基本信息
鲍习琛  男  博导  中国科学院广州生物医药与健康研究院
电子邮件: bao_xichen@gibh.ac.cn
通信地址: Kaiyuan Avenue 190, Guangzhou Science city
邮政编码: 510530

研究领域

系统分离RNA结合蛋白,研究细胞中RNA-蛋白相互作用在细胞命运、病理、生理调控中的功能和分子机制。

招生信息

期待对生命科学兴趣浓厚、励志从事相关研究的学生加盟。

招生专业
071009-细胞生物学
招生方向
非编码RNA和细胞命运转变

教育背景

2006-09--2011-06   中国科学技术大学   博士
2002-09--2006-06   安徽大学   本科

工作经历

工作简历
2015-01~2018-01,中国科学院广州生物医药与健康研究院, 副研究员
2011-07~2014-12,中国科学院广州生物医药与健康研究院, 助理研究员

专利与奖励

奖励信息
(1) iPS细胞诱导过程中的间质-上皮转化过程(MET)研究, 一等奖, 省级, 2015
(2) iPS细胞诱导过程中的间质-上皮转化过程(MET)研究, 一等奖, 市地级, 2015
专利成果
[1] 裴端卿, 米格尔·安格尔·艾斯特班, 鲍习琛, 廖宝剑, 张必良, 阿塔那希奥斯·泽沃伊丽斯. 一种将微小核糖核酸簇用于改变细胞命运的方法. 中国: CN102199622A, 2011-09-28.

