071006-神经生物学

抑郁症和焦虑症的神经机制及其干预治疗策略
药物成瘾的神经机制

1996-09--1999-01   中科院上海生理所   博士
1990-09--1993-04   华南理工大学   硕士
1979-09--1983-07   沈阳理工大学   学士

   

2020-05~2021-06,西奈山伊坎医学院, 教授
2015-01~2020-04,西奈山伊坎医学院, 副教授
2009-12~2014-12,西奈山伊坎医学院, 助理教授

2012-12-01-2021-06-25,美国 国立卫生研究院 研究项目评审委员会, 委员

   

（1） 美国神经心理药理学院会士, 特等奖, 其他, 2020

   

[1] Lu, Qingbo, Wu, Fangfang, Jiao, Jiao, Xue, Le, Song, Ruize, Shi, Yachen, Kong, Yan, Sun, Jianfei, Gu, Ning, Han, Ming-Hu, Zhang, Zhijun. Selective activation of ABCA1/ApoA1 signaling in the V1 by magnetoelectric stimulation ameliorates depression via regulation of synaptic plasticity. ISCIENCE[J]. 2022, 第 10 作者  通讯作者  25(5): http://dx.doi.org/10.1016/j.isci.2022.104201.
[2] Zhang, Ying, Roy, Dheeraj, Morel, Carole, Han, Ming-Hu. Tracing the brain circuitry underlying movement and mood symptoms in Parkinson's disease. NATURE[J]. 2022, 第 4 作者http://dx.doi.org/10.1038/d41586-022-01465-w.
[3] Morel, Carole, Montgomery, Sarah E, Li, Long, Durandde Cuttoli, Romain, Teichman, Emily M, Juarez, Barbara, Tzavaras, Nikos, Ku, Stacy M, Flanigan, Meghan E, Cai, Min, Walsh, Jessica J, Russo, Scott J, Nestler, Eric J, Calipari, Erin S, Friedman, Allyson K, Han, Ming-Hu. Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors. NATURE COMMUNICATIONS[J]. 2022, 第 16 作者  通讯作者  13(1): http://dx.doi.org/10.1038/s41467-022-29155-1.
[4] Costi, Sara, Morris, Laurel S, Kirkwood, Katherine A, Hoch, Megan, Corniquel, Morgan, VoLe, Brittany, Iqbal, Tabish, Chadha, Nisha, Pizzagalli, Diego A, Whitton, Alexis, Bevilacqua, Laura, Jha, Manish K, Ursu, Stefan, Swann, Alan C, Collins, Katherine A, Salas, Ramiro, Bagiella, Emilia, Parides, Michael K, Stern, Emily R, Iosifescu, Dan, V, Han, Ming-Hu, Mathew, Sanjay J, Murrough, James W. Impact of the KCNQ2/3 Channel Opener Ezogabine on Reward Circuit Activity and Clinical Symptoms in Depression: Results Froma Randomized Controlled Trial. AMERICAN JOURNAL OF PSYCHIATRY[J]. 2021, 第 21 作者178(5): 437-446, http://dx.doi.org/10.1176/appi.ajp.2020.20050653.
[5] Haynes, Sherod E, Han, Ming-Hu. A Novel Role for Hypothalamic AgRP Neurons in Mediating Depressive Behavior. TRENDS IN NEUROSCIENCES[J]. 2021, 第 2 作者  通讯作者  44(4): 243-246, http://dx.doi.org/10.1016/j.tins.2021.02.005.
[6] Tan, Aaron, Costi, Sara, Morris, Laurel S, Van Dam, Nicholas T, Kautz, Marin, Whitton, Alexis E, Friedman, Allyson K, Collins, Katherine A, Ahle, Gabriella, Chadha, Nisha, Do, Brian, Pizzagalli, Diego A, Iosifescu, Dan, V, Nestler, Eric J, Han, Ming-Hu, Murrough, James W. Effects of the KCNQ channel opener ezogabine on functional connectivity of the ventral striatum and clinical symptoms in patients with major depressive disorder. MOLECULAR PSYCHIATRY[J]. 2020, 第 15 作者25(6): 1323-1333, https://www.webofscience.com/wos/woscc/full-record/WOS:000534909000015.
[7] Carole Morel, Sarah Montgomery, Ming-Hu Han. SK Channels: Key Circuit Determinant for Stress-Induced Amygdala Dysfunction. BIOLOGICAL PSYCHIATRY[J]. 2020, 第 3 作者  通讯作者  85(10): 784-786, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7595424/.
[8] Hongxing Zhang, Dipesh Chaudhury, Alexander R Nectow, Allyson K Friedman, Song Zhang, Barbara Juarez, He Liu, Madeline L Pfau, Hossein Aleyasin, Cheng Jiang, Marshall Crumiller, Erin S Calipari, Stacy M Ku, Carole Morel, Nikos Tzavaras, Sarah E Montgomery, Michelle He, Stephen R Salton, Scott J Russo, Eric J Nestler, Jeffrey M Friedman, Jun-Li Cao, Ming-Hu Han. α1- and β3-Adrenergic Receptor–Mediated Mesolimbic Homeostatic Plasticity Confers Resilience to Social Stress in Susceptible Mice. BIOLOGICALPSYCHIATRY[J]. 2019, 第 23 作者  通讯作者  85(3): 226-236, http://dx.doi.org/10.1016/j.biopsych.2018.08.020.
