基本信息
闫学海  男  博导  中国科学院过程工程研究所
电子邮件: yanxh@ipe.ac.cn
通信地址: 北京市海淀区中关村北二条1号
邮政编码: 100190

招生信息

   
招生专业
081703-生物化工
080502-材料学
081701-化学工程
招生方向
生物分子组装,纳米载体,佐剂和生物催化剂,生物医药工程

教育背景

2005-09--2008-06   中国科学院化学研究所   博士
1998-09--2005-06   中国矿业大学化工学院   本科/硕士

专利与奖励

   
专利成果
( 1 ) 一种基于白蛋白的纳米粒子、其制备方法及用途, 发明, 2016, 第 1 作者, 专利号: 201310456200.3
( 2 ) 纳米金的胶原凝胶、其制备方法及用途, 发明, 2015, 第 1 作者, 专利号: 201510125084.6
( 3 ) 基于络合包覆的难溶性药物纳米粒制剂、其制备方法和用途, 发明, 2014, 第 1 作者, 专利号: 20141014885.5
( 4 ) 一种光敏剂纳米粒及其制备方法和用途, 发明, 2015, 第 1 作者, 专利号: 201510373286.2
( 5 ) 一种低分子量肝素缓释制剂及其制备方法和应用, 发明, 2015, 第 1 作者, 专利号: 201510359524.4

