General

Xuehai Yan is currently a professor of chemistry at the Institute of Process Engineering (IPE), the Chinese Academy of Sciences (CAS) and the principle investigator of the biomolecular assembly and engineering group. He obtained his PhD with distinction in physical chemistry at the Institute of Chemistry, CAS in 2008.After that, he moved to the Max Planck Institute of Colloids and Interfaces in Germany, where he won a research fellowship from the Alexander von Humboldt Foundation (2009-2011).

Research Group of Prof. Yan, National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences  

Tel: 86-10-82545004; 86-10-82545024   

Fax: 86-10-82545024   

E-mail: yanxh@ipe.ac.cn  

 Address: 1 North 2nd Street, Zhongguancun, Haidian District, Beijing, PR China   

Research Areas








●Self-assembly from molecular level to nanoscale to microscale, even to macroscale


Self-assembly is a key function in the “process of life”. Learning the self-organization way from nature would direct us in design and fabrication of functional nanomaterials. Research interest in Yan’s group is mainly focused on self-assembly and nanoengineering of biomolecules (such as amino acids, peptides and proteins as well as biomacromolecules), structural mechanism and biomedical applications. These include:

  • 1)Engineering and assemblyof chemical or biological nanoreactorsas biocatalysts and vaccine adjuvants;
  • 2)Development of new-type drug delivery vectors, nanomedicine and formulations towards photodynamic therapy (PDT), immunotherapy and chemotherapy against tumor;
  • 3)Design and creation of model abiotic celluarity and biomimetic protocells for study of prebiotic photosynthesis and biochemical process in cell.


Education


2005.09-2008.07    Doctor of Philosophy (PHD)    Physical Chemistry at the Institute of Chemistry, the Chinese Academy of Sciences (CAS)
2002.09-2005.07    Master (M.A.)    China University of Mining and Technology (CUMT)
1998.09-2002.07    Bachelor    China University of Mining and Technology (CUMT)


Experience


2013-Now    Professor,  Principle Investigator of the Biomolecular Assembly and Engineering group    Institute of Process Engineering (IPE), the Chinese Academy of Sciences (CAS)

2008-2013     Postdoctor, Research fellowship  from the Alexander von Humboldt Foundation   Max Planck Institute of Colloids and Interfaces, Germany

Publications

40)  J. Wang, K. Liu, R. R. Xing, X. H. Yan*, Peptide Self-Assembly: Thermodynamics and Kinetics, Chem. Soc. Rev. 2016, 45, 5589-5604 (Cover).  (IF: 34.09)

39)  K. Liu, R. R. Xing, Y. X. Li, Q. L. Zou, H. Möhwald, X. H. Yan*, Sustainable Hydrogen Evolution Based on Peptide-Porphyrin Co-Assemblies with Self-Mineralized Reaction Center towards Mimicking Primitive Photobacteria, Angew. Chem. Int. Ed. 2016, 55, 12503-12507.  (IF: 11.709).






38)  N. Zhang, F. F. Zhao, G. Z. Shen, Q. L. Zou, Y. X. Li, G. H. Ma, X. H. Yan*, Multi-Triggered Tumor-Responsive Drug Delivery Vehicles Based on Protein and Polypeptide Co-Assembly for Enhanced Photodynamic Tumor Ablation, Small 2016, 12, 5936-5943. (Frontispiece)




37)  K. Liu, Y. Kang*, G. H. Ma, H. Möhwald, X. H. Yan*, Molecular and Mesoscale Mechanism for Hierarchical Self-Assembly of Dipeptide and Porphyrin Light-Harvesting System, Phys. Chem. Chem. Phys. 2016, 18, 16738-16747


36)   K. Liu, R. R. Xing, Q. L. Zou, G. H. Ma, H. Möhwald, X. H. Yan*, Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy,  Angew. Chem. Int. Ed. 2016, 55, 3036-3039.

