wenhui. Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus. MEDCHEMCOMM[J]. 2015, 6(4): 727-731, http://dx.doi.org/10.1039/c4md00515e.
[97] Xu, Shilin, Mao, Liufeng, Ding, Ping, Zhuang, Xiaoxi, Zhou, Yang, Yu, Lei, Liu, Yingxue, Nie, Tao, Xu, Tingting, Xu, Yong, Liu, Jinsong, Smaill, Jeff, Ren, Xiaomei, Wu, Donghai, Ding, Ke. 1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor gamma and promote the browning of white adipose. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2015, 23(13): 3751-3760, http://ir.foo.ac.cn/handle/2SETSVCV/107.
[98] Xu, Peijun, Wang, Jinguang, Xu, Yong, Chu, Huiying, Liu, Jiahui, Zhao, Meixia, Zhang, Depeng, Mao, Yingchen, Li, Beibei, Ding, Yang, Li, Guohui, Wei, D, Xu, Q, Zhao, T, Dai, H. Advancement of Polarizable Force Field and Its Use for Molecular Modeling and Design. ADVANCE IN STRUCTURAL BIOINFORMATICS[J]. 2015, 827: 19-32, http://cas-ir.dicp.ac.cn/handle/321008/146024.
[99] Yan ZHANG, Xiao-yu LUO, Dong-hai WU, Yong XU. ROR nuclear receptors: structures, related diseases, and drug discovery. 中国药理学报:英文版. 2015, 71-87, http://lib.cqvip.com/Qikan/Article/Detail?id=663907404.
[100] Wu, Xue, Xu, Peijun, Wang, Jinguang, Xu, Yong, Fu, Ting, Zhao, Meixia, Zhang, Depeng, Liu, Jiahui, Shen, Hujun, Xiu, Zhilong, Li, Guohui, Wei, D, Xu, Q, Zhao, T, Dai, H. Theoretical Studies on the Folding Mechanisms for Different DNA G-quadruplexes. ADVANCE IN STRUCTURAL BIOINFORMATICS[J]. 2015, 827: 123-141, http://cas-ir.dicp.ac.cn/handle/321008/146027.
[101] Liu, Tianzhou, Wang, Bangxing, Guo, Jintao, Zhou, Yang, Julius, Mugweru, Njire, Moses, Cao, Yuanyuan, Wu, Tian, Liu, Zhiyong, Wang, Changwei, Xu, Yong, Zhang, Tianyu. Role of folP1 and folP2 Genes in the Action of Sulfamethoxazole and Trimethoprim Against Mycobacteria. JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY[J]. 2015, 25(9): 1559-1567, http://ir.foo.ac.cn/handle/2SETSVCV/609.
[102] Zhang, Yan, Luo, Xiaoyu, Wu, Donghai, Xu, Yong. ROR nuclear receptors: structures, related diseases, and drug discovery. ACTA PHARMACOLOGICA SINICAnull. 2015, 36(1): 71-87, http://lib.cqvip.com/Qikan/Article/Detail?id=663907404.
[103] Xu, Peijun, Wang, Jinguang, Xu, Yong, Chu, Huiying, Shen, Hujun, Zhang, Depeng, Zhao, Meixia, Liu, Jiahui, Li, Guohui, Wei, D, Xu, Q, Zhao, T, Dai, H. Binding Modes and Interaction Mechanism Between Different Base Pairs and Methylene Blue Trihydrate: A Quantum Mechanics Study. ADVANCE IN STRUCTURAL BIOINFORMATICS[J]. 2015, 827: 187-203, http://cas-ir.dicp.ac.cn/handle/321008/146040.
[104] Wu, Xue, Xu, Peijun, Wang, Jinguang, Xu, Yong, Fu, Ting, Zhang, Depeng, Zhao, Meixia, Liu, Jiahui, Shen, Hujun, Xiu, Zhilong, Li, Guohui, Wei, D, Xu, Q, Zhao, T, Dai, H. Folding Mechanisms of Trefoil Knot Proteins Studied by Molecular Dynamics Simulations and Go-model. ADVANCE IN STRUCTURAL BIOINFORMATICS[J]. 2015, 827: 93-110, http://cas-ir.dicp.ac.cn/handle/321008/146034.
[105] Li, Yingjun, Cheng, Huimin, Zhang, Zhang, Zhuang, Xiaoxi, Luo, Jinfeng, Long, Huoyou, Zhou, Yang, Xu, Yong, Taghipouran, Rana, Li, Dan, Patterson, Adam, Smaill, Jeff, Tu, Zhengchao, Wu, Donghai, Ren, Xiaomei, Ding, Ke. N-(3-Ethynyl-2,4-difluorophenyl)sulfonamide Derivatives as Selective Raf Inhibitors. ACS MEDICINAL CHEMISTRY LETTERS[J]. 2015, 6(5): 543-547, http://ir.gibh.ac.cn/handle/344009/549.
[106] Zhao, Xin, Zhang, ZhenWei, Cui, Wei, Chen, Shengwei, Zhou, Yang, Dong, Jianghong, Jie, Yanling, Wan, Junting, Xu, Yong, Hu, Wenhui. Identification of camphor derivatives as novel M2 ion channel inhibitors of influenza A virus. MEDCHEMCOMM[J]. 2015, 6(4): 727-731, http://dx.doi.org/10.1039/c4md00515e.
