General

Dr. Yang Li, is an associate professor and the lab head of Laboratory of Immunology and Nanomedicine at the Shenzhen Institute of Advanced Technology, Chinese Academy of Science.


Dr. Li obtained a Master degree in Physiology (molecular biology) in China, followed a PhD degree in Immunology/Nanoscience in Europe (Italian National Research Council and Salzburg University, Austria) with a Marie Curie Fellowship funded by EU FP7 programme. He studied immunology and focused on the activation of innate immunity and inflammatory mechanisms, with particular focus on monocytes and macrophages and IL-1 family cytokines and receptors, upon interaction with nanomaterials/nanomedicines. After his PhD in Europe, he moved to USA for his post-doctoral trainings on nano-immune interactions at the Nanotechnology Innovation Center of the Kansas State University, and on tumor immunology (inflammasome in tumor and PD-1/PD-L1 targeting tumor therapy) at the University of Colorado. He then moved back to China with a position of Associate Professor at the Shenzhen Institutes of Advanced Technology, Chinese Academy of Science. There, he has started his own research group focusing on Immunology, Cancer immunology/Cancer therapy, Nanomedicine, and Nano-bio interactions.


Lab page: https://www.lilaboratory.org/ 


Research Areas

1. Immunology

2. Cancer research

3. Nanomedicine

4. Nano-bio interation

Publications

2021

25. Ximing Shao, Zhihao Ding, Wenhua Zhou, Yanyan Li, Zhibin Li, Haodong Cui, Xian Lin, Guoli Cao, Binghua Cheng, Haiyan Sun, Meiqing Li, Ke Liu, Danyi Lu, Shengyong Geng, Wenli Shi, Guofang Zhang, Qingle Song, Liang Chen, Guocheng Wang, Wu Su, Lintao Cai, Lijing Fang, David Tai Leong, Yang Li*, XueFeng Yu* & Hongchang Li*, Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase. Nature Nanotechnology, 2021, online. doi: https://doi.org/10.1038/s41565-021-00952-x

24.  Giacomo Della Camera,  Mariusz Madej, Anna M. Ferretti, Rita L. Spina,  Yang Li,  Annunziata Corteggio,  Tommaso Heinzl, Gergö Sipos,  Sabrina Gioria,  Alessandro Ponti,  Paola Italiani*, Diana Boraschi*,  Personalised Profiling of Immune Memory Induced by Nano-imaging Particles in Human Monocytes. Frontiers in Immunology, 2021, Accepted

23. Qingle Song, Guofang Zhang, Bo Wang, Guoli Cao, Dongjie Li, Yu Wang, Yuqian Zhang, Jin Geng, Hongchang Li, Yang Li*, Reinforce the Combinational Immuno-Oncotherapy of Switching “Cold” Tumor to “Hot” by Responsive Penetrating Nanogels. ACS Applied Materials and Interfaces, 2021. doi: https://doi.org/10.1021/acsami.1c08201

21. Yuqian Zhang, Guofang Zhang, Guocheng Wang, Lidong Wu, Nancy A Monteiro-Riviere, Yang Li*, The synergistic strategies for the immuno-oncotherapy with photothermal nanoagents. WIREs: Nanomedicine and Nanobiotechnology, 2021, e1717

20. Qiang Cao, Na Liu, Yushi Xiao, Rong Huang, Yang Li*, Lidong Wu*, Hybrid Magnetic Hydrogels Used as Artificial Marine Animals for Noncontact Cleaning, ACS Applied Polymer Materials 3 (2), 2021, 1182-1189

19. Anna M Ferretti, Sandro Usseglio, Sara Mondini, Carmelo Drago, Rosa La Mattina, Bice Chini, Claudia Verderio, Marianna Leonzino, Cinzia Cagnoli, Pooja Joshi, Diana Boraschi, Paola Italiani, Yang Li, Benjamin J Swartzwelter, Luigi Sironi, Paolo Gelosa, Laura Castiglioni, Uliano Guerrini, Alessandro Ponti. Towards bio-compatible magnetic nanoparticles: Immune-related effects, in-vitro internalization, and in-vivo bio-distribution of zwitterionic ferrite nanoparticles with unexpected renal clearance. Journal of Colloid and Interface Science, 2021, 582, 678-700

18. Shi Qiu, Jiawen Ji, Wei Sun, Jia Pei, Jian He, Yang Li, Jiao Jiao Li, Guocheng Wang, Recent Advances in Surface Manipulation Using Micro-contact Printing for Biomedical Applications, Smart Materials in Medicine, 2021, 2, 65-73

2020

17. Jing Zhao, Danping Lu, Sergio Moya, Haoying Yan, Miaojuan Qiu, JunZong Chen, Xincheng Wang, Yang Li, Haobo Pan, Guochuang Chen, Guocheng Wang. Bispecific T-cell engager (BiTE) immunotherapy of ovarian cancer based on MIL-88A MOF/MC gene delivery system. Applied Materials Today. 2020, 20, 100701

16. Shu Zhang, Ming Xiao, Yuqian Zhang, Yang Li, Huan Liu, Gang Han, Brijesh Rathi, Kaiyu Lyu, Lidong Wu. Mimicking neuromelanin nanoparticles as a selective Pb2+ probe. Analytica Chimica Acta, 2020, 105, 208-213

