真菌天然药物发现与生物合成

   

100705-微生物与生化药学

天然产物化学
天然产物生物合成

2005-09--2009-06   中国科学院微生物研究所   博士
2002-09--2005-06   中国科学院成都生物研究所   硕士

   

2020-10~现在, 中国科学院微生物研究所, 研究员
2016-11~2018-12,加州大学洛杉矶分校, 访问学者
2011-07~2020-10,中国科学院微生物研究所, 副研究员
2009-07~2011-06,中国科学院微生物研究所, 助理研究员

2022-04-01-今,中国海洋湖沼学会药物学分会, 理事
2021-10-01-今,中国微生物学会普通微生物学专业委员会, 委员
2019-04-19-今,中国天然药物青年编委,
2019-01-01-2024-12-31,中国海洋药物博士论坛青年委员会委员,
2018-07-01-今,菌物化学专业委员会委员,
2018-01-01-今,菌物学报编委,

   

（1） 首批“中国科学院卓越青年科学家”, 部委级, 2014
（2） 中国科学院优秀博士学位论文提名奖, 部委级, 2010

（ 1 ） 抗幽门螺旋杆菌活性的化合物及其制备方法和应用, 发明专利, 2020, 第 1 作者, 专利号: CN110951620A

（ 2 ） 一种抗幽门螺旋杆菌活性的聚酮化合物及其制备方法和应用, 发明专利, 2020, 第 1 作者, 专利号: CN110982700A

（ 3 ） 抗幽门螺旋杆菌活性的蒽醌类化合物及其应用, 发明专利, 2020, 第 1 作者, 专利号: CN110951619A

（ 4 ） 一种抗肿瘤活性的新化合物及其制备方法和应用, 发明专利, 2013, 第 3 作者, 专利号: CN103130757A

（ 5 ） 一种从胡芦巴种子中分离4－羟基异亮氨酸的方法, 发明专利, 2007, 第 1 作者, 专利号: CN1955160

   