出版信息

   
发表论文
[1] Li, Zhiliang, Li, Shukun, Guo, Yanhui, Yuan, Chengqian, Yan, Xuehai, Schanze, Kirk S. Metal-Free Nanoassemblies of Water-Soluble Photosensitizer and Adenosine Triphosphate for Efficient and Precise Photodynamic Cancer Therapy. ACS NANO[J]. 2021, 15(3): 4979-4988, http://dx.doi.org/10.1021/acsnano.0c09913.
[2] Li, Shukun, Zhang, Wenjia, Xing, Ruirui, Yuan, Chengqian, Xue, Huadan, Yan, Xuehai. Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy. ADVANCED MATERIALS[J]. 2021, 33(21): http://dx.doi.org/10.1002/adma.202100595.
[3] Liu, Yamei, Naumenko, Ekaterina, Akhatova, Farida, Zou, Qianli, Fakhrullin, Rawil, Yan, Xuehai. Self-assembled peptide nanoparticles for enhanced dark-field hyperspectral imaging at the cellular and invertebrate level. CHEMICAL ENGINEERING JOURNAL[J]. 2021, 424: http://dx.doi.org/10.1016/j.cej.2021.130348.
[4] Min, Fanyi, Zhou, Peng, Huang, Zhandong, Qiao, Yali, Yu, Changhui, Qu, Zhiyuan, Shi, Xiaosong, Li, Zheng, Jiang, Lang, Zhang, Zhen, Yan, Xuehai, Song, Yanlin. A Bubble-Assisted Approach for Patterning Nanoscale Molecular Aggregates. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2021, 60(30): 16547-16553, http://dx.doi.org/10.1002/anie.202103765.
[5] Geng, Rui, Chang, Rui, Zou, Qianli, Shen, Guizhi, Jiao, Tifeng, Yan, Xuehai. Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules. SMALL[J]. 2021, 17(19): http://dx.doi.org/10.1002/smll.202008114.
[6] Zhao, Kaili, Xing, Ruirui, Yan, Xuehai. Cyclic dipeptides: Biological activities and self-assembled materials. PEPTIDE SCIENCEnull. 2021, 113(2): http://dx.doi.org/10.1002/pep2.24202.
[7] Rozhina, Elvira, Batasheva, Svetlana, Miftakhova, Regina, Yan, Xuehai, Vikulina, Anna, Volodkin, Dmitry, Fakhrullin, Rawil. Comparative cytotoxicity of kaolinite, halloysite, multiwalled carbon nanotubes and graphene oxide. APPLIED CLAY SCIENCE[J]. 2021, 205: http://dx.doi.org/10.1016/j.clay.2021.106041.
[8] Hong, Huadong, Zou, Qianli, Liu, Yamei, Wang, Shaozhen, Shen, Guizhi, Yan, Xuehai. Supramolecular Nanodrugs Based on Covalent Assembly of Therapeutic Peptides toward In Vitro Synergistic Anticancer Therapy. CHEMMEDCHEM[J]. 2021, 16(15): 2381-2385, http://dx.doi.org/10.1002/cmdc.202100236.
[9] Abbas, Manzar, Atiq, Atia, Xing, Ruirui, Yan, Xuehai. Silver-incorporating peptide and protein supramolecular nanomaterials for biomedical applications. JOURNAL OF MATERIALS CHEMISTRY Bnull. 2021, 9(22): 4444-4458, http://dx.doi.org/10.1039/d1tb00025j.
[10] 闫学海. Tumor Therapy Based on Self-Assembling Peptides Nanotechnology. View. 2020, [11] Yuan, Chengqian, Yang, Mengyao, Ren, Xiaokang, Zou, Qianli, Yan, Xuehai. Porphyrin/Ionic-Liquid Co-assembly Polymorphism Controlled by Liquid-Liquid Phase Separation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(40): 17456-17460, https://www.webofscience.com/wos/woscc/full-record/WOS:000557829000001.
[12] Chang, Rui, Nikoloudakis, Emmanouil, Zou, Qianli, Mitraki, Anna, Coutsolelos, Athanassios G, Yan, Xuehai. Supramolecular Nanodrugs Constructed by Self-Assembly of Peptide Nucleic Acid-Photosensitizer Conjugates for Photodynamic Therapy. ACS APPLIED BIO MATERIALSnull. 2020, 3(1): 2-9, [13] Zou, Qianli, Chang, Rui, Yan, Xuehai. Self-Assembling Proteins for Design of Anticancer Nanodrugs. CHEMISTRY-AN ASIAN JOURNALnull. 2020, 15(9): 1405-1419, http://dx.doi.org/10.1002/asia.202000135.
[14] Zou, Qianli, Chang, Rui, Xing, Ruirui, Yuan, Chengqian, Yan, Xuehai. Injectable self-assembled bola-dipeptide hydrogels for sustained photodynamic prodrug delivery and enhanced tumor therapy. JOURNAL OF CONTROLLED RELEASE[J]. 2020, 319: 344-351, http://dx.doi.org/10.1016/j.jconrel.2020.01.002.
[15] Li, Yongxin, Wong, Roy C H, Yan, Xuehai, Ng, Dennis K P, Lo, PuiChi. Self-Assembled Nanophotosensitizing Systems with Zinc(II) Phthalocyanine-Peptide Conjugates as Building Blocks for Targeted Chemo-Photodynamic Therapy. ACS APPLIED BIO MATERIALS[J]. 2020, 3(9): 5463-5473, [16] Liu, Yilin, Zhao, Luyang, Shen, Guizhi, Chang, Rui, Zhang, Yi, Yan, Xuehai. Coordination self-assembly of natural flavonoids into robust nanoparticles for enhanced in vitro chemo and photothermal cancer therapy. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2020, 598: http://dx.doi.org/10.1016/j.colsurfa.2020.124805.
[17] 闫学海. Injectable Self-assembled Bola-dipeptide Hydrogels for Sustained Photodynamic Prodrug Delivery and Enhanced Tumors Therapy. J. Control. Release. 2020, [18] Tian, Yajie, Li, Jieling, Zhao, Luyang, Zhang, Xianglan, Wang, Anhe, Jian, Honglei, Bai, Shuo, Yan, Xuehai. Peptide assembly assisted triplet-triplet annihilation photon upconversion in non-deoxygenated water. BIOMATERIALS SCIENCE[J]. 2020, 8(11): 3072-3077, https://www.webofscience.com/wos/woscc/full-record/WOS:000539368700005.
[19] 闫学海. Supramolecular Immunotherapy of Cancer Based on the Self-assembling Peptide Design. Small Structures. 2020, [20] Sun, Bingbing, Chang, Rui, Cao, Shoupeng, Yuan, Chengqian, Zhao, Luyang, Yang, Haowen, Li, Junbai, Yan, Xuehai, van Hest, Jan C M. Acid-Activatable Transmorphic Peptide-Based Nanomaterials for Photodynamic Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2020, 59(46): 20582-20588, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7693186/.
