0710J6-再生医学

再生医学

2010-09--2014-06   中国科学院遗传与发育生物学研究所   博士学位
2007-09--2010-06   军事医学科学院   硕士学位
2003-09--2007-06   山东大学（威海）   学士学位

   

2024-01~现在, 中国科学院动物研究所, 研究员
2018-01~2024-01,中国科学院动物研究所, 副研究员
2014-07~2018-01,中国科学院动物研究所, 博士后
2010-09~2014-06,中国科学院遗传与发育生物学研究所, 博士学位
2007-09~2010-06,军事医学科学院, 硕士学位
2003-09~2007-06,山东大学（威海）, 学士学位

   

（1） 中国科学院杰出科技成就奖集体奖, 部委级, 2020
（2） 全国妇幼健康科学技术奖自然科学奖, 一等奖, 其他, 2019

   

（1） Reconstruction of functional uterine tissues through recellularizing the decellularized rat uterine scaffolds by MSCs in vivo and in vitro, BIOMEDICAL MATERIALS, 2021, 第 8 作者
（2） TRANSCRIPTOME AND DNA METHYLATION PROFILES OF MOUSE FETUS AND PLACENTA GENERATED BY ROUND SPERMATID INJECTION, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 通讯作者
（3） Overcoming Autocrine FGF Signaling-Induced Heterogeneity in Naive Human ESCs Enables Modeling of Random X Chromosome Inactivation, CELL STEM CELL, 2020, 第 2 作者
（4） Impaired lipid metabolism by age-dependent DNA methylation alterations accelerates aging, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 4 作者
（5） Overcoming Intrinsic H3K27me3 Imprinting Barriers Improves Post-implantation Development after Somatic Cell Nuclear Transfer, CELL STEM CELL, 2020, 第 6 作者
（6） Domesticated cynomolgus monkey embryonic stem cells allow the generation of neonatal interspecies chimeric pigs, PROTEIN & CELL, 2020, 第 6 作者
（7） Transcriptional repression of p21 by EIF1AX promotes the proliferation of breast cancer cells, CELL PROLIFERATION, 2020, 第 4 作者
（8） Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis, Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis, CELL RESEARCH, 2020, 第 21 作者
（9） Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon, Rapid construction of a whole-genome mutant library by combining haploid stem cells and inducible self-inactivating PiggyBac transposon, PROTEIN & CELL, 2020, 第 4 作者
（10） Rbm14 maintains the integrity of genomic DNA during early mouse embryogenesis via mediating alternative splicing, CELL PROLIFERATION, 2020, 第 3 作者
（11） Generation of qualified clinical-grade functional hepatocytes from human embryonic stem cells in chemically defined conditions, CELLDEATHDISEASE, 2019, 第 9 作者
（12） Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I, JOURNAL OF CELL BIOLOGY, 2019, 第 5 作者
（13） Enhanced mammalian genome editing by new Cas12a orthologs with optimized crRNA scaffolds, GENOME BIOLOGY, 2019, 第 7 作者
（14） Derivation of Mouse Haploid Trophoblast Stem Cells, CELL REPORTS, 2019, 第 5 作者
（15） Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I, THE JOURNAL OF CELL BIOLOGY, 2019, 第 5 作者
（16） Asymmetric Expression of LincGET Biases Cell Fate in Two-Cell Mouse Embryos, CELL, 2018, 第 3 作者
（17） MeCP2 deficiency promotes cell reprogramming by stimulating IGF1/AKT/mTOR signaling and activating ribosomal protein-mediated cell cycle gene translation, JOURNALOFMOLECULARCELLBIOLOGY, 2018, 第 2 作者
（18） SIRT6 deficiency results in developmental retardation cynomolgus monkeys, NATURE, 2018, 第 3 作者
（19） SIRT6 deficiency results in developmental retardation in cynomolgus monkeys., NATURE, 2018, 第 3 作者
（20） RBM14 is indispensable for pluripotency maintenance and mesoderm development of mouse embryonic stem cells, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 第 4 作者
（21） MicroRNA-494 promotes cancer progression and targets adenomatous polyposis coli in colorectal cancer, MOLECULAR CANCER, 2018, 第 4 作者
（22） Generation of Bimaternal and Bipaternal Mice from Hypomethylated Haploid ESCs with Imprinting Region Deletions, CELL STEM CELL, 2018, 第 4 作者
（23） Repurposing CRISPR-Cas12b for mammalian genome engineering, CELLDISCOVERY, 2018, 第 3 作者
（24） Mitochondrially produced ATP affects stem cell pluripotency via ActI6a-mediated histone acetylation, FASEB JOURNAL, 2018, 第 4 作者
（25） Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis, CELL RESEARCH, 2018, 第 7 作者
（26） Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-Wide Genetic Screening, CELL REPORTS, 2017, 第 5 作者
（27） Mettl3-Mediated m6A Regulates Spermatogonial Differentiation and Meiosis Initiation, CELL RESEARCH, 2017, 第 3 作者
（28） Rat Embryonic Stem Cells Produce Fertile Offspring Through Tetraploid Complementation, PNAS, 2017, 第 2 作者
（29） Rat embryonic stem cells produce fertile offspring through tetraploid complementation, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 2 作者
（30） Birth of Fertile Bimaternal Offspring Following Intracytoplasmic Injection of Parthenogenetic Haploid Embryonic Stem Cells, CELL RESEARCH, 2016, 第 3 作者
（31） Ubiquitously Expressed Genes Participate in Cell-Specific Functions via Alternative Promoter Usage, EMBO REPORTS, 2016, 第 1 作者

   

（ 1 ） 中国科学院青年创新促进会项目, 负责人, 中国科学院计划, 2019-01--2022-12