基本信息
蔡文通 男 中国科学院深圳先进技术研究院
电子邮件： wt.cai@siat.ac.cn
通信地址： 广东省深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码： 518055
电子邮件： wt.cai@siat.ac.cn
通信地址： 广东省深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码： 518055
研究领域
细菌（包括病原菌和益生菌）与宿主互作机理；病原菌致病机制与宿主免疫机理；基于细菌信号转导系统的生物传感器的构建与应用。
招生信息
欢迎生物工程、微生物学、生物信息学、兽医学等相关专业的同学报考！有上进心、勤奋努力的同学优先考虑。
教育背景
2009-09--2017-06 南京农业大学-美国艾奥瓦州立大学 博士
2006-09--2009-06 南京农业大学 硕士
2002-09--2006-06 南京农业大学 学士
2006-09--2009-06 南京农业大学 硕士
2002-09--2006-06 南京农业大学 学士
工作经历
工作简历
2017-07~2023-05,中国农业科学院哈尔滨兽医研究所, 助理研究员与副研究员
专利与奖励
2013 校长颁发“优秀科研奖”，艾奥瓦州立大学
2011 促专业发展奖学金(PAG)， 艾奥瓦州立大学
2009-2013 植物研究所奖学金（Fellowship），艾奥瓦州立大学
专利成果
（ 1 ） 一种细菌限制-修饰系统及其应用, 发明专利, 2021, 第 1 作者, 专利号: CN113265380A
（ 2 ） 与布氏杆菌毒力相关的基因及其在布氏杆菌毒力评价及制备弱毒布氏杆菌中的应用, 发明专利, 2021, 第 1 作者, 专利号: CN112941088A
（ 2 ） 与布氏杆菌毒力相关的基因及其在布氏杆菌毒力评价及制备弱毒布氏杆菌中的应用, 发明专利, 2021, 第 1 作者, 专利号: CN112941088A
出版信息
发表论文
[1] Dongfang Zhao, Haobo Zhang, Xinyang Zhang, Fengwei Jiang, Yijing Li, Wentong Cai, Ganwu Li. The virulence regulator AbsR in avian pathogenic Escherichia coli has pleiotropic effects on bacterial physiology. JOURNAL OF INTEGRATIVE AGRICULTURE[J]. 2024, 第 6 作者 通讯作者 23(2): 649-668, http://dx.doi.org/10.1016/j.jia.2023.07.035.
[2] Yang, Dawei, Yang, Yongwu, Qiao, Pengfei, Jiang, Fengwei, Zhang, Xinyang, Zhao, Zihui, Cai, Tao, Li, Ganwu, Cai, Wentong. Genomic Island-Encoded Histidine Kinase and Response Regulator Coordinate Mannose Utilization with Virulence in Enterohemorrhagic Escherichia coli. MBIO[J]. 2023, 第 9 作者 通讯作者 14(2): http://dx.doi.org/10.1128/mbio.03152-22.
[3] Fengwei Jiang, Yan Yang, Zhao Mao, Wentong Cai, Ganwu Li. ArcA positively regulates the expression of virulence genes and contributes to virulence of porcine Shiga toxin-producing enterotoxigenic Escherichia coli. MICROBIOLOGY SPECTRUM[J]. 2023, 第 4 作者 通讯作者 11(6): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714933/.
[4] Liu, Yingyu, Li, Huoming, Chen, Xuhua, Tong, Panpan, Zhang, Yan, Zhu, Mingyue, Su, Zhanqiang, Yao, Gang, Li, Ganwu, Cai, Wentong. Characterization of Shiga toxin-producing Escherichia coli isolated from Cattle and Sheep in *** province, China, using whole-genome sequencing. TRANSBOUNDARY AND EMERGING DISEASES[J]. 2022, 第 10 作者 通讯作者 69(2): 413-422, http://dx.doi.org/10.1111/tbed.13999.
[5] Li, Huoming, Hu, Sen, Yan, Xin, Yang, Yan, Liu, Wenxing, Bu, Zhigao, Li, Ganwu, Cai, Wentong. An Extracytoplasmic Function Sigma/Anti-Sigma Factor System Regulates Hypochlorous Acid Resistance and Impacts Expression of the Type IV Secretion System in Brucella melitensis. JOURNAL OF BACTERIOLOGY[J]. 2021, 第 8 作者 通讯作者 203(12): http://dx.doi.org/10.1128/JB.00127-21.
[6] Zhang, Xinyang, Huang, Dongyan, Zhao, Zihui, Cai, Xuwang, Cai, Wentong, Li, Ganwu. Bis-molybdopterin guanine dinucleotide modulates hemolysin expression under anaerobiosis and contributes to fitness in vivo in uropathogenic Escherichia coli. MOLECULAR MICROBIOLOGY[J]. 2021, 第 5 作者 通讯作者 116(4): 1216-1231, http://dx.doi.org/10.1111/mmi.14809.