[21] Li, Shukun, Zhang, Wenjia, Xue, Huadan, Xing, Ruirui, Yan, Xuehai. Tumor microenvironment-oriented adaptive nanodrugs based on peptide self-assembly. CHEMICAL SCIENCE[J]. 2020, 11(33): 8644-8656, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8163399/.
[22] Zhao, Luyang, Liu, Yamei, Xing, Ruirui, Yan, Xuehai. Supramolecular Photothermal Effects: A Promising Mechanism for Efficient Thermal Conversion. ANGEWANDTE CHEMIE-INTERNATIONAL EDITIONnull. 2020, 59(10): 3793-3801, https://www.webofscience.com/wos/woscc/full-record/WOS:000496870700001.
[23] 闫学海. Fe3+-Driven Assembly of Catalase-Like Supramolecular Photosensitizing Nanozymes for Combating Hypoxic Tumor. Angew. Chem. Int. Ed.. 2020, [24] Ji, Wei, Yuan, Chengqian, Chakraborty, Priyadarshi, Makam, Pandeeswar, Bera, Santu, RencusLazar, Sigal, Li, Junbai, Yan, Xuehai, Gazit, Ehud. Coassembly-Induced Transformation of Dipeptide Amyloid-Like Structures into Stimuli-Responsive Supramolecular Materials. ACS NANO[J]. 2020, 14(6): 7181-7190, https://www.webofscience.com/wos/woscc/full-record/WOS:000543744100077.
[25] Han, Jingjing, Zou, Qianli, Su, Weiwei, Yan, Xuehai. Minimal metallo-nanozymes constructed through amino acid coordinated self-assembly for hydrolase-like catalysis. CHEMICAL ENGINEERING JOURNAL[J]. 2020, 394: http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000551901000047.
[26] Xing, Ruirui, Zou, Qianli, Yan, Xuehai. Peptide-based Supramolecular Colloids. ACTA PHYSICO-CHIMICA SINICAnull. 2020, 36(10): http://dx.doi.org/10.3866/PKU.WHXB201909048.
[27] Song, Jingwen, Yuan, Chengqian, Jiao, Tifeng, Xing, Ruirui, Yang, Mengyao, Adams, Dave J, Yan, Xuehai. Multifunctional Antimicrobial Biometallohydrogels Based on Amino Acid Coordinated Self-Assembly. SMALL[J]. 2020, 16(8): http://dx.doi.org/10.1002/smll.201907309.
[28] Zhang, Han, Kang, Lei, Zou, Qianli, Xin, Xia, Yan, Xuehai. Coordination-assembled supramolecular nanoplatforms: structural modulation and theranostic applications. CURRENT OPINION IN BIOTECHNOLOGYnull. 2019, 58: 45-52, http://dx.doi.org/10.1016/j.copbio.2018.11.007.
[29] Zhao, Luyang, Zou, Qianli, Yan, Xuehai. Self-Assembling Peptide-Based Nanoarchitectonics. BULLETIN OF THE CHEMICAL SOCIETY OF JAPANnull. 2019, 92(1): 70-79, http://ir.ipe.ac.cn/handle/122111/27671.
[30] Yang, Mengyao, Xing, Ruirui, Shen, Guizhi, Yuan, Chengqian, Yan, Xuehai. A versatile cyclic dipeptide hydrogelator: Self-assembly and rheology in various physiological conditions. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2019, 572: 259-265, http://dx.doi.org/10.1016/j.colsurfa.2019.04.020.
[31] Yuan, Chengqian, Levin, Aviad, Chen, Wei, Xing, Ruirui, Zou, Qianli, Herling, Therese W, Challa, Pavan Kumar, Knowles, Tuomas P J, Yan, Xuehai. Nucleation and Growth of Amino Acid and Peptide Supramolecular Polymers through Liquid-Liquid Phase Separation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(50): 18116-18123, [32] Li, Jieling, Wang, Anhe, Ren, Peng, Yan, Xuehai, Bai, Shuo. One-step co-assembly method to fabricate photosensitive peptide nanoparticles for two-photon photodynamic therapy. CHEMICAL COMMUNICATIONS[J]. 2019, 55(22): 3191-3194, http://ir.ipe.ac.cn/handle/122111/28282.
[33] Xing, Ruirui, Liu, Yamei, Zou, Qianli, Yan, Xuehai. Self-assembled injectable biomolecular hydrogels towards phototherapy. NANOSCALEnull. 2019, 11(46): 22182-22195, http://dx.doi.org/10.1039/c9nr06266a.
[34] Li, Shukun, Zhao, Luyang, Chang, Rui, Xing, Ruirui, Yan, Xuehai. Spatiotemporally Coupled Photoactivity of Phthalocyanine-Peptide Conjugate Self-Assemblies for Adaptive Tumor Theranostics. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2019, 25(58): 13429-13435, https://www.webofscience.com/wos/woscc/full-record/WOS:000486442100001.
[35] 闫学海. Self-assembling Study of PNA-Porphyrin and PNA-BODIPY Hybrids in Mixed Solvent Systems. Nanoscale. 2019, [36] Rai, Xiaokang, Zou, Qianli, Yuan, Chengqian, Chang, Rui, Xing, Ruirui, Yan, Xuehai. The Dominant Role of Oxygen in Modulating the Chemical Evolution Pathways of Tyrosine in Peptides: Dityrosine or Melanin. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(18): 5872-5876, http://ir.ipe.ac.cn/handle/122111/28230.
[37] Chang, Rui, Zou, Qianli, Xing, Ruirui, Yan, Xuehai. Peptide-Based Supramolecular Nanodrugs as a New Generation of Therapeutic Toolboxes against Cancer. ADVANCED THERAPEUTICSnull. 2019, 2(8): http://dx.doi.org/10.1002/adtp.201900048.
[38] Zhao, Luyang, Liu, Yamei, Chang, Rui, Xing, Ruirui, Yan, Xuehai. Supramolecular Photothermal Nanomaterials as an Emerging Paradigm toward Precision Cancer Therapy. ADVANCED FUNCTIONAL MATERIALSnull. 2019, 29(4): http://ir.ipe.ac.cn/handle/122111/27788.
[39] Xing, Ruirui, Zou, Qianli, Yuan, Chengqian, Zhao, Luyang, Chang, Rui, Yan, Xuehai. Self-Assembling Endogenous Biliverdin as a Versatile Near-Infrared Photothermal Nanoagent for Cancer Theranostics. ADVANCED MATERIALS[J]. 2019, 31(16): http://ir.ipe.ac.cn/handle/122111/28233.
[40] Yang, Mengyao, Yuan, Chengqian, Shen, Guizhi, Chang, Rui, Xing, Ruirui, Yan, Xuehai. Cyclic dipeptide nanoribbons formed by dye-mediated hydrophobic self-assembly for cancer chemotherapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE[J]. 2019, 557: 458-464, http://dx.doi.org/10.1016/j.jcis.2019.09.049.
