光声内窥成像系统的开发及应用；新型微小光学元件的设计与开发

可招收光学和光学工程；电子信息工程；机械工程；图像处理方向的学生若干名

080300-光学工程

光声成像

2012-12--2016-07   勃艮第-弗朗士-孔泰大学   博士
2009-09--2012-12   中国科学院长春光学精密机械与物理研究所   硕士
2005-09--2009-06   山东师范大学   学士

博士研究生

博士

   

2022-01~现在, 中国科学院深圳先进技术研究院, 副研究员
2016-10~2021-12,中国科学院深圳先进技术研究院, 助理研究员
2012-02~2012-11,深圳华星光电有限公司, 助理工程师

   

（ 1 ） 一种光声内窥成像装置及基于该装置的光声内窥成像方法, 发明专利, 2021, 第 2 作者, 专利号: CN112493997A

（ 2 ） 超声探头、内窥镜、内窥成像系统以及内窥成像方法, 发明专利, 2021, 第 4 作者, 专利号: CN112450882A

（ 3 ） 血管内窥成像装置, 发明专利, 2021, 第 3 作者, 专利号: CN112515631A

   

[1] Xie, Zhihua, Liu, Jiamei, Ren, Yaguang, Huang, Jiqing, Lin, Riqiang, Wang, Xiatian, Tan, Qingyuan, Lv, Shengmiao, Song, Liang, Liu, Chengbo, Ma, Teng, Gong, Xiaojing. Circular array transducer based-photoacoustic/ultrasonic endoscopic imaging with tunable ring-beam excitation. PHOTOACOUSTICS[J]. 2023, 第 1 作者29: http://dx.doi.org/10.1016/j.pacs.2022.100441.
[2] Zhang, Jinke, Du, Meng, Fang, Jinghui, Lv, Shengmiao, Lou, Wenjin, Xie, Zhihua, Chen, Zhiyi, Gong, Xiaojing. In vivo evaluation of endometrium through dual-modality intrauterine endoscopy. BIOMEDICAL OPTICS EXPRESS[J]. 2022, 第 6 作者  通讯作者  13(5): 2554-2565, 
[3] Fangfang Liu, Yang Mao, Jiaqi Yan, Yu Sun, Zhihua Xie, 李飞, 严飞, Hongbo Zhang, Pengfei Zhang. Bionic Microbubble Neutrophil Composite for Inflammation-Responsive Atherosclerotic Vulnerable Plaque Pluripotent Intervention. RESEARCH[J]. 2022, 第 5 作者
[4] LENG, J, I, ZHANG, J I N K E, LI, C H E N G U A N G, SHU, C H E N G Y O U, WANG, B O Q U A N, LIN, R I Q I A N G, LIANG, Y A N M E I, WANG, K E Q I A N G, SHEN, L, I, LAM, KWOKHO, XIE, Z H I H U A, GONG, X I A O J I N G, GE, J U N B O, SONG, L I A N G. Multi-spectral intravascular photoacoustic/ultrasound/optical coherence tomography tri-modality system with a fully-integrated 0.9-mm full field-of-view catheter for plaque vulnerability imaging. BIOMEDICAL OPTICS EXPRESS[J]. 2021, 第 11 作者  通讯作者  12(4): 1934-1946, http://dx.doi.org/10.1364/BOE.420724.
[5] Lin, Lejian, Xie, Zhihua, Xu, Mengqi, Wang, Yabin, Li, Sulei, Yang, Ning, Gong, Xiaojing, Liang, Ping, Zhang, Xu, Song, Liang, Cao, Feng. IVUS\IVPA hybrid intravascular molecular imaging of angiogenesis in atherosclerotic plaques via RGDfk peptide-targeted nanoprobes. PHOTOACOUSTICS[J]. 2021, 第 2 作者22: https://doaj.org/article/62acafad1ade4905876b6a9baf8ed34c.
[6] Xie, Zhihua, Yang, Yanqing, He, Yaqiong, Shu, Chengyou, Chen, Dong, Zhang, Jinke, Chen, Jingqin, Liu, Chengbo, Sheng, Zonghai, Liu, Huadong, Liu, Jie, Gong, Xiaojing, Song, Liang, Dong, Shaohong. In vivo assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging. THERANOSTICS[J]. 2020, 第 1 作者10(10): 4694-4704, https://www.webofscience.com/wos/woscc/full-record/WOS:000522665800029.
