基本信息
刘丰亮  男  硕导  中国科学院昆明动物研究所
电子邮件: liufl@mail.kiz.ac.cn
通信地址: 云南省昆明市教场东路32号分子免疫药理实验室
邮政编码:

招生信息

   
招生专业
100102-免疫学
招生方向
病毒免疫学
疫苗学,疫苗免疫学
免疫学

教育背景

2008-09--2011-06   中国科学院研究生院   理学博士
2005-09--2008-06   云南大学   理学硕士
2001-09--2005-06   山东省潍坊学院   理学学士

工作经历

   
工作简历
2019-01~现在, 中国科学院昆明动物研究所, 副研究员
2018-08~2018-12,中国科学院昆明动物研究所, 助理研究员
2015-06~2018-05,美国德克萨斯大学医学分部, 博士后
2015-01~2015-05,美国南阿拉巴马大学, 博士后
2011-07~2014-06,中国科学院昆明动物研究所, 助理研究员
2008-09~2011-06,中国科学院研究生院, 理学博士
2005-09~2008-06,云南大学, 理学硕士
2001-09~2005-06,山东省潍坊学院, 理学学士

专利与奖励

   
奖励信息
(1) Travel Award of 6th Annual Vaccine Development Center of San Antonio Conference, 其他, 2017
(2) Travel Award of 5th Annual Vaccine Development Center of San Antonio Conference, 其他, 2016
(3) 中国科学院朱李月华优秀博士生奖学金, 院级, 2011
(4) 第十届云南省优秀科技论文奖, 一等奖, 省级, 2011
(5) 第十届云南省优秀科技论文奖, 二等奖, 省级, 2011
专利成果
( 1 ) 一种基于CRISPR-Cas9系统构建EPB41基因敲除THP-1细胞系的方法, 2021, 第 4 作者, 专利号: CN112481305A