[1] Journla of Fungi. 2024,   通讯作者  
[2] 杨骁, 任晋玮, 徐利剑, 刘玲. 海洋真菌Fusarium sp.HL21活性次级代谢产物研究. 中国抗生素杂志[J]. 2023, 第 4 作者48(8): 879-884, http://lib.cqvip.com/Qikan/Article/Detail?id=7110588732.
[3] Dong, JiaYu, Tang, ManCheng, Liu, Ling. α-Pyrone Derivatives from Calcarisporium arbuscula Discovered by Genome Mining. JOURNAL OF NATURAL PRODUCTS[J]. 2023, 第 3 作者  通讯作者  86(11): 2496-2501, http://dx.doi.org/10.1021/acs.jnatprod.3c00685.
[4] Lin, Jie, Huo, RuiYun, Hou, Lin, Jiang, Shan, Wang, ShuLin, Deng, YanLing, Liu, Ling. New polyketides from the basidiomycetous fungus Pholiota sp.. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2023, 第 7 作者  通讯作者  25(7): 674-682, http://dx.doi.org/10.1080/10286020.2022.2132481.
[5] Frontiers in Microbiology. 2023,   通讯作者  
[6] Magnetic Reson in Chemistry. 2023,   通讯作者  
[7] 中国海洋药物. 2023,   通讯作者  
[8] Xiao Yang, Hongjia Yu, Jinwei Ren, Lei Cai, Lijian Xu, Ling Liu. Sulfoxide-Containing Bisabolane Sesquiterpenoids with Antimicrobial and Nematicidal Activities from the Marine-Derived Fungus Aspergillussydowii LW09. JOURNAL OF FUNGI[J]. 2023, 第 6 作者  通讯作者  9(3): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10057145/.
[9] Guobo Guan, Li Tao, Chao Li, Ming Xu, Ling Liu, Richard J Bennett, Guanghua Huang. Glucose depletion enables Candida albicans mating independently ofthe epigenetic white-opaque switch. NATURE COMMUNICATIONS[J]. 2023, 第 5 作者14(1): 2067, https://doaj.org/article/1937225567ca4ec8b64d4b3a632694ee.
[10] 张金新, 段园园, 毕洪凯, 蔡磊, 刘玲. 一株海洋真菌Aspergillus jensenii LW128的次级代谢产物及其抗菌活性研究. 微生物学报[J]. 2023, 第 5 作者  通讯作者  63(1): 419-429, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7387770&detailType=1.
[11] International Journal of Biological Macromolecules. 2023,   通讯作者  
[12] Zhang, Jinxin, Zhang, Baodan, Cai, Lei, Liu, Ling. New Dibenzo-alpha-pyrone Derivatives with alpha-Glucosidase Inhibitory Activities from the Marine-Derived Fungus Alternaria alternata. MARINE DRUGS[J]. 2022, 第 4 作者  通讯作者  20(12): 
[13] Yu, ZhiPu, An, Chunyan, Yao, Yongpeng, Wang, ChangYun, Sun, Zhoutong, Cui, Chengsen, Liu, Ling, Gao, ShuShan. A combined strategy for the overproduction of complex ergot alkaloid agroclavine. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2022, 第 7 作者  通讯作者  7(4): 1126-1132, http://dx.doi.org/10.1016/j.synbio.2022.08.003.
[14] Jinxin Zhang, Baodan Zhang, Lei Cai, Ling Liu. New Dibenzo- α -pyrone Derivatives with α -Glucosidase Inhibitory Activities from the Marine-Derived Fungus Alternaria alternata. MARINE DRUGS[J]. 2022, 第 4 作者  通讯作者  20(12): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785194/.
[15] Hou, Bolin, Li, Erwei, Liang, Jingnan, Liu, Shuchun, Yang, Huaiyi, Liu, Ling, Jiang, Xuejun. The unique Akt inhibitor SC66 suppressed AMPK activity and abolished autophagy through the EGFR-p62 pathway. CELL BIOLOGY INTERNATIONAL[J]. 2022, 第 6 作者  通讯作者  46(2): 311-322, http://dx.doi.org/10.1002/cbin.11732.
[16] Huo, Ruiyun, Zhang, Jinxin, Niu, Shubin, Liu, Ling. New prenylated indole diketopiperazine alkaloids and polyketides from the mangrove-derived fungus Penicillium sp. FRONTIERS IN MARINE SCIENCE[J]. 2022, 第 4 作者  通讯作者  9: 1097594, http://dx.doi.org/10.3389/fmars.2022.1097594.
[17] 于洪佳, 薛雅馨, 洪葵, 贾佳, 毕洪凯, 徐利剑, 刘玲. 一株红树林曲霉菌Aspergillus sp.WHUF0343的次级代谢产物研究. 微生物学报[J]. 2022, 第 7 作者62(7): 2658-2670, https://actamicro.ijournals.cn/actamicrocn/article/abstract/20220717?st=article_issue.
[18] Hou, Bolin, Huang, Haiwen, Li, Yueqian, Liang, Jingnan, Xi, Zhijun, Jiang, Xuejun, Liu, Ling, Li, Erwei. Grb2 interacts with necrosome components and is involved in rasfonin-induced necroptosis. CELL DEATH DISCOVERY[J]. 2022, 第 7 作者  通讯作者  8(1): 
