基本信息
梁丽媛  女  硕导  中国科学院重庆绿色智能技术研究院
电子邮件: liangliyuan@cigit.ac.cn
通信地址: 重庆市北碚区方正大道266号
邮政编码:

招生信息

   
招生专业
080501-材料物理与化学
0703Z1-化学生物学
0710J1-纳米科学与技术
招生方向
纳米孔单分子分析
生物大分子构效解析
无机材料表面功能化及应用

教育背景

2008-09--2011-07   法国波尔多第一大学   博士

工作经历

   
工作简历
2012-09~2014-09,牛津大学, 玛丽居里学者
2011-09~2012-09,多伦多大学, 博士后
2008-09~2011-07,法国波尔多第一大学, 博士

教授课程

纳米孔单分子检测技术及应用
国科大前沿讲座-纳米孔单分子分析
国科大前沿讲座-纳米孔功能化及单分子检测应用

专利与奖励

   
奖励信息
(1) 北碚区科技创新巾帼建功标兵, 市地级, 2022
(2) 重庆市杰出青年, 省级, 2021
(3) 重庆市高层次引进人才第四类, 省级, 2016
(4) 欧盟玛丽居里奖学金, 其他, 2011
专利成果
( 1 ) 芳香手性螺旋分子与无机氮化硅复合纳米通道的构建方法, 2023, 第 1 作者, 专利号: 202310334175.5