出版信息

   
发表论文
[1] Meifeng Zheng, Yingying Lin, Wei Wang, Yu Zhao, Xichen Bao. Application of nucleoside or nucleotide analogues in RNA dynamics and RNA-binding protein analysis. Wiley Interdiscip Rev RNA[J]. 2022, [2] Guo, Xiangpeng, Tariq, Muqddas, Lai, Yiwei, Kanwal, Shahzina, Lv, Yuan, Wang, Xiwei, Li, Na, Jiang, Mengling, Meng, Jin, Hu, Jieyi, Yuan, Jianwen, Luo, Zhiwei, Ward, Carl, Volpe, Giacomo, Wang, Dongye, Yin, Menghui, Qin, Baoming, Zhang, Biliang, Bao, Xichen, Esteban, Miguel A. Capture of the newly transcribed RNA interactome using click chemistry. NATURE PROTOCOLS[J]. 2021, 16(11): 5193-5219, http://dx.doi.org/10.1038/s41596-021-00609-y.
[3] Liu, Jiadong, Gao, Mingwei, He, Jiangping, Wu, Kaixin, Lin, Siyuan, Jin, Lingmei, Chen, Yaping, Liu, He, Shi, Junjie, Wang, Xiwei, Chang, Lei, Lin, Yingying, Zhao, YuLi, Zhang, Xiaofei, Zhang, Man, Luo, GuanZheng, Wu, Guangming, Pei, Duanqing, Wang, Jie, Bao, Xichen, Chen, Jiekai. The RNA m(6)A reader YTHDC1 silences retrotransposons and guards ES cell identity. NATURE[J]. 2021, 591(7849): 322-+, http://dx.doi.org/10.1038/s41586-021-03313-9.
[4] Hou, Linlin, Wei, Yuanjie, Lin, Yingying, Wang, Xiwei, Lai, Yiwei, Yin, Menghui, Chen, Yanpu, Guo, Xiangpeng, Wu, Senbin, Zhu, Yindi, Yuan, Jie, Tariq, Muqddas, Li, Na, Sun, Hao, Wang, Huating, Zhang, Xiaofei, Chen, Jiekai, Bao, Xichen, Jauch, Ralf. Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2. NUCLEIC ACIDS RESEARCH[J]. 2020, 48(7): 3869-3887, https://www.webofscience.com/wos/woscc/full-record/WOS:000525957700037.
[5] Zhang, Meng, Lai, Yiwei, Krupalnik, Vladislav, Guo, Pengcheng, Guo, Xiangpeng, Zhou, Jianguo, Xu, Yan, Yu, Zhijun, Liu, Longqi, Jiang, Ao, Li, Wenjuan, Ma, Gang, Li, Na, Fu, Xiuling, Lv, Yuan, Jiang, Mengling, Tariq, Muqddas, Kanwal, Shahzina, Liu, Hao, Xu, Xueting, Zhang, Hui, Huang, Yinghua, Wang, Lulu, Chen, Shuhan, Babarinde, Isaac A, Luo, Zhiwei, Wang, Dongye, Zhou, Tiantian, Ward, Carl, He, Minghui, Ibanez, David P, Li, Yunpan, Zhou, Jiajian, Yuan, Jie, Feng, Yayan, Arumugam, Karthik, Di Vicino, Umberto, Bao, Xichen, Wu, Guangming, Schambach, Axel, Wang, Huating, Sun, Hao, Gao, Fei, Qin, Baoming, Hutchins, Andrew P, Doble, Bradley W, Hartmann, Christine, Cosma, Maria Pia, Qin, Yan, Xu, GuoLiang, Chen, Runsheng, Volpe, Giacomo, Chen, Liang, Hanna, Jacob H, Esteban, Miguel A. beta-Catenin safeguards the ground state of mouse pluripotency by strengthening the robustness of the transcriptional apparatus. SCIENCE ADVANCES[J]. 2020, 6(29): https://www.webofscience.com/wos/woscc/full-record/WOS:000552227800011.
