基本信息
李一叶  女  博导  国家纳米科学中心
电子邮件: liyy@nanoctr.cn
通信地址: 北京市海淀区中关村北一条11号
邮政编码: 100190

招生信息

   
招生专业
0710J1-纳米科学与技术
071010-生物化学与分子生物学
招生方向
纳米生物医学
纳米生物效应
胰腺癌治疗

工作经历

   
工作简历
2019-03~现在, 国家纳米科学中心, 研究员
2015-03~现在, 国家纳米科学中心, 副研究员

教授课程

纳米生物材料

专利与奖励

   
奖励信息
(1) 北京市科学技术奖:自然科学奖, 一等奖, 省级, 2021
专利成果
( 1 ) 一种靶向性杂化纳米体系及其制备方法和应用, 2020, 第 3 作者, 专利号: ZL201710470938.3

( 2 ) 一种纳米粒子及其制备方法和用途, 2019, 第 3 作者, 专利号: 201910132345.5

( 3 ) 一种IDO1 多肽纳米抑制剂及其制备方法和应用, 2018, 第 3 作者, 专利号: ZL201811188781.6

( 4 ) 人颗粒酶B 蛋白衍生物及其在靶向治疗腺癌中的用途, 2013, 第 2 作者, 专利号: ZL 200810223366.X

出版信息

   
发表论文
(1) Multifunctional biomolecule nanostructures for cancer therapy, Nature Reviews Materials, 2021, 第 1 作者
(2) Penetration Cascade of Size Switchable Nanosystem in Desmoplastic Stroma for Improved Pancreatic Cancer Therapy, ACS Nano, 2021, 通讯作者
(3) Bacterial cytoplasmic membranes synergistically enhance the antitumor activity of autologous cancer vaccines, Science Translational Medicine, 2021, 第 10 作者
(4) Emerging nanomedicines for anti-stromal therapy against desmoplastic tumors, Biomaterials, 2020, 通讯作者
(5) Modularly Designed Peptide Nanoprodrug Augments Anti-Tumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2, 3-Dioxygenase, Journal of the American Chemical Society, 2020, 通讯作者
(6) A graphdiyne oxide-based iron sponge with photothermally-enhanced tumor-specific Fenton chemistry, Advanced Materials, 2020, 通讯作者
(7) An Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy, ACS NANO, 2019, 通讯作者
(8) Targeted Co-delivery of the Iron Chelator Deferoxamine and a HIF1α Inhibitor Impairs Pancreatic Tumor Growth, ACS NANO, 2019, 第 5 作者
(9) Biomimetic Metal-Organic Framework Nanoparticles for Cooperatively Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy, Advanced Materials, 2019, 通讯作者
(10) Precise Design of Nanomedicines: Perspectives for Cancer Treatment, National Science Review, 2019, 第 1 作者
(11) Synthesis and Imaging of Biocompatible Graphdiyne Quantum Dots, ACS Applied Materials & Interfaces, 2019, 通讯作者
(12) Cellular Responses to Exposure to Outdoor Air from the Chinese Spring Festival at the Air–Liquid Interface, Environmental Science & Technology, 2019, 第 6 作者
(13) Sulforaphane Mediates Glutathione Depletion via Polymeric Nanoparticles to Restore Cisplatin Chemosensitivity, ACS NANO, 2019, 通讯作者
(14) Plasmon-Enhanced Oxidase-Like Activity and Cellular Effect of Pd-Coated Gold Nanorods, ACS Applied Materials & Interfaces, 2019, 第 2 作者
(15) Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem, Nature Communications, 2018, 通讯作者
(16) Highly Fluorescent Chiral N-S-Doped Carbon Dots from Cysteine Affect Cellular Energy Metabolism, Angewandte Chemie International Edition, 2018, 第 1 作者
(17) Nanomaterial Libraries and Model Organisms for Rapid High Content Analysis of Nanosafety, National Science Review, 2018, 第 1 作者
(18) Photothermal Effect Enhanced Cascade-Targeting Strategy for Improved Pancreatic Cancer Therapy by Gold Nanoshell@Mesoporous Silica Nanorod., ACS Nano, 2017, 通讯作者
(19) Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis., Theranostics, 2017, 第 9 作者
(20) Precision combination therapy for triple negative breast cancer via biomimetic polydopamine polymer core-shell nanostructures, Biomaterials, 2017, 第 7 作者
(21) Integration of photothermal therapy and synergistic chemotherapy by a porphyrin self-assembled micelle confers chemosensitivity in triplenegative breast cancer, Biomaterials, 2016, 第 3 作者
(22) Aspect ratios of gold nanoshell capsules mediated melanoma ablation by synergistic photothermal therapy and chemotherapy, Nanomedicine: Nanotechnology, Biology, and Medicine, 2016, 通讯作者
(23) An MMP‑2 Responsive Liposome Integrating Antifibrosis and Chemotherapeutic Drugs for Enhanced Drug Perfusion and Efficacy in Pancreatic Cancer, ACS Applied Materials & Interfaces, 2016, 第 8 作者
(24) Analytical methods for nano-bio interface interactions, Science China-Chemistry, 2016, 第 3 作者
(25) Triple-punch” Strategy for Triple Negative Breast Cancer Therapy with Minimized Drug Dosage and Improved Antitumor Efficacy, ACS NANO, 2015, 第 1 作者
(26) Co-delivery of HIF1α siRNA and gemcitabine via biocompatible lipid-polymer hybrid nanoparticles for effective treatment of pancreatic cancer, Biomaterials, 2015, 第 1 作者
(27) Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy,  ACS Nano, 2014, 第 1 作者
(28) Cellular uptake and distribution of graphene oxide coated with layer-by-layer assembled polyelectrolytes,  Journal of Nanoparticle Research, 2014, 第 1 作者
(29) Antineoplastic activities of Gd@C82(OH)22 nanoparticles: tumor microenvironment regulation, Science China-Life Sciences, 2012, 第 1 作者
(30) Exosomes as extrapulmonary signaling conveyors for nanoparticle-induced systemic immune activation, Small, 2012, 第 2 作者
(31) Deciphering an underlying mechanism of differential cellular effects of nanoparticles: An example of Bach-1 dependent induction of HO-1 expression by gold nanorod, Biointerphases, 2012, 第 3 作者
(32) Chirality of glutathione surface coating affects the cytotoxicity of quantum dots,  Angewandte Chemie International Edition, 2011, 第 1 作者