( 2 ) 基于固态纳米孔检测NCL 构象及其G4 复合物的方法, 2023, 第 1 作者, 专利号: 202310207119.5

( 3 ) 基于固态纳米孔技术的抗衰寡肽的单分子检测方法, 2023, 第 1 作者, 专利号: 202310181444.9

( 4 ) 固态纳米孔及其制备方法、小肽检测方法与应用, 2023, 第 1 作者, 专利号: 202310103474.8

( 5 ) 基于化学修饰的纳米孔对整合素构象检测的方法, 2021, 第 1 作者, 专利号: 202111543733.6

( 6 ) 一种不同癌基因的单分子拓扑结构鉴别方法, 2021, 第 1 作者, 专利号: 202210505887.4

( 7 ) 基于固态纳米孔技术对脂多糖定性或菌种来源鉴定的方法, 2021, 第 1 作者, 专利号: 202111413112.6

( 8 ) 一种基于固态纳米孔的功能蛋白光电联合检测方法, 2021, 第 1 作者, 专利号: 202111431094.4

( 9 ) 用于高分子聚合物自组装结构检测的检测体系及检测方法, 2021, 第 1 作者, 专利号: 202111403213.5

( 10 ) 一种液相微纳加工方法和设备, 2021, 第 12 作者, 专利号: CN112034741B

( 11 ) 基于复合固态纳米孔单分子技术的C反应蛋白检测方法, 2021, 第 1 作者, 专利号: CN112834757A

( 12 ) 一种基于真空法的玻璃针尖纳米孔充灌装置及其使用方法, 2020, 第 5 作者, 专利号: CN112146956A

( 13 ) 一种调控和动态监测G-四联体构象变化的纳米孔体系和方法, 2020, 第 1 作者, 专利号: CN111289586A

( 14 ) 一种用于DNA测序的通道结构及其制备和测序的方法, 2020, 第 2 作者, 专利号: CN111154848A

( 15 ) 一种自动精确定位制备固态纳米孔阵列的系统及方法, 2019, 第 10 作者, 专利号: CN110436406A

( 16 ) 一种基于针尖纳米孔单分子检测技术的实时监控酶切反应的方法, 2019, 第 5 作者, 专利号: CN110132921A

( 17 ) 一种动态监测G-四联体形成过程的纳米孔单分子体系及其监测方法和应用, 2019, 第 1 作者, 专利号: CN109557157A

( 18 ) 基于氧化锌纳米线的微囊藻毒素传感器及制备方法、应用, 2019, 第 1 作者, 专利号: CN109490262A

( 19 ) 一种基于固态纳米孔技术的多糖单分子结构解析方法, 2019, 第 2 作者, 专利号: CN109358106A

( 20 ) 氧化锌纳米线/二茂铁基聚噻吩复合材料、金电极及其制备方法, 2019, 第 1 作者, 专利号: CN109301073A

( 21 ) 一种基于常压化学气相沉积的大面积单层二硫化钨薄膜的制备方法和产品, 2018, 第 10 作者, 专利号: CN108559972A

( 22 ) 一种基于适配体-纳米金传感的纳米孔检测微囊藻毒素的新方法, 2018, 第 1 作者, 专利号: CN108344863A

( 23 ) 一种用于拉曼光谱表征的局域电磁场增强器件及其制备方法、应用和使用方法, 2018, 第 8 作者, 专利号: CN108226133A

( 24 ) 一种基于藻细胞特征拉曼散射的水环境扰动评估方法, 2018, 第 8 作者, 专利号: CN107941783A

( 25 ) 一种适用于复杂样品环境中拉曼痕量检测的芯片及其制备方法和使用方法, 2018, 第 5 作者, 专利号: CN107907529A

( 26 ) 带DNA分子探针的石墨烯微电极电化学检测传感器, 2017, 第 10 作者, 专利号: CN107167507A

( 27 ) 一种用于痕量微囊藻毒素检测的多孔阵列电磁场增强SERS器件、制备方法及检测方法, 2017, 第 9 作者, 专利号: CN107121423A

( 28 ) 单分子操纵的石墨烯纳米孔DNA测序仪, 2017, 第 6 作者, 专利号: CN106596645A

( 29 ) 一种泡沫混凝土, 2017, 第 6 作者, 专利号: CN106431487A

( 30 ) 一种具有良好导电性能的泡沫混凝土, 2017, 第 6 作者, 专利号: CN106431115A

( 31 ) 一种防霉抗菌涂料, 2017, 第 6 作者, 专利号: CN106349850A

( 32 ) 一种隔热保温涂料, 2016, 专利号: CN106147460A

( 33 ) 一种泡沫混凝土, 2016, 第 6 作者, 专利号: CN105541394A

( 34 ) 一种隔热保温涂料, 2015, 第 6 作者, 专利号: CN104293001A

出版信息

   
发表论文
(1) Characterization and modulation of the unimolecular conformation of integrins with nanopore sensors, Chem. Eng. J., 2024, 
(2) Construction and applications of hybrid nanochannels with helical foldamers and solid-state nanopores, Chem. Eng. J., 2024, 
(3) Research Progress in Nanopore Materials and Sensors, Chin. J. Anal. Chem., 2023, 
(4) Single-molecule lipopolysaccharides identification and the interplay with biomolecules via nanopore readout, Biosens. Bioelectron., 2023, 
(5) Single-molecule recognition of Nucleolin and the interactions with DNA/ RNA G-quadruplexes via nanopore decoding, Chem. Eng. J., 2023, 
(6) DNA nanostructure-assisted detection of carcinoembryonic antigen with a solid-state nanopore, BIOELECTROCHEMISTRY, 2023, 第 7 作者
(7) Nanopore discrimination and sensitive plasma detection of multiple natriuretic peptides: The representative biomarker of human heart failure, BIOSENSORS AND BIOELECTRONICS, 2023, 第 7 作者
(8) Overview of the materials design and sensing strategies of nanopore devices, COORDINATION CHEMISTRY REVIEWS, 2023, 第 11 作者
(9) Simultaneous Dual-Site Identification of 5(m)C/8(o)G in DNA Triplex Using a Nanopore Sensor, ACS APPLIED MATERIALS & INTERFACES, 2022, 第 6 作者
(10) Simultaneous, site-specific identification of 5mC/8oG in DNA triplex at single nucleotide resolution using a nanopore sensor, Acs Applied Materials & Interfaces, 2022, 