[41] Yuan, Chengqian, Ji, Wei, Xing, Ruirui, Li, Junbai, Gazit, Ehud, Yan, Xuehai. Hierarchically oriented organization in supramolecular peptide crystals. NATURE REVIEWS CHEMISTRYnull. 2019, 3(10): 567-588, http://apps.webofknowledge.com/CitedFullRecord.do?product=UA&colName=WOS&SID=5CCFccWmJJRAuMzNPjj&search_mode=CitedFullRecord&isickref=WOS:000489142200005.
[42] Han, Jingjing, Liu, Kai, Chang, Rui, Zhao, Luyang, Yan, Xuehai. Photooxidase-Mimicking Nanovesicles with Superior Photocatalytic Activity and Stability Based on Amphiphilic Amino Acid and Phthalocyanine Co-Assembly. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2019, 58(7): 2000-2004, http://ir.ipe.ac.cn/handle/122111/27998.
[43] Mei, Enci, Li, Shukun, Song, Jingwen, Xing, Ruirui, Li, Zhiming, Yan, Xuehai. Self-assembling Collagen/Alginate hybrid hydrogels for combinatorial photothermal and immuno tumor therapy. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2019, 577: 570-575, http://dx.doi.org/10.1016/j.colsurfa.2019.06.023.
[44] Sun, Haifeng, Chang, Rui, Zou, Qianli, Xing, Ruirui, Qi, Wei, Yan, Xuehai. Supramolecular Protein Nanodrugs with Coordination- and Heating-Enhanced Photothermal Effects for Antitumor Therapy. SMALL[J]. 2019, 15(52): http://dx.doi.org/10.1002/smll.201905326.
[45] Li, Shukun, Zou, Qianli, Xing, Ruirui, Govindaraju, Thimmaiah, Fakhrullin, Rawil, Yan, Xuehai. Peptide-modulated self-assembly as a versatile strategy for tumor supramolecular nanotheranostics. THERANOSTICSnull. 2019, 9(11): 3249-3261, http://ir.ipe.ac.cn/handle/122111/28357.
[46] Liu, Yamei, Shen, Guizhi, Zhao, Luyang, Zou, Qianli, Jiao, Tifeng, Yan, Xuehai. Robust Photothermal Nanodrugs Based on Covalent Assembly of Nonpigmented Biomolecules for Antitumor Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2019, 11(45): 41898-41905, http://dx.doi.org/10.1021/acsami.9b13966.
[47] You, Yongcai, Xing, Ruirui, Zou, Qianli, Shi, Feng, Yan, Xuehai. High-tolerance crystalline hydrogels formed from self-assembling cyclic dipeptide. Beilstein Journal of Nanotechnology[J]. 2019, 10(1): 1894-1901, https://doaj.org/article/eebc87ef4ad64dc6a46b56b3bb57950d.
[48] Li, Jieling, Wang, Anhe, Zhao, Luyang, Dong, Qianqian, Wang, Meiyue, Xu, Haolan, Yan, Xuehai, Bai, Shuo. Self-Assembly of Monomeric Hydrophobic Photosensitizers with Short Peptides Forming Photodynamic Nanoparticles with Real-Time Tracking Property and without the Need of Release in Vivo. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(34): 28420-28427, http://www.irgrid.ac.cn/handle/1471x/1764420.
[49] 闫学海. Covalent assembled dipeptide nanoparticles with adjustable fluorescence emission for multi-color bio-imaging. ChemBioChem. 2018, [50] Xing, Ruirui, Yuan, Chengqian, Li, Shukun, Song, Jingwen, Li, Junbai, Yan, Xuehai. Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from beta-Sheet to alpha-Helix. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(6): 1537-1542, https://www.webofscience.com/wos/woscc/full-record/WOS:000423494500017.
[51] Li, Shukun, Xing, Ruirui, Chang, Rui, Zou, Qianli, Yan, Xuehai. Nanodrugs based on peptide-modulated self-assembly: Design, delivery and tumor therapy. CURRENT OPINION IN COLLOID & INTERFACE SCIENCEnull. 2018, 35: 17-25, http://dx.doi.org/10.1016/j.cocis.2017.12.004.
[52] Zhang, Yuankai, Zhang, Han, Zou, Qianli, Xing, Ruirui, Jiao, Tifeng, Yan, Xuehai. An injectable dipeptide-fullerene supramolecular hydrogel for photodynamic antibacterial therapy. JOURNAL OF MATERIALS CHEMISTRY B[J]. 2018, 6(44): 7335-7342, http://dx.doi.org/10.1039/c8tb01487f.
[53] 闫学海. Supramolecular photothermal nanomaterials as an emerging paradigm towards precision cancer therapy. Adv. Funct. Mater.. 2018, [54] 李峻柏. Charge-Induced Secondary Structure Transformation of Amyloid-Derived Dipeptide Assemblies from b-Sheet to a-Helix. Angew. Chem. Int. Ed.. 2018, [55] Sun, Haifeng, Li, Shukun, Qi, Wei, Xing, Ruirui, Zou, Qianli, Yan, Xuehai. Stimuli-responsive nanoparticles based on co-assembly of naturally-occurring biomacromolecules for in vitro photodynamic therapy. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2018, 538: 795-801, http://dx.doi.org/10.1016/j.colsurfa.2017.11.072.
[56] Xie, Zengchun, Liu, Kai, Ren, Xiaokang, Zhang, Han, Xin, Xia, Zou, Qianli, Yan, Xuehai. Amino-Acid-Mediated Biomimetic Formation of Light-Harvesting Antenna Capable of Hydrogen Evolution. ACS APPLIED BIO MATERIALS[J]. 2018, 1(3): 748-755, [57] Zhou, Lingyun, Lv, Fengting, Liu, Libing, Shen, Guizhi, Yan, Xuehai, Bazan, Guillermo C, Wang, Shu. Cross-Linking of Thiolated Paclitaxel-Oligo(p-phenylene vinylene) Conjugates Aggregates inside Tumor Cells Leads to "Chemical Locks" That Increase Drug Efficacy. ADVANCED MATERIALS[J]. 2018, 30(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000426720400007.
[58] Abbas, Manzar, Xing, Ruirui, Zhang, Ning, Zou, Qianli, Yan, Xuehai. Antitumor Photodynamic Therapy Based on Dipeptide Fibrous Hydrogels with Incorporation of Photosensitive Drugs. ACS BIOMATERIALS SCIENCE & ENGINEERING[J]. 2018, 4(6): 2046-2052, http://dx.doi.org/10.1021/acsbiomaterials.7b00624.
[59] Yan, Xuehai, van Hest, Jan C M. Chemical Tools and Materials for Biological/Medicinal Applications. CHEMISTRY-AN ASIAN JOURNALnull. 2018, 13(22): 3331-3332, http://ir.ipe.ac.cn/handle/122111/26639.
