071010-生物化学与分子生物学

表观遗传学，DNA甲基化，肿瘤诊断
单细胞转录组数据挖掘

2003-09--2010-06   中国科学院上海生命科学研究院   博士
1999-09--2003-06   华中科技大学   学士

   

2020-01~现在, 中国科学院分子细胞科学卓越创新中心, 研究员
2014-08~2019-07,Dana-Farber Cancer Institute, Research Associate
2012-06~2014-08,Harvard T.H. Chan School of Public Health, Research Fellow
2010-06~2012-05,Illumina (Shanghai), Bioinformatics Support Scientist

生物信息学

   

（1） 年度最佳论文（瑞金医院）, 一等奖, 研究所（学校）, 2010

（ 1 ） UNIVERSAL EARLY CANCER DIAGNOSTICS, 发明专利, 2018, 第 4 作者, 专利号: PCT/US2018/032612

   

[1] Nucleic Acids Research. 2023,   通讯作者  
[2] Briefings in Bioinformatics. 2023,   通讯作者  
[3] Genome Research. 2023,   通讯作者  
[4] Nature Communications. 2023,   通讯作者  
[5] Ding, Yi, Cai, Kangwen, Liu, Leiqin, Zhang, Zhiqiang, Zheng, Xiaoqi, Shi, Jiantao. mHapTk: a comprehensive toolkit for the analysis of DNA methylation haplotypes. BIOINFORMATICS. 2022, 第 6 作者  通讯作者  
[6] Qiong Xu, Qiongfang Cha, Hui Qin, Bin Liu, Xueling Wu, Jiantao Shi. Identification of Master Regulators Driving Disease Progression, Relapse, and Drug Resistance in Lung Adenocarcinoma. FRONTIERS IN BIOINFORMATICS[J]. 2022, 第 6 作者2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9580914/.
[7] Zhang, Zhiqiang, Dan, Yuhao, Xu, Yaochen, Zhang, Jiarui, Zheng, Xiaoqi, Shi, Jiantao. The DNA methylation haplotype (mHap) format and mHapTools. BIOINFORMATICS[J]. 2021, 第 6 作者  通讯作者  37(24): 4892-4894, http://dx.doi.org/10.1093/bioinformatics/btab458.
[8] Smith, Zachary D, Shi, Jiantao, Gu, Hongcang, Donaghey, Julie, Clement, Kendell, Cacchiarelli, Davide, Gnirke, Andreas, Michor, Franziska, Meissner, Alexander. Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer. NATURE[J]. 2017, 第 2 作者549(7673): 543-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000411930000055.
[9] Mishima, Yuji, Paiva, Bruno, Shi, Jiantao, Park, Jihye, Manier, Salomon, Takagi, Satoshi, Massoud, Mira, PerillaGlen, Adriana, Aljawai, Yosra, Huynh, Daisy, Roccaro, Aldo M, Sacco, Antonio, Capelletti, Marzia, Detappe, Alexandre, Alignani, Diego, Anderson, Kenneth C, Munshi, Nikhil C, Prosper, Felipe, Lohr, Jens G, Ha, Gavin, Freeman, Samuel S, Van Allen, Eliezer M, Adalsteinsson, Viktor A, Michor, Franziska, San Miguel, Jesus F, Ghobrial, Irene M. The Mutational Landscape of Circulating Tumor Cells in Multiple Myeloma. CELL REPORTS[J]. 2017, 第 3 作者19(1): 218-224, http://dx.doi.org/10.1016/j.celrep.2017.03.025.
[10] Shi Jiantao. Exome sequencing reveals recurrent germline variants in patients with familial Waldenstrom's macroglobulinemia. Blood. 2016, 第 1 作者
[11] Shi, Jiantao, Yang, Wentao, Chen, Mingjie, Du, Yanzhi, Zhang, Ji, Wang, Kankan. AMD, an Automated Motif Discovery Tool Using Stepwise Refinement of Gapped Consensuses. PLOS ONE[J]. 2011, 第 1 作者  通讯作者  6(9): http://dx.doi.org/10.1371/journal.pone.0024576.
[12] Wang, Kankan, Wang, Ping, Shi, Jiantao, Zhu, Xuehua, He, Miaomiao, Jia, Xiaohong, Yang, Xianwen, Qiu, Fei, Jin, Wen, Qian, Maoxiang, Fang, Hai, Mi, Jianqing, Yang, Xuzhi, Xiao, Huasheng, Minden, Mark, Du, Yanzhi, Chen, Zhu, Zhang, Ji. PML/RAR alpha Targets Promoter Regions Containing PU.1 Consensus and RARE Half Sites in Acute Promyelocytic Leukemia. CANCER CELL[J]. 2010, 第 3 作者17(2): 186-197, http://www.corc.org.cn/handle/1471x/2412379.

   

（ 1 ） 肿瘤DNA甲基化分子特征及转化应用, 负责人, 中国科学院计划, 2020-01--2022-12
（ 2 ） 肿瘤DNA甲基化单体分析方法与应用研究, 负责人, 国家任务, 2023-01--2026-12

（1）Epigenetic restriction of extraembryonic lineages mirrors the somatic transition to cancer   2017-10-17
（2）Knowledge-based integratiion of microarray data   2009-08-03

现指导学生

王家豪  硕士研究生  085238-生物工程