Zhibin Wang

Ph.D., Full Professor,

Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS)

1068 Xueyuan Avenue, Shenzhen University Town, Xili, Nanshan, Shenzhen 518055, China. 

Research Areas

Epigenetic mechanisms of human growth and development, disease occurrence and development, and related epigenetic drug development


2000-2006  Ohio State University, USA   Ph.D in Horticulture and Crop science (Molecular Genetics and Biotechnology)

1995-1998  Biotechnology Research Institute, Chinese Academy of Agricultural Sciences (CAAS), China   M.S. in Molecular Biology

1988-1992  Qingdao Agricultural University, China   B.S. in Crop Science

Work Experience

2022-PresentSchool of Pharmaceutical Sciences, Shenzhen Institute of Advanced Technology Chinese Academy of Sciences, Full Professor

Center of Cancer Immunity Research, Institute of Biomedicine and Biotechnology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Researcher

2017-2022, Associate Professor

Johns Hopkins Bloomberg School of Public HealthEnvironmental Health and Engineering

Johns Hopkins University School of Medicine, Department of Cancer, Kimmel Comprehensive Cancer Center, Center for Epigenetics

2010-2017, Assistant Professor

Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health

Department of cancerology, Kimmel Comprehensive Cancer Center, Center for Epigenetics, Johns Hopkins University School of Medicine

2006-2010, Postdoctor

Molecular immunology department, Heart, Lung and Blood Institute, National Institutes of Health, USA

1998-2000, Assistant Researcher

Department of Molecular Biology, Institute of Biotechnology, Chinese Academy of Agricultural Sciences



1. Huang M, Lou D, Charli A, Kong D, Jin H, Anantharam V, Kanthasamy A, Wang Z†, and Kanthasamy AG†. Mitochondrial dysfunction induces epigenetic dysregulation by H3K27 hyperacetylation to perturb active enhancers in Parkinson’s disease models. JCI insight 2021 Sep 8; 6(17):e138088. doi: 10.1172/jci.insight.138088. PMID: 34494552. PMCID: PMC8492320 († co-correspondence author).

2. Freeman DM, Lou D, Li Y, Martos, SN, and Wang Z. The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure. Epigenetics and Chromatin 2020 Mar 16; 13(1):17. doi: 10.1186/s13072-020-00338-8 PMID: 32178731. PMC7076959.

3. Freeman DM, O’Neal R, Zhang Q, Bouwer E, and Wang Z. Manganese-induced Parkinsonism in mice is reduced using a novel contaminated water sediment exposure model. Environmental Toxicology and Pharmacology 2020 Aug;78:103399. doi: 10.1016/j.etap.2020.103399. PMID: 32380377.

4. Wu S, Lei L, Liu M, Song Y, Lu S, Lou D, Shi Y, Wang Z† , and He D† . Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism. Experimental Neurology 2018 Nov;309:67-78. doi: 10.1016/j.expneurol.2018.07.018. PMID:30076829. PMCID: PMC6579610 († co-correspondence author).

5. TaRGET II Consortium, Bartolomei MS, Walker CL, Tyson FL. The NIEHS TaRGET II Consortium and environmental epigenomes. Nature Biotechnology 2018, 36, 225-227. doi: 10.1038/nbt.4099. PMID: 29509741. PMCID: PMC5991835.

6. Zhu Y, Li Y , Lou D, Gao Y, Yu J, Kong D, Zhang Q, Jia Y, Zhang H, and Wang Z. Sodium arsenite exposure inhibits histone acetyltransferase p300 for attenuating H3K27ac at enhancers in mouse embryonic fibroblast cells. Toxicology and Applied Pharmacology 2018 Oct 15; 357:70-79. doi: 10.1016/j.taap.2018.08.011 PMID: 30130555. PMCID: PMC6526104.

7. Martos SN, Li T, Bossardi R, Lou D, Dai H, Xu J, Gao G, Wang Q, An C, Zhang X, Jia Y, Dawson V, Dawson TM, Ji HK, and Wang Z. Two approaches revealed a new paradigm of ‘switchable or genetics-influenced allele-specific DNA methylation (ASM)’ with potential in human disease. Cell Discovery 2017 Nov 14; 3:17038. doi: 10.1038/celldisc.2017.38. PMID: 29387450. PMCID: PMC5787696.

8. Dhar S, Lee SH, Chen K, Zhu G, Oh WK, Alton K, Gafni O, Kim YZ, Barton M, Hanna JH, Wang Z† , Li W† , Lee MG† . An essential role for UTX in resolution and activation of bivalent promoters. Nucleic Acids Research. 2016 May 5; 44(8):3659-74. doi: 10.1093/nar/gkv1516. ( †co-correspondence author) PMCID: PMC4856969.