[6] Yinghua Huang, Hui Zhang, Lulu Wang, Chuanqing Tang, Xiaogan Qin, Xinyu Wu, Meifang Pan, Yujia Tang, Zhongzhou Yang, Isaac A Babarinde, Runxia Lin, Guanyu Ji, Yiwei Lai, Xueting Xu, Jianbin Su, Xue Wen, Takashi Satoh, Tanveer Ahmed, Vikas Malik, Carl Ward, Giacomo Volpe, Lin Guo, Jinlong Chen, Li Sun, Yingying Li, Xiaofen Huang, Xichen Bao, Fei Gao, Baohua Liu, Hui Zheng, Ralf Jauch, Liangxue Lai, Guangjin Pan, Jiekai Chen, Giuseppe Testa, Shizuo Akira, Jifan Hu, Duanqing Pei, Andrew P Hutchins, Miguel A Esteban, Baoming Qin. JMJD3 acts in tandem with KLF4 to facilitate reprogramming to pluripotency. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-18900-z.
[7] Liu, Xu, Wang, Xiaolin, Li, Jingxin, Hu, Shanshan, Deng, Yuqi, Yin, Hao, Bao, Xichen, Zhang, Qiangfeng Cliff, Wang, Geng, Wang, Baolong, Shi, Qinghua, Shan, Ge. Identification of mecciRNAs and their roles in the mitochondrial entry of proteins. SCIENCE CHINA-LIFE SCIENCES[J]. 2020, 63(10): 1429-1449, http://lib.cqvip.com/Qikan/Article/Detail?id=7103000095.
[8] Liu, Jiadong, Gao, Mingwei, Xu, Shuyang, Chen, Yaping, Wu, Kaixin, Liu, He, Wang, Jie, Yang, Xuejie, Wang, Junwei, Liu, Weiwei, Bao, Xichen, Chen, Jiekai. YTHDF2/3 Are Required for Somatic Reprogramming through Different RNA Deadenylation Pathways. CELL REPORTS[J]. 2020, 32(10): http://dx.doi.org/10.1016/j.celrep.2020.108120.
[9] Kanwal, Shahzina, Guo, Xiangpeng, Ward, Carl, Volpe, Giacomo, Qin, Baoming, Esteban, Miguel A, Bao, Xichen. Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency. GENOMICS PROTEOMICS & BIOINFORMATICSnull. 2020, 18(1): 16-25, http://lib.cqvip.com/Qikan/Article/Detail?id=00002HUHLL7G7JP0MPDO8JP1MJR.
[10] Yu Zhao, Jiajian Zhou, Liangqiang He, Yuying Li, Jie Yuan, Kun Sun, Xiaona Chen, Xichen Bao, Miguel A Esteban, Hao Sun, Huating Wang. MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation. Nature Communications[J]. 2019, 10(1): 1-17, http://dx.doi.org/10.1038/s41467-019-13598-0.
[11] Yang, Jiayin, Wong, LaiYung, Tian, XiaoYu, Wei, Rui, Lai, WingHon, Au, KaWing, Luo, Zhiwei, Ward, Carl, Ho, WaiIn, Ibanez, David P, Liu, Hao, Bao, Xichen, Qin, Baoming, Huang, Yu, Esteban, Miguel A, Tse, HungFat. A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes. JOVE-JOURNAL OF VISUALIZED EXPERIMENTS[J]. 2018, https://www.webofscience.com/wos/woscc/full-record/WOS:000456210900032.
[12] Bao, Xichen, Guo, Xiangpeng, Yin, Menghui, Tariq, Muqddas, Lai, Yiwei, Kanwal, Shahzina, Zhou, Jiajian, Li, Na, Lv, Yuan, PulidoQuetglas, Carlos, Wang, Xiwei, Ji, Lu, Khan, Muhammad J, Zhu, Xihua, Luo, Zhiwei, Shao, Changwei, Lim, DoHwan, Liu, Xiao, Li, Nan, Wang, Wei, He, Minghui, Liu, YuLin, Ward, Carl, Wang, Tong, Zhang, Gong, Wang, Dongye, Yang, Jianhua, Chen, Yiwen, Zhang, Chaolin, Jauch, Ralf, Yang, YunGui, Wang, Yangming, Qin, Baoming, Anko, MinnaLiisa, Hutchins, Andrew P, Sun, Hao, Wang, Huating, Fu, XiangDong, Zhang, Biliang, Esteban, Miguel A. Capturing the interactome of newly transcribed RNA. NATURE METHODS[J]. 2018, 15(3): 213-+, http://ir.siat.ac.cn:8080/handle/172644/13418.
