基本信息
施一  男  博导  中国科学院微生物研究所
电子邮件: shiyi@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号中国科学院微生物研究所A427
邮政编码: 100101

教育背景

2006-09--2011-06   中国科学院微生物研究所   博士
2002-10--2006-07   浙江大学生命科学学院   学士

工作经历

   
工作简历
2018-07~现在, 中国科学院微生物研究所, 病原室副主任、研究员
2016-03~现在, 中国科学院微生物研究所, 研究员
2013-08~2016-02,中国科学院北京生命科学研究院, 副研究员
2013-03~2013-07,中国科学院北京生命科学研究院, 助理研究员
2011-07~2013-02,中国科学院微生物研究所, 助理研究员
2006-09~2011-06,中国科学院微生物研究所, 博士
2002-10~2006-07,浙江大学生命科学学院, 学士
社会兼职
2023-11-15-2025-11-15,hLife, 执行主编
2021-10-01-2026-10-01,微生物学报, 编委
2021-01-01-2028-01-31,北京免疫学会, 常务理事
2020-10-12-今,中国免疫学会, 理事
2020-05-01-2025-05-01,The Innovation, 编委
2019-11-01-今,中国科学院青年创新促进会, 理事长
2019-07-31-今,中国青年科技工作者协会, 理事
2018-09-21-今,中西医结合学会 第四届传染病专业委员会, 青年委员
2018-07-01-今,中国科学院武汉国家生物安全实验室科技指导委员会, 委员
2018-06-21-今,中国畜牧兽医学会, 高级会员
2018-04-17-2021-10-31,中国微生物学会微生物生物安全委员会第一届青年学组, 委员
2017-11-01-2022-10-31,中国微生物学会《生物工程学报》第五届编辑委员会, 编委
2017-10-01-2021-09-30,中国医药生物技术协会实验室生物安全专业委员会第二届委员会, 委员
2017-06-22-今,北京药学会第十六届理事会药物化学生物学专业委员会, 委员
2017-01-01-今,北京生物化学与分子生物学会第二届青年委员会委员,
2016-12-27-今,中国研究型医院学会空间微生物学与感染专业委员会青年委员会, 副主任委员
2016-12-27-今,中国研究型医院学会空间微生物学与感染专业委员会, 常务委员
2014-03-01-2018-12-31,中国免疫学学会青年工作委员会, 委员
2013-03-01-2017-12-31,中国微生物学会病毒学专业委员会青年委员会, 委员
-今,

教授课程

结构生物学与医学研究
药物设计方法学
分子病毒学

专利与奖励

   
奖励信息
(1) 全球高被引科学家, 其他, 2023
(2) 全球高被引科学家, , 其他, 2022
(3) 求是杰出科技成就集体奖, , 其他, 2019
(4) 中国科学院青年创新促进会优秀会员, 院级, 2019
(5) 中国科学院北京分院第四届“启明星”复合型人才奖, , 院级, 2018
(6) 中华预防医学会科学技术奖, 一等奖, 其他, 2017
(7) 中源协和生命医学创新突破奖, 其他, 2016
(8) 国家优秀青年基金资助, , 国家级, 2016
(9) 中国生命科学领域十大进展奖, 其他, 2016
(10) 中国科学院青年创新促进会会员, 院级, 2015
(11) 中国科学院卢家锡青年人才奖, , 院级, 2014
(12) 中国科学院卓越青年科学家资助项目, 院级, 2014
专利成果
( 1 ) 3-AP在制备抑制应病毒的药物中的应用, 2023, 第 2 作者, 专利号: 202211439204.6

