基本信息
成文翔  女  硕导  中国科学院深圳先进技术研究院
电子邮件: wx.cheng@siat.ac.cn
通信地址: 广东省深圳市南山区学苑大道1068号
邮政编码:

研究领域

炎性骨病、药物治疗、破骨功能、蛋白质结构

招生信息

   
招生专业
071010-生物化学与分子生物学
071009-细胞生物学
0710J3-生物信息学
招生方向
破骨发育,炎症,中药药理机制,组织工程

教育背景

2016-09--2020-07   中国科学院大学   博士
2004-09--2007-07   汕头大学   硕士

工作经历

   
工作简历
2011-01~现在, 中国科学院深圳先进技术研究院, 副研究员
2007-07~2011-01,阿斯利康中国创新中心, 助理科学家

专利与奖励

   
奖励信息
(1) 3D打印个性化骨缺损修复植入体关键技术与临床应用, 二等奖, 省级, 2021
专利成果
[1] 成文翔, 王新峦, 张鹏, 孟祥波. 葫芦素E在制备治疗血管新生不足相关疾病药物或生物医用材料中的用途和应用其的产品. CN: CN109157537B, 2021-02-19.
[2] 王新峦, 张鹏, 成文翔. 一种用于治疗心肌缺血的生物医用材料. CN: CN112220793A, 2021-01-15.
[3] 张鹏, 王新峦, 成文翔. 葫芦素E在制备治疗闭塞性脉管炎药物或生物医用材料中的用途和应用其的产品. CN: CN112057458A, 2020-12-11.
[4] 王新峦, 张鹏, 成文翔. 葫芦素E在制备治疗侧支循环代偿建立不足药物或生物医用材料中的用途和应用其的产品. CN: CN112022861A, 2020-12-04.
[5] 张鹏, 甘东浩, 成文翔, 柯丽青. 吡非尼酮在制备防治类风湿性关节炎的药物中的应用. CN: CN111991393A, 2020-11-27.
[6] 张鹏, 甘东浩, 成文翔, 柯丽青. 吡非尼酮在制备促血管生成药物中的应用. CN: CN111166748A, 2020-05-19.
[7] 张鹏, 李健, 白雪岭, 成文翔, 王新峦, 赖毓霄. 镁锶-磷酸硅盐材料及制备方法、包含其的结构可控的多孔骨修复复合支架材料. CN: CN110776315A, 2020-02-11.
[8] 黄欢, 张鹏, 成文翔, 虎义平, 郑钲坛, 陈健海. 静蹲辅助器. 中国: CN207856197U, 2018.09.14.
[9] 张鹏, 虎义平, 马应亚, 岳野, 成文翔, 汪洁. 一种炎症伴发骨折复合疾病动物模型及其构建方法和应用. 中国: CN105769371A, 2016-07-20.
[10] 王新峦, 秦岭, 赖毓霄, 曹会娟, 李玲, 李龙, 成文翔, 张鹏. 一种生物复合材料及其制备方法. 中国: CN105727374A, 2016-07-06.
[11] 张鹏, 汪洁, 李金超, 岳野, 成文翔, 虎义平, 马应亚. 一种治疗类风湿性关节炎的药物组合物、制备方法及其贴剂. 中国: CN104547472A, 2015-04-29.