[13] Zhuang, Qiang, Li, Wenjuan, Benda, Christina, Huang, Zhijian, Ahmed, Tanveer, Liu, Ping, Guo, Xiangpeng, Ibanez, David P, Luo, Zhiwei, Zhang, Meng, Abdul, Mazid Md, Yang, Zhongzhou, Yang, Jiayin, Huang, Yinghua, Zhang, Hui, Huang, Dehao, Zhou, Jianguo, Zhong, Xiaofen, Zhu, Xihua, Fu, Xiuling, Fan, Wenxia, Liu, Yulin, Xu, Yan, Ward, Carl, Khan, Muhammad Jadoon, Kanwal, Shahzina, Mirza, Bushra, Tortorella, Micky D, Tse, HungFat, Chen, Jiayu, Qin, Baoming, Bao, Xichen, Gao, Shaorong, Hutchins, Andrew P, Esteban, Miguel A. NCoR/SMRT co-repressors cooperate with c-MYC to create an epigenetic barrier to somatic cell reprogramming. NATURE CELL BIOLOGY[J]. 2018, 20(4): 400-+, [14] Wang, XiWen, Hao, Jing, Guo, WenTing, Liao, LeQi, Huang, SiYue, Guo, Xiangpeng, Bao, Xichen, Esteban, Miguel A, Wang, Yangming. A DGCR8-Independent Stable MicroRNA Expression Strategy Reveals Important Functions of miR-290 and miR-183-182 Families in Mouse Embryonic Stem Cells. STEM CELL REPORTS[J]. 2017, 9(5): 1618-1629, http://dx.doi.org/10.1016/j.stemcr.2017.08.027.
[15] Yang, Jiayin, Wang, Yu, Zhou, Ting, Wong, LaiYung, Tian, XiaoYu, Hong, Xueyu, Lai, WingHon, Au, KaWing, Wei, Rui, Liu, Yuqing, Cheng, LaiHung, Liang, Guichan, Huang, Zhijian, Fan, Wenxia, Zhao, Ping, Wang, Xiwei, Ibanez, David P, Luo, Zhiwei, Li, Yingying, Zhong, Xiaofen, Chen, Shuhan, Wang, Dongye, Li, Li, Lai, Liangxue, Qin, Baoming, Bao, Xichen, Hutchins, Andrew P, Siu, ChungWah, Huang, Yu, Esteban, Miguel A, Tse, HungFat. Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells. STEM CELL REPORTS[J]. 2017, 8(3): 605-618, https://doaj.org/article/c8b746bcc4d14c1ea35c0ee1de8c99b8.
[16] Li, Li, Zhang, Quanjun, Yang, Huaqiang, Zou, Qingjian, Lai, Chengdan, Jiang, Fei, Zhao, Ping, Luo, Zhiwei, Yang, Jiayin, Chen, Qian, Wang, Yan, Newsome, Philip N, Frampton, Jon, Maxwell, Patrick H, Li, Wenjuan, Chen, Shuhan, Wang, Dongye, Siu, TakShing, Tam, Sidney, Tse, HungFat, Qin, Baoming, Bao, Xichen, Esteban, Miguel A, Lai, Liangxue. Fumarylacetoacetate Hydrolase Knock-out Rabbit Model for Hereditary Tyrosinemia Type 1. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2017, 292(11): 4755-4763, http://dx.doi.org/10.1074/jbc.M116.764787.
[17] Chen, Xiaona, He, Liangqiang, Zhao, Yu, Li, Yuying, Zhang, Suyang, Sun, Kun, So, Karl, Chen, Fengyuan, Zhou, Liang, Lu, Leina, Wang, Lijun, Zhu, Xihua, Bao, Xichen, Esteban, Miguel A, Nakagawa, Shinichi, Prasanth, Kannanganattu V, Wu, Zhenguo, Sun, Hao, Wang, Huating. Malat1 regulates myogenic differentiation and muscle regeneration through modulating MyoD transcriptional activity. CELL DISCOVERY[J]. 2017, 3: 17002-, https://www.webofscience.com/wos/woscc/full-record/WOS:000414903200001.
[18] Xu, Yan, Zhang, Meng, Li, Wenjuan, Zhu, Xihua, Bao, Xichen, Qin, Baoming, Hutchins, Andrew P, Esteban, Miguel A. Transcriptional Control of Somatic Cell Reprogramming. TRENDS IN CELL BIOLOGYnull. 2016, 26(4): 272-288, http://dx.doi.org/10.1016/j.tcb.2015.12.003.