( 2 ) 多年冻土微生物DNA样本获取及DNA的提取和检测方法, 2023, 第 4 作者, 专利号: ZL202210792689.0

( 3 ) 小分子化合物在抗非洲猪瘟病毒感染中的应用, 2021, 第 4 作者, 专利号: CN111789861B

( 4 ) 一种流感病毒小分子抑制剂, 2021, 第 1 作者, 专利号: CN113679724A

( 5 ) 卡泊芬净在制备抑制冠状病毒的产品中的应用, 2021, 第 1 作者, 专利号: CN111298098B

( 6 ) 一种寨卡病毒小分子抑制剂, 2021, 第 1 作者, 专利号: CN109045041B

( 7 ) 一种β冠状病毒抗原、其制备方法和应用, 2021, 第 9 作者, 专利号: CN113416259A

( 8 ) LTX-315在制备抑制冠状病毒的产品中的应用, 2020, 第 1 作者, 专利号: CN111150833A

( 9 ) 原花青素类化合物在制备抗寨卡病毒的药物中的应用, 2019, 第 3 作者, 专利号: CN109394755A

( 10 ) 一种人源化单克隆抗体及应用, 2018, 第 6 作者, 专利号: CN107586335A

( 11 ) 一种针对T细胞受体可变区特异性单抗的制备方法, 2011, 第 2 作者, 专利号: CN102295702A

出版信息

   
发表论文
(1) Structure of monkeypox virus DNA polymerase holoenzyme, SCIENCE, 2023, 第 7 作者  通讯作者
(2) Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer, MABS, 2023, 第 16 作者  通讯作者
(3) Promotion of astrocyte-neuron glutamate-glutamine shuttle by SCFA contributes to the alleviation of Alzheimer's disease, REDOX BIOLOGY, 2023, 第 9 作者  通讯作者
(4) Molecular mechanism of de novo replication by the Ebola virus polymerase, Nature, 2023, 
(5) Structure of the Ebola virus polymerase complex, NATURE, 2022, 第 8 作者  通讯作者
(6) SARS-CoV-2 501Y.V2 variants lack higher infectivity but do have immune escape, CELL, 2021, 第 20 作者
(7) 从基础研究走向实际应用的探索与思考——以中国科学院病原微生物与免疫学重点实验室为例, Thoughts on Basic Research to Practical Application:Case Study on CAS Key Laboratory of Pathogenic Microbiology and Immunology, 中国科学院院刊, 2021, 第 1 作者
(8) 冰冻圈微生物演变与生物安全, Microbial Evolution of Cryosphere and Biosecurity Concerns, 中国科学院院刊, 2021, 第 3 作者
(9) Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir, Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir, 创新(英文), 2021, 第 8 作者  通讯作者
(10) Identification of antibiotic resistance genes and associated mobile genetic elements in permafrost, Identification of antibiotic resistance genes and associated mobile genetic elements in permafrost, SCIENCE CHINA-LIFE SCIENCES, 2021, 第 6 作者  通讯作者
(11) Avian influenza A(H7N9)virus:from low pathogenic to highly pathogenic, Avian influenza A (H7N9) virus: from low pathogenic to highly pathogenic, FRONTIERS OF MEDICINE, 2021, 第 8 作者
(12) 新型冠状病毒结合穿山甲ACE2受体的分子机制, 科学通报, 2021, 第 7 作者
(13) A broadly protective antibody that targets the flavivirus NS1 protein, SCIENCE, 2021, 第 22 作者  通讯作者
(14) Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals, NATURE MICROBIOLOGY, 2021, 第 15 作者  通讯作者
(15) Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir, Structural basis for the inhibition of the SARS-CoV-2 main protease by the anti-HCV drug narlaprevir, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 10 作者  通讯作者
(16) Structural Basis of SARS-CoV-2 Polymerase Inhibition by Favipiravir, The Innovation, 2021, 
(17) The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro, The effect of whey protein on viral infection and replication of SARS-CoV-2 and pangolin coronavirus in vitro, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 第 9 作者
(18) Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease, NATURE COMMUNICATIONS, 2020, 第 12 作者
(19) Single-Cell Sequencing of Peripheral Mononuclear Cells Reveals Distinct Immune Response Landscapes of COVID-19 and Influenza Patients, IMMUNITY, 2020, 第 35 作者
(20) Structural insight into arenavirus replication machinery, NATURE, 2020, 第 12 作者  通讯作者