 

 

35)  Q. L. Zou, K. Liu, M. Abbas, X. H. Yan*, Peptide-Modulated Self-Assembly of Chromophores towards Biomimetic Light-Harvesting Nanoarchitectonics, Adv. Mater. 2016, 28, 1031-1043. (Invited review)

 

34)   R. R. Xing, K. Liu, T. F. Jiao*, N. Zhang, K. Ma, R. Y. Zhang, Q. L. Zou, G. H. Ma, X. H. Yan*, An injectable self-assembling collagen-gold hybrid hydrogel for combinatorial antitumor photothermal/photodynamic therapy, Adv. Mater. 2016, 28, 3669-3676.

 

33)  J. Wang,  K. Liu,  L. Y. Yan,  A. H. Wang, S. Bai, X. H. Yan*, Trace Solvent as a Predominant Factor To Tune Dipeptide Self-Assembly, ACS Nano 2016, 10, 2138-2143.

 

32)  Y. X. Li, L. Y. Yan, K. Liu, J. Wang, A. H. Wang, S. Bai*, X. H. Yan*, Solvothermally-Mediated Self-Assembly of Ultralong Peptide Nanobelts Capable of Optical Waveguiding, Small 2016, DOI: 10.1002/smll.201600230.                                                                      

31)   C. J. Chen,  S. K. Li, K. Liu, G. H. Ma, X. H. Yan*, Co-Assembly of Heparin and Polypeptide Hybrid Nanoparticles for Biomimetic Delivery and Anti-Thrombus Therapy, Small 2016, DOI: 10.1002/smll.201600328. (Invited paper)

 

30)  Kai Liu, Ruiyun Zhang, Yongxin Li, Tifeng Jiao, Dan Ding, X. H. Yan*, Tunable Aggregation-Induced Emission of Tetraphenylethylene via Short Peptide-Directed Self-Assembly, Adv. Mater. Interfaces 2016, DOI: 10.1002/admi.201600183. (Invited paper)

 

29)   Shen, Guizhi ; Zhang, Ning; Yan, Linyin; Chen, Chengjun; Ma, Guanghu, X. H. Yan*, Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long-Term Stable Hydrophobic Nanodrugs towards Effective Anticancer Therapy, ACS Nano 2016, 10,  5720-5729.

        

28)   R. R. Xing, T. F. Jiao*, K. Ma, G. H. Ma, H. Möhwald, X. H. Yan*, Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles. Scientific Reports, 2016, 6, 26506.

 

 

27)   R. R. Xing, T. F. Jiao*, Y. M. Liu, K. Ma, Q. L. Zou, G. H. Ma, X. H. Yan*, Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy, Polymers 2016,  8, 181. (Invited paper)

 

 

26)   Ruiyun Zhang, Ruirui Xing, Tifeng Jiao*, Kai Ma, Chengjun Chen, Guanghui Ma, X. H. Yan*, Carrier-free, Chemo-photodynamic Dual Nanodrugs via Self-assembly for Synergistic Antitumor Therapy, ACS Appl. Mater. Interfaces  2016, 8, 13262-13269.

 

25)  C. J. Chen, K. Liu, J. B. Li, X. H. Yan*, Functional architectures based on self-assembly of bio-inspired dipeptides: structure modulation and its photoelectronic applications, Adv. Colloid Interface Sci. 2015, 225, 177-193. (IF: 7.776)

24) K. Liu, R.R. Xing, C.J. Chen, G.Z. Shen, L.Y. Yan, Q.L. Zou, G.H. Ma, H. Möhwald, X.H. Yan*,Peptide-Induced Hierarchical Long-Range Order of Porphyrin Self-Assemblies and their Photocatalytic Activity. Angew. Chem. Int. Ed. 54, 500–505, 2015


23) H.Q. Wang*, X.H. Yan*, G.L. Li, C. Pilz-Allen, H. Möhwald, D. Shchukin, Sono-Assembly of Highly Biocompatible Polysaccharide Capsules for Hydrophobic Drug Delivery, Adv. Healthcare. Mater., 3, 825–831, 2014.


22) T.F. Jiao*, Y.J. Wang, Q.R. Zhang, X.H. Yan*, X.Q. Zhao, J.X. Zhou, F.M. Gao, Self-Assembly and Headgroup Effect in Nanostructured Organogels via Cationic Amphiphile-Graphene Oxide Composites. PLoS ONE, 9(7): 101620, 2014

21) F.F. Zhao, G.Z. Shen, C.J. Chen, R.R. Xing, Q.L. Zou, G.M. Ma, X.H. Yan*. Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools, Chem. Eur. J. 20, 6880-6887, 2014.