[60] Liu, Yamei, Zhao, Luyang, Xing, Ruirui, Jiao, Tifeng, Song, Weixing, Yan, Xuehai. Covalent Assembly of Amphiphilic Bola-Amino Acids into Robust and Biodegradable Nanoparticles for In Vitro Photothermal Therapy. CHEMISTRY-AN ASIAN JOURNAL[J]. 2018, 13(22): 3526-3532, http://ir.ipe.ac.cn/handle/122111/26588.
[61] Zou, Qianli, Yan, Xuehai. Amino Acid Coordinated Self-Assembly. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2018, 24(4): 755-761, http://www.irgrid.ac.cn/handle/1471x/1764173.
[62] Li, Yongxin, Zou, Qianli, Yuan, Chengqian, Li, Shukun, Xing, Ruirui, Yan, Xuehai. Amino Acid Coordination Driven Self-Assembly for Enhancing both the Biological Stability and Tumor Accumulation of Curcumin. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2018, 57(52): 17084-17088, http://ir.ipe.ac.cn/handle/122111/27704.
[63] 闫学海. Amino Acid Coordination-Driven Self-Assembly for Enhancing both Biological Stability and Tumor Accumulation of Curcumin. Angew. Chem. Int. Ed.. 2018, [64] Liu, Kai, Ren, Xiaokang, Sun, Jianxuan, Zou, Qianli, Yan, Xuehai. Primitive Photosynthetic Architectures Based on Self-Organization and Chemical Evolution of Amino Acids and Metal Ions. ADVANCED SCIENCE[J]. 2018, 5(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000435765900007.
[65] Song, Jingwen, Xing, Ruirui, Jiao, Tifeng, Peng, Qiuming, Yuan, Chengqian, Moehwald, Helmuth, Yan, Xuehai. Crystalline Dipeptide Nanobelts Based on Solid-Solid Phase Transformation Self-Assembly and Their Polarization Imaging of Cells. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(3): 2368-2376, http://www.irgrid.ac.cn/handle/1471x/1764046.
[66] Zhang, Han, Liu, Kai, Li, Shukun, Xin, Xia, Yuan, Shiling, Ma, Guanghui, Yan, Xuehai. Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy. ACS NANO[J]. 2018, 12(8): 8266-8276, https://www.webofscience.com/wos/woscc/full-record/WOS:000443525600078.
[67] 闫学海. Kinetically Controlled Self-Assembly of Phthalocyanine-Peptide Conjugate Nanofibrils Enabling Super-Large Redshifted Absorption. CCS Chem.. 2018, [68] Li, Shukun, Zou, Qianli, Li, Yongxin, Yuan, Chengqian, Xing, Ruirui, Yan, Xuehai. Smart Peptide-Based Supramolecular Photodynamic Metallo-Nanodrugs Designed by Multicomponent Coordination Self-Assembly. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2018, 140(34): 10794-10802, [69] Cui, Lingyun, Jiao, Yang, Wang, Anhe, Zhao, Luyang, Dong, Qianqian, Yan, Xuehai, Bai, Shuo. Regulating morphologies and near-infrared photothermal conversion of perylene bisimide via sequence-dependent peptide self-assembly. CHEMICAL COMMUNICATIONS[J]. 2018, 54(18): 2208-2211, https://www.webofscience.com/wos/woscc/full-record/WOS:000426701900004.
[70] Liu, Kai, Zhang, Ruiyun, Li, Yongxin, Jiao, Tifeng, Ding, Dan, Yan, Xuehai. Tunable Aggregation-Induced Emission of Tetraphenylethylene via Short Peptide-Directed Self-Assembly. ADVANCED MATERIALS INTERFACES[J]. 2017, 4(1): 1600183-1-1600183-6, http://ir.ipe.ac.cn/handle/122111/22454.
[71] Wang, Juan, Yuan, Chengqian, Han, Yuchun, Wang, Yilin, Liu, Xiaomin, Zhang, Suojiang, Yan, Xuehai. Trace Water as Prominent Factor to Induce Peptide Self-Assembly: Dynamic Evolution and Governing Interactions in Ionic Liquids. SMALL[J]. 2017, 13(44): https://www.webofscience.com/wos/woscc/full-record/WOS:000416040600008.
[72] Xing, Ruirui, Li, Shukun, Zhang, Ning, Shen, Guizhi, Mohwald, Helmuth, Yan, Xuehai. Self-Assembled Injectable Peptide Hydrogels Capable of Triggering Antitumor Immune Response. BIOMACROMOLECULES[J]. 2017, 18(11): 3514-3523, http://dx.doi.org/10.1021/acs.biomac.7b00787.
[73] 闫学海. Enzyme-Immobilized Clay Nanotube-Chitosan Membranes with Sustainable Biocatalytic Activity. Phys. Chem. Chem. Phys.. 2017, [74] Yuan, Chengqian, Li, Shukun, Zou, Qianli, Ren, Ying, Yan, Xuehai. Multiscale simulations for understanding the evolution and mechanism of hierarchical peptide self-assembly. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2017, 19(35): 23614-23631, https://www.webofscience.com/wos/woscc/full-record/WOS:000410585900006.
[75] Zou, Qianli, Abbas, Manzar, Zhao, Luyang, Li, Shukun, Shen, Guizhi, Yan, Xuehai. Biological Photothermal Nanodots Based on Self-Assembly of Peptide Porphyrin Conjugates for Antitumor Therapy. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2017, 139(5): 1921-1927, https://www.webofscience.com/wos/woscc/full-record/WOS:000393848400041.
[76] Liu, Kai, Yuan, Chengqian, Zou, Qianli, Xie, Zengchun, Yan, Xuehai. Self-Assembled Zinc/Cystine-Based Chloroplast Mimics Capable of Photoenzymatic Reactions for Sustainable Fuel Synthesis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2017, 56(27): 7876-7880, http://dx.doi.org/10.1002/anie.201704678.
[77] Abbas, Manzar, Zou, Qianli, Li, Shukun, Yan, Xuehai. Self-Assembled Peptide- and Protein-Based Nanomaterials for Antitumor Photodynamic and Photothermal Therapy. ADVANCED MATERIALS[J]. 2017, 29(12): https://www.webofscience.com/wos/woscc/full-record/WOS:000396998800009.
[78] Sun, Jiajia, Guo, Ying, Xing, Ruirui, Jiao, Tifeng, Zou, Qianli, Yan, Xuehai. Synergistic in vivo photodynamic and photothermal antitumor therapy based on collagen-gold hybrid hydrogels with inclusion of photosensitive drugs. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS[J]. 2017, 514: 155-160, http://dx.doi.org/10.1016/j.colsurfa.2016.11.062.