(11) Single-molecule Identification of the Conformations of Human C-reactive Protein and Its Aptamer complex with Solid-State Nanopore, Acs Applied Materials & Interfaces, 2022, 第 11 作者
(12) An ultrasensitive aptasensor of SARS-CoV-2N protein based on ion current rectification with nanopipettes, SENSORS AND ACTUATORS. B, CHEMICAL, 2022, 第 5 作者
(13) Comparison Study on Single Nucleotides Transport Phenomena in Carbon Nanotubes, Nano Letters, 2022, 
(14) De novo profiling of insect-resistant proteins of rice via nanopore peptide differentiation, BIOSENSORS & BIOELECTRONICS, 2022, 第 8 作者
(15) 固态纳米孔检测不同结构DNA分子, Detection of DNA Molecules with Different Structures Using Solid-State Nanopores, 微纳电子技术, 2022, 第 7 作者
(16) Tungsten Disulfide Field-Effect Transistor Biosensor for Label-free and Highly Sensitive Detection of DNA Hybridization, ACS Appl. Nano Mater., 2022, 
(17) De novo Nanopore Profiling of Peptidome Encoded by Insect-2 resistant Gene in Rice, Biosensors and Bioelectronics, 2022, 
(18) 基于别构因子效应的固态纳米孔尿酸分子检测, Detection of Uric Acid Molecules by Solid-State Nanopores Based on Allosteric Factor Effect, 微纳电子技术, 2022, 第 6 作者
(19) Highly Sensitive and Selective Solid-State Nanopore Aptasensor for Vanillin Detection in Food Samples, Food Chem, Food Chemistry, 2022, 
(20) A solid-state nanopore-based single-molecule approach for label-free characterization of plant polysaccharides, A solid-state nanopore-based single-molecule approach for label-free characterization of plant polysaccharides, PLANTCOMMUNICATIONS, 2021, 第 3 作者
(21) Visualizing of AuNPs protection aptamer from DNase I enzyme digestion based on Nanopipette and its use for Microcystin-LR detection, ANALYTICA CHIMICA ACTA, 2021, 第 4 作者
(22) The Raman band shift of suspended graphene impacted by the substrate edge and helium ion irradiation, Nano Express, 2021, 第 1 作者
(23) Enzyme Hinders HIV-1 Tat Viral Transport and Real-Time Measured with Nanopores, ACS SENSORS, 2021, 第 7 作者
(24) Reversible photo-regulation on the folding/unfolding of telomere G-quadruplexes with solid-state nanopores, ANALYST, 2021, 第 11 作者
(25) Investigation on the competition of duplex/ G-quadruplex/ i-motif in telomere sequences and c-MYC gene with a solid-state nanopore sensor, SENSORS AND ACTUATORS B-CHEMICAL, 2021, 第 11 作者
(26) Nanopore detects ��-radiation inhibited HIV-1 protease activity, BIOSENSORSANDBIOELECTRONICS, 2021, 第 5 作者
(27) Cross Disjoint Mortise Confined Solid-State Nanopore, ACS Applied Nano Materials, 2021, 
(28) Reversible Photo-regulation on the folding/unfolding of Telomere G-quadruplexes with Solid-State Nanopore, Analyst, 2021, 第 11 作者
(29) Nanocrystalline graphite nanopores for DNA sensing, CARBON, 2021, 第 6 作者
(30) Direct optical observation of DNA clogging motions near controlled dielectric breakdown silicon nitride nanopores, SENSORS AND ACTUATORS B-CHEMICAL, 2021, 第 5 作者
(31) Label-Free Single-Molecule Identification and Exploration of Folding Process on Telomere Gquadruplexes With a Solid-State Nanopore Sensor, RSC. Adv., 2020, 第 11 作者
(32) Reduction chemistry-assisted nanopore determination method for immunoglobulin isotypes, NANOSCALE, 2020, 第 9 作者
(33) Label-free single-molecule identification of telomere G-quadruplexes with a solid-state nanopore sensor, RSC ADVANCES, 2020, 第 11 作者
(34) Nanopore Fabrication via Transient High Electric Field Controlled Breakdown and Detection of Single RNA, ACS APPLIED BIO MATERIALS, 2020, 第 4 作者
