干细胞多能性以及重编程机制；

细胞命运决定机制。

2009-09--2014-06   中国科学院广州生物医药与健康研究院   理学博士
2005-09--2009-06   南京农业大学   理学学士

   

2018-01~现在, 中国科学院广州生物医药与健康研究院, 副研究员
2014-08~2017-01,中国科学院广州生物医药与健康研究院, 助理研究员

动物胚胎学
干细胞概论
干细胞技术综合实验

   

（1） 干细胞多能性与重编程机理, 部委级, 2017

（ 1 ） 人源化ACE2基因改造小鼠胚胎干细胞模型制备方法及应用, 2023, 第 7 作者, 专利号: CN113355325B

（ 2 ） 人源化ACE2基因改造小鼠胚胎干细胞模型制备方法及应用, 发明专利, 2021, 第 7 作者, 专利号: CN113355325A

   

[1] Liu, Yuting, He, Jiangping, Chen, Ruhai, Liu, He, Chen, Jocelyn, Liu, Yujian, Wang, Bo, Guo, Lin, Pei, Duanqing, Wang, Jie, Liu, Jing, Chen, Jiekai. AP-1 activity is a major barrier of human somatic cell reprogramming. CELLULAR AND MOLECULAR LIFE SCIENCES[J]. 2021, 第 8 作者78(15): 5847-5863, http://dx.doi.org/10.1007/s00018-021-03883-x.
[2] Lai, Xiaowei, Li, Qian, Wu, Fang, Lin, Jiechun, Chen, Jiekai, Zheng, Hui, Guo, Lin. Epithelial-Mesenchymal Transition and Metabolic Switching in Cancer: Lessons From Somatic Cell Reprogramming. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY[J]. 2020, 第 7 作者  通讯作者  8: https://doaj.org/article/1921c0ce736d42bbacdaa8f5e0ee1ca3.
[3] Yu, Shengyong, Zhou, Chunhua, Cao, Shangtao, He, Jiangping, Cai, Baomei, Wu, Kaixin, Qin, Yue, Huang, Xingnan, Xiao, Lizhan, Ye, Jing, Xu, Shuyang, Xie, Wenxiu, Kuang, Junqi, Chu, Shilong, Guo, Jing, Liu, He, Pang, Wei, Guo, Lin, Zeng, Mengying, Wang, Xiaoshan, Luo, Rongping, Li, Chen, Zhao, Guoqing, Wang, Bo, Wu, Linlin, Chen, Jiekai, Liu, Jing, Pei, Duanqing. BMP4 resets mouse epiblast stem cells to naive pluripotency through ZBTB7A/B-mediated chromatin remodelling. NATURE CELL BIOLOGY[J]. 2020, 第 18 作者22(6): 651-+, https://search.proquest.com/docview/2401805529.
[4] Yinghua Huang, Hui Zhang, Lulu Wang, Chuanqing Tang, Xiaogan Qin, Xinyu Wu, Meifang Pan, Yujia Tang, Zhongzhou Yang, Isaac A Babarinde, Runxia Lin, Guanyu Ji, Yiwei Lai, Xueting Xu, Jianbin Su, Xue Wen, Takashi Satoh, Tanveer Ahmed, Vikas Malik, Carl Ward, Giacomo Volpe, Lin Guo, Jinlong Chen, Li Sun, Yingying Li, Xiaofen Huang, Xichen Bao, Fei Gao, Baohua Liu, Hui Zheng, Ralf Jauch, Liangxue Lai, Guangjin Pan, Jiekai Chen, Giuseppe Testa, Shizuo Akira, Jifan Hu, Duanqing Pei, Andrew P Hutchins, Miguel A Esteban, Baoming Qin. JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. NATURE COMMUNICATIONS[J]. 2020, 第 22 作者11(1): http://dx.doi.org/10.1038/s41467-020-18900-z.
[5] Wu, Kaixin, Liu, He, Wang, Yaofeng, He, Jiangping, Xu, Shuyang, Chen, Yaping, Kuang, Junqi, Liu, Jiadong, Guo, Lin, Li, Dongwei, Shi, Ruona, Shen, Li, Wang, Yangming, Zhang, Xiaofei, Wang, Jie, Pei, Duanqing, Chen, Jiekai. SETDB1-Mediated Cell Fate Transition between 2C-Like and Pluripotent States. CELL REPORTS[J]. 2020, 第 9 作者30(1): 25-+, http://dx.doi.org/10.1016/j.celrep.2019.12.010.
[6] Guo, Lin, Lin, Lihui, Wang, Xiaoshan, Gao, Mingwei, Cao, Shangtao, Mai, Yuanbang, Wu, Fang, Kuang, Junqi, Liu, He, Yang, Jiaqi, Chu, Shilong, Song, Hong, Li, Dongwei, Liu, Yujian, Wu, Kaixin, Liu, Jiadong, Wang, Jinyong, Pan, Guangjin, Hutchins, Andrew P, Liu, Jing, Pei, Duanqing, Chen, Jiekai. Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq. MOLECULAR CELL[J]. 2019, 第 1 作者73(4): 815-+, http://dx.doi.org/10.1016/j.molcel.2019.01.042.
[7] Li, Dongwei, Liu, Jing, Yang, Xuejie, Zhou, Chunhua, Guo, Jing, Wu, Chuman, Qin, Yue, Guo, Lin, He, Jiangping, Yu, Shenyong, Liu, He, Wang, Xiaoshan, Wu, Fang, Kuang, Junqi, Hutchins, Andrew P, Chen, Jiekai, Pei, Duanqing. Chromatin Accessibility Dynamics during iPSC Reprogramming. CELL STEM CELL[J]. 2017, 第 8 作者21(6): 819-+, http://dx.doi.org/10.1016/j.stem.2017.10.012.