(21) Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex, CELLULAR & MOLECULAR IMMUNOLOGY, 2020, 第 9 作者
(22) Diversity and abundance of resistome in rhizosphere soil, Diversity and abundance of resistome in rhizosphere soil, SCIENCE CHINA-LIFE SCIENCES, 2020, 第 4 作者  通讯作者
(23) Cryo-EM structure of the varicella-zoster virus A-capsid, NATURE COMMUNICATIONS, 2020, 第 7 作者
(24) Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2, CELL REPORTS, 2020, 第 12 作者  通讯作者
(25) Structure-Based Modification of an Anti-neuraminidase Human Antibody Restores Protection Efficacy against the Drifted Influenza Virus, MBIO, 2020, 第 11 作者
(26) Molecular basis for feedback inhibition of tyrosine-regulated 3-deoxy- d - arabino- heptulosonate-7-phosphate synthase from Escherichia coli, JOURNAL OF STRUCTURAL BIOLOGY, 2019, 第 11 作者
(27) 沙粒病毒聚合酶C端的表达纯化与结晶条件筛选*, Expression and Purification of C-terminal of Arenavirus Polymerase and Screening of Crystallization Conditions, 中国生物工程杂志, 2019, 第 5 作者
(28) Structural insight into RNA synthesis by influenza D polymerase, NATURE MICROBIOLOGY, 2019, 第 17 作者  通讯作者
(29) Cryo-EM Structure of the African Swine Fever Virus, CELL HOST & MICROBE, 2019, 第 18 作者  通讯作者
(30) 沙粒病毒聚合酶C端的表达纯化与结晶条件筛选 *;, 中国生物工程杂志, 2019, 第 5 作者
(31) Molecular Basis of Arthritogenic Alphavirus Receptor MXRA8 Binding to Chikungunya Virus Envelope Protein, CELL, 2019, 第 16 作者
(32) Neutralization mechanism of human monoclonal antibodies against rift valley fever virus, NATURE MICROBIOLOGY, 2019, 第 22 作者
(33) Antibiotic resistance gene reservoir in live poultry markets, JOURNAL OF INFECTION, 2019, 第 8 作者
(34) Intact Glycopeptide Analysis of Influenza A/H1N1/09 Neuraminidase Revealing the Effects of Host and Glycosite Location on Site-Specific Glycan Structures, PROTEOMICS, 2019, 第 10 作者  通讯作者
(35) Light chain modulates heavy chain conformation to change protection profile of monoclonal antibodies against influenza A viruses, CELL DISCOVERY, 2019, 第 20 作者
(36) Avian-to-Human Receptor-Binding Adaptation of Avian H7N9 Influenza Virus Hemagglutinin, CELL REPORTS, 2019, 第 14 作者
(37) Human Neonatal Fc Receptor Is the Cellular Uncoating Receptor for Enterovirus B, CELL, 2019, 第 23 作者
(38) Structure-function analysis of neutralizing antibodies to H7N9 influenza from naturally infected humans, NATURE MICROBIOLOGY, 2019, 第 22 作者  通讯作者
(39) Structural insight into multistage inhibition of CRISPR-Cas12a by AcrVA4, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 第 10 作者  通讯作者
(40) Double Lock of a Human Neutralizing and Protective Monoclonal Antibody Targeting the Yellow Fever Virus Envelope, CELL REPORTS, 2019, 第 19 作者
(41) Disrupting LILRB4/APOE Interaction by an Efficacious Humanized Antibody Reverses T-cell Suppression and Blocks AML Development, CANCER IMMUNOLOGY RESEARCH, 2019, 第 19 作者
(42) Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation, Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation, CELLULAR & MOLECULAR IMMUNOLOGY, 2019, 第 7 作者
(43) Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein, ANTIVIRAL RESEARCH, 2018, 第 10 作者  通讯作者
(44) An adenovirus serotype 2-vectored ebolavirus vaccine generates robust antibody and cell-mediated immune responses in mice and rhesus macaques, EMERGING MICROBES & INFECTIONS, 2018, 第 7 作者
