基本信息

姚胜  男  研究员,课题组长,博士生导师  中国科学院大学/中国科学院上海药物研究所
电子邮件: yaosheng@simm.ac.cn
通信地址: 上海浦东祖冲之路555号
邮政编码: 201203

研究领域

1、结构新颖的活性天然产物的发现

2、中草药传统功效的药效物质基础研究

3、天然先导结构的发现、结构改造与优化研究

招生信息

   
招生专业
100701-药物化学
100800-中药学
招生方向
天然药物化学
中药化学

教育背景

2005-09--2008-07   中国科学院上海药物研究所   获理学博士学位
2002-09--2005-07   中国药科大学 中药学院   理学硕士
1998-09--2002-07   武汉大学药学院   获医学硕士
学位

理学博士,药物化学专业

工作经历

   
工作简历
2022-07~现在, 中国科学院上海药物研究所, 研究员,课题组长,博士生导师
2017-10~2022-07,中国科学院上海药物研究所, 研究员
2012-10~2017-09,中国科学院上海药物研究所, 副研究员
2008-11~2011-01,德国Wuppertal University, 博士后
2008-08~2012-09,中国科学院上海药物研究所, 助理研究员
社会兼职
2020-08-28-今,上海市药学会中药学专业委员会, 委员

专利与奖励

   
专利成果
( 1 ) 一类多氧孕甾烷化合物、前药化合物或其组合物及其用途, 发明专利, 2018, 第 3 作者, 专利号: ZL201380031642

( 2 ) 具有降血脂活性的竹柏内酯类化合物,其制备方法及用途, 发明专利, 2016, 第 3 作者, 专利号: CN2016100893763

( 3 ) 具有降血脂活性的松香烷型二萜类化合物,其制备方法及用途, 发明专利, 2015, 第 3 作者, 专利号: CN2015100863782

出版信息

   
发表论文
(1) Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease, NATURE COMMUNICATIONS, 2021, 第 2 作者
(2) Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1 beta production in macrophages through activating autophagy, BIOORGANIC CHEMISTRY, 2020, 第 5 作者
(3) Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway, SCIENTIFIC REPORTS, 2020, 第 8 作者
(4) Neuroprotective and Anti-inflammatory Ditetrahydrofuran-Containing Diarylheptanoids from Tacca chantrieri, JOURNAL OF NATURAL PRODUCTS, 2020, 第 6 作者
(5) Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients, Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients, ACTA PHARMACOLOGICA SINICA, 2020, 第 2 作者
(6) Targeted isolation of two disesquiterpenoid macrocephadiolides A and B fromAinsliaea macrocephalausing a molecular networking-based dereplication strategy, ORGANIC CHEMISTRY FRONTIERS, 2020, 第 6 作者
(7) Tricarabrols A-C, three anti-inflammatory sesquiterpene lactone trimers featuring a methylene-tethered linkage from Carpesium faberi, ORGANIC CHEMISTRY FRONTIERS, 2020, 第 6 作者
(8) Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain, INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2020, 第 3 作者
(9) Sesquiterpene lactone dimers from Artemisia lavandulifolia inhibit interleukin-1β production in macrophages through activating autophagy, Bioorganic Chemistry, 2020, 第 5 作者
(10) Discovery and characterization of natural products as novel indoleamine 2,3-dioxygenase 1 inhibitors through high-throughput screening, ACTA PHARMACOLOGICA SINICA, 2020, 第 2 作者
(11) Cytotoxic Germacrane-Type Sesquiterpene Lactones from the Whole Plant of Carpesium lipskyi, JOURNAL OF NATURAL PRODUCTS, 2019, 第 7 作者
(12) Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity, FITOTERAPIA, 2019, 第 9 作者
(13) Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer, PHYTOMEDICINE, 2019, 第 3 作者
(14) Tetramerized Sesquiterpenoid Ainsliatetramers A and B from Ainsliaea fragrans and Their Cytotoxic Activities, ORGANIC LETTERS, 2019, 第 6 作者
(15) 3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/ STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells, 3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/ STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells, 中国药理学报:英文版, 2019, 第 2 作者
(16) pretreatmentwithbroadspectrumantibioticsaltersthepharmacokineticsofmajorconstituentsofshaoyaogancaodecoctioninratsafteroraladministration, 中国药理学报英文版, 2019, 通讯作者