[19] Lin, Jie, Huo, RuiYun, Hou, Lin, Jiang, Shan, Wang, ShuLin, Deng, YanLing, Liu, Ling. New polyketides from the basidiomycetous fungus Pholiota sp.. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. 2022, 第 7 作者  通讯作者  
[20] Liu, Gaoran, Huo, Ruiyun, Niu, Shubin, Song, Fuhang, Liu, Ling. Two New Cytotoxic Decalin Derivatives from Marine-Derived Fungus Talaromyces sp.. CHEMISTRY & BIODIVERSITY[J]. 2022, 第 5 作者  通讯作者  19(3): http://dx.doi.org/10.1002/cbdv.202100990.
[21] Huo, RuiYun, Zhang, JinXin, Jia, Jia, Bi, HongKai, Liu, Ling. Alternarialone A, a new curvularin-type metabolite from the mangrove-derived fungus Alternaria longipes. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH. 2022, 第 5 作者  通讯作者  
[22] Yu Zhipu, An Chunyan, Yao Yongpeng, Wang Changyun, Sun Zhoutong, Cui Chengsen, Liu Ling, Gao Shushan. A combined strategy for the overproduction of complex ergot alkaloid agroclavine. SYNTHETIC AND SYSTEMS BIOTECHNOLOGY[J]. 2022, 第 7 作者  通讯作者  7(4): 1126-1132, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7414703&detailType=1.
[23] Zhang, Ruohan, Zhang, Jinxin, Huo, Ruiyun, Xue, Yaxin, Hong, Kui, Liu, Ling. Sulfur-containing benzofurans and a-pyrones from the mangrove-derived fungus Talaromyces sp. WHUF0341. FRONTIERS IN MARINE SCIENCE[J]. 2022, 第 6 作者  通讯作者  9: 1034945, 
[24] Yao, Yongpeng, Wang, Wei, Shi, Wenyu, Yan, Rui, Zhang, Jun, Wei, Guangzheng, Liu, Ling, Che, Yongsheng, An, Chunyan, Gao, ShuShan. Overproduction of medicinal ergot alkaloids based on a fungal platform. METABOLIC ENGINEERING[J]. 2022, 第 7 作者69: 198-208, http://dx.doi.org/10.1016/j.ymben.2021.12.002.
[25] Duan, Chengbao, Wang, Shiyuan, Huo, Ruiyun, Li, Erwei, Wang, Min, Ren, Jinwei, Pan, Yuanyuan, Liu, Ling, Liu, Gang. Sorbicillinoid Derivatives with the Radical Scavenging Activities from the Marine-Derived Fungus Acremonium chrysogenum C10. JOURNAL OF FUNGI[J]. 2022, 第 8 作者  通讯作者  8(5): http://dx.doi.org/10.3390/jof8050530.
[26] Guo, Zhe, Huo, Ruiyun, Niu, Shubin, Liu, Xingzhong, Liu, Ling. Alternariasin A, new pentacyclic cytochalasin from the fungus Alternaria alternate. JOURNAL OF ANTIBIOTICS[J]. 2021, 第 5 作者  通讯作者  74(9): 596-600, http://dx.doi.org/10.1038/s41429-021-00443-0.
[27] Liu, Gaoran, Niu, Shubin, Liu, Ling. Alterchromanone A, one new chromanone derivative from the mangrove endophytic fungusAlternaria longipes. JOURNAL OF ANTIBIOTICS[J]. 2021, 第 3 作者  通讯作者  74(2): 152-155, http://dx.doi.org/10.1038/s41429-020-00364-4.
[28] Tian, Sufei, Bing, Jian, Chu, Yunzhuo, Chen, Jingjing, Cheng, Shitong, Wang, Qihui, Zhang, Jingping, Ma, Xiaochun, Zhou, Baosen, Liu, Ling, Huang, Guanghua, Shang, Hong. Genomic epidemiology of Candida auris in a general hospital in Shenyang, China: a three-year surveillance study. EMERGINGMICROBESINFECTIONS[J]. 2021, 第 10 作者10(1): 1088-1096, http://dx.doi.org/10.1080/22221751.2021.1934557.
[29] Hou, Bolin, Liu, Sushi, Huo, Ruiyun, Li, Yueqian, Ren, Jinwei, Wang, Wenzhao, Wei, Tao, Jiang, Xuejun, Yin, Wenbing, Liu, Hongwei, Liu, Ling, Li, Erwei. New Diterpenoids and Isocoumarin Derivatives from the Mangrove-Derived Fungus Hypoxylon sp.. MARINE DRUGS[J]. 2021, 第 11 作者  通讯作者  19(7): http://dx.doi.org/10.3390/md19070362.
[30] 程璐, 翟亚楠, 孙立彦, 刘玲. 地衣及其内生真菌活性次级代谢产物研究进展. 菌物学报[J]. 2021, 第 4 作者  通讯作者  40(1): 14-30, http://lib.cqvip.com/Qikan/Article/Detail?id=7104321563.
[31] Ren, Jinwei, Huo, Ruiyun, Liu, Gaoran, Liu, Ling. New Andrastin-Type Meroterpenoids from the Marine-Derived Fungus Penicillium sp.. MARINE DRUGS[J]. 2021, 第 4 作者  通讯作者  19(4): http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000643220100001.
[32] Guo zhe, Huo, Ruiyun, Niu, Shubin, liu xingzhong, Liu, Ling. Alternariasin A, new pentacyclic cytochalasin from the fungus Alternaria alternate.. J Antibiot.[J]. 2021, 第 5 作者  通讯作者  74: 596, 
