基本信息
孙宝发  男  硕导  未知
email: sunbf@big.ac.cn
address: 北京市朝阳区北辰西路1号104楼
postalCode: 100101

招生信息

   
招生专业
0710J3-生物信息学
0710Z1-基因组学
0710Z2-计算生物学
招生方向
RNA甲基化表观转录调控

教育背景

2009-09--2013-01   中国科学院大学   博士
2006-09--2009-09   汕头大学   硕士
2002-09--2006-09   湖南科技大学   学士

工作经历

   
工作简历
2016-01~现在, 中国科学院北京基因组研究所, 副研究员
2013-07~2015-12,中国科学院北京基因组研究所, 助理研究员
2009-09~2013-01,中国科学院大学, 博士
2006-09~2009-09,汕头大学, 硕士
2002-09~2006-09,湖南科技大学, 学士

教授课程

面向数据科学的Unix和Python编程
生物化学与分子生物学实验

专利与奖励

   
奖励信息
(1) 中国科学院青年创新促进会会员, 院级, 2016

出版信息

   
发表论文
(1) Epitranscriptomic 5-methylcytosine profile in PM2.5-induced mouse pulmonary fibrosis, Genomics Proteomics Bioinformatics, 2020, 第 8 作者
(2) RNA structural dynamics regulate early embryogenesis through controlling transcriptome fate and function, Genome Biology, 2020, 第 7 作者
(3) OsNSUN2-mediated 5-methylcytosine mRNA modification enhances rice adaptation to high temperature, Developmental Cell, 2020, 第 8 作者
(4) Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma, Cell Res, 2019, 第 1 作者
(5) 5-methylcytosine promotes pathogenesis of bladder cancer through stabilizing mRNAs, Nature Cell Biology, 2019, 第 1 作者
(6) A novel m6A reader Prrc2a controls oligodendroglial specification and myelination, Cell Research, 2019, 第 1 作者
(7) Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1, Science Translational Medicine, 2019, 第 1 作者
(8) mRNA m6A plays opposite role in regulating UCP2 and PNPLA2 protein expression in adipocytes, Int J Obes (Lond), 2018, 第 1 作者
(9) METTL3-mediated m6A modification is required for cerebellar development, Plos Biology, 2018, 第 7 作者
(10) Circulating tumor DNA 5-hydroxymethylcytosine as a novel diagnostic biomarker for esophageal cancer, Cell Research, 2018, 第 1 作者
(11) 5-Hydroxymethylome in Circulating Cell-free DNA as A Potential Biomarker for Non-small-cell Lung Cancer, Genomics Proteomics Bioinformatics, 2018, 通讯作者
(12) Cytoplasmic m6A reader YTHDF3 promotes mRNA translation, Cell Research, 2017, 通讯作者
(13) Mettl3-mediated m6A regulates spermatogonial differentiation and meiosis initiation, Cell Research, 2017, 第 1 作者
(14) 5-methylcytosine promotes mRNA export - NSUN2 as the methyltransferase and ALYREF as an m5C reader., Cell Research, 2017, 第 1 作者
(15) m6A modulates haematopoietic stem and progenitor cell specification, Nature, 2017, 第 1 作者
(16) A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size, Dev Cell, 2017, 第 5 作者
(17) Nuclear m6A reader YTHDC1 regulates mRNA splicing, Molecular Cell, 2016, 第 1 作者
(18) Deep RNA sequencing analysis of syncytialization-related genes during BeWo cell fusion, Reproduction, 2016, 第 5 作者
(19) Bacteriophage WO can mediate horizontal gene transfer in endosymbiotic Wolbachia genomes, Front Microbiol, 2016, 第 2 作者
(20) Contribution of Multiple Inter-Kingdom Horizontal Gene Transfers to Evolution and Adaptation of Amphibian-Killing Chytrid, Batrachochytrium dendrobatidis, Front Microbiol, 2016, 第 1 作者
(21) Molecular analysis of DNA in blastocoele fluid using next-generation sequencing, J Assist Reprod Genet, 2016, 通讯作者
(22) Dynamic m6A modification and its emerging regulatory role in mRNA splicing, Science Bulletin, 2015, 第 1 作者
(23) Genome-wide 5-hydroxymethylcytosine modification pattern is a novel epigenetic feature of globozoospermia, Oncotarget, 2015, 第 2 作者
(24) Discriminative host sanction together with relatedness promote the cooperation in fig/fig wasp mutualism, J Anim Ecol, 2015, 第 2 作者
(25) Non-quantitative adjustment of offspring sex ratios in pollinating fig wasps, Sci Rep, 2015, 第 2 作者
(26) Regulation of transcription factors on sexual dimorphism of fig wasps, Sci Rep, 2015, 第 1 作者
(27) Horizontal functional gene transfer from bacteria to fishes, Sci Rep, 2015, 第 1 作者
(28) Smg6/Est1 licenses embryonic stem cell differentiation via nonsense-mediated mRNA decay, EMBO J, 2015, 第 5 作者
(29) FTO and obesity: mechanisms of association, Diabetes Reports, 2014, 第 2 作者
(30) Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase, Cell Research, 2014, 第 1 作者
(31) FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis, Cell Research, 2014, 第 1 作者
(32) Discriminative host sanctions in a fig-wasp mutualism, Ecology, 2014, 第 3 作者
(33) Redox-active quinones induces genome-wide DNA methylation changes by an iron-mediated and Tet-dependent mechanism, Nucleic Acids Res, 2014, 第 10 作者
(34) piRBase: a web resource assisting piRNA functional study, Database, 2014, 第 4 作者
(35) Multiple ancient horizontal gene transfers and duplications in lepidopteran species, Insect molecular biology, 2013, 第 1 作者
(36) Multiple interkingdom horizontal gene transfers in Pyrenophora and closely related species and their contributions to phytopathogenic lifestyles, PLoS One, 2013, 第 1 作者
(37) Obligate mutualism within a host drives the extreme specialization of a fig wasp genome, Genome biology, 2013, 第 2 作者

科研活动

   
科研项目
( 1 ) m5C调控mRNA翻译的功能研究, 负责人, 国家任务, 2017-01--2020-12
( 2 ) RNA m6A甲基化修饰调控mRNA选择性剪接机制研究, 负责人, 国家任务, 2015-01--2017-12
( 3 ) RNA m6A 修饰甲基转移酶复合物及其表观调控因子鉴定和作用机制研究, 参与, 国家任务, 2015-01--2018-12
( 4 ) mRNA甲基化调控儿童TEL/AML1阳性急性淋巴细胞白血病发生发展机制研究, 参与, 国家任务, 2015-01--2018-12
( 5 ) 污染物诱发核酸损伤、修复与基因突变的分子机制, 参与, 中国科学院计划, 2014-06--2014-12
( 6 ) 可逆化学修饰调控lncRNA二级结构机制及其功能研究, 参与, 国家任务, 2018-01--2020-12
( 7 ) 2016年青年创新促进会, 负责人, 中国科学院计划, 2016-01--2019-12
( 8 ) RNA结构对斑马鱼胚胎发育的调控机制研究, 负责人, 国家任务, 2019-01--2022-12