(45) 艾滋病疫苗突破需要颠覆性思维, HIV vaccine development needs unconventional and creative approach, 科学通报, 2018, 第 1 作者
(46) Crystal Structure of the Capsid Protein from Zika Virus, JOURNAL OF MOLECULAR BIOLOGY, 2018, 第 3 作者
(47) The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice, SCIENCE CHINA-LIFE SCIENCES, 2018, 第 6 作者
(48) Structures of Zika Virus E & NS1: Relations with Virus Infection and Host Immune Responses, DENGUE AND ZIKA: CONTROL AND ANTIVIRAL TREATMENT STRATEGIES, 2018, 第 1 作者
(49) 埃博拉病毒入侵宿主细胞的分子机制, The molecular basis of Ebola virus entry into host cells, 科技导报, 2018, 第 4 作者
(50) The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice, The S190R mutation in the hemagglutinin protein of pandemic H1N1 2009 influenza virus increased its pathogenicity in mice, 中国科学:生命科学英文版, 2018, 第 6 作者
(51) Recombinant Chimpanzee Adenovirus Vaccine AdC7-M/E Protects against Zika Virus Infection and Testis Damage, JOURNAL OF VIROLOGY, 2018, 第 16 作者
(52) Alternate binding modes of anti-CRISPR viral suppressors AcrF1/2 to Csy surveillance complex revealed by cryo-EM structures, CELL RESEARCH, 2017, 第 9 作者
(53) Natural killer cells are activated and play a protective role against ZIKA virus infection in mice, SCIENCE BULLETIN, 2017, 第 9 作者
(54) CASCIRE Surveillance Network and Work on Avian Influenza Viruses, SCIENCE CHINA-LIFE SCIENCES, 2017, 第 28 作者
(55) Pediatric Drug Nitazoxanide: A Potential Choice for Control of Zika, OPEN FORUM INFECTIOUS DISEASES, 2017, 第 7 作者
(56) Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein, VIROLOGY, 2017, 第 9 作者  通讯作者
(57) Two classes of protective antibodies against Pseudorabies virus variant glycoprotein B: Implications for vaccine design, PLOS PATHOGENS, 2017, 第 17 作者  通讯作者
(58) Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains, NATURE COMMUNICATIONS, 2017, 第 10 作者  通讯作者
(59) Structural basis of nectin-1 recognition by pseudorabies virus glycoprotein D, PLOS PATHOGENS, 2017, 第 7 作者
(60) Structural basis of anti-PD-L1 monoclonal antibody avelumab for tumor therapy., CELL RESEARCH, 2017, 第 7 作者
(61) Structures of human-infecting Thogotovirus fusogens support a common ancestor with insect baculovirus, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 4 作者
(62) Structural Biology of the Zika Virus, TRENDS IN BIOCHEMICAL SCIENCES, 2017, 第 1 作者  通讯作者
(63) Conserved V delta 1 Binding Geometry in a Setting of Locus-Disparate pHLA Recognition by delta/alpha beta T Cell Receptors (TCRs): Insight into Recognition of HIV Peptides by TCRs, JOURNAL OF VIROLOGY, 2017, 第 1 作者
(64) Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies, ONCOTARGET, 2017, 第 6 作者
(65) Structures of phlebovirus glycoprotein Gn and identification of a neutralizing antibody epitope, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 17 作者
(66) An unexpected N-terminal loop in PD-1 dominates binding by nivolumab, NATURE COMMUNICATIONS, 2017, 第 13 作者
(67) The crystal structure of Zika virus NS5 reveals conserved drug targets, EMBO JOURNAL, 2017, 第 7 作者  通讯作者
(68) Selective inhibition of Ebola entry with selective estrogen receptor modulators by disrupting the endolysosomal calcium, SCIENTIFIC REPORTS, 2017, 第 9 作者
(69) Conserved V��1 Binding Geometry in a Setting of Locus-Disparate pHLA Recognition by ��/���� T Cell Receptors (TCRs): Insight into Recognition of HIV Peptides by TCRs, JOURNAL OF VIROLOGY, 2017, 第 1 作者
