Weiqi ZHANG  Ph.D

Principal Investigator


Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS)

Address: building 104, courtyard 1, Beichen West Road, Chaoyang District, Beijing

Postal Code: 100101

Research Areas

Mechanism of aging and aging-related diseases

Potential interventions and mechanisms to delay aging

​Disease modeling and drug screening based on human pluripotent stem cells


2005 – 2011, Ph.D., Cell biology, Peking University

2001 – 2005, B.Sc., Bioengineering, Nanchang University


2019 – Present, Professor, Beijing Institute of Genomics, CAS

2016 – 2019, Professor, Institute of Biophysics, CAS

2015 – 2016, Associate Professor, Institute of Biophysics, CAS

2011 – 2015, Research Associate, Institute of Biophysics, CAS


1.       Sun S#, Li J#, Wang S#, Li J#, Ren J#, Bao Z#, Sun L#, Ma X#, Zheng F, Ma S, Sun L, Wang M, Yu Yan, Ma M, Wang Q, Chen Z, Ma H, Wang X, Wu Z, Zhang H, Yan K, Yang Y, Zhang Y, Zhang S, Lei J, Teng ZQ, Liu CM, Bai G, Wang YJ, Li J, Wang X, Zhao G, Jiang T, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. CHIT1-positive microglia drive motor neuron aging in the primate spinal cord. Nature. 2023 Oct 31. doi: 10.1038/s41586-023-06783-1.

2.       Li J#, Xiong M#, Fu XH#, Fan Y#, Dong C#, Sun X, Zheng F, Wang SW, Liu L, Xu M, Wang C, Ping J, Che S, Wang Q, Yang K, Zuo Y, Lu X, Zheng Z, Lan T, Wang S, Ma S, Sun S, Zhang B, Chen CS, Cheng KY, Ye J, Qu J, Xue Y, Yang YG*, Zhang F*, Zhang W*, Liu GH*. Determining a multimodal aging clock in a cohort of chinese women. Med. 2023 Jul 24: S2666-6340(23)00197-6. doi: 10.1016/j.medj.2023.06.010. (Lead contact)

3.       Li H#, Wu S#, Li J#, Xiong Z#, Yang K#, Ye W#, Ren J#, Wang Q, Xiong M, Zheng Z, Zhang S, Han Z, Yang P, Jiang B, Ping J, Zuo Y, Lu X, Zhai Q, Yan H, Wang S, Ma S, Zhang B, Ye J, Qu J, Yang YG*, Zhang F*, Liu GH*, Bao Y*, Zhang W*. HALL: a comprehensive database for human aging and longevity studies. Nucleic Acids Research. 2023 Oct 23: gkad880. doi: 10.1093/nar/gkad880.

4.       Wang C#, Yang K#, Liu X#, Wang S, Song M, Belmonte JC, Qu J*, Liu GH*, Zhang W*. MAVS antagonizes human stem cell senescence as a mitochondrial stabilizer. Research. 2023. 2023 Jul 27;6:0192. doi: 10.34133/research.0192.

5.       Liu X#, Liu Z#, Wu Z#, Ren J#, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C, Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell. 2023 Jan 19;186(2):287-304.e26. doi: 10.1016/j.cell.2022.12.017.

6.       Sun S#, Ma S#, Cai Y#, Wang S#, Ren J#, Yang Y#, Ping J, Wang X, Zhang Y, Yan H, Li W, Esteban CR, Yu Y, Liu F, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body. Innovation. 2023 Jan 5;4(1):100380. doi: 10.1016/j.xinn.2023.100380.

7.       Ma S#, Wang S#, Ye Y#, Ren J#, Chen R#, Li W, Li J, Zhao L, Zhao Q, Sun G, Jing Y, Zuo Y, Xiong M, Yang Y, Wang Q, Lei J, Sun S, Long X, Song M, Yu S, Chan P, Wang J, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues. Cell Stem Cell. 2022 Jun 2;29(6):990-1005.e10. doi: 10.1016/j.stem.2022.04.017.

8.       Liu Z#, Ji Q#, Ren J#, Yan P#, Wu Z#, Wang S, Sun L, Wang Z, Li J, Sun G, Liang C, Sun R, Jiang X, Hu J, Ding Y, Wang Q, Bi S, Wei G, Cao G, Zhao G, Wang H, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging. Dev Cell. 2022 Jun 6;57(11):1347-1368.e12. doi: 10.1016/j.devcel.2022.05.004.

9.       Zhang S#, Wu Z#, Shi Y#, Wang S#, Ren J#, Yu Z, Huang D, Yan K, He Y, Liu X, Ji Q, Liu B, Liu Z, Qu J, Liu GH*, Ci W*, Wang X*, Zhang W*. FTO stabilizes MIS12 and counteracts senescence. Protein Cell. 2022 Dec;13(12):954-960. doi: 10.1007/s13238-022-00914-6.