15. Yanfeng Liu, Shishi Tao, Lijuan Liao, Yang Li, Hongchang Li, Zhihuan Li, Lilong Lin, Xiaochun Wan, Xiaolu Yang, Liang Chen. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. Nature communications, 2020, 11 (1), 1-13

14. Litian Zhang, Lukman O Afolabi, Xiaochun Wan, Yang Li*, Liang Chen*. Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins. Frontiers in Cell and Developmental Biology, 2020, 8:802

2019

13. Yuqian Zhang, Guofang Zhang, Liang Chen, Yang Li*. Modulation of the inflammatory tumor microenvironment - a new approach for photothermal-synergized cancer immunotherapy. Nanomedicine, 2019, 14(16), 2101–2104

2017

12. Yang Li*, Zhenzhen Shi, Isabella Radauer-Preim, Ancuela Andosch, Eudald Casals, Ursula Luetz-Meindl, Jutta Horejs-Hoeck, Martin Himly, Nancy A. Monteiro-Riviere, Victor Puntus, Albert Duschl, Diana Boraschi. Bacterial endotoxin (LPS) binds to the surface of gold nanoparticles, interferes with protein corona formation and triggers inflammation. Nanotoxicology, 2017, 11(9-10): 1157-1175.

​B

11. Dinoop Ravindran Menon, Yuchun Luo, John Arcaroli, Sucai Liu, Lekha KrishnanKutty, Douglas Osborne, Yang Li, Jenny Mae Samson, Stacey Bagby, Aik-Choon Tan, William Robinson, Wells Messersmith, and Mayumi Fujita. CDK1 interacts with Sox2 and promotes tumor initiation in human melanoma. Cancer Research, 2018, 78(23):6561-6574

10. Yang Li*, Mayumi Fujita, Diana Boraschi. The endotoxin contamination in nanoparticles leads a misunderstanding of nano-triggering inflammation. Front. Immunol. 2017, 8: 472. 

9. Yang Li, Nancy A. Monteiro-Riviere. Mechanisms of cell uptake, inflammatory potential and protein corona effects with gold nanoparticles. Nanomedicine, 2016. 11(24): 3185-3203.

8. Yang Li*, Paola Italiani, Eudald Casals, Dirk Valkenborg, Inge Mertens, Geert Baggerman, Inge Nelissen, Victor F. Puntes, Diana Boraschi. Assessing the immunosafety of engineered nanoparticles with a novel in vitro model based on human primary monocytes. ACS Appl. Mater. Interfaces. 2016, 8(42): 28437–28447

7. Yang Li*, Diana Boraschi. Endotoxin contamination: a key element for interpretation of nanosafety studies. Nanomedicine, 2016 11(3): 269-287. (2016-2018, most read paper in Nanomedicine)

6. Yang Li*, Paola Italiani, Eudald Casals, Ngoc Tran, Victor Puntes, Diana Boraschi. Optimising the use of commercial LAL assays for the analysis of endotoxin contamination in metal colloids and metal oxide nanoparticles. Nanotoxicology, 2015, 9(4): 462-473

5. Murali Kumarasamy, Kata Kenesei, Yang Li, Kornél Demeter, Zsuzsanna Környei, Emilia Madarász. Uptake and bio-reactivity of polystyrene nanoparticles is affected by surface modifications, ageing and LPS adsorption: in vitro studies on neural tissue cells. Nanoscale, 2015, 7(9): 4199-4210.

4. Peng Wang, Xin Nie, Yue Wang, Yang Li, Cuicui Ge, Lili Zhang, Liming Wang, Ru Bai, Zhiyun Chen, Yuliang Zhao, Chunying Chen. Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF-β/Smad signaling pathway. Small, 2013, 9(22): 3799-3811.

3. Cuicui Ge, Yang Li, Jun-Jie Yin, Ying Liu, Liming Wang, Yuliang Zhao, Chunying Chen. The contributions of metal impurities and tube structure to the toxicity of carbon nanotube materials. NPG Asia Materials, 2012, 4(12): e32.

2. Yang Li, Ying Liu, Yujian Fu, Taotao Wei, Laurent Le Guyader, Ge Gao, Ru-Shi Liu, Yanzhong Chang, Chunying Chen. The triggering of apoptosis in macrophages by pristine graphene through the MAPK and TGF-beta signaling pathways. Biomaterials, 2012, 33(2), 402-411. (ISI web of knowledge-Essential Science Indicators, Highly cited papers)

1. Cuicui Ge, Li Meng, Ligeng Xu, Ru Bai, Jiangfeng Du, Lili Zhang, Yang Li, Yanzhong Chang, Yuliang Zhao, Chunying Chen. Acute pulmonary and moderate cardiovascular responses of spontaneously hypertensive rats after exposure to single-wall carbon nanotubes. Nanotoxicology, 2012, 6(5), 526-542


Research Interests

Innate immunity, IL-1 cytokines, Macrophages/monocytes, Apoptosis, Nanomedicine, Nanotoxicology and nanosafety, Drug delivery and cancer therapy, Lung fibrosis, Tumor immunology.



Students

现指导学生

王梁  硕士研究生  085600-材料与化工  

Honors & Distinctions

​Marie Curie Fellowship, 2011