[9] Koo, Ja Wook, Chaudhury, Dipesh, Han, Ming-Hu, Nestler, Eric J. Role of Mesolimbic Brain-Derived Neurotrophic Factor in Depression. BIOLOGICAL PSYCHIATRY[J]. 2019, 第 3 作者  通讯作者  86(10): 738-748, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814503/.
[10] Juarez, Barbara, Morel, Carole, Ku, Stacy M, Liu, Yutong, Zhang, Hongxing, Montgomery, Sarah, Gregoire, Hilledna, Ribeiro, Efrain, Crumiller, Marshall, RomanOrtiz, Ciorana, Walsh, Jessica J, Jackson, Kelcy, Croote, Denise E, Zhu, Yingbo, Zhang, Song, Vendruscolo, Leandro F, Edward, Scott, Roberts, Amanda, Hodes, Georgia E, Lu, Yongke, Calipari, Erin S, Chaudhury, Dipesh, Friedman, Allyson K, Han, Ming-Hu. Midbrain circuit regulation of individual alcohol drinking behaviors in mice. NATURE COMMUNICATIONS[J]. 2017, 第 24 作者  通讯作者  8(1): https://doaj.org/article/c7189739a90a4202b1484c7c8679ab16.
[11] Calipari, Erin S*, Juarez, Barbara*, Morel, Carole, Walker, Deena M, Cahill, Michael E, Ribeiro, Efrain, RomanOrtiz, Ciorana, Ramakrishnan, Charu, Deisseroth, Karl, Han, Ming-Hu, Nestler, Eric J. Dopaminergic dynamics underlying sex-specific cocaine reward. NATURE COMMUNICATIONS[J]. 2017, 第 10 作者  通讯作者  8(1): https://doaj.org/article/e0c9ffcc0e3446528630e91b45a3633a.
[12] Allyson K Friedman, Barbara Juarez, Stacy M Ku, Hongxing Zhang, Rhodora C Calizo, Jessica J Walsh, Dipesh Chaudhury, Song Zhang, Angel Hawkins, David M Dietz, James W Murrough, Maria Ribadeneira, Erik H Wong, Rachael L Neve, Ming-Hu Han. KCNQ channel openers reverse depressive symptoms via an active resilience mechanism. NATURE COMMUNICATIONS[J]. 2016, 第 15 作者  通讯作者  7(1): https://doaj.org/article/27a25b5d540741f383c902474985df50.
[13] Juarez, Barbara, Han, Ming-Hu. Diversity of Dopaminergic Neural Circuits in Response to Drug Exposure. NEUROPSYCHOPHARMACOLOGY[J]. 2016, 第 2 作者  通讯作者  41(10): 2424-2446, https://www.webofscience.com/wos/woscc/full-record/WOS:000381653400002.
[14] Friedman, Allyson K, Walsh, Jessica J, Juarez, Barbara, Ku, Stacy M, Chaudhury, Dipesh, Wang, Jing, Li, Xianting, Dietz, David M, Pan, Nina, Vialou, Vincent F, Neve, Rachael L, Yue, Zhenyu, Han, Ming-Hu. Enhancing Depression Mechanisms in Midbrain Dopamine Neurons Achieves Homeostatic Resilience. SCIENCE[J]. 2014, 第 13 作者  通讯作者  344(6181): 313-319, https://www.webofscience.com/wos/woscc/full-record/WOS:000334474500040.
[15] Walsh, Jessica J, Friedman, Allyson K, Sun, Haosheng, Heller, Elizabeth A, Ku, Stacy M, Juarez, Barbara, Burnham, Veronica L, MazeiRobison, Michelle S, Ferguson, Deveroux, Golden, Sam A, Koo, Ja Wook, Chaudhury, Dipesh, Christoffe, Daniel J, Pomeranz, Lisa, Friedman, Jeffrey M, Russo, Scott J, Nestler, Eric J, Han, Ming-Hu. Stress and CRF gate neural activation of BDNF in the mesolimbic reward pathway. NATURE NEUROSCIENCE[J]. 2014, 第 18 作者  通讯作者  17(1): 27-29, https://www.webofscience.com/wos/woscc/full-record/WOS:000329080000009.