[79] Liu, Yamei, Ma, Kai, Jiao, Tifeng, Xing, Ruirui, Shen, Guizhi, Yan, Xuehai. Water-Insoluble Photosensitizer Nanocolloids Stabilized by Supramolecular Interfacial Assembly towards Photodynamic Therapy. SCIENTIFIC REPORTS[J]. 2017, 7: http://ir.ipe.ac.cn/handle/122111/21957.
[80] Zhao, Luyang, Shen, Guizhi, Ma, Guanghui, Yan, Xuehai. Engineering and delivery of nanocolloids of hydrophobic drugs. ADVANCES IN COLLOID AND INTERFACE SCIENCE[J]. 2017, 249: 308-320, http://dx.doi.org/10.1016/j.cis.2017.04.008.
[81] Liu, Kai, Zhang, Han, Xing, Ruirui, Zou, Qianli, Yan, Xuehai. Biomimetic Oxygen-Evolving Photobacteria Based on Amino Acid and Porphyrin Hierarchical Self-Organization. ACS NANO[J]. 2017, 11(12): 12840-12848, https://www.webofscience.com/wos/woscc/full-record/WOS:000418990200115.
[82] Xing, Ruirui, Jiao, Tifeng, Liu, Yamei, Ma, Kai, Zou, Qianli, Ma, Guanghui, Yan, Xuehai. Co-Assembly of Graphene Oxide and Albumin/Photosensitizer Nanohybrids towards Enhanced Photodynamic Therapy. POLYMERS[J]. 2016, 8(5): http://ir.ipe.ac.cn/handle/122111/21166.
[83] Zou, Qianli, Liu, Kai, Abbas, Manzar, Yan, Xuehai. Peptide-Modulated Self-Assembly of Chromophores toward Biomimetic Light-Harvesting Nanoarchitectonics. ADVANCED MATERIALS[J]. 2016, 28(6): 1031-1043, http://www.irgrid.ac.cn/handle/1471x/1048132.
[84] Wang, Juan, Liu, Kai, Yan, Linyin, Wang, Anhe, Bai, Shuo, Yan, Xuehai. Trace Solvent as a Predominant Factor To Tune Dipeptide Self-Assembly. ACS NANO[J]. 2016, 10(2): 2138-2143, http://www.irgrid.ac.cn/handle/1471x/1048129.
[85] Xing, Ruirui, Jiao, Tifeng, Ma, Kai, Ma, Guanghui, Moehwald, Helmuth, Yan, Xuehai. Regulating Cell Apoptosis on Layer-by-Layer Assembled Multilayers of Photosensitizer-Coupled Polypeptides and Gold Nanoparticles. SCIENTIFIC REPORTS[J]. 2016, 6(MAY): http://ir.ipe.ac.cn/handle/122111/21084.
[86] Liu, Kai, Xing, Ruirui, Zou, Qianli, Ma, Guanghui, Mohwald, Helmuth, Yan, Xuehai. Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(9): 3036-3039, http://www.irgrid.ac.cn/handle/1471x/1048134.
[87] Shen, Guizhi, Xing, Ruirui, Zhang, Ning, Chen, Chengjun, Ma, Guanghui, Yan, Xuehai. Interfacial Cohesion and Assembly of Bioadhesive Molecules for Design of Long Term Stable Hydrophobic Nanodrugs toward Effective Anticancer Therapy. ACS NANO[J]. 2016, 10(6): 5720-5729, http://ir.ipe.ac.cn/handle/122111/21170.
[88] Chen, Chengjun, Li, Shukun, Liu, Kai, Ma, Guanghui, Yan, Xuehai. Co-Assembly of Heparin and Polypeptide Hybrid Nanoparticles for Biomimetic Delivery and Anti-Thrombus Therapy. SMALL[J]. 2016, 12(34): 4719-4725, http://ir.ipe.ac.cn/handle/122111/21338.
[89] Wang, Juan, Shen, Guizhi, Ma, Kai, Jiao, Tifeng, Liu, Kai, Yan, Xuehai. Dipeptide concave nanospheres based on interfacially controlled self-assembly: from crescent to solid. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2016, 18(45): 30926-30930, http://www.irgrid.ac.cn/handle/1471x/1179143.
[90] Li, Yongxin, Yan, Linyin, Liu, Kai, Wang, Juan, Wang, Anhe, Bai, Shuo, Yan, Xuehai. Solvothermally Mediated Self-Assembly of Ultralong Peptide Nanobelts Capable of Optical Waveguiding. SMALL[J]. 2016, 12(19): 2575-2579, http://ir.ipe.ac.cn/handle/122111/21174.
[91] Liu, Kai, Kang, Yu, Ma, Guanghui, Moehwald, Helmuth, Yan, Xuehai. Molecular and mesoscale mechanism for hierarchical self-assembly of dipeptide and porphyrin light-harvesting system. PHYSICAL CHEMISTRY CHEMICAL PHYSICS[J]. 2016, 18(25): 16738-16747, http://ir.ipe.ac.cn/handle/122111/21173.
[92] Liu, Kai, Xing, Ruirui, Li, Yongxin, Zou, Qianli, Moehwald, Helmuth, Yan, Xuehai. Mimicking Primitive Photobacteria: Sustainable Hydrogen Evolution Based on Peptide-Porphyrin Co-Assemblies with a Self-Mineralized Reaction Center. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2016, 55(40): 12503-12507, http://ir.ipe.ac.cn/handle/122111/21611.
[93] Zhang, Ning, Zhao, Fenfang, Zou, Qianli, Li, Yongxin, Ma, Guanghui, Yan, Xuehai. Multitriggered Tumor-Responsive Drug Delivery Vehicles Based on Protein and Polypeptide Coassembly for Enhanced Photodynamic Tumor Ablation. SMALL[J]. 2016, 12(43): 5936-5943, http://www.irgrid.ac.cn/handle/1471x/1179154.
[94] Zhang, Ruiyun, Xing, Ruirui, Jiao, Tifeng, Ma, Kai, Chen, Chengjun, Ma, Guanghui, Yan, Xuehai. Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(21): 13262-13269, http://dx.doi.org/10.1021/acsami.6b02416.
[95] Ma, Kai, Xing, Ruirui, Jiao, Tifeng, Shen, Guizhi, Chen, Chengjun, Li, Junbai, Yan, Xuehai. Injectable Self-Assembled Dipeptide-Based Nanocarriers for Tumor Delivery and Effective In Vivo Photodynamic Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(45): 30759-30767, http://www.irgrid.ac.cn/handle/1471x/1179145.
[96] Wang, Juan, Liu, Kai, Xing, Ruirui, Yan, Xuehai. Peptide self-assembly: thermodynamics and kinetics. CHEMICAL SOCIETY REVIEWSnull. 2016, 45(20): 5589-5604, http://www.irgrid.ac.cn/handle/1471x/1147489.
[97] Xing, Ruirui, Liu, Kai, Jiao, Tifeng, Zhang, Ning, Ma, Kai, Zhang, Ruiyun, Zou, Qianli, Ma, Guanghui, Yan, Xuehai. An Injectable Self-Assembling Collagen-Gold Hybrid Hydrogel for Combinatorial Antitumor Photothermal/Photodynamic Therapy. ADVANCED MATERIALS[J]. 2016, 28(19): 3669-3676, http://dx.doi.org/10.1002/adma.201600284.
