海水贝类遗传性状的分子解析及遗传育种研究

​

070703-海洋生物学

大型底栖生物的生物矿化，内分泌生殖，生长发育，遗传育种

086001生物技术与工程

2006-09--2011-06   中山大学   博士
2002-09--2006-06   西南大学   学士

   

2017-12~现在, 中国科学院南海海洋研究所, 副研究员
2011-07~2017-11,中国科学院南海海洋研究所, 助理研究员

   

（ 1 ） 一种与马氏珠母贝生长性状关联的InDel标记、检测引物组及开发方法, 发明专利, 2022, 第 4 作者, 专利号: CN111607652B

（ 2 ） 一种促进华贵栉孔扇贝生长的养殖方法, 发明专利, 2020, 第 1 作者, 专利号: CN111280097A

（ 3 ） 一种能被马氏珠母贝SMAD1/5基因抑制的MSX启动子及其应用, 发明专利, 2020, 第 1 作者, 专利号: CN110904105A

（ 4 ） 一种筛选具有优良生长性状的马氏珠母贝活体亲本的方法, 专利授权, 2018, 第 3 作者, 专利号: CN108715896A

   

[1] 石禹. Comparative Transcriptome Analysis of Shell-Matrix-Protein Genes and Observation of the Shell Microstructure in the Deep-Sea Clam Calyptogena marissinica. Journal of Ocean University of China[J]. 2024, 第 1 作者23(3): 797-810, http://www.ouc.edu.cn/xbywb/.
[2] Shi, Yu, Yao, Gaoyou, He, Maoxian. Transcriptome Analysis of Mantle Tissues Reveals Potential Shell-Matrix-Protein Genes in Gigantidas haimaensis. JOURNAL OF OCEAN UNIVERSITY OF CHINA[J]. 2023, 第 1 作者22(4): 1087-1097, http://dx.doi.org/10.1007/s11802-023-5478-8.
[3] Shi, Yu, Yao, Gaoyou, Zhang, Hua, Jia, Huixia, Xiong, Panpan, He, Maoxian. Proteome and Transcriptome Analysis of Gonads Reveals Intersex in Gigantidas haimaensis. BMC GENOMICS[J]. 2022, 第 1 作者23(1): https://doaj.org/article/a7256aa1866f4dda8430135f93454990.
[4] Shi, Yu, Pan, Xiaolan, Xu, Meng, Liu, Huiru, Xu, Hanzhi, He, Maoxian. The role of Smad6 in immunity of the pearl oyster Pinctada fucata martensii. JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2022, 第 1 作者40(3): 1135-1147, http://dx.doi.org/10.1007/s00343-021-1088-8.
[5] Shi, Yu, Pan, Xiaolan, Xu, Meng, Liu, Huiru, Xu, Hanzhi, He, Maoxian. The role of Smad1/5 in mantle immunity of the pearl oyster Pinctada fucata martensii. FISH & SHELLFISH IMMUNOLOGY[J]. 2021, 第 1 作者113: 208-215, http://dx.doi.org/10.1016/j.fsi.2021.04.001.
[6] Shi, Yu, Zhao, Mi, He, Maoxian. PfSMAD1/5 Can Interact with PfSMAD4 to Inhibit PfMSX to Regulate Shell Biomineralization in Pinctada fucata martensii. MARINE BIOTECHNOLOGY[J]. 2020, 第 1 作者22(2): 246-262, https://www.webofscience.com/wos/woscc/full-record/WOS:000520822500008.
[7] Zhang, Hua, Yi, Xuejie, Guan, Yunyan, Shi, Yu, Ou, Zekui, He, Maoxian. The role of the chondroitin sulfate synthase-1 gene in the immune response of the pearl oyster Pinctada fucata. FISHERIES SCIENCE[J]. 2020, 第 4 作者86(3): 487-494, http://dx.doi.org/10.1007/s12562-020-01420-6.
[8] Shi, Yu, Xu, Meng, Huang, Jing, Zhang, Hua, Liu, Wenguang, Ou, Zekui, He, Maoxian. Transcriptome analysis of mantle tissues reveals potential biomineralization-related genes in Tectus pyramis Born. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS[J]. 2019, 第 1 作者29: 131-144, http://dx.doi.org/10.1016/j.cbd.2018.11.010.
[9] Xu, Meng, Huang, Jing, Shi, Yu, Zhang, Hua, He, Maoxian. Comparative transcriptomic and proteomic analysis of yellow shell and black shell pearl oysters, Pinctada fucata martensii. BMC GENOMICS[J]. 2019, 第 3 作者20(1): https://doaj.org/article/d85d81110665485a8b23700a671ca86b.
[10] Liang, Yaosi, Ding, Xu, Yu, Xue, Wang, Yu, Zhou, Ying, He, Jianan, Shi, Yu, Zhang, Yong, Lin, Haoran, Lu, Danqi. Identification and functional characterization of Toll-like receptor 13 from orange-spotted grouper (Epinephelus coioides). FISH & SHELLFISH IMMUNOLOGY[J]. 2018, 第 7 作者74: 309-317, http://dx.doi.org/10.1016/j.fsi.2017.12.054.
[11] Zhang, Hua, Huang, Xiande, Shi, Yu, Liu, Wenguang, He, Maoxian. Identification and analysis of an MKK4 homologue in response to the nucleus grafting operation and antigens in the pearl oyster, Pinctada fucata. FISH & SHELLFISH IMMUNOLOGY[J]. 2018, 第 3 作者73: 279-287, http://dx.doi.org/10.1016/j.fsi.2017.12.023.
[12] Shi, Yu, Liu, Wenguang, He, Maoxian. Proteome and Transcriptome Analysis of Ovary, Intersex Gonads, and Testis Reveals Potential Key Sex Reversal/Differentiation Genes and Mechanism in Scallop Chlamys nobilis. MARINE BIOTECHNOLOGY[J]. 2018, 第 1 作者20(2): 220-245, https://www.webofscience.com/wos/woscc/full-record/WOS:000429402200010.
[13] Wang Qi, Shi Yu, He Maoxian. Pf-Dmrt4, a potential factor in sexual development in the pearl oyster Pinctada fucata. JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2018, 第 2 作者36(6): 2337-2350, http://lib.cqvip.com/Qikan/Article/Detail?id=7000957514.