20) Q.L. Zou, L. Zhang, X.H. Yan*, A.H. Wang, G.H. Ma, J.B. Li, H. Mohwald, S. Mann. Multifunctional porous microspheres based on Peptide-porphyrin hierarchical co-assembly. Angew. Chem. Int. Ed., 53, 2366-2370, 2014.


 

Year 2010-2013 (Representatives)


19) X.H. Yan*, J.B. Li*, H. Möhwald, Templating Assembly of Multifunctional Hybrid Colloidal Spheres, Adv. Mater. 24, 2663–2667, 2012 (Frontispiece). Top 2 of this week’s Advanced Materials Top 40 most-read articles. Press release: Max Planck Society.

18) X.H. Yan*, J. Blacklock, J.B. Li*, H. Möhwald, One-Pot synthesis of polypeptide-gold nanoconjugates for in vitro gene transfection, ACS Nano 6, 111–117, 2012.

 17) X.H. Yan*, Y. Su, J. B. Li*, J. Früh, Uniaxially-oriented peptide crystals for optical waveguiding, Angew. Chem. Int. Ed. 50, 11186–11191, 2011.

16) X.H. Yan, J.B. Li*, H. Möhwald, Self-assembly of hexagonal peptide microtubes and their optical waveguiding, Adv. Mater. 23, 2796-2801, 2011.

15) X.H. Yan, P.L. Zhu, J.B. Li*, Self-assembly and application of diphenylalanine-based nanostructures, Chem. Soc. Rev. 39, 1877-1890, 2010 (Front Cover).

14) X.H. Yan, P.L. Zhu, J.B. Fei, J.B. Li*, Self-assembly of peptide-inorganic hybrid spheres for adaptive encapsulation of guests, Adv. Mater. 22, 1283-1287, 2010.

13) L. Duan, X.H. Yan, A.H., Wang, H. Möhwald, J.B. Li, Highly Loaded Hemoglobin Spheres as Promising Artificial Oxygen Carriers, ACS Nano 6, 6897–6904, 2012.

12) P.L., Zhu1, X.H. Yan.1, Y. Su, Y. Yang, J.B. Li, Solvent Induced Nanostructure Transition of Self-Assembled Dipeptide: From Organogels to Microcrystals. Chem. Eur. J. 16, 3176-3183, 2010. (The first two authors contributed equally)

11) Y. Su, X.H. Yan, A.H. Wang, J.B. Fei, Q. He, J.B. Li, A Peony-Flower-like Hierarchical Mesocrystal formed by Diphenylalanine. J. Mater. Chem. 20, 6734-6740, 2010.

 

Before 2010 (Representatives)


10) X.H Yan, Y. Cui, W. Qi, Y. Su, Y. Yang, Q. He, J.B. Li, Self-assembly of peptide-based colloids containing lipophilic nanocrystals. Small, 4, 1687-1693, 2008.

9) X.H. Yan, Y. Cui, Q. He, K.W. Wang, J.B. Li, W.H. Mu, B.L. Wang, Z.C. Ou-yang. Reversible transitions between peptide nanotubes and vesicle-like structures including theoretical modeling studies. Chem. Eur. J., 14, 5974-5980, 2008.

8) X.H. Yan, Q. He, K.W. Wang, L. Duan, Y. Cui, J.B. Li, Transition of cationic dipeptide nanotubes into vesicles and oligonucleotide delivery. Angew. Chem. Int. Ed, 46, 2431-2434, 2007.

7) X.H. Yan, Cui, Y., He, Q., Wang, K. W. and Li, J.B.: Organogels based on self-assembly of dipeptide and their application to immobilize quantum dots. Chem. Mater. 20, 1522-1526, 2008.

6) W. Qi, X.H. Yan, L. Duan, J.B. Li, Glucose-Sensitive Microcapsules from Glutaraldehyde Cross-Linked Hemoglobin and Glucose Oxidase. Biomacromolecules 10, 1212-1216, 2009.