[33] Liu, Gaoran, Huo, Ruiyun, Zhai, Yanan, Liu, Ling. New Bioactive Sesquiterpeniods From the Plant Endophytic Fungus Pestalotiopsis theae. FRONTIERS IN MICROBIOLOGY[J]. 2021, 第 4 作者  通讯作者  12: https://www.webofscience.com/wos/woscc/full-record/WOS:000639829800001.
[34] Guo, Longfang, Lin, Jie, Niu, Shubin, Liu, Shuchun, Liu, Ling. Pestalotiones A-D: Four New Secondary Metabolites from the Plant Endophytic Fungus Pestalotiopsis Theae. MOLECULES[J]. 2020, 第 5 作者  通讯作者  25(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000515384800040.
[35] Guo LongFang, Liu GaoRan, Liu Ling. Caryophyllene-type sesquiterpenoids and alpha-furanones from the plant endophytic fungus Pestalotiopsis theae. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2020, 第 3 作者  通讯作者  18(4): 261-267, https://www.webofscience.com/wos/woscc/full-record/WOS:000532266300005.
[36] Longfang Guo, Jie Lin, Shubin Niu, Shuchun Liu, Ling Liu. Pestalotiones A–D: Four New Secondary Metabolites from the Plant Endophytic Fungus Pestalotiopsis Theae. MOLECULES[J]. 2020, 第 5 作者25(3): https://doaj.org/article/514c3408d5a84d6981bf6fbfdf6921aa.
[37] Zhao, Chen, Liu, Gaoran, Liu, Xingzhong, Zhang, Lan, Li, Lin, Liu, Ling. Pycnidiophorones A-D, four new cytochalasans from the wetland derived fungus Pycnidiophora dispersa. RSC ADVANCES[J]. 2020, 第 6 作者  通讯作者  10(66): 40384-40390, https://www.webofscience.com/wos/woscc/full-record/WOS:000587926200044.
[38] Lv, JianMing, Gao, YaoHui, Zhao, Huan, Awakawa, Takayoshi, Liu, Ling, Chen, GuoDong, Yao, XinSheng, Hu, Dan, Abe, Ikuro, Gao, Hao. Biosynthesis of Biscognienyne B Involving a Cytochrome P450-Dependent Alkynylation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 第 5 作者59(32): 13531-13536, https://www.webofscience.com/wos/woscc/full-record/WOS:000535042600001.
[39] Guo, Longfang, Niu, Shubin, Chen, Shuanglin, Liu, Ling. Diaporone A, a new antibacterial secondary metabolite from the plant endophytic fungus Diaporthe sp.. JOURNAL OF ANTIBIOTICS[J]. 2020, 第 4 作者  通讯作者  73(2): 116-119, https://www.webofscience.com/wos/woscc/full-record/WOS:000507497100007.
[40] Guo, Longfang, Zhang, Caining, Gao, Quan, Hou, Bolin, Liu, Ling, Yang, Huaiyi, Jiang, Xuejun. Chloropupukeananin and Pestalofone C Regulate Autophagy through AMPK and Glycolytic Pathway. CHEMISTRY & BIODIVERSITY[J]. 2020, 第 5 作者17(3): http://dx.doi.org/10.1002/cbdv.201900583.
[41] Zhang, Jinyu, Li, Yumei, Ren, Fengxia, Zhang, Yang, Liu, Xingzhong, Liu, Ling, Che, Yongsheng. Phomanolides C-F from a Phoma sp.: Meroterpenoids Generated via Hetero-Diels-Alder Reactions. JOURNAL OF NATURAL PRODUCTS[J]. 2019, 第 6 作者  通讯作者  82(6): 1678-1685, https://www.webofscience.com/wos/woscc/full-record/WOS:000473827300033.
[42] Qu, XinYing, Ren, JinWei, Peng, AiHong, Lin, ShiQi, Lu, DanDan, Du, QianQian, Liu, Ling, Li, Xia, Li, ErWei, Xie, WeiDong. Cytotoxic, Anti-Migration, and Anti-Invasion Activities on Breast Cancer Cells of Angucycline Glycosides Isolated from a Marine-Derived Streptomyces sp.. MARINE DRUGS[J]. 2019, 第 7 作者17(5): http://dx.doi.org/10.3390/md17050277.
[43] Liu, Ling, Tang, ManCheng, Tang, Yi. Fungal Highly Reducing Polyketide Synthases Biosynthesize Salicylaldehydes That Are Precursors to Epoxycyclohexenol Natural Products. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2019, 第 1 作者141(50): 19538-19541, https://www.webofscience.com/wos/woscc/full-record/WOS:000503917800004.
[44] Hou, Bolin, Xu, Shanshan, Xu, Yang, Gao, Quan, Zhang, Caining, Liu, Ling, Yang, Huaiyi, Jiang, Xuejun, Che, Yongsheng. Grb2 binds to PTEN and regulates its nuclear translocation to maintain the genomic stability in DNA damage response. CELLDEATHDISEASE[J]. 2019, 第 6 作者10(8): http://dx.doi.org/10.1038/s41419-019-1762-3.
