086000-生物与医药

表观遗传学，DNA甲基化，肿瘤诊断
肿瘤基因组

2003-09--2010-06   中国科学院上海生命科学研究院   博士
1999-09--2003-06   华中科技大学   学士

   

2014-08~2019-07,Dana-Farber Cancer Institute, Research Associate
2012-06~2014-08,Harvard T.H. Chan School of Public Health, Research Fellow
2010-06~2012-05,Illumina (Shanghai), Bioinformatics Support Scientist

   

（1） 年度最佳论文（瑞金医院）, 一等奖, 研究所（学校）, 2010

（ 1 ） UNIVERSAL EARLY CANCER DIAGNOSTICS, 发明, 2018, 第 4 作者, 专利号: PCT/US2018/032612

   

[1] Ding, Yi, Cai, Kangwen, Liu, Leiqin, Zhang, Zhiqiang, Zheng, Xiaoqi, Shi, Jiantao. mHapTk: a comprehensive toolkit for the analysis of DNA methylation haplotypes. BIOINFORMATICS. 2022, [2] Qiong Xu, Qiongfang Cha, Hui Qin, Bin Liu, Xueling Wu, Jiantao Shi. Identification of Master Regulators Driving Disease Progression, Relapse, and Drug Resistance in Lung Adenocarcinoma. FRONTIERS IN BIOINFORMATICS[J]. 2022, 2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580914/.
[3] Zhang, Zhiqiang, Dan, Yuhao, Xu, Yaochen, Zhang, Jiarui, Zheng, Xiaoqi, Shi, Jiantao. The DNA methylation haplotype (mHap) format and mHapTools. BIOINFORMATICS[J]. 2021, 37(24): 4892-4894, http://dx.doi.org/10.1093/bioinformatics/btab458.
[4] Smith, Zachary D, Shi, Jiantao, Gu, Hongcang, Donaghey, Julie, Clement, Kendell, Cacchiarelli, Davide, Gnirke, Andreas, Michor, Franziska, Meissner, Alexander. Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer. NATURE[J]. 2017, 549(7673): 543-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000411930000055.
[5] Mishima, Yuji, Paiva, Bruno, Shi, Jiantao, Park, Jihye, Manier, Salomon, Takagi, Satoshi, Massoud, Mira, PerillaGlen, Adriana, Aljawai, Yosra, Huynh, Daisy, Roccaro, Aldo M, Sacco, Antonio, Capelletti, Marzia, Detappe, Alexandre, Alignani, Diego, Anderson, Kenneth C, Munshi, Nikhil C, Prosper, Felipe, Lohr, Jens G, Ha, Gavin, Freeman, Samuel S, Van Allen, Eliezer M, Adalsteinsson, Viktor A, Michor, Franziska, San Miguel, Jesus F, Ghobrial, Irene M. The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma. CELL REPORTS[J]. 2017, 19(1): 218-224, http://dx.doi.org/10.1016/j.celrep.2017.03.025.
[6] Shi Jiantao. Exome sequencing reveals recurrent germline variants in patients with familial Waldenstrom's macroglobulinemia. Blood. 2016, [7] Shi, Jiantao, Yang, Wentao, Chen, Mingjie, Du, Yanzhi, Zhang, Ji, Wang, Kankan. AMD, an Automated Motif Discovery Tool Using Stepwise Refinement of Gapped Consensuses. PLOS ONE[J]. 2011, 6(9): http://dx.doi.org/10.1371/journal.pone.0024576.
[8] Wang, Kankan, Wang, Ping, Shi, Jiantao, Zhu, Xuehua, He, Miaomiao, Jia, Xiaohong, Yang, Xianwen, Qiu, Fei, Jin, Wen, Qian, Maoxiang, Fang, Hai, Mi, Jianqing, Yang, Xuzhi, Xiao, Huasheng, Minden, Mark, Du, Yanzhi, Chen, Zhu, Zhang, Ji. PML/RAR alpha Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia. CANCER CELL[J]. 2010, 17(2): 186-197, http://www.corc.org.cn/handle/1471x/2412379.

   

（ 1 ） 肿瘤DNA甲基化分子特征及转化应用, 主持, 部委级, 2020-01--2022-12

（1）Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer   2017-10-17
（2）Knowledge-based integratiion of microarray data   2009-08-03

现指导学生

王家豪  硕士研究生  085238-生物工程