[19] Wu, Yasong, Li, Yuan, Zhang, Hui, Huang, Yinghua, Zhao, Ping, Tang, Yujia, Qiu, Xiaohui, Ying, Yue, Li, Wen, Ni, Su, Zhang, Meng, Liu, Longqi, Xu, Yan, Zhuang, Qiang, Luo, Zhiwei, Benda, Christina, Song, Hong, Liu, Baohua, Lai, Liangxue, Liu, Xingguo, Tse, HungFat, Bao, Xichen, Chan, WaiYee, Esteban, Miguel A, Qin, Baoming, Pei, Duanqing. Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. NATURE CELL BIOLOGY[J]. 2015, 17(6): 715-+, http://ir.gibh.ac.cn/handle/344009/536.
[20] Wang, Lijun, Zhao, Yu, Bao, Xichen, Zhu, Xihua, Kwok, Yvonne KaYin, Sun, Kun, Chen, Xiaona, Huang, Yongheng, Jauch, Ralf, Esteban, Miguel A, Sun, Hao, Wang, Huating. LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration. CELL RESEARCH[J]. 2015, 25(3): 335-350, http://ir.gibh.ac.cn/handle/344009/578.
[21] Zhou, Liang, Sun, Kun, Zhao, Yu, Zhang, Suyang, Wang, Xuecong, Li, Yuying, Lu, Leina, Chen, Xiaona, Chen, Fengyuan, Bao, Xichen, Zhu, Xihua, Wang, Lijun, Tang, LingYin, Esteban, Miguel A, Wang, ChiChiu, Jauch, Ralf, Sun, Hao, Wang, Huating. Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1. NATURE COMMUNICATIONS[J]. 2015, 6: http://ir.foo.ac.cn/handle/2SETSVCV/615.
[22] Bao, Xichen, Wu, Haitao, Zhu, Xihua, Guo, Xiangpeng, Hutchins, Andrew P, Luo, Zhiwei, Song, Hong, Chen, Yongqiang, Lai, Keyu, Yin, Menghui, Xu, Lingxiao, Zhou, Liang, Chen, Jiekai, Wang, Dongye, Qin, Baoming, Frampton, Jon, Tse, HungFat, Pei, Duanqing, Wang, Huating, Zhang, Biliang, Esteban, Miguel A. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. CELL RESEARCH[J]. 2015, 25(1): 80-92, http://ir.gibh.ac.cn/handle/344009/616.
[23] Tian, Weihua, Wang, Yu, Xu, Yan, Guo, Xiangpeng, Wang, Bo, Sun, Li, Liu, Longqi, Cui, Fenggong, Zhuang, Qiang, Bao, Xichen, Schley, Gunnar, Chung, TungLiang, Laslett, Andrew L, Willam, Carsten, Qin, Baoming, Maxwell, Patrick H, Esteban, Miguel A. The Hypoxia-inducible Factor Renders Cancer Cells More Sensitive to Vitamin C-induced Toxicity. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2014, 289(6): 3339-3351, http://dx.doi.org/10.1074/jbc.M113.538157.
[24] Liu, Longqi, Xu, Yan, He, Minghui, Zhang, Meng, Cui, Fenggong, Lu, Leina, Yao, Mingze, Tian, Weihua, Benda, Christina, Zhuang, Qiang, Huang, Zhijian, Li, Wenjuan, Li, Xiangchun, Zhao, Ping, Fan, Wenxia, Luo, Zhiwei, Li, Yuan, Wu, Yasong, Hutchins, Andrew P, Wang, Dongye, Tse, HungFat, Schambach, Axel, Frampton, Jon, Qin, Baoming, Bao, Xichen, Yao, Hongjie, Zhang, Biliang, Sun, Hao, Pei, Duanqing, Wang, Huating, Wang, Jun, Esteban, Miguel A. Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming. CELL STEM CELL[J]. 2014, 15(5): 574-588, http://dx.doi.org/10.1016/j.stem.2014.09.018.
[25] Wang, Lihui, Wang, Linli, Huang, Wenhao, Su, Huanxing, Xue, Yanting, Su, Zhenghui, Liao, Baojian, Wang, Haitao, Bao, Xichen, Qin, Dajiang, He, Jufang, Wu, Wutian, So, Kwok Fai, Pan, Guangjin, Pei, Duanqing. Generation of integration-free neural progenitor cells from cells in human urine. NATURE METHODS[J]. 2013, 10(1): 84-U124, http://ir.foo.ac.cn/handle/2SETSVCV/129.