9. Li N, Li Y, Lv J, Zheng X, Wen H, Shen H, Zhu G, Chen T-Y, Dhar SS, Kan PY, Wang Z, Shiekhattar R, Shi X, Lan F, Chen K, Li W, Li H, Lee MG. ZMYND8 reads the dual histone mark H3K4me1-H3K14ac to antagonize the expression of metastasis-linked genes. Molecular Cell 2016 Aug 4; 63(3):470-84. doi: 10.1016/j.molcel.2016.06.035. PMID: 27477906.

10. Li Z, Dai H, Martos SN, Xu B, Gao Y, Zhu G, Li T, Schones DE, and Wang Z. Distinct roles of DNMT1-dependent and DNMT1-independent methylation patterns in the genome of mouse embryonic stem cells. Genome Biology 2015 Jun 2; 16(1):115. doi: 10.1186/s13059-015-0685-2. PMID: 26032981. PMCID: PMC4474455.

11. Wu H, D'Alessio ACD, Ito S, Xia K, Wang Z, Cui K, Zhao K, Sun YE, and Zhang Y. Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells. Nature 2011 May 19; 473(7347):389-93. doi: 10.1038/nature09934.

12. Wu H, D'Alessio ACD, Ito S, Wang Z, Cui K, Zhao K, Sun YE, and Zhang Y. Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells. Genes & Development 2011 Apr 1; 25(7):679-84. doi: 10.1101/gad.2036011.

13. Qi HH, Sarkissian M, *Hu G-q, *Wang Z, Bhattacharjee A, Gordon DB, Lan F, Ongusaha PP, Huarte M, Yaghi NK, Lim H, Garcia BA, Brizuela L, Zhao K, Roberts TM, and Shi Y. Histone H3K9/H4K20 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature 2010 Jul 22; 466(7305):503-7. doi: 10.1038/nature09261 ( These authors contribute equally; * These authors contribute equally to ChIP-seq analyses) PMC3072215.

14. Daniel JA, *Santos MA, *Wang Z, *Zang C, Jankovic M, Gazumyan A, Kristopher R, Schwab KR, Yamane A, Filsuf D, Cho Y-W, Ge K, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, and Nussenzweig A. PTIP promotes chromatin changes critical for immunoglobulin switch recombination. Science 2010 Aug 20;329(5994):917-23. doi: 10.1126/science.1187942. (*Co-second author) PMC3008398.

15. Zhou J, Wang C, Wang Z, Dampier W, Wu K, Casimiro MC, Yu Z, Wang M, Liang B, Chepelev L, Popov VM, Sune C, Quong A, Lisanti MP, Tozeren A, Zhao K, and Pestell RG. Attenuation of forkhead signaling by the retinal determination factor DACH1. Proceedings of the National Academy of Sciences USA 2010 Apr 13;107(15):6864-9. doi: 10.1073/pnas.1002746107.

16. Wang Z, Zang C, Cui K, Schones DE, Barski A, Peng W, and Zhao K. Genome-wide mapping of HATs and HDACs reveals distinct 5unctions in active and inactive genes. Cell 2009 Sep 4;138(5):1019-31. doi: 10.1016/j.cell.2009.06.049. PMID:19698979. PMC2750862.

17. *Araki Y, *Wang Z, Zang C, Wood W III, Schones DE, Lhotsky B, Westo R, Peng W, Becker K, Zhao K, and Weng N-p. (2009) Genome-wide analysis of histone methylation reveals chromatin state-based complex regulation of gene transcription and function of memory CD8 + T cells. Immunity 2009 Jun 19;30(6):912-25. doi: 10.1016/j.immuni.2009.05.006 (* co-first author) PMID:19523850.

18. Wang Z, Zang C, Rosenfeld JA, Schones DE, Barski A, Cuddapah S, Cui K, Roh T-y, Peng W, Zhang M, Zhao K. (2008). Combinatorial patterns of histone acetylations and methylations in the human genome. Nature Genetics 2008 Jul;40(7):897-903. doi: 10.1038/ng.154 PMID:18552846.

19. Schones DE, Cui K, Cuddapah S, Roh T-y, Barski A, Wang Z, Wei G, Zhao K. Dynamic regulation of nucleosome positioning in the human genome. Cell 2008 Mar 7;132(5):887-98. doi: 10.1016/j.cell.2008.02.022.

20. *Barski A, *Cuddapah S, *Cui K, *Roh T-y, *Schones DE, *Wang Z, *Wei G, Chepelev I, Zhao K. High-resolution profiling of histone methylations in the human genome. Cell 2007 May 18;129(4):823-37. doi: 10.1016/j.cell.2007.05.009. PMID:17512414 ( *Contribute equally and are listed alphabetically).


Currently instructs students

Yu Zhang Postgraduate 086000- Biology and Medicine  

Honors & Distinctions

1999  The 5th Outstanding Young Scientist Selection and Outstanding Paper Selection of Chinese Academy of Agricultural Sciences, First Prize

2009  Lenfant Scholar of American  

2011  Faculty Innovation Award of Johns Hopkins University, USA 

2012  Kimmel Scholar of American

2016  Catalyst Award of Johns Hopkins University, USA