出版信息

   
发表论文
[1] Gan, Donghao, Cheng, Wenxiang, Ke, Liqing, Sun, Antonia RuJia, Jia, Qingyun, Chen, Jianhai, Lin, Jietao, Li, Jian, Xu, Zhanwang, Zhang, Peng. Repurposing of Pirfenidone (Anti-Pulmonary Fibrosis Drug) for Treatment of Rheumatoid Arthritis. FRONTIERS IN PHARMACOLOGY[J]. 2021, 12: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7973213/.
[2] Chen, Jianhai, Li, Jian, Chen, Jinqing, Cheng, Wenxiang, Lin, Jietao, Ke, Liqing, Liu, Gang, Bai, Xueling, Zhang, Peng. Treatment of collagen-induced arthritis rat model by using Notch signalling inhibitor. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2021, 28: 100-107, http://dx.doi.org/10.1016/j.jot.2021.01.003.
[3] Cheng, Wenxiang, Gan, Donghao, Hu, Yiping, Zheng, Zhengtan, Zeng, Qingqiang, Li, Ling, Wang, Xinluan, Zhang, Yong, Xu, Zhanwang, Qin, Ling, Zhang, Peng. The effect and mechanism of QufengZhitong capsule for the treatment of osteoarthritis in a rat model. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2021, 28: 65-73, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7932897/.
[4] 成文翔. 葫芦素在骨组织工程血管化中的作用及机制研究. 2020, [5] Cheng, WenXiang, Zhong, Shan, Meng, XiangBo, Zheng, NianYe, Zhang, Peng, Wang, Yun, Qin, Ling, Wang, XinLuan. Cinnamaldehyde Inhibits Inflammation of Human Synoviocyte Cells Through Regulation of Jak/Stat Pathway and Ameliorates Collagen-Induced Arthritis in Rats. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS[J]. 2020, 373(2): 302-310, https://www.webofscience.com/wos/woscc/full-record/WOS:000551155200016.
[6] Hu, Yiping, Zhang, Tiantian, Chen, Jingqin, Cheng, WenXiang, Chen, Jianhai, Zheng, Zhengtan, Lin, Jietao, Zhu, Guoyuan, Zhang, Yong, Bai, Xueling, Wang, Yan, Song, Bing, Wang, Qingwen, Qin, Ling, Zhang, Peng. Downregulation of Hypoxia-Inducible Factor-1 alpha by RNA Interference Alleviates the Development of Collagen-Induced Arthritis in Rats. MOLECULAR THERAPY-NUCLEIC ACIDS[J]. 2020, 19: 1330-1342, https://www.webofscience.com/wos/woscc/full-record/WOS:000519557700109.
[7] Li, Ling, Yi, Xiaomin, Huang, Cuishan, Shi, Keda, Wang, Jiani, Zeng, Qingqiang, Cheng, Wenxiang, He, Xiangjiu, Zhang, Peng, Qiu, Guixing, Qin, Ling, Wang, Xinluan. Qu Feng Zhi Tong capsule increases mechanical properties of cortical bone in ovariectomised rats. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2020, 25: 115-124, http://dx.doi.org/10.1016/j.jot.2020.02.001.
[8] Cheng, WenXiang, Huang, Huan, Chen, JianHai, Zhang, TianTian, Zhu, GuoYuan, Zheng, ZhengTan, Lin, JieTao, Hu, YiPing, Zhang, Yong, Bai, XueLing, Wang, Yan, Xu, ZhanWang, Song, Bing, Mao, YiYing, Yang, Fei, Zhang, Peng. Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway. JOURNAL OF ORTHOPAEDIC TRANSLATION[J]. 2020, 22: 92-100, https://www.webofscience.com/wos/woscc/full-record/WOS:000536593000013.
[9] 林结桃, 李健, 成文翔, SUN, Antonia, 陈建海, 柯丽青, 甘东浩, 张鹏. THP-1源巨噬细胞上清液对类风湿性关节炎成纤维细胞和血管内皮细胞的作用. 集成技术. 2020, 9(4): 1-10, http://lib.cqvip.com/Qikan/Article/Detail?id=7102508635.