10.    Li W#, Zou Z#, Cai Y#, Yang K#, Wang S#, Liu Z, Geng L, Chu Q, Ji Z, Chan P, Liu GH*, Song M*, Qu J*, Zhang W*. Low-dose chloroquine treatment extends the lifespan of aged rats. Protein Cell. 2022 Jun;13(6):454-461. doi: 10.1007/s13238-021-00903-1.

11.    Wang S#, Cheng F#, Ji Q#, Song M#, Wu Z, Zhang Y, Ji Z, Feng H, Belmonte JCI, Zhou Q, Qu J*, Li W*, Liu GH*, Zhang W*. Hyperthermia differentially affects specific human stem cells and their differentiated derivatives. Protein Cell. 2022 Aug;13(8):615-622. doi: 10.1007/s13238-021-00887-y.

12.    Zhang W. The quest to understand aging during and after COVID-19. Cell Stem Cell. 2021 May 6;28(5):805-807. doi: 10.1016/j.stem.2021.04.020.

13.    Aging Atlas Consortium. Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Res. 2021 Jan 8;49(D1): D825-D830. doi: 10.1093/nar/gkaa894.

14.    Wang W#, Zheng Y#, Sun S#, Li W#, Song M, Ji Q, Wu Z, Liu Z, Fan Y, Liu F, Li J, Esteban CR, Wang S, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Tang F*, Liu GH*. A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence. Sci Transl Med. 2021 Jan 6;13(575): eabd2655. doi: 10.1126/scitranslmed.abd2655.

15.    Zou Z#, Long X#, Zhao Q#, Zheng Y#, Song M#, Ma S#, Jing Y, Wang S, He Y, Esteban CR, Yu N, Huang J, Chan P, Chen T, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A single-cell transcriptomic atlas of human skin aging. Dev Cell. 2021 Feb 8;56(3):383-397.e8. doi: 10.1016/j.devcel.2020.11.002.

16.    Ma S#, Sun S#, Li J#, Fan Y#, Qu J#, Sun L#, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-cell transcriptomic atlas of primate cardiopulmonary aging. Cell Res. 2021 Apr;31(4):415-432. doi: 10.1038/s41422-020-00412-6.

17.    Ma S#, Sun S#, Geng L#, Song M#, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Esteban CR, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI*, Zhang W*, Qu J*, Liu GH*. Caloric restriction reprograms the single-cell transcriptional landscape of Rattus Norvegicus aging. Cell. 2020 Mar 5;180(5):984-1001.e22. doi: 10.1016/j.cell.2020.02.008.

18.    Wang S#, Zheng Y#, Li J#, Yu Y#, Zhang W#, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Ma L, Esteban CR, Chan P, Qiao J, Zhou Q, Belmonte JCI*, Qu J*, Tang F*, Liu GH*. Single-cell transcriptomic atlas of primate ovarian aging. Cell. 2020 Feb 6;180(3):585-600.e19. doi: 10.1016/j.cell.2020.01.009.

19.    Zhang W#, Qu J, Liu GH*, Belmonte JCI*. The ageing epigenome and its rejuvenation. Nat Rev Mol Cell Biol. 2020 Mar;21(3):137-150. doi: 10.1038/s41580-019-0204-5.

20.    Zhang W#, Zhang S#, Yan P#, Ren J#, Song M, Li J, Lei J, Pan H, Wang S, Ma X, Ma S, Li H, Sun F, Wan H, Li W, Chan P, Zhou Q, Liu GH*, Tang F*, Qu J*. A single-cell transcriptomic landscape of primate arterial aging. Nat Commun. 2020 May 5;11(1):2202. doi: 10.1038/s41467-020-15997-0.

21.    Zhang W#, Wan H#, Feng G#, Qu J#, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*. SIRT6 deficiency results in developmental retardation in cynomolgus monkeys. Nature. 2018 Aug;560(7720):661-665. doi: 10.1038/s41586-018-0437-z.

22.    Zhang W#, Li J#, Suzuki K#, Qu J#, Wang P, Zhou J, Liu X, Ren R, Xu X, Ocampo A, Yuan T, Yang J, Li Y, Shi L, Guan D, Pan H, Duan S, Ding Z, Li M, Yi F, Bai R, Wang Y, Chen C, Yang F, Li X, Wang Z, Aizawa E, Goebl A, Soligalla RD, Reddy P, Esteban CR, Tang F*, Liu GH*, Belmonte JCI*. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science. 2015 Jun 5;348(6239):1160-3. doi: 10.1126/science.aaa1356.