[14] Zhang, Hua, Ou, Zekui, Xu, Meng, Huang, Xiande, Liu, Wenguang, Shi, Yu, He, Maoxian. Molecular cloning and characterization of a putative mitogen-activated protein kinase (Erk1/2) gene: Involvement in mantle immunity of Pinctada fucata. FISH & SHELLFISH IMMUNOLOGY[J]. 2018, 第 6 作者80: 63-70, http://dx.doi.org/10.1016/j.fsi.2018.05.047.
[15] Zhang, Hua, Zhao, Mi, Yi, Xuejie, Ou, Zekui, Li, Yaoguo, Shi, Yu, He, Maoxian. Characterization of the distal-less homologue gene, PfDlx, involved in regulating the expression of Pif in the pearl oyster, Pinctada fucata. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY[J]. 2017, 第 6 作者  通讯作者  212: 51-58, http://dx.doi.org/10.1016/j.cbpb.2017.06.007.
[16] Zhang, Hua, Shi, Yu, He, Maoxian. Molecular identification of an insulin growth factor binding protein (IGFBP) and its potential role in an insulin-like peptide system of the pearl oyster, Pinctada fucata. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY[J]. 2017, 第 2 作者214: 27-35, http://dx.doi.org/10.1016/j.cbpb.2017.09.003.
[17] Zhao, Mi, He, Maoxian, Huang, Xiande, Wang, Qi, Shi, Yu. Functional characterization and molecular mechanism exploration of three granulin epithelin precursor splice variants in biomineralization of the pearl oyster Pinctada fucata. MOLECULAR GENETICS AND GENOMICS[J]. 2016, 第 5 作者291(1): 399-409, http://ir.scsio.ac.cn/handle/344004/15504.
[18] Zhao, Mi, Shi, Yu, He, Maoxian, Huang, Xiande, Wang, Qi. PfSMAD4 plays a role in biomineralization and can transduce bone morphogenetic protein-2 signals in the pearl oyster Pinctada fucata. BMC DEVELOPMENTAL BIOLOGY[J]. 2016, 第 2 作者16: http://dx.doi.org/10.1186/s12861-016-0110-4.
[19] Peng, Wan, Shi, Yu, Li, GaoFei, He, LiangGe, Liang, YaoSi, Zhang, Yong, Zhou, LiBin, Lin, HaoRan, Lu, DanQi. Tetraodon nigroviridis: A model of Vibrio parahaemolyticus infection. FISH & SHELLFISH IMMUNOLOGY[J]. 2016, 第 2 作者56: 388-396, http://dx.doi.org/10.1016/j.fsi.2016.07.017.
[20] Shi, Yu, He, Maoxian. PfIRR Interacts with HrIGF-I and Activates the MAP-kinase and PI3-kinase Signaling Pathways to Regulate Glycogen Metabolism in Pinctada fucata. SCIENTIFIC REPORTS[J]. 2016, 第 1 作者6: http://ir.scsio.ac.cn/handle/344004/15494.
[21] Li, Yaoguo, Huang, Xiande, Guan, Yunyan, Shi, Yu, Zhang, Hua, He, Maoxian. DNA methylation is associated with expression level changes of galectin gene in mantle wound healing process of pearl oyster, Pinctada fucata. FISH & SHELLFISH IMMUNOLOGY[J]. 2015, 第 4 作者45(2): 912-918, http://dx.doi.org/10.1016/j.fsi.2015.06.016.
[22] Shi, Yu, Wang, Qi, He, Maoxian. Molecular identification of dmrt2 and dmrt5 and effect of sex steroids on their expressions in Chlamys nobilis. AQUACULTURE[J]. 2014, 第 1 作者426: 21-30, http://dx.doi.org/10.1016/j.aquaculture.2014.01.021.
[23] Han, Feifei, Guo, Changlong, Yu, Dan, Zhu, Jin, Gong, Lili, Li, Guangrun, Lv, Yali, Liu, He, An, Guangyu, Liu, Lihong. Associations between UGT1A1*6 or UGT1A1*6/*28 polymorphisms and irinotecan-induced neutropenia in Asian cancer patients. CANCER CHEMOTHERAPY AND PHARMACOLOGY[J]. 2014, 第 3 作者73(4): 779-788, http://www.corc.org.cn/handle/1471x/2217249.
[24] Shi, Yu, Guan, Yunyan, He, Maoxian. Molecular identification of insulin-related peptide receptor and its potential role in regulating development in Pinctada fucata. AQUACULTURE[J]. 2013, 第 1 作者408: 118-127, http://dx.doi.org/10.1016/j.aquaculture.2013.05.038.
[25] Huang, XianDe, Liu, WenGuang, Wang, Qi, Zhao, Mi, Wu, ShanZeng, Guan, YunYan, Shi, Yu, He, MaoXian. Molecular characterization of interferon regulatory factor 2 (IRF-2) homolog in pearl oyster Pinctada fucata. FISH & SHELLFISH IMMUNOLOGY[J]. 2013, 第 7 作者34(5): 1279-1286, http://dx.doi.org/10.1016/j.fsi.2013.02.003.
[26] Huang, XianDe, Zhao, Mi, Liu, WenGuang, Guan, YunYan, Shi, Yu, Wang, Qi, Wu, ShanZeng, He, MaoXian. Gigabase-Scale Transcriptome Analysis on Four Species of Pearl Oysters. MARINE BIOTECHNOLOGY[J]. 2013, 第 5 作者15(3): 253-264, https://www.webofscience.com/wos/woscc/full-record/WOS:000317845500001.