[45] Pan, Yuanyuan, Liu, Ling, Guan, Feifei, Li, Erwei, Jin, Jin, Li, Jinyang, Che, Yongsheng, Liu, Gang. Characterization of a Prenyltransferase for Iso-A82775C Biosynthesis and Generation of New Congeners of Chloropestolides. ACS CHEMICAL BIOLOGY[J]. 2018, 第 2 作者13(3): 703-711, https://www.webofscience.com/wos/woscc/full-record/WOS:000428003000028.
[46] Yan, Siyuan, Liu, Ling, Ren, Fengxia, Gao, Quan, Xu, Shanshan, Hou, Bolin, Wang, Yange, Jiang, Xuejun, Che, Yongsheng. Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1. CELL DEATH & DISEASE[J]. 2017, 第 2 作者8(8): e2988, https://www.webofscience.com/wos/woscc/full-record/WOS:000409550500025.
[47] Lin, Jie, Wang, Renlei, Xu, Guohua, Ding, Zhengfeng, Zhu, Xueshen, Li, Erwei, Liu, Ling. Two new polyketides from the ascomycete fungus Leptosphaeria sp. JOURNAL OF ANTIBIOTICS[J]. 2017, 第 7 作者  通讯作者  70(6): 743-746, https://www.webofscience.com/wos/woscc/full-record/WOS:000402447800005.
[48] Han, Junjie, Liu, Congcong, Li, Li, Zhou, Hui, Liu, Li, Bao, Li, Chen, Qian, Song, Fuhang, Zhang, Lixin, Li, Erwei, Liu, Ling, Pei, Yunfei, Jin, Cheng, Xue, Yanfen, Yin, Wenbing, Ma, Yanhe, Liu, Hongwei. Decalin-Containing Tetramic Acids and 4-Hydroxy-2-pyridones with Antimicrobial and Cytotoxic Activity from the Fungus Coniochaeta cephalothecoides Collected in Tibetan Plateau (Medog). JOURNAL OF ORGANIC CHEMISTRY[J]. 2017, 第 11 作者82(21): 11474-11486, https://www.webofscience.com/wos/woscc/full-record/WOS:000414724000016.
[49] Zheng, Yanjing, Ma, Ke, Lyu, Haining, Huang, Ying, Liu, Hongwei, Liu, Ling, Che, Yongsheng, Liu, Xingzhong, Zou, Huixi, Yin, WenBing. Genetic Manipulation of the COP9 Signalosome Subunit PfCsnE Leads to the Discovery of Pestaloficins in Pestalotiopsis fici. ORGANIC LETTERS[J]. 2017, 第 6 作者19(17): 4700-4703, https://www.webofscience.com/wos/woscc/full-record/WOS:000409566400073.
[50] Lin, Jie, Niu, Shubin, Ding, Zhengfeng, Wang, Renlei, Dai, Qun, Wei, Wei, Luo, Rongrong, Liu, Ling. Isolation and Characterization of Aphidicolin Derivatives from Tolypocladium inflatum. MOLECULES[J]. 2017, 第 8 作者  通讯作者  22(7): https://doaj.org/article/da75ddfef3f44cf797fdd16c7d3f383b.
[51] Lee, Seungjun, Kim, DongCheol, Park, JinSoo, Son, JaeYoung, Sohn, Jae Hak, Liu, Ling, Che, Yongsheng, Oh, Hyuncheol. Penicillospirone from a marine isolate of Penicillium sp (SF-5292) with anti-inflammatory activity. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2017, 第 6 作者27(15): 3516-3520, http://dx.doi.org/10.1016/j.bmcl.2017.05.066.
[52] Yan, Siyuan, Wei, Xiaoli, Xu, Shanshan, Sun, Hui, Wang, Weijun, Liu, Ling, Jiang, Xuejun, Zhang, Yongxiang, Che, Yongsheng. 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway. ONCOTARGET[J]. 2017, 第 6 作者8(46): 80909-80922, https://www.webofscience.com/wos/woscc/full-record/WOS:000412465700070.
[53] Lin, Jie, Wang, Renlei, Xu, Guohua, Ding, Zhengfeng, Zhu, Xueshen, Liu, Xingzhong, Zou, Jian, Chen, Guodong, Li, Li, Liu, Ling. New cadinane sesquiterpenoids from the basidiomycetous fungus Pholiota sp.. RSC ADVANCES[J]. 2016, 第 10 作者  通讯作者  6(113): 112527-112533, https://www.webofscience.com/wos/woscc/full-record/WOS:000389708700102.
[54] Liu, Ling, Han, Yu, Xiao, Junhai, Li, Li, Guo, Liangdong, Jiang, Xuejun, Kong, Lingyi, Che, Yongsheng. Chlorotheolides A and B, Spiroketals Generated via Diels-Alder Reactions in the Endophytic Fungus Pestalotiopsis theae. JOURNAL OF NATURAL PRODUCTS[J]. 2016, 第 1 作者79(10): 2616-2623, http://dx.doi.org/10.1021/acs.jnatprod.6b00550.