[7] Chen, Xuhua, Liu, Wenxing, Li, Huoming, Yan, Shigan, Jiang, Fengwei, Cai, Wentong, Li, Ganwu. Whole genome sequencing analysis of avian pathogenic Escherichia coli from China. VETERINARY MICROBIOLOGY[J]. 2021, 第 6 作者 通讯作者 259: http://dx.doi.org/10.1016/j.vetmic.2021.109158.
[8] Yang, Dawei, Jiang, Fengwei, Huang, Xinxin, Li, Ganwu, Cai, Wentong. Transcriptomic and Metabolomic Profiling Reveals That KguR Broadly Impacts the Physiology of Uropathogenic Escherichia coli Under in vivo Relevant Conditions. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 5 作者 通讯作者 12: http://dx.doi.org/10.3389/fmicb.2021.793391.
[9] Gu, Hongwei, Cai, Xuwang, Zhang, Xinyang, Luo, Jie, Zhang, Xiaoyang, Hu, Xiao, Cai, Wentong, Li, Ganwu. A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis. PLOS PATHOGENS[J]. 2021, 第 7 作者 通讯作者 17(10): http://dx.doi.org/10.1371/journal.ppat.1010005.
[10] Yan, Xin, Hu, Sen, Yang, Yan, Xu, Da, Liu, Wenxing, Li, Ganwu, Cai, Wentong, Bu, Zhigao. Proteomics Investigation of the Time Course Responses of RAW264.7 Macrophages to Infections With the Wild-Type and Twin-Arginine Translocation Mutant Strains of Brucella melitensis. FRONTIERSINCELLULARANDINFECTIONMICROBIOLOGY[J]. 2021, 第 7 作者 通讯作者 11: http://dx.doi.org/10.3389/fcimb.2021.679571.
[11] Yan, Xin, Hu, Sen, Yang, Yan, Xu, Da, Li, Huoming, Liu, Wenxing, He, Xijun, Li, Ganwu, Cai, Wentong, Bu, Zhigao. The Twin-Arginine Translocation System Is Important for Stress Resistance and Virulence of Brucella melitensis. INFECTION AND IMMUNITY[J]. 2020, 第 9 作者 通讯作者 88(11): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573438/.
[12] Cai, Wentong, Cai, Xuwang, Yang, Yongwu, Yan, Shigan, Zhang, Haibin. Transcriptional Control of Dual Transporters Involved in alpha-Ketoglutarate Utilization Reveals Their Distinct Roles in Uropathogenic Escherichia coli. FRONTIERS IN MICROBIOLOGY[J]. 2017, 第 1 作者8: http://dx.doi.org/10.3389/fmicb.2017.00275.
[13] Cai, Wentong, Wannemuehler, Yvonne, DellAnna, Giuseppe, Nicholson, Bryon, Barbieri, Nicolle L, Kariyawasam, Subhashinie, Feng, Yaping, Logue, Catherine M, Nolan, Lisa K, Li, Ganwu. A Novel Two-Component Signaling System Facilitates Uropathogenic Escherichia coli's Ability to Exploit Abundant Host Metabolites. PLOS PATHOGENS[J]. 2013, 第 1 作者9(6): http://dx.doi.org/10.1371/journal.ppat.1003428.
[14] Cai, Tao, Cai, Wentong, Zhang, Jiang, Zheng, Huiming, Tsou, Amy M, Xiao, Lin, Zhong, Zengtao, Zhu, Jun. Host legume-exuded antimetabolites optimize the symbiotic rhizosphere. MOLECULAR MICROBIOLOGY[J]. 2009, 第 2 作者73(3): 507-517, https://www.webofscience.com/wos/woscc/full-record/WOS:000268792700015.
[2] Yang, Dawei, Yang, Yongwu, Qiao, Pengfei, Jiang, Fengwei, Zhang, Xinyang, Zhao, Zihui, Cai, Tao, Li, Ganwu, Cai, Wentong. Genomic Island-Encoded Histidine Kinase and Response Regulator Coordinate Mannose Utilization with Virulence in Enterohemorrhagic Escherichia coli. MBIO[J]. 2023, 第 9 作者 通讯作者 14(2): http://dx.doi.org/10.1128/mbio.03152-22.
[3] Fengwei Jiang, Yan Yang, Zhao Mao, Wentong Cai, Ganwu Li. ArcA positively regulates the expression of virulence genes and contributes to virulence of porcine Shiga toxin-producing enterotoxigenic Escherichia coli. MICROBIOLOGY SPECTRUM[J]. 2023, 第 4 作者 通讯作者 11(6): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10714933/.
[4] Liu, Yingyu, Li, Huoming, Chen, Xuhua, Tong, Panpan, Zhang, Yan, Zhu, Mingyue, Su, Zhanqiang, Yao, Gang, Li, Ganwu, Cai, Wentong. Characterization of Shiga toxin-producing Escherichia coli isolated from Cattle and Sheep in *** province, China, using whole-genome sequencing. TRANSBOUNDARY AND EMERGING DISEASES[J]. 2022, 第 10 作者 通讯作者 69(2): 413-422, http://dx.doi.org/10.1111/tbed.13999.