(70) Crystal Structure of the Marburg Virus Nucleoprotein Core Domain Chaperoned by a VP35 Peptide Reveals a Conserved Drug Target for Filovirus, JOURNAL OF VIROLOGY, 2017, 第 4 作者
(71) Avian-to-Human Receptor-Binding Adaptation by Influenza A Virus Hemagglutinin H4, CELL REPORTS, 2017, 第 8 作者
(72) Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus, SCIENCE CHINA-LIFE SCIENCES, 2017, 第 6 作者
(73) Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection, CELL, 2016, 第 11 作者
(74) Contribution of intertwined loop to membrane association revealed by zika virus full-length ns1 structure, EMBO JOURNAL, 2016, 第 7 作者  通讯作者
(75) Ebola Viral Glycoprotein Bound to Its Endosomal Receptor Niemann-Pick C1, CELL, 2016, 第 2 作者
(76) Structural and functional analysis of an anchorless fibronectin-binding protein FBPS from Gram-positive bacterium Streptococcus suis, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 第 13 作者
(77) A Bat-Derived Putative Cross-Family Recombinant Coronavirus with a Reovirus Gene, PLOS PATHOGENS, 2016, 第 7 作者
(78) Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies, PROTEIN & CELL, 2016, 第 6 作者
(79) Structures of the Zika Virus Envelope Protein and Its Complex with a Flavivirus Broadly Protective Antibody, CELL HOST & MICROBE, 2016, 第 13 作者
(80) Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus, SCIENCE TRANSLATIONAL MEDICINE, 2016, 第 31 作者
(81) Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies, Crystal clear: visualizing the intervention mechanism of the PD-1/PD-L1 interaction by two cancer therapeutic monoclonal antibodies, 蛋白质与细胞:英文版, 2016, 第 6 作者
(82) Ribavirin is effective against drug-resistant H7N9 influenza virus infections, Ribavirin is effective against drug-resistant H7N9 influenza virus infections, PROTEIN & CELL, 2016, 第 6 作者  通讯作者
(83) Effects of a Single Escape Mutation on T Cell and HIV-1 Co-adaptation, CELL REPORTS, 2016, 第 2 作者
(84) In vitro assembly of Ebola virus nucleocapsidlike complex expressed in E. coil, In vitro assembly of Ebola virus nucleocapsidlike complex expressed in E. coil, 蛋白质与细胞:英文版, 2016, 第 6 作者
(85) Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2016, 第 4 作者  通讯作者
(86) Zika virus NS1 structure reveals a diversified electrostatic surface for flavivirus, Nature Structural and Molecular Biology, 2016, 第 1 作者  通讯作者
(87) An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism, PLOS PATHOGENS, 2016, 第 8 作者
(88) In vitro assembly of Ebola virus nucleocapsid-like complex expressed in E. coli, PROTEIN & CELL, 2016, 第 6 作者
(89) Potent neutralizing monoclonal antibodies against Ebola virus infection, SCIENTIFIC REPORTS, 2016, 第 13 作者
(90) Structural basis of collagen recognition by human osteoclast-associated receptor and design of osteoclastogenesis inhibitors, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 第 7 作者
(91) Molecular Basis of Antibody-Mediated Neutralization and Protection Against Flavivirus, IUBMB LIFE, 2016, 第 4 作者
(92) 禽流感病毒跨种传播的分子机制, Molecular mechanisms on interspecies transmission of avian influenza viruses, 生命科学, 2015, 第 2 作者
(93) A potent broad-spectrum protective human monoclonal antibody crosslinking two haemagglutinin monomers of influenza A virus, NATURE COMMUNICATIONS, 2015, 第 12 作者