[55] Zhang, Yang, Zhang, Zhuowei, Wang, Bo, Liu, Ling, Che, Yongsheng. Design and synthesis of natural product derivatives with selective and improved cytotoxicity based on a sesquiterpene scaffold. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS[J]. 2016, 第 4 作者26(8): 1885-1888, http://dx.doi.org/10.1016/j.bmcl.2016.03.022.
[56] Wang, Bo, Zhang, Zhuowei, Guo, Liangdong, Liu, Ling. New Cytotoxic Meroterpenoids from the Plant Endophytic Fungus Pestalotiopsis fici. HELVETICA CHIMICA ACTA[J]. 2016, 第 4 作者  通讯作者  99(2): 151-156, https://www.webofscience.com/wos/woscc/full-record/WOS:000370326000010.
[57] Wang, Xiuna, Zhang, Xiaoling, Liu, Ling, Xiang, Meichun, Wang, Wenzhao, Sun, Xiang, Che, Yongsheng, Guo, Liangdong, Liu, Gang, Guo, Liyun, Wang, Chengshu, Yin, WenBing, Stadler, Marc, Zhang, Xinyu, Liu, Xingzhong. Genomic and transcriptomic analysis of the endophytic fungus Pestalotiopsis fici reveals its lifestyle and high potential for synthesis of natural products. BMC GENOMICS[J]. 2015, 第 3 作者16(1): http://dx.doi.org/10.1186/s12864-014-1190-9.
[58] Guo, Zhe, Ren, Fengxia, Che, Yongsheng, Liu, Gang, Liu, Ling. New Bergamotane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense. MOLECULES[J]. 2015, 第 5 作者20(8): 14611-14620, https://doaj.org/article/b0b6d637c1d4410a8b14b85f9fe50873.
[59] Liu, Ling, Chen, Xiaoyan, Li, Dong, Zhang, Yang, Li, Li, Guo, Liangdong, Cao, Ya, Che, Yongsheng. Bisabolane Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense. JOURNAL OF NATURAL PRODUCTS[J]. 2015, 第 1 作者78(4): 746-753, 
[60] Zhang, Jinyu, Liu, Ling, Wang, Bo, Zhang, Yang, Wang, Lili, Lie, Xingzhong, Che, Yongsheng. Phomanolides A and B from the Fungus Phoma sp.: Meroterpenoids Derived from a Putative Tropolonic Sesquiterpene via Hetero-Diels-Alder Reactions. JOURNAL OF NATURAL PRODUCTS[J]. 2015, 第 2 作者78(12): 3058-3066, http://dx.doi.org/10.1021/acs.jnatprod.5b00969.
[61] Wang, Xiuna, Wu, Fan, Liu, Ling, Liu, Xingzhong, Che, Yongsheng, Keller, Nancy P, Guo, Liyun, Yin, WenBing. The bZIP transcription factor PfZipA regulates secondary metabolism and oxidative stress response in the plant endophytic fungus Pestalotiopsis fici. FUNGAL GENETICS AND BIOLOGY[J]. 2015, 第 3 作者81: 221-228, http://dx.doi.org/10.1016/j.fgb.2015.03.010.
[62] Liu, Ling, Zhao, Chen, Li, Li, Guo, Liangdong, Che, Yongsheng. Pestalotriols A and B, new spiro2.5octane derivatives from the endophytic fungus Pestalotiopsis fici. RSC ADVANCES[J]. 2015, 第 1 作者5(96): 78708-78711, https://www.webofscience.com/wos/woscc/full-record/WOS:000361675800039.
[63] Xu, Xinxin, Liu, Ling, Zhang, Fan, Wang, Wenzhao, Li, Jinyang, Guo, Liangdong, Che, Yongsheng, Liu, Gang. Identification of the First Diphenyl Ether Gene Cluster for Pestheic Acid Biosynthesis in Plant Endophyte Pestalotiopsis fici. CHEMBIOCHEM[J]. 2014, 第 2 作者15(2): 284-292, http://dx.doi.org/10.1002/cbic.201300626.
[64] Liu, Ling, Li, Yan, Li, Li, Cao, Ya, Guo, Liangdong, Liu, Gang, Che, Yongsheng. Spiroketals of Pestalotiopsis fici Provide Evidence for a Biosynthetic Hypothesis Involving Diversified Diels-Alder Reaction Cascades. JOURNAL OF ORGANIC CHEMISTRY[J]. 2013, 第 1 作者78(7): 2992-3000, http://dx.doi.org/10.1021/jo302804h.
[65] Liu, Shuchun, Liu, Xiangyu, Guo, Liangdong, Che, Yongsheng, Liu, Ling. 2H-Pyran-2-one and 2H-Furan-2-one Derivatives from the Plant Endophytic Fungus Pestalotiopsis fici. CHEMISTRY & BIODIVERSITY[J]. 2013, 第 5 作者10(11): 2007-2013, http://dx.doi.org/10.1002/cbdv.201200361.
[66] Liu, Shuchun, Guo, Liangdong, Che, Yongsheng, Liu, Ling. Pestaloficiols Q-S from the plant endophytic fungus Pestalotiopsis fici. FITOTERAPIA[J]. 2013, 第 4 作者85: 114-118, http://dx.doi.org/10.1016/j.fitote.2013.01.010.