[10] Peng, Lihua, Xing, Rui, Liu, Dongbing, Bao, Li, Cheng, Wenxiang, Wang, Hongyi, Yu, Yuan, Liu, Xiaofeng, Jiang, Lu, Wu, Yan, An, Zhongxue, Liang, Qiaoyi, Kim, Ryong Nam, Shin, Young Kee, Yang, Huanming, Wang, Jian, Yu, Jun, Zhang, Xiuqing, Xu, Xun, Yang, Jiaan, Wu, Kui, Zhu, Shida, Lu, Youyong. Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing. SCIENCE BULLETIN[J]. 2019, 64(4): 236-244, http://lib.cqvip.com/Qikan/Article/Detail?id=7001689597.
[11] Lihua Peng, Rui Xing, Dongbing Liu, Li Bao, Wenxiang Cheng, Hongyi Wang, Yuan Yu, Xiaofeng Liu, Lu Jiang, Yan Wu, Zhongxue An, Qiaoyi Liang, Ryong Nam Kim, Young Kee Shin, Huanming Yang, Jian Wang, Jun Yu, Xiuqing Zhang, Xun Xu, Jiaan Yang, Kui Wu, Shida Zhu, Youyong Lu. Characterization and validation of somatic mutation spectrum to reveal heterogeneity in gastric cancer by single cell sequencing. 科学通报:英文版[J]. 2019, 64(4): 236-244, http://lib.cqvip.com/Qikan/Article/Detail?id=7001689597.
[12] Hu, Yiping, Zhang, Tiantian, Huang, Huan, Cheng, Wenxiang, Lai, Yuxiao, Bai, Xueling, Chen, Jianhai, Yue, Ye, Zheng, Zhengtan, Guo, Chengshan, Qin, Ling, Zhang, Peng. Fracture healing in a collagen-induced arthritis rat model: Radiology and histology evidence. JOURNAL OF ORTHOPAEDIC RESEARCH[J]. 2018, 36(11): 2876-2885, http://ir.siat.ac.cn:8080/handle/172644/14424.
[13] Huang, Huan, Cheng, WenXiang, Hu, YiPing, Chen, JianHai, Zheng, ZhengTan, Zhang, Peng. Relationship between heterotopic ossification and traumatic brain injury Why severe traumatic brain injury increases the risk of heterotopic ossification. JOURNAL OF ORTHOPAEDIC TRANSLATIONnull. 2018, 12: 16-25, http://ir.siat.ac.cn:8080/handle/172644/14420.
[14] Wang, Jiali, Xu, Jiankun, Fu, Weimin, Cheng, Wenxiang, Chan, Kaiming, Yung, Patrick Shuhang, Qin, Ling. Biodegradable Magnesium Screws Accelerate Fibrous Tissue Mineralization at the Tendon-Bone Insertion in Anterior Cruciate Ligament Reconstruction Model of Rabbit. SCIENTIFIC REPORTS[J]. 2017, 7: http://www.chinair.org.cn/handle/1471x/1747585.
[15] Jia, Qingyun, Cheng, Wenxiang, Yue, Ye, Hu, Yipping, Zhang, Jian, Pan, Xiaohua, Xu, Zhanwang, Zhang, Peng. Cucurbitacin E inhibits TNF-alpha-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-kappa B pathways. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2015, 29(2): 884-890, https://www.webofscience.com/wos/woscc/full-record/WOS:000366764800082.
[16] 马应亚, 岳野, 虎义平, 成文翔, 汪洁, 王均, 张鹏. 骨折愈合的影响因素概述. 中国当代医药. 2015, 22(11): 25-30, http://lib.cqvip.com/Qikan/Article/Detail?id=664529774.
[17] 汪洁, 汪洁, 岳野, 成文翔, 虎义平, 马应亚, 王均, 张鹏. 类风湿性关节炎与IL-1/IL-1Ra平衡关系的研究进展. 中国当代医药. 2015, 22(12): 30-35, http://lib.cqvip.com/Qikan/Article/Detail?id=664595383.
[18] Yue, Ye, Liu, Ruoxi, Cheng, Wenxiang, Hu, Yiping, Li, Jinchao, Pan, Xiaohua, Peng, Jiang, Zhang, Peng. GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-kappa B signaling pathway through the alpha 7 nicotinic acetylcholine receptor. INTERNATIONAL IMMUNOPHARMACOLOGY[J]. 2015, 29(2): 504-512, https://www.webofscience.com/wos/woscc/full-record/WOS:000366764800034.
[19] Li, Jinchao, Li, Jun, Yue, Ye, Hu, Yiping, Cheng, Wenxiang, Liu, Ruoxi, Pan, Xiaohua, Zhang, Peng. Genistein suppresses tumor necrosis factor alpha-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor kappa B and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells. DRUG DESIGN DEVELOPMENT AND THERAPY[J]. 2014, 8: 315-323, https://doaj.org/article/89419d2cc3d940ccab5d81b02ee618b9.