(94) Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference, EMBO JOURNAL, 2015, 第 10 作者
(95) Structural basis for preferential avian receptor binding by the human-infecting H10N8 avian influenza virus, NATURECOMMUNICATIONS, 2015, 第 14 作者
(96) Superimposed Epitopes Restricted by the Same HLA Molecule Drive Distinct HIV-Specific CD8(+) T Cell Repertoires, JOURNAL OF IMMUNOLOGY, 2014, 第 3 作者
(97) Analysis of Influenza Virus Receptor Specificity Using Glycan-Functionalized Gold Nanoparticles, ACS NANO, 2014, 第 7 作者
(98) Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses, NATURE REVIEWS MICROBIOLOGY, 2014, 第 1 作者  通讯作者
(99) Crystal Structure of the Interferon Gamma Receptor Alpha Chain from Chicken Reveals an Undetected Extra Helix Compared with the Human Counterparts, JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 2014, 第 5 作者
(100) Bat-derived influenza-like viruses H17N10 and H18N11, TRENDS IN MICROBIOLOGY, 2014, 第 4 作者
(101) Peptide-dependent Conformational Fluctuation Determines the Stability of the Human Leukocyte Antigen Class I Complex, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 第 3 作者
(102) N-alpha-Terminal Acetylation for T Cell Recognition: Molecular Basis of MHC Class I-Restricted N-alpha-Acetylpeptide Presentation, JOURNAL OF IMMUNOLOGY, 2014, 第 5 作者
(103) Superimposed Epitopes Restricted by the Same HLA Molecule Drive Distinct HIV-Specific CD8+ T Cell Repertoires, AMERICAN ASSOCIATION OF IMMUNOLOGISTS, 2014, 第 5 作者
(104) Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection, SCIENTIFIC REPORTS, 2013, 第 12 作者
(105) Amino Acid 316 of Hemagglutinin and the Neuraminidase Stalk Length Influence Virulence of H9N2 Influenza Virus in Chickens and Mice, JOURNAL OF VIROLOGY, 2013, 第 5 作者
(106) Bat-Derived Influenza Hemagglutinin H17 Does Not Bind Canonical Avian or Human Receptors and Most Likely Uses a Unique Entry Mechanism, CELL REPORTS, 2013, 第 2 作者
(107) Molecular Basis of the Receptor Binding Specificity Switch of the Hemagglutinins from both the 1918 and 2009 Pandemic Influenza A Viruses by a D225G Substitution, JOURNAL OF VIROLOGY, 2013, 第 2 作者
(108) Crystal structures of the two membrane-proximal Ig-like domains(D3D4)of LILRB1/B2:alternative models for their involvement in peptide-HLA binding, Crystal structures of the two membrane-proximal Ig-like domains (D3D4) of LILRB1/B2: alternative models for their involvement in peptide-HLA binding, PROTEIN & CELL, 2013, 第 2 作者
(109) Origin and molecular characterization of the human-infecting H6N1 infl uenza virus in Taiwan, Origin and molecular characterization of the human-infecting H6N1 influenza virus in Taiwan, PROTEIN & CELL, 2013, 第 2 作者
(110) Structure and Receptor Binding Specificity of Hemagglutinin H13 from Avian Influenza A Virus H13N6, JOURNAL OF VIROLOGY, 2013, 第 3 作者
(111) THE LANCET, 2013, 
(112) An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level, SCIENCE, 2013, 
(113) Structures and Receptor Binding of Hemagglutinins from Human-Infecting H7N9 Influenza Viruses, SCIENCE, 2013, 
(114) Origin and Diversity of Novel Avian Influenza A H7N9 Viruses Causing Human Infection: Phylogenetic, Structural, and Coalescent Analyses, LANCET, 2013, 第 3 作者