[7] Shu, Chengyou, Xie, Zhihua, Yang, Daya, Chen, Zhiyi, Song, Liang, Gong, Xiaojing, Luo, Q, Li, X, Gu, Y, Tang, Y, Zhu, D. High-speed intravascular photoacoustic imaging with blood flushing. OPTICS IN HEALTH CARE AND BIOMEDICAL OPTICS IX. 2020, 第 2 作者11190: 
[8] Xie, Zhihua, Shu, Chengyou, Yang, Daya, Chen, Hao, Chen, Chaobin, Dai, Gang, Lam, Kwok Ho, Zhang, Jinke, Wang, Xiatian, Sheng, Zonghai, Gao, Duyang, Liu, Chengbo, Song, Liang, Gong, Xiaojing. In vivo intravascular photoacoustic imaging at a high speed of 100 frames per second. BIOMEDICAL OPTICS EXPRESS[J]. 2020, 第 1 作者11(11): 6721-6731, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7687943/.
[9] Xie, Zhihua, Shu, Chengyou, Gong, Xiaojing, Song, Liang, Luo, Q, Li, X, Gu, Y, Tang, Y, Zhu, D. Carotid atherosclerosis detection using photoacoustic imaging system. OPTICS IN HEALTH CARE AND BIOMEDICAL OPTICS IX. 2020, 第 1 作者11190: 
[10] Yang, Yanqing, Chen, Jingqin, Yang, Yuming, Xie, Zhihua, Song, Liang, Zhang, Peng, Liu, Chengbo, Liu, Jie. A 1064 nm excitable semiconducting polymer nanoparticle for photoacoustic imaging of gliomas. NANOSCALE[J]. 2019, 第 4 作者11(16): 7754-7760, 
[11] Chen, Jingqin, Li, Xueshen, Liu, Xiaoyang, Yan, Huixiang, Xie, Zhihua, Sheng, Zonghai, Gong, Xiaojing, Wang, Lidai, Liu, Xin, Zhang, Peng, Zheng, Hairong, Song, Liang, Liu, Chengbo. Hybrid MoSe2-indocyanine green nanosheets as a highly efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy. BIOMATERIALS SCIENCE[J]. 2018, 第 5 作者6(6): 1503-1516, https://www.webofscience.com/wos/woscc/full-record/WOS:000433604100019.
[12] Xie, Zhihua, Lefier, Yannick, Suarez, Miguel Angel, Mivelle, Mathieu, Salut, Roland, Merolla, JeanMarc, Grosjean, Thierry. Doubly Resonant Photonic Antenna for Single Infrared Quantum Dot Imaging at Telecommunication Wavelengths. NANO LETTERS[J]. 2017, 第 1 作者17(4): 2152-2158, https://www.webofscience.com/wos/woscc/full-record/WOS:000399354500007.
[13] Xie, Zhihua, Maradj, Hichem, Suarez, MiguelAngel, Viau, Lydie, Moutarlier, Virginie, Filiatre, Claudine, Fauquet, Carole, Tonneau, Didier, Grosjean, Thierry. Ultracompact x-ray dosimeter based on scintillators coupled to a nano-optical antenna. OPTICS LETTERS[J]. 2017, 第 1 作者42(7): 1361-1364, http://dx.doi.org/10.1364/OL.42.001361.

   

（ 1 ） 用于消化道肿瘤多维功能信息获取的大深度高分辨光声内窥成像, 负责人, 地方任务, 2021-01--2023-12
（ 2 ） 高速血管内光声/超声双模态成像系统, 负责人, 地方任务, 2018-03--2020-03
（ 3 ） 基于贝塞尔光束的大深度范围高分辨血管内光声成像方法的研究, 负责人, 国家任务, 2018-01--2020-12
（ 4 ） 基于贝塞尔光束激发的血管内光声成像方法的研究, 负责人, 国家任务, 2016-11--2018-12

现指导学生

蓝嘉乐  硕士研究生  085400-电子信息