1. 发展用于线粒体功能调控的新技术和新方法；

2. 发展用于疾病模型中的多重刺激响应型生物材料。

   

070322-生物无机化学

化学生物学

   

分别在武汉大学和新加坡国立大学取得学士和博士学位。之后在哈佛大学医学院生化和分子医药系，以及哈佛医学院/Brigham & Women 医院从事博士后研究。

博士

代表工作： 

1. Ruan, L. F., Chen, J., Du, C. C., Lu, H. R., Zhang, J. Y., Cai, X. M., Dou, R., Lin, W. C., Chai, Z. F., Nie, G. J. & Hu, Y. Mitochondrial temperature-responsive drug delivery reverses drug resistance in lung cancer. Bioact. Mater. 2022, 13, 191-199.
2.  Biofabricated macrophage and fibroblast membranes synergistically promote skin wound healing. Bioengineering & Translational Medicine
3. Du, C., Zhou, M., Jia, F., Ruan, L., Lu, H., Zhang, J., Zhu, B., Liu, X., Chen, J., Chai, Z. & Hu, Y. D-arginine-loaded metal-organic frameworks nanoparticles sensitize osteosarcoma to radiotherapy. Biomaterials 2021, 269, 120642.
4. Zhang, J., Song, X., Xia, M., Xue, Y., Zhou, M., Ruan, L., Lu, H., Chen, J., Wang, D., Chai, Z. & Hu, Y. The proximity of the G-quadruplex to hemin impacts the intrinsic DNAzyme activity in mitochondria. Chem. Commun. 2021, 57, 3038-3041. 
   
5. Fu, M., Sun, Y., Kenry, Zhang, M., Zhou, H., Shen, W., Hu, Y. & Zhu, Q. A dual-rotator fluorescent probe for analyzing the viscosity of mitochondria and blood. Chem. Commun. 2021, 57, 3508-3511.
6. Wang, D., Xue, M., Chen, J., Chen, H., Liu, J., Li, Q., Xie, Y., Hu, Y., Ni, Y. & Zhou, Q. Macrophage-derived implantable vaccine prevents postsurgical tumor recurrence. Biomaterials 2021, 278, 121161.   
7. Yang, L., Peltier, R., Zhang, M., Song, D., Huang, H., Chen, G., Chen, Y., Zhou, F., Hao, Q., Bian, L., He, M.-l., Wang, Z., Hu, Y. & Sun, H. Desuccinylation-triggered peptide self-assembly: Live cell imaging of SIRT5 activity and mitochondrial activity modulation. J. Am. Chem. Soc. 2020, 142, 18150–18159.
8. Zhou, M.X., Huang, H., Wang, D.Q., Lu, H.R., Chen, J., Chai, Z.F., Yao, S.Q. & Hu, Y. Light-triggered PEGylation/dePEGylation of the nanocarriers for enhanced tumor penetration. Nano Lett. 2019, 19, 3671-3675.
9. Wang, D.Q., Huang, H., Zhou, M.X., Lu, H.R., Chen, J., Chang, Y.T., Gao, J.M., Chai, Z. & Hu, Y. A thermoresponsive nanocarrier for mitochondria-targeted drug delivery. Chem. Commun. 2019, 55, 4051-4054.
10. Ruan, L., Zhou, M., Chen, J., Huang, H., Zhang, J., Sun, H., Chai, Z. & Hu, Y. Thermoresponsive drug delivery to mitochondria in vivo. Chem. Commun. 2019, 55, 14645-14648.
11. Wen, K.K., Xu, X.Z., Chen, J., Lv, L., Wu, L.F., Hu, Y., Wu, X.X., Liu, G.Z., Peng, A.D. & Huang, H. Triplet tellurophene-based semiconducting polymer nanoparticles for near-infrared-mediated cancer theranostics. ACS Appl. Mater. Interfaces 2019, 11, 17884-17893.
12. Wang, D., Zhou, M., Huang, H., Ruan, L., Lu, H., Zhang, J., Chen, J., Gao, J., Chai, Z. & Hu, Y. Gold nanoparticle-based probe for analyzing mitochondrial temperature in living cells. ACS Appl. Bio Mater. 2019, 2, 3178-3182.
13. Zhou, M.X., Zhang, X.C., Xie, J., Qi, R.X., Lu, H.R., Leporatti, S., Chen, J. & Hu, Y. pH-sensitive poly(beta-amino ester)s nanocarriers facilitate the inhibition of drug resistance in breast cancer cells. Nanomaterials 2018, 8, 952.
14. Tan, Y., Zhang, L., Man, K.H., Peltier, R., Chen, G.C., Zhang, H.T., Zhou, L.Y., Wang, F., Ho, D., Yao, S.Q., Hu, Y. & Sun, H.Y. Reaction-based off-on near-infrared fluorescent probe for imaging alkaline phosphatase activity in living cells and mice. ACS Appl. Mater. Interfaces 2017, 9, 6796-6803.
15. Gao, H., Bi, Y., Chen, J., Peng, L.R., Wen, K.K., Ji, P., Ren, W.F., Li, X.Q., Zhang, N., Gao, J.M., Chai, Z. & Hu, Y.  Near-infrared light-triggered switchable nanoparticles for targeted chemo/photothermal cancer therapy. ACS Appl. Mater. Interfaces 2016, 8, 15103-15112.
16. Chen, G.C., Xie, Y.S., Peltier, R., Lei, H.P., Wang, P., Chen, J., Hu, Y., Wang, F., Yao, X. & Sun, H.Y. Peptide-decorated gold nanoparticles as functional nano-capping agent of mesoporous silica container for targeting drug delivery. ACS Appl. Mater. Interfaces 2016, 8, 11204-11209.
17. Qin, Y.P., Chen, J., Bi, Y., Xu, X.H., Zhou, H., Gao, J.M., Hu, Y., Zhao, Y.L. & Chai, Z.F. Near-infrared light remote-controlled intracellular anti-cancer drug delivery using thermo/pH sensitive nanovehicle. Acta Biomater. 2015, 17, 201-209.