[107] Xu, Shilin, Mao, Liufeng, Ding, Ping, Zhuang, Xiaoxi, Zhou, Yang, Yu, Lei, Liu, Yingxue, Nie, Tao, Xu, Tingting, Xu, Yong, Liu, Jinsong, Smaill, Jeff, Ren, Xiaomei, Wu, Donghai, Ding, Ke. 1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor gamma and promote the browning of white adipose. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2015, 23(13): 3751-3760, http://ir.foo.ac.cn/handle/2SETSVCV/107.
[108] Xu, Peijun, Wang, Jinguang, Xu, Yong, Chu, Huiying, Liu, Jiahui, Zhao, Meixia, Zhang, Depeng, Mao, Yingchen, Li, Beibei, Ding, Yang, Li, Guohui, Wei, D, Xu, Q, Zhao, T, Dai, H. Advancement of Polarizable Force Field and Its Use for Molecular Modeling and Design. ADVANCE IN STRUCTURAL BIOINFORMATICS[J]. 2015, 827: 19-32, http://cas-ir.dicp.ac.cn/handle/321008/146024.
[109] Wang, Wenna, Kong, Dexin, Cheng, Huimin, Tan, Li, Zhang, Zhang, Zhuang, Xiaoxi, Long, Huoyou, Zhou, Yang, Xu, Yong, Yang, Xiaohong, Ding, Ke. New benzimidazole-2-urea derivates as tubulin inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2014, 24(17): 4250-4253, http://dx.doi.org/10.1016/j.bmcl.2014.07.035.
[110] 薛晓纤, 张岩, 许永, 宋宏锐. 孤儿核受体RORγ拮抗剂的合成及其初步活性研究. 中国药物化学杂志[J]. 2014, 24(4): 279-285, http://lib.cqvip.com/Qikan/Article/Detail?id=661863946.
[111] Zhang, Yan, Xue, Xiaoqian, Jin, Xiangyu, Song, Yu, Li, Jing, Luo, Xiaoyu, Song, Ming, Yan, Weiqun, Song, Hongrui, Xu, Yong. Discovery of 2-oxo-1,2-dihydrobenzocdindole-6-sulfonamide derivatives as new ROR gamma inhibitors using virtual screening, synthesis and biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2014, 78: 431-441, http://ir.gibh.ac.cn/handle/344009/342.
[112] Wang, Wenna, Kong, Dexin, Cheng, Huimin, Tan, Li, Zhang, Zhang, Zhuang, Xiaoxi, Long, Huoyou, Zhou, Yang, Xu, Yong, Yang, Xiaohong, Ding, Ke. New benzimidazole-2-urea derivates as tubulin inhibitors. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2014, 24(17): 4250-4253, http://dx.doi.org/10.1016/j.bmcl.2014.07.035.
[113] 薛晓纤, 张岩, 许永, 宋宏锐. 孤儿核受体RORγ拮抗剂的合成及其初步活性研究. 中国药物化学杂志[J]. 2014, 24(4): 279-285, http://lib.cqvip.com/Qikan/Article/Detail?id=661863946.
[114] Zhang, Yan, Xue, Xiaoqian, Jin, Xiangyu, Song, Yu, Li, Jing, Luo, Xiaoyu, Song, Ming, Yan, Weiqun, Song, Hongrui, Xu, Yong. Discovery of 2-oxo-1,2-dihydrobenzocdindole-6-sulfonamide derivatives as new ROR gamma inhibitors using virtual screening, synthesis and biological evaluation. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2014, 78: 431-441, http://ir.gibh.ac.cn/handle/344009/342.
[115] Cao, Minjie, Liu, Xue, Zhang, Yan, Xue, Xiaoqian, Zhou, X Edward, Melcher, Karsten, Gao, Pan, Wang, Fuxing, Zeng, Liang, Zhao, Yang, Zhao, Yang, Deng, Pan, Zhong, Dafang, Zhu, JianKang, Xu, H Eric, Xu, Yong. An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. CELL RESEARCH[J]. 2013, 23(8): 1043-1054, http://ir.gibh.ac.cn/handle/344009/713.
[116] Gao, Mingshan, Duan, Lei, Luo, Jinfeng, Zhang, Lianwen, Lu, Xiaoyun, Zhang, Yan, Zhang, Zhang, Tu, Zhengchao, Xu, Yong, Ren, Xiaomei, Ding, Ke. Discovery and Optimization of 3-(2-(Pyrazolo1,5-apyrimidin-6-yl)-ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2013, 56(8): 3281-3295, http://ir.foo.ac.cn/handle/2SETSVCV/470.
[117] Zhao, LiHua, Zhou, X Edward, Wu, ZhongShan, Yi, Wei, Xu, Yong, Li, Suling, Xu, TingHai, Liu, Yue, Chen, RunZe, Kovach, Amanda, Kang, Yangyong, Hou, Li, He, Yuanzheng, Xie, Cen, Song, Wanling, Zhong, Dafang, Xu, Yechun, Wang, Yonghong, Li, Jiayang, Zhang, Chenghai, Melcher, Karsten, Xu, H Eric. Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. CELL RESEARCHnull. 2013, 23(3): 436-439, http://ir.gibh.ac.cn/handle/344009/759.
[118] Cao, Minjie, Liu, Xue, Zhang, Yan, Xue, Xiaoqian, Zhou, X Edward, Melcher, Karsten, Gao, Pan, Wang, Fuxing, Zeng, Liang, Zhao, Yang, Zhao, Yang, Deng, Pan, Zhong, Dafang, Zhu, JianKang, Xu, H Eric, Xu, Yong. An ABA-mimicking ligand that reduces water loss and promotes drought resistance in plants. CELL RESEARCH[J]. 2013, 23(8): 1043-1054, http://ir.gibh.ac.cn/handle/344009/713.