5) W. Qi, X.H. Yan, Y. Cui, , J.B. Fei., A.H. Wang, J.B. Li, Triggered release of insulin from glucose-sensitive enzyme multilayer shells. Biomaterials 30, 2799-2806, 2009.

4) Q. He, L. Duan, W. Qi, K.W. Wang, Y. Cui, X.H. Yan, J.B. Li, Microcapsules containing biomolecular motor for ATP biosynthesis. Adv. Mater. 20, 2933-2937, 2008.

3) W. Qi, L. Duan, K.W. Wang, X.H. Yan, Y. Cui, Q. He, J.B. Li, ATP synthesis catalyzed by motor protein CF0F1 reconstituted in lipid-coated hemoglobin microcapsules. Adv. Mater. 20, 601-605, 2008.

2) J.B. Fei, Y. Cui, X.H. Yan, W. Qi, Y. Yang, K.W. Wang, Q. He, J.B. Li, Controlled preparation of MnO2 hierarchical hollow nanostructures and their application in water treatment. Adv. Mater. 20, 452-456, 2008.

1) L. Duan, Q. He, K.W. Wang,X.H. Yan, H. Möhwald, J.B. Li, ATP biosynthesis catalyzed by the FoF1-ATP synthase assembled in polymer microcapsules. Angew. Chem. Int. Ed. 46, 6996-7000, 2007.


Books

(1) Li, J. B., He, Q., and Yan, X. H. (2011): Molecular assembly of biomimetic systems, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. Print ISBN: 978-3-527-32542-9 (doi: 10.1002/9783527634125). (Book)

(2) Yan, X. H., Su, Y., Qi W., and Li, J. B. (2012): Biomedical applications of assembled peptide and protein micro- or nano-structures in “Self-Assembled Peptide Nanostructures: Advances and Applications in Nanobiotechnology” edited by Jaime Castillo-León, Luigi Sasso, and Winnie E. Svendsen, Pan Stanford Publishing Pte Ltd, Singapore. ISBN 978-981-4316-94-1 (Hardcover), 978-981-4364-47-8 (eBook). (Book Chapter)

 


Conferences

  1. Xuehai Yan, International Conference on Porphyrins and Phthalocyanines (ICPP), 2016, Nanjing, China (Invited presentation)
  2. Xuehai Yan, Humboldt Kolleg on Green Technology and Chemistry, 2016, Shanghai, China (Keynote presentation)
  3. Xuehai Yan, 21st International Symposium on Surfactants in Solution, 2016, Jinan, China (Oral presentation, Session Chair)
  4. Xuehai Yan, Colloid and Interface Chemistry Session, The 30th academic conference of Chinese Chemical Society, 2016, Dalian, China (Invited presentation)
  5. Xuehai Yan, 2015 International Chemical Congress of Pacific Basin Societies (Pacifichem), 2015, Honolulu, Hawaii, USA (Invited presentation)
  6. Xuehai Yan, The 15th Conference of the International Association of Colloid and Interface Scientists, 2015, Mainz, Germany (Oral presentation)
  7. Xuehai Yan, 5th Asian Symposium on Emulsion Polymerization, 2015, Suzhou, China (Invited presentation, Session Chair)
  8. Xuehai Yan, The 5th China-Europe Symposium on Biomaterials in Regenerative Medicine, 2015, Hangzhou, China (Invited presentation, Session Chair)
  9. Xuehai Yan, The 7th World Congress of Particle Technology, 2014, Beijing, China (Invited presentation)
  10. Xuehai Yan, Molecular Frontier Science Conference for Humboltians, 2013, Shanghai, China (Invited presentation, Session Chair)

Students

Staff:

  • Qianli Zou
  • Guizhi Shen


Postdoctors:

  • Juan Wang
  • Chengqian Yuan
  • Luyang Zhao


Students:

  • Manzar Abbas
  • Kai Liu
  • Ruirui Xing
  • Han Zhang
  • Yongxin Li
  • Jiajia Sun
  • Yamei Liu
  • Shukun Li
  • Haifeng Sun
  • Zengchun Xie
  • Jingwen Song


Project staff:
  • Ruiyun Zhang


Graduated students:

  • Fenfang Zhao
  • Yazhou Liu
  • Kai Ma