[5] Li, Huoming, Hu, Sen, Yan, Xin, Yang, Yan, Liu, Wenxing, Bu, Zhigao, Li, Ganwu, Cai, Wentong. An Extracytoplasmic Function Sigma/Anti-Sigma Factor System Regulates Hypochlorous Acid Resistance and Impacts Expression of the Type IV Secretion System in Brucella melitensis. JOURNAL OF BACTERIOLOGY[J]. 2021, 第 8 作者 通讯作者 203(12): http://dx.doi.org/10.1128/JB.00127-21.
[6] Zhang, Xinyang, Huang, Dongyan, Zhao, Zihui, Cai, Xuwang, Cai, Wentong, Li, Ganwu. Bis-molybdopterin guanine dinucleotide modulates hemolysin expression under anaerobiosis and contributes to fitness in vivo in uropathogenic Escherichia coli. MOLECULAR MICROBIOLOGY[J]. 2021, 第 5 作者 通讯作者 116(4): 1216-1231, http://dx.doi.org/10.1111/mmi.14809.
[7] Chen, Xuhua, Liu, Wenxing, Li, Huoming, Yan, Shigan, Jiang, Fengwei, Cai, Wentong, Li, Ganwu. Whole genome sequencing analysis of avian pathogenic Escherichia coli from China. VETERINARY MICROBIOLOGY[J]. 2021, 第 6 作者 通讯作者 259: http://dx.doi.org/10.1016/j.vetmic.2021.109158.
[8] Yang, Dawei, Jiang, Fengwei, Huang, Xinxin, Li, Ganwu, Cai, Wentong. Transcriptomic and Metabolomic Profiling Reveals That KguR Broadly Impacts the Physiology of Uropathogenic Escherichia coli Under in vivo Relevant Conditions. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 5 作者 通讯作者 12: http://dx.doi.org/10.3389/fmicb.2021.793391.
[9] Gu, Hongwei, Cai, Xuwang, Zhang, Xinyang, Luo, Jie, Zhang, Xiaoyang, Hu, Xiao, Cai, Wentong, Li, Ganwu. A previously uncharacterized two-component signaling system in uropathogenic Escherichia coli coordinates protection against host-derived oxidative stress with activation of hemolysin-mediated host cell pyroptosis. PLOS PATHOGENS[J]. 2021, 第 7 作者 通讯作者 17(10): http://dx.doi.org/10.1371/journal.ppat.1010005.
[10] Yan, Xin, Hu, Sen, Yang, Yan, Xu, Da, Liu, Wenxing, Li, Ganwu, Cai, Wentong, Bu, Zhigao. Proteomics Investigation of the Time Course Responses of RAW264.7 Macrophages to Infections With the Wild-Type and Twin-Arginine Translocation Mutant Strains of Brucella melitensis. FRONTIERSINCELLULARANDINFECTIONMICROBIOLOGY[J]. 2021, 第 7 作者 通讯作者 11: http://dx.doi.org/10.3389/fcimb.2021.679571.
[11] Yan, Xin, Hu, Sen, Yang, Yan, Xu, Da, Li, Huoming, Liu, Wenxing, He, Xijun, Li, Ganwu, Cai, Wentong, Bu, Zhigao. The Twin-Arginine Translocation System Is Important for Stress Resistance and Virulence of Brucella melitensis. INFECTION AND IMMUNITY[J]. 2020, 第 9 作者 通讯作者 88(11): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573438/.
[12] Cai, Wentong, Cai, Xuwang, Yang, Yongwu, Yan, Shigan, Zhang, Haibin. Transcriptional Control of Dual Transporters Involved in alpha-Ketoglutarate Utilization Reveals Their Distinct Roles in Uropathogenic Escherichia coli. FRONTIERS IN MICROBIOLOGY[J]. 2017, 第 1 作者8: http://dx.doi.org/10.3389/fmicb.2017.00275.
[13] Cai, Wentong, Wannemuehler, Yvonne, DellAnna, Giuseppe, Nicholson, Bryon, Barbieri, Nicolle L, Kariyawasam, Subhashinie, Feng, Yaping, Logue, Catherine M, Nolan, Lisa K, Li, Ganwu. A Novel Two-Component Signaling System Facilitates Uropathogenic Escherichia coli's Ability to Exploit Abundant Host Metabolites. PLOS PATHOGENS[J]. 2013, 第 1 作者9(6): http://dx.doi.org/10.1371/journal.ppat.1003428.
[14] Cai, Tao, Cai, Wentong, Zhang, Jiang, Zheng, Huiming, Tsou, Amy M, Xiao, Lin, Zhong, Zengtao, Zhu, Jun. Host legume-exuded antimetabolites optimize the symbiotic rhizosphere. MOLECULAR MICROBIOLOGY[J]. 2009, 第 2 作者73(3): 507-517, https://www.webofscience.com/wos/woscc/full-record/WOS:000268792700015.
科研活动
科研项目
（ 1 ） 病原菌毒力因子组织嗜性的机制研究, 参与, 地方任务, 2023-11--2026-11