[119] Gao, Mingshan, Duan, Lei, Luo, Jinfeng, Zhang, Lianwen, Lu, Xiaoyun, Zhang, Yan, Zhang, Zhang, Tu, Zhengchao, Xu, Yong, Ren, Xiaomei, Ding, Ke. Discovery and Optimization of 3-(2-(Pyrazolo1,5-apyrimidin-6-yl)-ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2013, 56(8): 3281-3295, http://ir.foo.ac.cn/handle/2SETSVCV/470.
[120] Zhao, LiHua, Zhou, X Edward, Wu, ZhongShan, Yi, Wei, Xu, Yong, Li, Suling, Xu, TingHai, Liu, Yue, Chen, RunZe, Kovach, Amanda, Kang, Yangyong, Hou, Li, He, Yuanzheng, Xie, Cen, Song, Wanling, Zhong, Dafang, Xu, Yechun, Wang, Yonghong, Li, Jiayang, Zhang, Chenghai, Melcher, Karsten, Xu, H Eric. Crystal structures of two phytohormone signal-transducing alpha/beta hydrolases: karrikin-signaling KAI2 and strigolactone-signaling DWARF14. CELL RESEARCHnull. 2013, 23(3): 436-439, http://ir.gibh.ac.cn/handle/344009/759.
[121] Cheng, Huimin, Wan, Junting, Lin, MengI, Liu, Yingxue, Lu, Xiaoyun, Liu, Jinsong, Xu, Yong, Chen, Jianxin, Tu, Zhengchao, Cheng, YihShyun E, Ding, Ke. Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2012, 55(5): 2144-2153, https://www.webofscience.com/wos/woscc/full-record/WOS:000301170000030.
[122] Fu, Ting, Min, Hanyi, Xu, Yong, Chen, Jianzhong, Li, Guohui. Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESnull. 2012, 13(8): 9709-9740, http://www.irgrid.ac.cn/handle/1471x/721383.
[123] Xu, Shilin, Zhang, Lianwen, Chang, Shaohua, Luo, Jinfeng, Lu, Xiaoyun, Tu, Zhengchao, Liu, Yingxue, Zhang, Zhang, Xu, Yong, Ren, Xiaomei, Ding, Ke. Design, synthesis and biological evaluation of new molecules inhibiting epidermal growth factor receptor threonine(790) -> methionine(790) mutant. MEDCHEMCOMM[J]. 2012, 3(9): 1155-1159, https://www.webofscience.com/wos/woscc/full-record/WOS:000307902400017.
[124] Chang, Shaohua, Zhang, Lianwen, Xu, Shilin, Luo, Jinfeng, Lu, Xiaoyun, Zhang, Zhang, Xu, Tianfeng, Liu, Yingxue, Tu, Zhengchao, Xu, Yong, Ren, Xiaomei, Geng, Meiyu, Ding, Jian, Pei, Duanqing, Ding, Ke. Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine(790) -> Methionine(790) Mutant. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2012, 55(6): 2711-2723, https://www.webofscience.com/wos/woscc/full-record/WOS:000301767000016.
[125] Cheng, Huimin, Wan, Junting, Lin, MengI, Liu, Yingxue, Lu, Xiaoyun, Liu, Jinsong, Xu, Yong, Chen, Jianxin, Tu, Zhengchao, Cheng, YihShyun E, Ding, Ke. Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2012, 55(5): 2144-2153, https://www.webofscience.com/wos/woscc/full-record/WOS:000301170000030.
[126] Fu, Ting, Min, Hanyi, Xu, Yong, Chen, Jianzhong, Li, Guohui. Molecular Dynamic Simulation Insights into the Normal State and Restoration of p53 Function. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESnull. 2012, 13(8): 9709-9740, http://www.irgrid.ac.cn/handle/1471x/721383.
[127] Xu, Shilin, Zhang, Lianwen, Chang, Shaohua, Luo, Jinfeng, Lu, Xiaoyun, Tu, Zhengchao, Liu, Yingxue, Zhang, Zhang, Xu, Yong, Ren, Xiaomei, Ding, Ke. Design, synthesis and biological evaluation of new molecules inhibiting epidermal growth factor receptor threonine(790) -> methionine(790) mutant. MEDCHEMCOMM[J]. 2012, 3(9): 1155-1159, https://www.webofscience.com/wos/woscc/full-record/WOS:000307902400017.
[128] Chang, Shaohua, Zhang, Lianwen, Xu, Shilin, Luo, Jinfeng, Lu, Xiaoyun, Zhang, Zhang, Xu, Tianfeng, Liu, Yingxue, Tu, Zhengchao, Xu, Yong, Ren, Xiaomei, Geng, Meiyu, Ding, Jian, Pei, Duanqing, Ding, Ke. Design, Synthesis, and Biological Evaluation of Novel Conformationally Constrained Inhibitors Targeting Epidermal Growth Factor Receptor Threonine(790) -> Methionine(790) Mutant. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2012, 55(6): 2711-2723, https://www.webofscience.com/wos/woscc/full-record/WOS:000301767000016.

