100703-生药学
100800-中药学
071005-微生物学

天然产物鉴定及生物合成
酶催化机制
合成生物学

2013-09--2018-12   中国科学院植物生理生态研究所   博士
2009-09--2013-07   山东农业大学   学士

   

2019-03~2022-03,佛罗里达大学, 博后

   

（1） 博士研究生国家奖学金, 国家级, 2018
（2） 地奥奖学金, 二等奖, 院级, 2018

[1] 徐宝福, 陈宝, 刘丽君, 赵耀. 生产 GGPP 的工程菌和生产伪蕨素前体的工程菌、方法及应用. 202310288666.0, 2023-03-23.
[2] 肖友利, 徐宝福. 新型蛇足石杉来源的赖氨酸脱羧酶及其编码基因和应用. CN: CN107974444A, 2018-05-01.

   

[1] Jia-Ling Lin, Xin Fang, Jian-Xu Li, Zhi-Wen Chen, Wen-Kai Wu, Xiao-Xiang Guo, Ning-Jing Liu, Jia-Fa Huang, Fang-Yan Chen, Ling-Jian Wang, Baofu Xu, Cathie Martin, Xiao-Ya Chen, Jin-Quan Huang. Dirigent gene editing of gossypol enantiomers for toxicity-depleted cotton seeds. Nature Plants[J]. 2023, 9: 605-615, https://doi.org/10.1038/s41477-023-01376-2.
[2] Ran Zou, Bao Chen, Jie Sun, YueWei Guo, Baofu Xu. Recent advances of activation techniques-based discovery of new compounds from marine fungi. FITOTERAPIA. 2023, 167: http://dx.doi.org/10.1016/j.fitote.2023.105503.
[3] Zining Li, Baofu Xu, Volga Kojasoy, Teresa Ortega, Donovon A Adpressa, Wenbo Ning, Xiuting Wei, Jamin Liu, Dean J Tantillo, Sandra Loesgen, Jeffrey D Rudolf. First trans-eunicellane terpene synthase in bacteria. CHEM[J]. 2023, 9(3): 698-708, http://dx.doi.org/10.1016/j.chempr.2022.12.006.
[4] Wu, MengJun, Xu, Baofu, Guo, YueWei. Unusual Secondary Metabolites from the Mangrove Ecosystems: Structures, Bioactivities, Chemical, and Bio-Syntheses. MARINE DRUGSnull. 2022, 20(8): http://dx.doi.org/10.3390/md20080535.
[5] 徐宝福. Mutation of the eunicellane synthase Bnd4 alters its product profile and expands its prenylation ability. ORGANIC & BIOMOLECULAR CHEMISTRY[J]. 2022, https://pubs.rsc.org/en/content/articlelanding/2022/OB/D2OB01931K.
[6] Zeng, ZiRong, Chen, Jing, Wang, Hong, Zhang, HaiYan, Li, Jia, Xu, Baofu, Guo, YueWei. Bioactive Cembranoids from the Coral Sarcophyton trocheliophorum of Ximao Island. ACS OMEGA[J]. 2022, 7(45): 41678-41686, http://dx.doi.org/10.1021/acsomega.2c05687.
[7] Xu, Baofu, Tantillo, Dean J, Rudolf, Jeffrey D. Mechanistic Insights into the Formation of the 6,10-Bicyclic Eunicellane Skeleton by the Bacterial Diterpene Synthase Bnd4. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(43): 23159-23163, http://dx.doi.org/10.1002/anie.202109641.
[8] Xu, Baofu, Li, Zining, Alsup, Tyler A, Ehrenberger, Michelle A, Rudolf, Jeffrey D. Bacterial Diterpene Synthases Prenylate Small Molecules. ACS CATALYSIS[J]. 2021, 11(10): 5906-5915, http://dx.doi.org/10.1021/acscatal.1c01113.
[9] Rudolf, Jeffrey D, Alsup, Tyler A, Xu, Baofu, Li, Zining. Bacterial terpenome. NATURAL PRODUCT REPORTS[J]. 2021, 38(5): 905-980, http://dx.doi.org/10.1039/d0np00066c.
[10] Zhu, Chenxi, Xu, Baofu, Adpressa, Donovon A, Rudolf, Jeffrey D, Loesgen, Sandra. Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(25): 14163-14170, http://dx.doi.org/10.1002/anie.202102453.
[11] Ping, Yu, Li, Xiaodong, Xu, Baofu, Wei, Wei, Wei, Wenping, Kai, Guoyin, Zhou, Zhihua, Xiao, Youli. Building Microbial Hosts for Heterologous Production of N-Methylpyrrolinium. ACS SYNTHETIC BIOLOGY[J]. 2019, 8(2): 257-263, [12] Xu, Baofu, Fan, Zhen, Lei, Yongxing, Ping, Yu, Jaisi, Amit, Xiao, Youli. Insights into Pipecolic Acid Biosynthesis in Huperzia serrata. ORGANIC LETTERS[J]. 2018, 20(8): 2195-2198, https://www.webofscience.com/wos/woscc/full-record/WOS:000430898200016.
[13] He, Nisha, Wu, Pan, Lei, Yongxing, Xu, Baofu, Zhu, Xiaochen, Xu, Gudan, Gao, Yaojie, Qi, Jianzhao, Deng, Zixin, Tang, Gongli, Chen, Wenqing, Xiao, Youli. Construction of an octosyl acid backbone catalyzed by a radical S-adenosylmethionine enzyme and a phosphatase in the biosynthesis of high-carbon sugar nucleoside antibiotics. CHEMICAL SCIENCE[J]. 2017, 8(1): 444-451, https://www.webofscience.com/wos/woscc/full-record/WOS:000391454500051.
[14] Xu, Baofu, Lei, Lei, Zhu, Xiaocen, Zhou, Yiqing, Xiao, Youli. Identification and characterization of L-lysine decarboxylase from Huperzia serrata and its role in the metabolic pathway of lycopodium alkaloid. PHYTOCHEMISTRY[J]. 2017, 136: 23-30, http://dx.doi.org/10.1016/j.phytochem.2016.12.022.
[15] Yang, Mengquan, You, Wenjing, Wu, Shiwen, Fan, Zhen, Xu, Baofu, Zhu, Mulan, Li, Xuan, Xiao, Youli. Global transcriptome analysis of Huperzia serrata and identification of critical genes involved in the biosynthesis of huperzine A. BMC GENOMICS[J]. 2017, 18(1): http://dx.doi.org/10.1186/s12864-017-3615-8.

   

（ 1 ） 深海生物来源药源分子的高效发现与候选药物研究, 负责人, 国家任务, 2022-11--2025-10
（ 2 ） 科研启动经费, 负责人, 其他任务, 2022-06--2027-06

现指导学生

马梁  硕士研究生  105500-药学