科研活动

   
科研项目
( 1 ) 基于高通量纳米安全性评价系统的金纳米材料构效关系研究, 负责人, 国家任务, 2014-01--2016-12
( 2 ) 基于胰腺星状细胞调控的金纳米药物体系的设计与联合抗肿瘤研究, 负责人, 国家任务, 2016-01--2019-12
( 3 ) 机动车来源的大气超细颗粒物诱发自噬相关生物效应机制研究, 负责人, 国家任务, 2016-01--2018-12
( 4 ) 微环境响应型自组装生物纳米材料的表/界面调控及肿瘤治疗研究, 参与, 国家任务, 2018-07--2023-06
( 5 ) 光热/光动力调控型纳米材料的肿瘤微环境免疫激活效应及机制研究, 负责人, 地方任务, 2021-08--2025-08
( 6 ) 基于关键免疫靶点和新型递送系统的纳米工程化肿瘤治疗, 参与, 国家任务, 2021-12--2026-11
参与会议
(1)Enhanced delivery of nanomedicine to desmoplastic pancreatic tumors by restoring the homeostatic stroma   2019-08-17
(2)基于胰腺肿瘤微环境的精准纳米研究   中国抗癌协会胰腺癌专业委员会年会   2017-10-29
(3)光激活纳米体系增强的肿瘤联合治疗   纳米生物光子学创新发展专家论坛   2017-09-26
(4)Photoactivatable Nanoplatforms Enhanced Combination Cancer Therapy   2017-08-29
(5)Localized electric field of plasmonic nanoplatform enhanced photodynamic tumor therapy   李一叶   2015-03-24