[67] Ling Liu. α-Pyrone and α-furanone derivatives from the plant endophytic fungus Pestalotiopsis fici. Chem. Biodivers. 2013, 第 1 作者  通讯作者  
[68] Liu Ling, Tan Xiao Bin, Xu Peng, Wen Hong, Li, W, Zhao, Q. Research on a Multipath Routing for Multihop Cellular Network. PROCEEDINGS OF THE 31ST CHINESE CONTROL CONFERENCE. 2012, 第 1 作者5493-5498, 
[69] Liu, Ling, Bruhn, Torsten, Guo, Liangdong, Goetz, Daniel C G, Brun, Reto, Stich, August, Che, Yongsheng, Bringmann, Gerhard. Chloropupukeanolides C-E: Cytotoxic Pupukeanane Chlorides with a Spiroketal Skeleton from Pestalotiopsis fici. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2011, 第 1 作者17(9): 2604-2613, http://dx.doi.org/10.1002/chem.201003129.
[70] Liu Shuchun, Ye Xin, Guo Liangdong, Liu Ling. 源于植物内生无花果拟盘多毛孢真菌的新环氧环己二醇衍生物. 中国天然药物[J]. 2011, 第 4 作者9(5): 374-379, http://lib.cqvip.com/Qikan/Article/Detail?id=39149223.
[71] 刘述春, 叶昕, 郭良栋, 刘玲. 源于植物内生无花果拟盘多毛孢真菌的新环氧环己二醇衍生物. 中国天然药物[J]. 2011, 第 4 作者9(5): 374-379, http://lib.cqvip.com/Qikan/Article/Detail?id=39149223.
[72] Ling Liu. Cytotoxic isoprenylated epoxycyclohexanediols from the plant endophyte Pestalotiopsis fici. Chin. J. Nat. Med. 2011, 第 1 作者  通讯作者  
[73] Liu Ling. Bioactive metabolites from the plant endophyte Pestalotiopsis fici. MYCOLOGY[J]. 2011, 第 1 作者
[74] Liu, Ling, Gao, Hao, Chen, Xulin, Cai, Xiaoyue, Yang, Leilei, Guo, Liangdong, Yao, Xinsheng, Che, Yongsheng. Brasilamides A-D: Sesquiterpenoids from the Plant Endophytic Fungus Paraconiothyrium brasiliense. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2010, 第 1 作者2010(17): 3302-3306, http://dx.doi.org/10.1002/ejoc.201000284.
[75] 刘述春, 刘玲. 源于植物内生无花果拟盘多毛孢真菌的新色原酮类次生代谢产物研究. 菌物学报[J]. 2010, 第 2 作者29(4): 582-587, https://manu40.magtech.com.cn/Jwxb/CN/Y2010/V29/I4/582.
[76] Liu, Ling, Niu, Shubin, Lu, Xinhua, Chen, Xulin, Zhang, Hua, Guo, Liangdong, Che, Yongsheng. Unique metabolites of Pestalotiopsis fici suggest a biosynthetic hypothesis involving a Diels-Alder reaction and then mechanistic diversification. CHEMICAL COMMUNICATIONS[J]. 2010, 第 1 作者46(3): 460-462, http://www.corc.org.cn/handle/1471x/2375676.
[77] Ling Liu. Isoprenylated chromones from the plant endophytic fungus Pestalotiopsis fici. Mycosystema. 2010, 第 1 作者  通讯作者  
[78] Liu, Ling, Li, Yan, Liu, Shuchun, Zheng, Zhihui, Chen, Xulin, Zhang, Hua, Guo, Liangdong, Che, Yongsheng. Chloropestolide A, an Antitumor Metabolite with an Unprecedented Spiroketal Skeleton from Pestalotiopsis fici. ORGANIC LETTERS[J]. 2009, 第 1 作者11(13): 2836-2839, http://www.corc.org.cn/handle/1471x/2375574.
[79] Liu, Ling, Liu, Shuchun, Niu, Shubin, Guo, Liangdong, Chen, Xulin, Che, Yongsheng. Isoprenylated Chromone Derivatives from the Plant Endophytic Fungus Pestalotiopsis fici. JOURNAL OF NATURAL PRODUCTS[J]. 2009, 第 1 作者72(8): 1482-1486, http://dx.doi.org/10.1021/np900308s.
[80] Liu, Ling, Liu, Shuchun, Chen, Xulin, Guo, Liangdong, Che, Yongsheng. Pestalofones A-E, bioactive cyclohexanone derivatives from the plant endophytic fungus Pestalotiopsis fici. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2009, 第 1 作者17(2): 606-613, http://dx.doi.org/10.1016/j.bmc.2008.11.066.
[81] Liu, Ling, Liu, Shuchun, Jiang, Lihua, Chen, Xulin, Guo, Liangdong, Che, Yongsheng. Chloropupukeananin, the first chlorinated pupukeanane derivative, and its precursors from Pestalotiopsis fici. ORGANIC LETTERS[J]. 2008, 第 1 作者10(7): 1397-1400, http://www.corc.org.cn/handle/1471x/2375444.
[82] Liu, Ling, Tian, Renrong, Liu, Shuchun, Chen, Xulin, Guo, Liangdong, Che, Yongsheng. Pestaloficiols A-E, bioactive cyclopropane derivatives from the plant endophytic fungus Pestalotiopsis fici. BIOORGANIC & MEDICINAL CHEMISTRY[J]. 2008, 第 1 作者16(11): 6021-6026, http://dx.doi.org/10.1016/j.bmc.2008.04.052.