(17) A lipid-soluble extract of Pinellia pedatisecta Schott enhances antitumor T cell responses by restoring tumor-associated dendritic cell activation and maturation, JOURNAL OF ETHNOPHARMACOLOGY, 2019, 第 3 作者
(18) Pyrrole-Hemoglobin Adducts, a More Feasible Potential Biomarker of Pyrrolizidine Alkaloid Exposure, CHEMICAL RESEARCH IN TOXICOLOGY, 2019, 第 5 作者
(19) 3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells, ACTA PHARMACOLOGICA SINICA, 2019, 第 2 作者
(20) Immune modulation of a lipid-soluble extract of Pinellia pedatisecta Schott in the tumor microenvironment of an HPV+ tumor-burdened mouse model, JOURNAL OF ETHNOPHARMACOLOGY, 2018, 第 3 作者
(21) 7 alpha,8 alpha-Epoxynagilactones and their glucosides from the twigs of Podocarpus nagi: Isolation, structures, and cytotoxic activities, FITOTERAPIA, 2018, 第 5 作者
(22) Pretreatment with broad-spectrum antibiotics alters the pharmacokinetics of major constituents of Shaoyao-Gancao decoction in rats after oral administration, Acta Pharmacologica Sinica, 2018, 第 9 作者
(23) Birhodomolleins D and E, two new dimeric grayanane diterpenes with a 3-0-2' linkage from the fruits of Rhododendron pumilum, Chinese Chemical Letters, 2018, 第 4 作者
(24) Birhodomolleins D and E, two new dimeric grayanane diterpenes with a 3-O-2′ linkage from the fruits of Rhododendron pumilum, CHINESE CHEMICAL LETTERS, 2018, 第 4 作者
(25) Ainsliatriolides A and B, Two Guaianolide Trimers from Ainsliaea fragrans and Their Cytotoxic Activities, JOURNAL OF ORGANIC CHEMISTRY, 2018, 第 7 作者
(26) A Pair of Enantiomeric Bis-seco-abietane Diterpenoids from Cryptomeria fortunei, JOURNAL OF NATURAL PRODUCTS, 2018, 通讯作者
(27) The first phytochemical investigation of Rhododendron websterianum: triterpenoids and their cytotoxic activity, PHYTOCHEMISTRY LETTERS, 2018, 通讯作者
(28) Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage, Organic Letters, 2017, 第 8 作者
(29) Three new dimeric diterpenes from Rhododendi-on molle, CHINESE CHEMICAL LETTERS, 2017, 第 4 作者
(30) Cytotoxic sesquiterpene lactones from Artemisia anomala, PHYTOCHEMISTRY LETTERS, 2017, 第 4 作者
(31) Divaccinosides A–D, four rare iridoid glucosidic truxillate esters from the leaves of Vaccinium bracteatum, TETRAHEDRON LETTERS, 2017, 第 4 作者
(32) Pyrrole-hemoglobin adduct, a potential biomarker of pyrrolizidine alkaloid-induced hepatotoxicity, DRUG METABOLISM AND PHARMACOKINETICS, 2017, 第 3 作者
(33) Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes, JOURNAL OF ETHNOPHARMACOLOGY, 2017, 第 5 作者
(34) Cucurbitane Glucosides from the Crude Extract of Siraitia grosvenorii with Moderate Effects on PGC-1 alpha Promoter Activity, JOURNAL OF NATURAL PRODUCTS, 2017, 第 8 作者
(35) Three new dimeric diterpenes from Rhododendron molle, Chinese Chemical Letters, 2017, 第 4 作者
(36) Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa, Chinese Chemical Letters, 2017, 第 6 作者
(37) Cytotoxic germacrane-type sesquiterpene lactones from the whole plant of Inula cappa, CHINESE CHEMICAL LETTERS, 2017, 通讯作者
(38) Dicarabrol A, dicarabrone C and dipulchellin A, unique sesquiterpene lactone dimers from Carpesium abrotanoides, RSC ADVANCES, 2017, 第 4 作者
(39) Two new lignan-iridoid glucoside diesters from the leaves of Vaccinium bracteatum and their relative and absolute configuration determination by DFT NMR and TDDFT-ECD calculation, TETRAHEDRON, 2017, 第 6 作者