(35) Applications of Photo-Responsive Molecules in Nanopore-based Devices, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2020, 第 11 作者
(36) 基于纳米孔器件的光响应分子的应用, Applications of Photo-Responsive Molecules in Nanopore-based Devices, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2020, 第 11 作者
(37) Immobilization of telomere sequence on solid-state nanopore and monitoring the G-quadruplexes folding process, Micronanoelectr. Technol., 2020, 第 11 作者
(38) Single-Molecule Study on Interactions between Cyclic Nonribosomal Peptides and Protein Nanopore, ACS APPLIED BIO MATERIALS, 2020, 第 6 作者
(39) A solid-state nanopore-based single-molecule approach for label-free characterization of plant polysaccharides, PLANT COMMUNICATIONS, 2020, 第 3 作者
(40) 基于LiCl盐浓度梯度的固态纳米孔DNA分子检测, 微纳电子技术, 2020, 第 7 作者
(41) 固态纳米孔上端粒序列的共价修饰与G-四联体折叠监测, Covalent Modification of Telomere Sequence on Solid-State Nanopore and Monitoring for the G-Quadruplexes Folding Process, 微纳电子技术, 2020, 第 2 作者
(42) Single-molecular Detection of Polysaccharides with Chemically-Modified Nanopores, 2019 IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE (IEEE 3M-NANO), 2019, 第 2 作者
(43) Single-molecular detection of polysaccharides with chemically-modified nanopores, 9TH IEEE INTERNATIONAL CONFERENCE ON MANIPULATION, MANUFACTURING AND MEASUREMENT ON THE NANOSCALE, 3M-NANO 2019, 2019, 第 2 作者
(44) 基于二茂铁标记的电化学DNA生物传感器研究, Research on electrochemical DNA biosensors based on ferrocene labelling, 传感器与微系统, 2019, 第 5 作者
(45) Investigation of the adsorption behavior of bsa with tethered lipid layer-modified solid-state nanopores in a wide ph range, RSC ADVANCES, 2019, 第 11 作者
(46) Strong, Healable, and Recyclable Composite Paper Made from a Codispersion of Carbon Nanotube and Sulfonated Graphenal Polymer, MACROMOLECULAR MATERIALS AND ENGINEERING, 2018, 第 6 作者
(47) Oxygen plasma assisted enhanced photoresponse of ZnO nanowires fabricated by catalyst-free chemical vapor deposition, RSC ADVANCES, 2018, 第 3 作者
(48) Slowing down DNA translocation by a nanofiber meshed layer, JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2018, 第 8 作者
(49) Label-free sensitive detection of microcystin-lr via aptamer-conjugated gold nanoparticles based on solid-state nanopores, LANGMUIR, 2018, 第 11 作者
(50) Detection of Gold Nanoparticles with Different Sizes By Using Solid-state Nanopore,IEEE 3M-NANO International Conference, IEEE 3M-NANO International Conference, 2017, 第 11 作者
(51) Covalent Modification of SiliconNitride Nanoporeby Amphoteric Polylysine for Short DNA Detection, ACS OMEGA, 2017, 第 11 作者
(52) High-efficiency dispersion and sorting of single-walled carbon nanotubes via non-covalent interactions, JOURNALOFMATERIALSCHEMISTRYC, 2017, 第 11 作者
(53) Slowing Down DNA Translocation using Integrated Nanopore and Nanopillars Precisely Deposited by Helium Ion Beam, BIOPHYSICAL JOURNAL, 2017, 第 5 作者
(54) Rectification of Ion Current Determined by the Nanopore Geometry: Experiments and Modelling, Rectification of Ion Current Determined by the Nanopore Geometry: Experiments and Modelling, CHINESE PHYSICS LETTERS, 2016, 第 7 作者
(55) Rectification of Ion Current Determined by the Nanopore Geometry: Experiments and Modelling, Rectification of Ion Current Determined by the Nanopore Geometry: Experiments and Modelling, 中国物理快报:英文版, 2016, 第 7 作者
(56) Porous structure diamond films with super-hydrophilic performance, DIAMOND AND RELATED MATERIALS, 2015, 第 6 作者
(57) Catalysis Inside Dendrimers, SYNTHESIS-STUTTGART, 2015, 