[16] Chaudhury, Dipesh*, Walsh, Jessica J*, Friedman, Allyson K, Juarez, Barbara, Ku, Stacy M, Koo, Ja Wook, Ferguson, Deveroux, Tsai, HsingChen, Pomeranz, Lisa, Christoffel, Daniel J, Nectow, Alexander R, Ekstrand, Mats, Domingos, Ana, MazeiRobison, Michelle S, Mouzon, Ezekiell, Lobo, Mary Kay, Neve, Rachael L, Friedman, Jeffrey M, Russo, Scott J, Deisseroth, Karl, Nestler, Eric J, Han, Ming-Hu. Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. NATURE[J]. 2013, 第 22 作者  通讯作者  493(7433): 532-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000313871400038.
[17] Russo, Scott J, Murroughl, James W, Han, Ming-Hu, Charney, Dennis S, Nestler, Eric J. Neurobiology of resilience. NATURE NEUROSCIENCE[J]. 2012, 第 3 作者15(11): 1475-1484, https://www.webofscience.com/wos/woscc/full-record/WOS:000310424900006.
[18] Ming-Hu Han, William Renthal, Robert H Ring, Zia Rahman, Kassi Psifogeorgou, David Howland, Shari Birnbaum, Kathleen Young, Rachael Neve, Ivone Gomes, Lakshmi A Devi, Eric J Nestler, Venetia Zachariou. Brain Region Specific Actions of RGS4 Oppose Morphine Reward and Dependence but Promote Analgesia. BIOLOGICAL PSYCHIATRY[J]. 2011, 第 1 作者67(8): 761-769, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3077672/.
[19] Cao, Jun-Li, Covington, Herbert E, III, Friedman, Allyson K, Wilkinson, Matthew B, Walsh, Jessica J, Cooper, Donald C, Nestler, Eric J, Han, Ming-Hu. Mesolimbic Dopamine Neurons in the Brain Reward Circuit Mediate Susceptibility to Social Defeat and Antidepressant Action. JOURNAL OF NEUROSCIENCE[J]. 2010, 第 8 作者  通讯作者  30(49): 16453-16458, https://www.webofscience.com/wos/woscc/full-record/WOS:000285089100006.
[20] Cao, Jun-Li, Vialou, Vincent F, Lobo, Mary Kay, Robison, Alfred J, Neve, Rachael L, Cooper, Donald C, Nestler, Eric J, Han, Ming-Hu. Essential role of the cAMP-cAMP response-element binding protein pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2010, 第 8 作者  通讯作者  107(39): 17011-17016, http://dx.doi.org/10.1073/pnas.1010077107.
[21] Wallace, Deanna L*, Han, Ming-Hu*, Graham, Danielle L, Green, Thomas A, Vialou, Vincent, Iniguez, Sergio D, Cao, Jun-Li, Kirk, Anne, Chakravarty, Sumana, Kumar, Arvind, Krishnan, Vaishnav, Neve, Rachael L, Cooper, Don C, Bolanos, Carlos A, Barrot, Michel, McClung, Colleen A, Nestler, Eric J. CREB regulation of nucleus accumbens excitability mediates social isolation-induced behavioral deficits. NATURE NEUROSCIENCE[J]. 2009, 12(2): 200-209, https://www.webofscience.com/wos/woscc/full-record/WOS:000263182000021.
[22] Krishnan, Vaishnav*, Han, Ming-Hu*, Graham, Danielle L, Berton, Olivier, Renthal, William, Russo, Scott J, LaPlant, Quincey, Graham, Ami, Lutter, Michael, Lagace, Diane C, Ghose, Subroto, Reister, Robin, Tannous, Paul, Green, Thomas A, Neve, Rachael L, Chakravarty, Sumana, Kumar, Arvind, Eisch, Amelia J, Self, David W, Lee, Francis S, Tamminga, Carol A, Cooper, Donald C, Gershenfeld, Howard K, Nestler, Eric J. Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions. CELL[J]. 2007, 131(2): 391-404, http://dx.doi.org/10.1016/j.cell.2007.09.018.
[23] Han, MH, Bolanos, CA, Green, TA, Olson, VG, Neve, RL, Liu, RJ, Aghajanian, GK, Nestler, EJ. Role of cAMP response element-binding protein in the rat locus ceruleus: Regulation of neuronal activity and opiate withdrawal behaviors. JOURNAL OF NEUROSCIENCE[J]. 2006, 26(17): 4624-4629, https://www.webofscience.com/wos/woscc/full-record/WOS:000237271400021.

   

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现指导学生

孙星  硕士研究生  086000-生物与医药  

孟桐  硕士研究生  086000-生物与医药