[98] Zhang, He, Fei, Jinbo, Yan, Xuehai, Wang, Anhe, Li, Junbai. Enzyme-Responsive Release of Doxorubicin from Monodisperse Dipeptide-Based Nanocarriers for Highly Efficient Cancer Treatment In Vitro. ADVANCED FUNCTIONAL MATERIALS[J]. 2015, 25(8): 1193-1204, http://www.irgrid.ac.cn/handle/1471x/945075.
[99] Chen, Chengjun, Liu, Kai, Li, Junbai, Yan, Xuehai. Functional architectures based on self-assembly of bio-inspired dipeptides: Structure modulation and its photoelectronic applications. ADVANCES IN COLLOID AND INTERFACE SCIENCE[J]. 2015, 225(NOV): 177-193, http://dx.doi.org/10.1016/j.cis.2015.09.001.
[100] Xing, Ruirui, Jiao, Tifeng, Yan, Linyin, Ma, Guanghui, Liu, Lei, Dai, Luru, Li, Junbai, Moehwald, Helmuth, Yan, Xuehai. Colloidal Gold-Collagen Protein Core-Shell Nanoconjugate: One-Step Biomimetic Synthesis, Layer-by-Layer Assembled Film, and Controlled Cell Growth. ACS APPLIED MATERIALS & INTERFACES[J]. 2015, 7(44): 24733-24740, http://ir.ipe.ac.cn/handle/122111/19861.
[101] 闫学海. Peptide-Induced Hierarchical Long-Range Order of Porphyrin Self-Assemblies and their Photocatalytic Activity. Angew. Chem. Int. Ed.. 2015, [102] Jiao, Tifeng, Wang, Yujin, Zhang, Qingrui, Yan, Xuehai, Zhao, Xiaoqing, Zhou, Jingxin, Gao, Faming. Self-Assembly and Headgroup Effect in Nanostructured Organogels via Cationic Amphiphile-Graphene Oxide Composites. PLOS ONE[J]. 2014, 9(7): http://www.irgrid.ac.cn/handle/1471x/857854.
[103] 闫学海. Multi-functional Porous Microspheres Based on Peptide-Porpyhrin Hierarchical Co-assembly. Angew. Chem. Int. Ed.. 2014, [104] 闫学海. anoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools. Chem. Eur. J.. 2014, [105] Wang, Hongqiang, Yan, Xuehai, Li, Guo Liang, PilzAllen, Christine, Moehwald, Helmuth, Shchukin, Dmitry. Sono-Assembly of Highly Biocompatible Polysaccharide Capsules for Hydrophobic Drug Delivery. ADVANCED HEALTHCARE MATERIALS[J]. 2014, 3(6): 825-831, http://www.irgrid.ac.cn/handle/1471x/857762.
[106] Yan, Xuehai, Blacklock, Jenifer, Li, Junbai, Moehwald, Helmuth. One-Pot Synthesis of Polypeptide-Gold Nanoconjugates for in Vitro Gene Transfection. ACS NANO[J]. 2012, 6(1): 111-117, https://www.webofscience.com/wos/woscc/full-record/WOS:000299368300014.
[107] Yan, Xuehai, Li, Junbai, Moehwald, Helmuth. Templating Assembly of Multifunctional Hybrid Colloidal Spheres. ADVANCED MATERIALS[J]. 2012, 24(20): 2663-2667, https://www.webofscience.com/wos/woscc/full-record/WOS:000304043000001.
[108] Yan, Xuehai, Li, Junbai, Muehwald, Helmuth. Self-Assembly of Hexagonal Peptide Microtubes and Their Optical Waveguiding. ADVANCED MATERIALS[J]. 2011, 23(25): 2796-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000293379700003.
[109] 闫学海. Uniaxially-oriented peptide crystals for optical waveguiding. Angew. Chem. Int. Ed.. 2011, [110] Du, Mingchun, Zhu, Pengli, Yan, Xuehai, Su, Ying, Song, Weixing, Li, Junbai. Honeycomb Self-Assembled Peptide Scaffolds by the Breath Figure Method. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2011, 17(15): 4238-4245, https://www.webofscience.com/wos/woscc/full-record/WOS:000290101500023.
[111] Yan, Xuehai, Zhu, Pengli, Fei, Jinbo, Li, Junbai. Self-Assembly of Peptide-Inorganic Hybrid Spheres for Adaptive Encapsulation of Guests. ADVANCED MATERIALS[J]. 2010, 22(11): 1283-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000276056500017.
[112] Zhu, Pengli, Yan, Xuehai, Su, Ying, Yang, Yang, Li, Junbai. Solvent-Induced Structural Transition of Self-Assembled Dipeptide: From Organogels to Microcrystals. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2010, 16(10): 3176-3183, https://www.webofscience.com/wos/woscc/full-record/WOS:000275943400025.
[113] Yan, Xuehai, Zhu, Pengli, Li, Junbai. Self-assembly and application of diphenylalanine-based nanostructures. CHEMICAL SOCIETY REVIEWSnull. 2010, 39(6): 1877-1890, https://www.webofscience.com/wos/woscc/full-record/WOS:000278046100001.
[114] Qi, Wei, Yan, Xuehai, Juan, Li, Cui, Yue, Yang, Yang, Li, Junbai. Glucose-Sensitive Microcapsules from Glutaraldehyde Cross-Linked Hemoglobin and Glucose Oxidase. BIOMACROMOLECULES[J]. 2009, 10(5): 1212-1216, https://www.webofscience.com/wos/woscc/full-record/WOS:000265914200025.
[115] Fei, Jinbo, Cui, Yue, Yan, Xuehai, Yang, Yang, Su, Ying, Li, Junbai. Formation of PANI tower-shaped hierarchical nanostructures by a limited hydrothermal reaction. JOURNAL OF MATERIALS CHEMISTRY[J]. 2009, 19(20): 3263-3267, https://www.webofscience.com/wos/woscc/full-record/WOS:000266005100023.
[116] Yang, Yang, Yan, Xuehai, Cui, Yue, He, Qiang, Li, Dongxiang, Wang, Anhe, Fei, Jinbo, Li, Junbai. Preparation of polymer-coated mesoporous silica nanoparticles used for cellular imaging by a "graft-from'' method. JOURNAL OF MATERIALS CHEMISTRY[J]. 2008, 18(47): 5731-5737, https://www.webofscience.com/wos/woscc/full-record/WOS:000261745400003.
[117] Yan, Xuehai, Cui, Yue, He, Qiang, Wang, Kewei, Li, Junbai, Mu, Weihua, Wang, Bolin, Ouyang, Zhongcan. Reversible transitions between peptide nanotubes and vesicle-like structures including theoretical modeling studies. CHEMISTRY-A EUROPEAN JOURNAL[J]. 2008, 14(19): 5974-5980, https://www.webofscience.com/wos/woscc/full-record/WOS:000257574900030.
[118] 闫学海. 寡肽纳米结构的自组装及在生物中的应用. 2008, http://ir.iccas.ac.cn/handle/121111/31685.
发表著作
( 1 ) 无, Molecular assembly of biomimetic systems, Wiley-VCH, 2011-01, 第 3 作者