(58) Porous structure diamond films with super-hydrophilic performance, DIAMOND & RELATED MATERIALS, 2015, 第 6 作者
(59) Click Metallodendrimers and Their Functions, SYNLETT, 2015, 第 5 作者
(60) Dendritic Molecular Nanobatteries and the Contribution of Click Chemistry, JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS, 2013, 第 3 作者
(61) Reactions of phosphorus/boron frustrated Lewis pairs with SO2, CHEMICAL SCIENCE, 2013, 第 4 作者
(62) Multicompartmental Hollow Micelles Formed by Novel Linear ABC Triblock Copolymers in Aqueous Medium, J. Phys. Chem. B, 2013, 第 1 作者
(63) Click dendrimers and triazole-related aspects: catalysts, mechanism, synthesis, and functions. A bridge between dendritic architectures and nanomaterials., ACCOUNTS OF CHEMICAL RESEARCH, 2012, 第 2 作者
(64) Facile synthesis of electrophilic vinyl boranes: reactions of alkynyl-borates and diazonium salts., CHEMICAL COMMUNICATIONS (CAMBRIDGE, ENGLAND), 2012, 第 2 作者
(65) Catalysis in aqueous solvent of cross C-C coupling reactions by Bis- and Tris(ferrocenyltriazolylmethyl)arene-stabilized Pd(0) nanoparticles, Eur. J. Inorg. Chem., 2012, 第 1 作者
(66) Water-soluble glycodendrimers: synthesis and stabilization of catalytically active Pd and Pt nanoparticles, TETRAHEDRON LETTERS, 2011, 第 2 作者
(67) The copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) "click" reaction and its applications. An overview, COORDINATION CHEMISTRY REVIEWS, 2011, 第 1 作者
(68) The Efficient Copper(I) (Hexabenzyl)tren Catalyst and Dendritic Analogues for Green "Click" Reactions between Azides and Alkynes in Organic Solvent and in Water: Positive Dendritic Effects and Monometallic Mechanism, ADVANCED SYNTHESIS & CATALYSIS, 2011, 第 1 作者
(69) Redox recognition using "click" chemistry, INORGANICA CHIMICA ACTA, 2011, 第 4 作者
(70) "Click" Assembly of Carborane-Appended Polymers and Stabilization of Gold and Palladium Nanoparticles, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 2011, 第 1 作者
(71) Olefin metathesis in nano-sized systems, BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2011, 第 4 作者
(72) Interactions and encapsulation of vitamins C, B3, and B6 with dendrimers in water., CHEMISTRY (WEINHEIM AN DER BERGSTRASSE, GERMANY), 2010, 第 2 作者
(73) Click Syntheses of 1,2,3-Triazolylbiferrocenyl Dendrimers and the Selective Roles of the Inner and Outer Ferrocenyl Groups in the Redox Recognition of ATP(2-) and Pd2+, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2010, 第 3 作者
(74) Dendrimer-induced molecular catalysis in water: the example of olefin metathesis., CHEMISTRY (WEINHEIM AN DER BERGSTRASSE, GERMANY), 2010, 第 3 作者
(75) ���Click��� Synthesis of a Heterobifunctional Ferrocenyl Dendrimer with Molecular Recognition Properties and In���uence of the Ferrocenyl Redox Potential on the Formation of Gold Nanoparticles, J Inorg Organomet Polym., 2010, 第 1 作者
(76) A New Synthetic Approach to Asymmetric Amphiphilic ABA ' Block Copolymers by ATRP and Click Reactions, JOURNAL OF APPLIED POLYMER SCIENCE, 2009, 第 2 作者
(77) Synthesis of well-defined ABC triblock copolymers with polypeptide segments by ATRP and click reactions, EUROPEAN POLYMER JOURNAL, 2008, 第 2 作者
(78) Novel ABC 2-type liquid-crystalline block copolymers with azobenzene moieties prepared by atom transfer radical polymerization, EUROPEAN POLYMER JOURNAL, 2008, 第 4 作者
(79) Synthesis of novel linear PEO-b-PS-b-PCL triblock copolymers by the combination of ATRP, ROP, and a click reaction, MACROMOLECULAR CHEMISTRY AND PHYSICS, 2007, 第 2 作者