[26] Zhuang, Qiang, Qing, Xiaobing, Ying, Yue, Wu, Haitao, Benda, Christina, Lin, Jiao, Huang, Zhijian, Liu, Longqi, Xu, Yan, Bao, Xichen, Qin, Baoming, Pei, Duanqing, Esteban, Miguel A. Class IIa Histone Deacetylases and Myocyte Enhancer Factor 2 Proteins Regulate the Mesenchymal-to-Epithelial Transition of Somatic Cell Reprogramming. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2013, 288(17): 12022-12031, http://dx.doi.org/10.1074/jbc.M113.460766.
[27] Bao, Xichen, Zhu, Xihua, Liao, Baojian, Benda, Christina, Zhuang, Qiang, Pei, Duanqing, Qin, Baoming, Esteban, Miguel A. MicroRNAs in somatic cell reprogramming. CURRENT OPINION IN CELL BIOLOGY[J]. 2013, 25(2): 208-214, http://dx.doi.org/10.1016/j.ceb.2012.12.004.
[28] Zhou, Ting, Benda, Christina, Dunzinger, Sarah, Huang, Yinghua, Ho, Jenny Cy, Yang, Jiayin, Wang, Yu, Zhang, Ya, Zhuang, Qiang, Li, Yanhua, Bao, Xichen, Tse, HungFat, Grillari, Johannes, GrillariVoglauer, Regina, Pei, Duanqing, Esteban, Miguel A. Generation of human induced pluripotent stem cells from urine samples. NATURE PROTOCOLS[J]. 2012, 7(12): 2080-2089, https://www.webofscience.com/wos/woscc/full-record/WOS:000311894100002.
[29] Feng, Shipeng, Cong, Shujie, Zhang, Xin, Bao, Xichen, Wang, Wei, Li, Huiping, Wang, Zhe, Wang, Guoxin, Xu, Jianzhen, Du, Bowen, Qu, Dezhong, Xiong, Wei, Yin, Menghui, Ren, Xiaoshuai, Wang, Feifei, He, Jianxing, Zhang, Biliang. MicroRNA-192 targeting retinoblastoma 1 inhibits cell proliferation and induces cell apoptosis in lung cancer cells. NUCLEIC ACIDS RESEARCH[J]. 2011, 39(15): 6669-6678, https://www.webofscience.com/wos/woscc/full-record/WOS:000294555800037.
[30] Miguel A Esteban, Biliang Zhang. MicroRNA Cluster 302-367 Enhances Somatic Cell Reprogramming by Accelerating a Mesenchymal-to-Epithelial Transition. The Journal of Biological Chemistry[J]. 2011, 286(19): 17359-17364, http://dx.doi.org/10.1074/jbc.C111.235960.
[31] Liao, Baojian, Bao, Xichen, Liu, Longqi, Feng, Shipeng, Zovoilis, Athanasios, Liu, Wenbo, Xue, Yanting, Cai, Jie, Guo, Xiangpeng, Qin, Baoming, Zhang, Ruosi, Wu, Jiayan, Lai, Liangxue, Teng, Maikun, Niu, Liwen, Zhang, Biliang, Esteban, Miguel A, Pei, Duanqing. MicroRNA Cluster 302-367 Enhances Somatic Cell Reprogramming by Accelerating a Mesenchymal-to-Epithelial Transition. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2011, 286(19): 17359-17364, http://dx.doi.org/10.1074/jbc.C111.235960.
[32] Shahzina Kanwal, Xiangpeng Guo, Carl Ward, Giacomo Volpe, Baoming Qin, Miguel A Esteban, Xichen Bao. Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency. Genomics, Proteomics & Bioinformatics. http://dx.doi.org/10.1016/j.gpb.2019.06.003.

科研活动

   
科研项目
( 1 ) “利用‘点击化学’探讨小鼠‘胚胎干细胞’——‘外胚层干细胞’转化过程中RNA结合蛋白的功能和机制, 主持, 省级, 2018-05--2022-04
( 2 ) lincRNA-p21相关研究, 主持, 部委级, 2015-01--2018-12
( 3 ) 利用CRISPR-Cas9 技术探索胚胎干细胞中超级增强子的功能, 主持, 省级, 2016-05--2019-04