[8] Cao, Shangtao, Yu, Shengyong, Chen, Yan, Wang, Xiaoshan, Zhou, Chunhua, Liu, Yuting, Kuang, Junqi, Liu, He, Li, Dongwei, Ye, Jing, Qin, Yue, Chu, Shilong, Wu, Linlin, Guo, Lin, Li, Yinxiong, Shu, Xiaodong, Chen, Jiekai, Liu, Jing, Pei, Duanqing. Chemical reprogramming of mouse embryonic and adult fibroblast into endoderm lineage. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 第 14 作者292(46): 19122-19132, http://dx.doi.org/10.1074/jbc.M117.812537.
[9] Zhou, Zhiwei, Yang, Xuejie, He, Jiangping, Liu, Jing, Wu, Fang, Yu, Shengyong, Liu, Yuting, Lin, Runxia, Liu, He, Cui, Yuanbin, Zhou, Chunhua, Wang, Xiaoshan, Wu, Jian, Cao, Shangtao, Guo, Lin, Lin, Lihui, Wang, Tao, Peng, Xiaozhong, Qiang, Boqing, Hutchins, Andrew P, Pei, Duanqing, Chen, Jiekai. Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function. CELL REPORTS[J]. 2017, 第 15 作者21(8): 2160-2170, http://www.corc.org.cn/handle/1471x/2374237.
[10] Liu, Jing, Han, Qingkai, Peng, Tianran, Peng, Meixiu, Wei, Bei, Li, Dongwei, Wang, Xiaoshan, Yu, Shengyong, Yang, Jiaqi, Cao, Shangtao, Huang, Kaimeng, Hutchins, Andrew Paul, Liu, He, Kuang, Junqi, Zhou, Zhiwei, Chen, Jing, Wu, Haoyu, Guo, Lin, Chen, Yongqiang, Chen, You, Li, Xuejia, Wu, Hongling, Liao, Baojian, He, Wei, Song, Hong, Yao, Hongjie, Pan, Guangjin, Chen, Jiekai, Pei, Duanqing. The oncogene c-Jun impedes somatic cell reprogramming. NATURECELLBIOLOGY[J]. 2015, 第 18 作者17(7): 856-867, http://ir.foo.ac.cn/handle/2SETSVCV/407.
[11] Chen, Yulin, Guo, Lin, Chen, Jiekai, Zhao, Xiangjie, Zhou, Weichen, Zhang, Cheng, Wang, Jiucun, Jin, Li, Pei, Duanqing, Zhang, Feng. Genome-wide CNV analysis in mouse induced pluripotent stem cells reveals dosage effect of pluripotent factors on genome integrity. BMC GENOMICS[J]. 2014, 第 2 作者15(1): 79-79, http://ir.gibh.ac.cn/handle/344009/387.
[12] 徐国良. Vitamin C modulates Tet1 function during somatic cell reprogramming. NATURE GENETICS[J]. 2013, 45(12): 1504-U140, http://ir.foo.ac.cn/handle/2SETSVCV/44.
[13] Chen, Jiekai, Liu, He, Liu, Jing, Qi, Jing, Wei, Bei, Yang, Jiaqi, Liang, Hanquan, Chen, You, Chen, Jing, Wu, Yaran, Guo, Lin, Zhu, Jieying, Zhao, Xiangjie, Peng, Tianran, Zhang, Yixin, Chen, Shen, Li, Xuejia, Li, Dongwei, Wang, Tao, Pei, Duanqing. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. NATURE GENETICS[J]. 2013, 第 11 作者45(1): 34-U62, http://ir.foo.ac.cn/handle/2SETSVCV/321.
[14] Chen, Jiekai, Liu, Jing, Chen, You, Yang, Jiaqi, Chen, Jing, Liu, He, Zhao, Xiangjie, Mo, Kunlun, Song, Hong, Guo, Lin, Chu, Shilong, Wang, Deping, Ding, Ke, Pei, Duanqing. Rational optimization of reprogramming culture conditions for the generation of induced pluripotent stem cells with ultra-high efficiency and fast kinetics. CELL RESEARCH[J]. 2011, 第 10 作者21(6): 884-894, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=4220084&detailType=1.

   

（ 1 ） 新型表观遗传修饰体系的鉴定, 参与, 国家任务, 2016-07--2020-12
（ 2 ） 单细胞测序研究体细胞重编程机制, 负责人, 中国科学院计划, 2017-12--2020-12
（ 3 ） 基于谱系决定机制研究功能性免疫细胞再生新策略, 参与, 国家任务, 2019-09--2023-12
（ 4 ） 细胞周期结构影响干细胞多能性建立的机制研究, 负责人, 国家任务, 2021-01--2024-12
（ 5 ） 干细胞模拟人类胚胎着床后发育的物理-生物复合调控机制研究, 参与, 国家任务, 2022-01--2025-12
（ 6 ） 细胞周期调控2-细胞期样细胞转变的机制研究, 负责人, 地方任务, 2024-01--2026-12