科研活动

   
科研项目
( 1 ) 中科院西部之光青年学者, 负责人, 中国科学院计划, 2022-01--2024-12
( 2 ) 重庆市杰出青年基金, 负责人, 地方任务, 2021-10--2024-09
( 3 ) 北碚区科技人才与自主创新专项:功能化固态纳米孔的构建及其单分子结构解析, 负责人, 地方任务, 2021-07--2022-06
( 4 ) 军事医学研究院毒物药物研究所 纳米孔生物标志物检测, 参与, 其他国际合作项目, 2021-07--2022-12
( 5 ) 重庆市留学回国创新优秀项目, 负责人, 地方任务, 2017-12--2018-12
( 6 ) 石墨烯纳米孔-纳米粒子间隙捕获DNA分子光致电信号增强机制研究, 负责人, 地方任务, 2017-10--2020-12
( 7 ) 中国科学院青年创新促进会项目, 负责人, 中国科学院计划, 2017-01--2021-12
( 8 ) 基于CuAAC点击反应的二茂铁基聚噻吩的合成及其对氧化锌纳米线的共价表面修饰研究, 负责人, 国家任务, 2016-01--2018-12
( 9 ) 单分子操纵石墨烯纳米孔DNA测序仪, 参与, 中国科学院计划, 2016-01--2017-12
( 10 ) The Catalytic Synthesis of Sulfonamides, 负责人, 其他国际合作项目, 2012-09--2014-09
参与会议
(1)无   第34届化学年会   2024-06-14
(2)无   2024功能材料国际论坛   2024-05-17
(3)无   2024 武汉分析+国际峰会   2024-03-22
(4)纳米通道器件构筑及应用   2023 苏州纳米+国际峰会   2023-11-23
(5)无   化学会第32届学术年会   2023-06-17
(6)纳米孔单分子分析   微纳科技与先进材料会议   2023-06-11
(7)纳米孔单分子分析   青促会化材年会   2023-04-25
(8)纳米孔单分子分析   青促会学术年会   2023-04-12
(9)纳米孔单分子分析   纳米光电材料会议   2022-11-13
(10)纳米孔单分子分析   第一届分离材料交叉学科论坛   2021-07-16
(11)无   中国化学会第32届化学年会   2021-04-19
(12)Nanopore characterization of polysaccharides   2020-10-09
(13)无   第7届G4国际会议   2019-09-09
(14)纳米孔的功能化及其应用   • 中科院青年创新促进会若水论坛   2018-11-22
(15)纳米孔的制备及应用   全国软物质大会   2018-11-09
(16)无   • 第十三届全国分析化学年会   2018-06-14
(17)纳米孔的制备及应用   • 中科院青年创新促进会长江绿色发展论坛   2018-05-06
(18)纳米孔功能化及应用   中科院青促会青年生命论坛   2018-04-12
(19)基于纳米孔技术的单分子检测   重庆院-大连化物所青促会学术交流会   2017-06-01
(20)‘Click’ Synthesis of a Heterobifunctional Ferrocenyl Dendrimer with Molecular Recognition Properties and Influence of the Ferrocenyl Redox Potential on the Formation of Gold Nanoparticles   2010-10-05