科研活动

   
科研项目
( 1 ) 院启动, 主持, 市地级, 2011-09--2016-09
( 2 ) KCNQ钾离子通道家族的结构与功能研究, 参与, 国家级, 2013-01--2017-08
( 3 ) 特异性RORγ拮抗剂的设计、合成和抗炎作用机制研究, 主持, 国家级, 2014-01--2017-12
( 4 ) 靶向DDR的抗胰腺癌先导化合物的发现研究, 主持, 部委级, 2016-01--2016-12
( 5 ) 基于新作用机制的抗肿瘤FGFR抑制剂开发, 主持, 研究所(学校), 2016-01--2017-12
( 6 ) 特异性BET溴结构域抑制剂的设计、合成及抗肿瘤活性研究, 主持, 国家级, 2017-01--2020-12
( 7 ) 生物医药服务社区建设, 参与, 国家级, 2017-01--2020-12
( 8 ) 克服临床耐药的新型抗肿瘤药物研究, 参与, 省级, 2015-08--2020-08
( 9 ) 针对重大疾病的多组学大数据平台集成与应用, 参与, 省级, 2014-11--2017-12

指导学生

已指导学生

周洋  硕士研究生  078001-药物化学  

王蕊  硕士研究生  085216-化学工程  

向秋萍  硕士研究生  085216-化学工程  

莫程  博士研究生  100701-药物化学  

李学强  博士研究生  100701-药物化学  

谈理  博士研究生  100701-药物化学  

余蕾  博士研究生  100701-药物化学  

现指导学生

薛晓纤  博士研究生  100701-药物化学  

张茂风  博士研究生  100701-药物化学  

胡清清  博士研究生  100701-药物化学  

向秋萍  博士研究生  100701-药物化学  

张岩  博士研究生  100701-药物化学  

寻秋菊  博士研究生  100701-药物化学  

朱东盛  博士研究生  100701-药物化学  

黄敏浩  博士研究生  100701-药物化学  

崔圣阳  博士研究生  100701-药物化学  

罗国龙  硕士研究生  078001-药物化学  

邹龄娇   硕士研究生  078001-药物化学  

吴锡山  博士研究生  100701-药物化学  

卢吉布  博士研究生  100701-药物化学  

师语聃  硕士研究生  078001-药物化学  

沈慧  硕士研究生  078001-药物化学  

李俊骅  硕士研究生  078001-药物化学