出版信息

   
发表论文
(1) SARS-CoV-2 M-pro inhibitors with antiviral activity in a transgenic mouse model, SCIENCE, 2021, 第 4 作者
(2) SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target, CELL RESEARCH, 2021, 第 5 作者
(3) Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice, ZOOLOGICAL RESEARCH, 2021, 第 5 作者
(4) A proposal for clinical trials of COVID-19 treatment using homo-harringtonine, NATIONAL SCIENCE REVIEW, 2021, 第 2 作者
(5) Northern pig-tailed macaques (Macaca leonina) infected with SARS-CoV-2 show rapid viral clearance and persistent immune response, ZOOLOGICAL RESEARCH, 2021, 第 5 作者
(6) Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation, Rapid generation of ACE2 humanized inbred mouse model for COVID-19 with tetraploid complementation, NATIONAL SCIENCE REVIEW, 2021, 第 1 作者
(7) Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models, Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models, CELL RESEARCH, 2021, 第 4 作者
(8) Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques, Delayed severe cytokine storm and immune cell infiltration in SARS-CoV-2-infected aged Chinese rhesus macaques, ZOOLOGICAL RESEARCH, 2020, 第 6 作者
(9) Polymorphisms in the APOBEC3G gene of Chinese rhesus macaques affect resistance to ubiquitination and degradation mediated by HIV-2 Vif, ARCHIVES OF VIROLOGY, 2019, 通讯作者
(10) Association of TRIMCyp and TRIM5α from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition, Science China Life Sciences, 2018, 第 3 作者
(11) Activation of NF-kappa B induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque, MOLECULAR IMMUNOLOGY, 2018, 第 3 作者
(12) Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection, PLOS PATHOGENS, 2018, 第 2 作者
(13) Activation of NF-κB induced by TRIMCyp showing a discrepancy between owl monkey and northern pig-tailed macaque, Molecular Immunology, 2018, 第 3 作者
(14) Association of TRIMCyp and TRIM5 alpha from assam macaques leads to a functional trade-off between HIV-1 and N-MLV inhibition, SCIENCE CHINA-LIFE SCIENCES, 2018, 第 3 作者
(15) Heroin use is associated with lower levels of restriction factors and type I interferon expression and facilitates HIV-1 replication, MICROBES AND INFECTION, 2017, 第 2 作者
(16) Loss of immune control in HIV-infected patients: how does mucosal candidiasis occur?, FUTURE MICROBIOLOGY, 2017, 第 2 作者
(17) Priming and Activation of Inflammasome by Canarypox Virus Vector ALVAC via the cGAS/IFI16-STING-Type I IFN Pathway and AIM2 Sensor, JOURNAL OF IMMUNOLOGY, 2017, 第 1 作者
(18) The effects of TRIM5 alpha polymorphism on HIV-2ROD and SIVmac239 replication in PBMCs from Chinese rhesus macaques and Vietnamese-origin cynomolgus macaques, VIROLOGY, 2016, 第 2 作者
(19) Sequential dysfunction and progressive depletion of Candida albicans-specific CD4 T cell response in HIV-1 infection, EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 
(20) Lipopolysaccharide suppresses human immunodeficiency virus 1 reverse transcription in macrophages, ARCHIVES OF VIROLOGY, 2016, 第 1 作者
(21) Dysfunction and depletion of human antigen specific CD4 T cells by HIV: a mechanism for pathogen-specific immune failure in AIDS, JOURNAL OF IMMUNOLOGY, 2016, 第 2 作者
(22) High seroprevalence of toxoplasma gondii and HIV-1 co-infection among drug users in Yunnan province, southwest China, SCIENCE CHINA-LIFE SCIENCES, 2016, 第 4 作者
(23) Increased expression and dysregulated association of restriction factors and type I interferon in HIV, HCV mono- and co-infected patients, JOURNAL OF MEDICAL VIROLOGY, 2016, 第 2 作者
(24) HIV Susceptibility of human antigen-specific CD4 T cells in AIDS pathogenesis and vaccine response, EXPERT REVIEW OF VACCINES, 2016, 第 2 作者
(25) Mitochondrial DNA Haplogroup A Decreases the Risk of Drug Addiction but Conversely Increases the Risk of HIV-1 Infection in Chinese Addicts, MOLECULAR NEUROBIOLOGY, 2016, 
(26) Factors associated with needle sharing among people who inject drugs in Yunnan, China: a combined network and regression analysis, Infectious Diseases of Poverty, 2016, 第 4 作者
(27) A SDF1 genetic variant confers resistance to HIV-1 infection in intravenous drug users in China, INFECTION GENETICS AND EVOLUTION, 2015, 第 3 作者
(28) The Effect of Exon 7 Deletion during the Evolution of TRIMCyp Fusion Proteins on Viral Restriction, Cytoplasmic Body Formation and Multimerization, PLOS ONE, 2015, 第 1 作者
(29) Independent Birth of a Novel TRIMCyp in Tupaia belangeri with a Divergent Function from Its Paralog TRIM5, MOLECULAR BIOLOGY AND EVOLUTION, 2014, 第 4 作者
(30) 灵长类动物中TRIMCyp融合基因模式及对逆转录病毒复制的限制作用, The primate TRIMCyp fusion genes and mechanism of restricting retroviruses replication, 动物学研究, 2012, 第 2 作者
(31) Extensive and complex HIV-1 recombination between B ', C and CRF01_AE among IDUs in south-east Asia, AIDS, 2012, 第 6 作者
(32) 中国静脉吸毒人群TRIM5alpha基因多态性与HIV-1易感性研究, 2011, 第 1 作者
(33) 熊猴存在TRIM5/TRIMCyp杂合子基因型, Identification of the TRIM5/TRIMCyp heterozygous genotype in Macaca assamensis, 动物学研究, 2011, 第 3 作者
(34) 中国静脉吸毒人群TRIM5α基因多态性与HIV-1 易感性研究, 2011, 第 1 作者
(35) Human Rights, Ethics, and the Protection of Intravenous Drug Users Are Much Improved in China, JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2011, 通讯作者
(36) Comparison of HIV-, HBV-, HCV- and Co-Infection Prevalence between Chinese and Burmese Intravenous Drug Users of the China-Myanmar Border Region, PLOS ONE, 2011, 第 2 作者
(37) HIV-1限制因子及其基因多态性, HIV-1 restriction factors and their polymorphisms, 生命的化学, 2010, 第 1 作者
(38) 恒河猴TRIM5α的组织分布及不同刺激促进PBMC中TRIM5α转录水平的上调, 动物学研究, 2009, 第 4 作者

科研活动

   
科研项目
( 1 ) 病毒载体ALVAC介导的炎性小体活化对肠道CD4+TRM分布的影响及机制研究, 负责人, 国家任务, 2020-01--2023-12
( 2 ) 基于ZIKV感染北平顶猴新型模型研究其致睾丸损伤的特点及其机制, 参与, 国家任务, 2020-01--2023-12
( 3 ) FcγR信号通路调控天然免疫识别通路及后续获得性免疫反应的机制研究, 负责人, 地方任务, 2020-06--2023-05
( 4 ) 卡介苗重塑肺组织固有免疫记忆在新冠肺炎中的作用研究, 负责人, 中国科学院计划, 2022-01--2024-12
( 5 ) 特异占取S 蛋白侵染位点的纳米材料设计及其抗新冠研究, 参与, 国家任务, 2021-10--2023-09
参与会议
(1)Requirement of Type I IFN pathway for humoral response induced by viral vectored vaccines   2017-11-16