   

（ 1 ） 中国科学院卓越青年科学家项目, 负责人, 中国科学院计划, 2014-06--2017-06
（ 2 ） 无花果拟盘多毛孢菌独特化合物的深入研究, 负责人, 国家任务, 2014-01--2017-12
（ 3 ） 珍稀、药用生物替代品规模化关键技术研究与产品开发, 负责人, 国家任务, 2012-01--2015-12
（ 4 ） 植物内生真菌次生代谢产物结构与功能研究, 负责人, 中国科学院计划, 2011-06--2015-06
（ 5 ） 基于化学表观遗传方法的植物内生真菌中新结构、活性化合物的发现, 负责人, 研究所自主部署, 2013-01--2015-12
（ 6 ） 植物内生真菌来源独特化合物的结构、活性与生物合成途径, 负责人, 国家任务, 2011-01--2013-12
（ 7 ） 无花果拟盘多毛孢菌中丙二烯化合物的生物合成途径研究, 负责人, 国家任务, 2018-01--2021-12
（ 8 ） 海洋微生物天然产物的高效深度挖掘, 负责人, 国家任务, 2018-08--2021-12
（ 9 ） 绿木霉菌中环氧环己烯聚酮化合物的生物合成途径研究, 负责人, 国家任务, 2020-01--2023-12
（ 10 ） 微生物天然产物化学, 负责人, 国家任务, 2021-01--2023-12
（ 11 ） 微生物药物工业底盘构建与适配性优化, 负责人, 国家任务, 2021-07--2024-06
（ 12 ） 生物合成研究驱动的新型微生物抗感染药物创制, 负责人, 国家任务, 2022-07--2025-06

（1）特境真菌活性次级代谢产物研究   CJNM第二届青年编委会会议暨青年学者论坛   2019-11-16
（2）环氧环己二醇化合物生物合成研究   第十四届海洋药物学术年会暨 2019 国际海洋药物论坛   2019-11-11
（3）无花果拟盘多毛孢菌活性次级代谢产物研究   第十二届中美华人化学教授会议   2016-06-23

已指导学生

王燕鸽  硕士研究生  071010-生物化学与分子生物学  

现指导学生

刘高然  硕士研究生  085238-生物工程  

侯卜琳  博士研究生  071005-微生物学  

郭龙芳  博士研究生  071010-生物化学与分子生物学  

张若晗  硕士研究生  085238-生物工程