[20] Zhang, QingYing, Cheng, WenXiang, Li, WenMei, Au, William, Lu, YouYong. Occurrence of low frequency PIK3CA and AKT2 mutations in gastric cancer. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS[J]. 2014, 769: 108-112, http://dx.doi.org/10.1016/j.mrfmmm.2014.07.007.
[21] Hu, Yiping, Liu, Ruoxi, Li, Jinchao, Yue, Ye, Cheng, Wenxiang, Zhang, Peng. Attenuation of Collagen-Induced Arthritis in Rat by Nicotinic Alpha7 Receptor Partial Agonist GTS-21. BIOMED RESEARCH INTERNATIONAL[J]. 2014, 2014: https://doaj.org/article/c5298f09d30744e18802a1a853a162f4.
[22] Li, Jinchao, Li, Jun, Yue, Ye, Hu, Yiping, Cheng, Wenxiang, Liu, Ruoxi, Pan, Xiaohua, Zhang, Peng. Genistein suppresses tumor necrosis factor alpha-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor kappa B and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells. DRUG DESIGN DEVELOPMENT AND THERAPY[J]. 2014, 8: 315-323, https://doaj.org/article/89419d2cc3d940ccab5d81b02ee618b9.
[23] Hu, Yiping, Cheng, Wenxiang, Cai, Wenhong, Yue, Ye, Li, Jinchao, Zhang, Peng. Advances in research on animal models of rheumatoid arthritis. CLINICAL RHEUMATOLOGYnull. 2013, 32(2): 161-165, https://www.webofscience.com/wos/woscc/full-record/WOS:000314709200002.
[24] Li, Jinchao, Gang, Dong, Yu, Xiaowei, Hu, Yiping, Yue, Ye, Cheng, Wenxiang, Pan, Xiaohua, Zhang, Peng. Genistein: the potential for efficacy in rheumatoid arthritis. CLINICAL RHEUMATOLOGYnull. 2013, 32(5): 535-540, https://www.webofscience.com/wos/woscc/full-record/WOS:000319459200002.
[25] Wang, Nan, Wang, Xinluan, Cheng, Wenxiang, Cao, Huijuan, Zhang, Peng, Qin, Ling. Puerarin promotes osteogenesis and inhibits adipogenesis in vitro. CHINESE MEDICINE[J]. 2013, 8(1): 17-17, http://dx.doi.org/10.1186/1749-8546-8-17.
[26] Cheng, Wenxiang, Yue, Ye, Fan, Wenbin, Hu, Yiping, Wang, Xinluan, Pan, Xiaohua, Zhou, Xiaoxiao, Qin, Ling, Zhang, Peng. Effects of tetracyclines on bones: an ambiguous question needs to be clarified. PHARMAZIEnull. 2012, 67(5): 457-459, [27] 蔡文虹, 孙保东, 张宝凤, 岳野, 成文翔, 李金超, 虎义平, 张鹏. 尕代类风湿关节炎成纤维样滑膜细胞及成熟细胞系生长特性的比较. 中国当代医药. 2012, 19(20): 8-9, http://lib.cqvip.com/Qikan/Article/Detail?id=42624170.
[28] 蔡文虹, 孙保东, 张宝凤, 岳野, 成文翔, 虎义平, 张鹏. 类风湿性关节炎病因学概述. 中国当代医药. 2012, 19(5): 11-12, http://lib.cqvip.com/Qikan/Article/Detail?id=40876213.
[29] 蔡文虹, 孙保东, 张宝凤, 成文翔, 虎义平, 岳野, 张鹏. 中医在类风湿性关节炎治疗中的应用. 中国当代医药. 2012, 19(7): 10-11, http://lib.cqvip.com/Qikan/Article/Detail?id=41377477.
[30] 蔡文虹, 孙保东, 张宝凤, 成文翔, 岳野, 虎义平, 李金超, 张鹏. 两种方法分离培养类风湿性关节炎成纤维样滑膜细胞的比较. 中国当代医药. 2012, 19(21): 13-14, http://lib.cqvip.com/Qikan/Article/Detail?id=43927778.
[31] 蔡文虹, 孙保东, 张宝凤, 虎义平, 成文翔, 岳野, 张鹏. 类风湿性关节炎动物模型研究进展. 中国当代医药. 2012, 19(4): 10-12, http://lib.cqvip.com/Qikan/Article/Detail?id=40882407.
[32] Hu, Yiping, Tang, Guping, Liu, Jun, Cheng, Wenxiang, Yue, Ye, Li, Jinchao, Zhang, Peng. FGF Receptor-Mediated Gene Delivery Using Ligands Coupled to PEI-beta-CyD. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY[J]. 2012, https://www.webofscience.com/wos/woscc/full-record/WOS:000303736400001.