(115) Protein expression, crystallization and preliminary X-ray crystallographic analysis of chicken interferon-? receptor a chain, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, 2012, 第 2 作者
(116) Linking innate and adaptive immunity, CHINESE SCIENCE BULLETIN, 2012, 第 1 作者
(117) Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines (vol 2, pg 997, 2011), PROTEIN & CELL, 2012, 第 2 作者
(118) HLA-A*2402多肽复合物的两种构象——对Wolynes理论的补充, Two conformations of pHLA-A*2402: a supplement to Wolynes��� theory, 生物工程学报, 2012, 第 2 作者
(119) Protein expression, crystallization and preliminary X-ray crystallographic analysis of chicken interferon-? receptor a chain, ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, 2012, 第 2 作者
(120) Linking innate and adaptive immunity, Linking innate and adaptive immunity, 中国科学通报:英文版, 2012, 第 1 作者
(121) A Single Amino Acid at the Hemagglutinin Cleavage Site Contributes to the Pathogenicity and Neurovirulence of H5N1 Influenza Virus in Mice, JOURNAL OF VIROLOGY, 2012, 第 6 作者
(122) Reply to "Nuclear Export Signal and Immunodominant CD8 + T Cell Epitope in Influenza A Virus Matrix Protein 1", JOURNAL OF VIROLOGY, 2012, 第 2 作者
(123) Insights into Avian Influenza Virus Pathogenicity: the Hemagglutinin Precursor HA0 of Subtype H16 Has an Alpha-Helix Structure in Its Cleavage Site with Inefficient HA1/HA2 Cleavage, JOURNAL OF VIROLOGY, 2012, 第 2 作者
(124) Plasticity of human CD8 alpha alpha binding to peptide-HLA-A*2402, MOLECULARIMMUNOLOGY, 2011, 第 1 作者
(125) Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase, Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase, 中国科学通报:英文版, 2011, 第 4 作者
(126) LILRA3 Binds Both Classical and Non-Classical HLA Class I Molecules but with Reduced Affinities Compared to LILRB1/LILRB2: Structural Evidence, PLOS ONE, 2011, 第 7 作者
(127) Special features of the 2009 pandemic swine-origin influenza A H1N1 hemagglutinin and neuraminidase, CHINESE SCIENCE BULLETIN, 2011, 第 4 作者
(128) Structural vaccinology: structure-based design of influenza A virus hemagglutinin subtype-specific subunit vaccines, PROTEIN & CELL, 2011, 第 2 作者
(129) Crystal structure of the swine-origin A (H1N1)- 2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus, Crystal structure of the swine-origin A (H1N1)-2009 influenza A virus hemagglutinin (HA) reveals similar antigenicity to that of the 1918 pandemic virus, PROTEIN & CELL, 2010, 第 3 作者
(130) In silico characterization of the functional and structural modules of the hemagglutinin protein from the swine-origin influenza virus a (h1n1)-2009, SCIENCE CHINA-LIFE SCIENCES, 2010, 第 2 作者
(131) Structural immunology and crystallography help immunologists see the immune system in action: how t and nk cells touch their ligands, IUBMB LIFE, 2009, 第 2 作者
(132) Structural and biochemical characterization of nsp12-nsp7-nsp8 core polymerase complex from SARS-CoV-2, CELL REPORTS, 第 12 作者
(133) Single-cell sequencing of peripheral blood mononuclear cells reveals distinct immune response landscapes of COVID-19 and influenza patients, IMMUNITY, 第 35 作者
发表著作
( 1 ) 第二版《免疫学前沿进展》第七章, 《Advance in Immunology》Chapter 7, 人民卫生出版社, 2011-12, 第 2 作者
( 2 ) 免疫学前沿进展 第4版 第七章, 人民卫生出版社, 2017-04, 第 2 作者
( 3 ) 《寨卡病毒与寨卡病毒病》,第二章, 人民卫生出版社, 2019-05, 第 1 作者
( 4 ) 《生态基因组学》第25章, 科学出版社, 2019-09, 第 1 作者