   

（ 1 ） 马氏珠母贝Smad1/5与生物矿化信号通路中的MSX的相互作用, 负责人, 地方任务, 2019-10--2022-09
（ 2 ） 冷泉区甲烷渗漏的的环境生态效应, 参与, 地方任务, 2019-07--2022-06
（ 3 ） 冷泉化能生态系统生物连通性与适应机制, 参与, 地方任务, 2019-09--2024-08
（ 4 ） 马氏珠母贝Smad6抑制BMP2信号的调控机理及在贝壳生物矿化中的功能, 负责人, 地方任务, 2023-01--2025-12
（ 5 ） 双棘黄姑鱼良种培育技术攻关, 负责人, 地方任务, 2024-05--2029-06
（ 6 ） 高产优质贝类种质创制与示范推广, 参与, 地方任务, 2024-05--2029-06

1.挖掘马氏珠母贝性状优异基因，解析生长发育重要基因功能和调控机制，为优异种质创制提供理论基础，如珍珠质形成的功能基因等。 2.研究深海冷泉大型底栖生物的遗传多样性和种群连通性，探究极端环境下大型底栖生物的生态环境机制，助力大湾区冷泉资源的可持续利用和生态可持续发展。 3.研究礁栖功能螺类的基因组学，为螺类的生殖繁育和人工育苗等提供理论基础和指导。