科研活动

   
科研项目
( 1 ) 基于肽自组装的材料设计和功能调控, 主持, 国家级, 2013-01--2015-12
( 2 ) 仿生光合成系统中的介尺度结构和机制研究, 主持, 国家级, 2015-01--2017-12
( 3 ) 光敏剂功能化寡肽的自组装:分子设计、结构调控与光动力治疗应用研究, 主持, 国家级, 2015-01--2018-12
( 4 ) 生物分子组装, 主持, 国家级, 2016-01--2018-12
参与会议
(1)Self-assembly of smart biomolecule-based nanoparticles   Xuehai Yan, QianLi Zou, Chengjun Chen and Guizhi Shen   2014-05-19
(2)Self-Assembled Peptide-Porphyrin Microspheres as One Step towards A Prebiotic Photosynthetic Model   Xuehai Yan   2013-09-21
(3)寡肽调控光敏剂自组装及物化性质研究   中国化学会第十四届胶体与界面化学会议   闫学海,邹千里,李丹丹   2013-07-22

指导学生

已指导学生

赵芬芳  硕士研究生  085238-生物工程  

现指导学生

李永新  硕士研究生  085238-生物工程  

刘凯  博士研究生  081703-生物化工  

李淑坤  硕士研究生  081703-生物化工  

杨昕  博士研究生  081701-化学工程  

任朋   硕士研究生  081703-生物化工  

常蕊   博士研究生  081703-生物化工  

任重远  博士研究生  080502-材料学