科研活动

   
科研项目
( 1 ) 肺病毒和副黏病毒转录复制机制与干预策略研究, 参与, 地方任务, 2024-04--2028-09
( 2 ) 吸烟与呼吸道病毒感染的关系以及吸入式药物研发, 负责人, 其他, 2023-09--2025-08
( 3 ) 猴痘病毒DNA聚合酶复合体工作机制的研究, 负责人, 国家任务, 2023-01--2025-12
( 4 ) 潜在流行风险动物源性人兽共患病毒关键蛋白结构与功能研究, 负责人, 国家任务, 2022-01--2026-12
( 5 ) 病毒复制蛋白机器与广谱药物靶点研究, 负责人, 国家任务, 2021-12--2024-11
( 6 ) 多学科视角病毒溯源研究, 参与, 国家任务, 2021-04--2024-03
( 7 ) 冰川、冻土等极端生境和水体环境中“休眠”病毒复苏的潜在传播风险, 负责人, 中国科学院计划, 2021-01--2022-12
( 8 ) 科技前沿战略研究-青年科技工作者视角, 负责人, 中国科学院计划, 2021-01--2022-12
( 9 ) 新型冠状病毒复制转录复合物工作机制及抑制剂筛选研究, 负责人, 国家任务, 2020-03--2022-03
( 10 ) 非洲猪瘟研究应急项目, 负责人, 中国科学院计划, 2019-01--2021-12
( 11 ) 寨卡病毒药物研发与作用机制研究, 负责人, 国家任务, 2019-01--2022-12
( 12 ) 病毒溯源、跨种传播及致病机制, 负责人, 中国科学院计划, 2018-07--2023-07
( 13 ) 东非、中亚和东南亚等区域重要传染病防控关键保障技术研究, 负责人, 国家任务, 2018-01--2021-06
( 14 ) 大流感前疫苗研发, 负责人, 境内委托项目, 2017-01--2018-07
( 15 ) 病原感染与跨种传播, 负责人, 国家任务, 2017-01--2019-12
( 16 ) P9类多肽新药临床前病毒学研究, 负责人, 境内委托项目, 2016-07--2018-07
( 17 ) 一带一路”新发突发病原研究支撑计划, 参与, 中国科学院计划, 2016-01--2020-12
( 18 ) 中国科学院青年促进会项目, 负责人, 中国科学院计划, 2015-01--2018-12
( 19 ) 抗HIV 广谱中和抗体生成与重塑的分子基础, 参与, 国家任务, 2014-01--2018-08
参与会议
(1)病毒感染与广谱药物靶点   全国病毒学学术研讨会   2021-09-26
(2)Viral polymerase and design broad-spectrum drug   第十五届国际基因组学大会   2020-10-25
(3)病毒聚合酶与广谱药物设计   中国科学院青年创新促进会工程与装备分会   2020-10-22
(4)病毒聚合酶与广谱药物设计   第二届青年生命科学论坛   2020-09-24
(5)病毒聚合酶:广谱性药物靶点和传染病流行准备   中国生物工程学会第十三届学术年会暨 2019 年全国生物技术大会   2019-11-09
(6)Entry mechanisms of highly pathogenic coronaviruses: MERS-CoV and SARS-CoV   预防和应对流行病的多学科研究研讨会   2019-10-02
(7)Influenza virus replication and antiviral coutermeature development   第二届中国巴西传染病研究与控制中心(IDRPC)学术研讨会暨第一届CAS-TWAS新发突发传染病研究与交流卓越中心(CEEID)研讨会   2019-06-26
(8)Structural basis of Ebola virus neutralization by ZMappTM   中-肯传染病研讨会   2019-05-06
(9)Influenza virus entry and replication   靶标与配体:基于结构的药物设计35年历程   2019-04-07
(10)Influenza virus entry, neutralization and replication   第29届病毒学年会   2019-03-22
(11)无   中国研究型医院学会空间微生物学与感染专业委员会 第三届学术大会暨转化应用战略研讨会   2018-11-18
(12)Influenza virus and neutralizing antibodies   中国科学院青年创新促进会2018年学术年会暨“青促会讲堂   2018-11-06
(13)流感病毒、埃博拉病毒、寨卡病毒、中东呼吸综合征冠状病毒等病毒研究进展   第七届国际青年学者“流行病、传染病和动物传染病的快速诊断”会议及与斯马拉金采夫研究所的双边学术研讨会   2018-09-11
(14)Entry mechanisms of highly pathogenic coronaviruses: MERS-CoV and SARS-CoV   第三届突发新发病毒前言研讨会   2018-09-01
(15)病毒的致病机制   访问巴西Fiocruz基金会并洽谈传染病防控的合作   2018-07-26
(16)Cryo-electron microscopy structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains   2018年第28届国际病毒学年会   2018-03-14
(17)Host jump of Flu and MERS-CoV and Ebola   参加2018年美国德克莎斯大学加尔维斯医学部传染病讨论会   2018-01-16
(18)Ebola virus entry: target for membrane fusion inhibiti   27届病毒学年会   2017-03-22
(19)Structure of zika virus ns1: association with virus infection and immune system   参加首届国际寨卡病毒会议   2017-02-22
(20)Ebola viral glycoprotein bound to its endosomal receptor Niemann-Pick C1   参加第26届德国国际病毒学会   2016-04-05
(21)Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses   Yi Shi   2015-10-18
(22)Enabling the 'host jump': structural determinants of receptor-binding specificity in influenza A viruses   Yi Shi   2015-09-02
(23) 无   2014年国际微生物学大会    施一   2014-07-27
(24)禽流感H5N1/H7N9的跨种间传播机制   中国预防医学会第四届学术年会“新发传染病的挑战与应对”专题研讨会   施一   2013-11-08
(25)Structural basis of virulence-associated D225G substitution resulting in similar binding specificity shift in 1918 and 2009 pandemic influenza hemagglutinin   2011年国际微生物学大会   施一   2011-09-12
(26)CDR3 loop is responsible for the MHC restriction   中国免疫学会第六次全国会员代表大会暨第七届学术会议   施一   2010-10-24