(40) Taxodikaloids A and B, Two Dimeric Abietane-Type Diterpenoids from Taxodium ascendens Possessing an Oxazoline Ring Linkage, ORGANIC LETTERS, 2017, 通讯作者
(41) Cassane Diterpenoids from the Pericarps of Caesalpinia bonduc, JOURNAL OF NATURAL PRODUCTS, 2016, 第 3 作者
(42) Novel Diterpenoids from the Twigs of Podocarpus nagi, MOLECULES, 2016, 通讯作者
(43) Two new phenanthrenoid dimers from Juncus effusus, CHINESE CHEMICAL LETTERS, 2016, 通讯作者
(44) Two new phenanthrenoid dimers from Juncus effusus, Two new phenanthrenoid dimers from Juncus effusus, 中国化学快报:英文版, 2016, 第 6 作者
(45) Polyoxypregnane steroids with an open-chain sugar moiety from Marsdenia tenacissima and their chemoresistance reversal activity, PHYTOCHEMISTRY, 2016, 第 1 作者
(46) Rearranged diterpenoids from the seeds of Caesalpinia sappan, CHINESE CHEMICAL LETTERS, 2016, 第 4 作者
(47) A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice, CARDIOVASCULAR RESEARCH, 2016, 第 2 作者
(48) Anti-inflammatory Inositol Derivatives from the Whole Plant of Inula cappa, JOURNAL OF NATURAL PRODUCTS, 2015, 第 3 作者
(49) Polyoxypregnane Steroids from the Stems of Marsdenia tenacissima, JOURNAL OF NATURAL PRODUCTS, 2014, 第 1 作者
(50) Dictamins A–C, three unprecedented apotirucallane-type trinortriterpenoids from Dictamnus dasycarpus, TETRAHEDRON LETTERS, 2013, 通讯作者
(51) Triterpenoids from the Stem Bark of Melia toosendan and Determination of Their Absolute Configurations at C(24), CHEMISTRY & BIODIVERSITY, 2013, 通讯作者
(52) Humulane-type sesquiterpenoids from Pilea cavaleriei subsp crenata, ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, 第 3 作者
(53) ent-Labdane Diterpenes from the Stems of Mallotus japonicus, JOURNAL OF NATURAL PRODUCTS, 2013, 通讯作者
(54) Activation of AMPK by Bitter Melon Triterpenoids Involves CaMKK beta, PLOS ONE, 2013, 第 6 作者
(55) Sesquiterpene lactones from Inula cappa, PHYTOCHEMISTRY LETTERS, 2012, 第 4 作者
(56) Bicunningines A and B, Two New Dimeric Diterpenes from Cunninghamia lanceolata, ORGANIC LETTERS, 2012, 第 2 作者
(57) 2010年我国天然药物化学研究进展, Natural products chemistry research 2010's progress in China, 中国天然药物, 2012, 第 4 作者
(58) 2010年我国天然药物化学研究进展(英文), Natural products chemistry research 2010's progress in China, CHINESE JOURNAL OF NATURAL MEDICINES, 2012, 第 4 作者
(59) Stereochemistry of atropisomeric 9,10-dihydrophenanthrene dimers from Pholidota chinensis, TETRAHEDRON-ASYMMETRY, 2008, 第 1 作者
(60) Abietane diterpenoids from the bark of Cryptomeria fortunei., JOURNAL OF NATURAL PRODUCTS, 2008, 第 1 作者
(61) Secoiridoids and xanthones from Tylophora secamonoides Tsiang, JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2008, 第 1 作者
(62) Phochinenins A-F, Dimeric 9,10-Dihydrophenanthrene Derivatives, from Pholidota chinensis, HELVETICA CHIMICA ACTA, 2008, 第 1 作者
(63) 波罗蜜叶中新的查耳酮, 中国天然药物, 2005, 第 1 作者

科研活动

   
科研项目
( 1 ) 中药竹柏中具有抗多发性骨髓瘤作用的天然小分子化合物的发现与构效关系研究, 负责人, 国家任务, 2017-01--2020-12
( 2 ) 杉科植物中松香烷型二萜抗动脉粥样硬化活性的发现及构效关系研究, 负责人, 国家任务, 2015-01--2018-12
( 3 ) 罗汉松植物中具有降血脂活性的降二萜内酯类化合物的结构改造与初步构效关系研究, 负责人, 国家任务, 2014-01--2016-12
( 4 ) 天然异喹啉生物碱类抗阿尔茨海默症先导化合物的发现研究, 负责人, 中国科学院计划, 2016-09--2018-06
( 5 ) 个性化药物核心化学资源系统研究, 负责人, 中国科学院计划, 2016-01--2018-12

指导学生

现指导学生

王敏  硕士研究生  078100-中药学  

穆佳星  硕士研究生  078100-中药学