Using cellular systems, pharmacological approaches and animal genetics to study the hormonal and pathophysiological regulations contributing to metabolic diseases such as osteoporosis, fatty liver, diabetes and obesity.

Ph.D. Graduate Student                                Advisor: Prof. Lin Chen                                     

Sep 2006 – July 2009     Guangzhou Institute of Biomedicine and Health, CAS, China

Sep 2001 - July 2004                                    Jinan University, China                                                                            

B.S., Undergraduate Student 

Sep 1997 - July 2001                           Normal University of South China                                                                   

Principle Investigator

Jan 2013 – Present    Shenzhen Institutes of Advanced Technology, CAS, China

Postdoctoral Fellow                                     Advisor: Prof. Xu Cao

Dec 2011 – Dec 2012       Johns Hopkins University, School of Medicine, MD, USA

Postdoctoral Fellow                                 Advisors: Prof. Nancy E. Lane

Nov 2009- Nov 2011        University of California, Davis Medical Center, CA, USA

• TonglingHuang, XuekunFu,NaWang,MengYang,MinyiZhang,Binxu Wang, Tianke Chen, Sidra Majaz, Huaiyu Wang, Chi-Wai Wong, Jinsong Liu,Min Guan*.Andrographolide prevents bone loss via targeting ERRalpha-regulated metabolic adaption of osteoclastogenesis.British Journal of Pharmacology2021 Nov;178(21):4352-4367.IF 8.739

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• Meng Yang, Chang-An Geng, Xinguang Liu*,Min Guan*.Lipid Disorders in NAFLD and Chronic Kidney Disease.      Biomedicines2021,Oct 6;9(10):1405.IF 6.081

• Meng Yang^#, Feng Ma^#,Min Guan*. Role of Steroid Hormones in the Pathogenesis of Nonalcoholic Fatty Liver Disease.  Metabolites.2021 May 17;11(5):320.         IF 4.932

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• Meng Yang,Qingli Liu, Tongling Huang, Wenjuan Tan, Linbing Qu, Tianke Chen, Haobo Pan, Ling Chen, Jinsong Liu, Chi-Wai Wong, William W Lu ,Min Guan*.Dysfunction of estrogen-related receptor alpha-dependent hepatic VLDL secretion contributes to sex disparity in NAFLD/NASH development.Theranostics2020 Aug 29;10(24):10874-10891.IF11.556

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• Minyi Zhang, Meng Yang, Na Wang, Qingli Liu, Binxu Wang, Tongling Huang, Yan Tong, Yanlin Ming, Chi-Wai Wong , Jinsong Liu, Dongsheng Yao*,Min Guan*.Andrographolide modulates HNF4α activity imparting on hepatic metabolism.Molecular and Cellular Endocrinology.2020 Aug 1;513:110867.IF 4.102      
• Meng Yang^#, Minyi Zhang^#, Qingli Liu^#, Tingting Xu, Tongling Huang,DongshengYao, Chi-Wai Wong, Jinsong Liu,Min Guan*. 18b-Glycyrrhetinic acid acts through hepatocyte nuclear factor 4 alpha to modulate lipid and carbohydrate metabolism.Pharmacological Research.2020 Apr 28;157:104840.IF 7.658          

• Mengge Sun, Liqiu Hu, Shang Wang, Tongling Huang, Minyi Zhang , Meng Yang , Wanxin Zhen, Dazhi Yang, William Lu,Min Guan*, Songlin Peng*.Circulating MicroRNA-19b Identified From Osteoporotic Vertebral Compression Fracture PatientsIncreases Bone Formation.J Bone Miner Res.2020 Feb;35(2):306-316.IF 6.741              

• Tongling Huang^#, Guoyong Yan^#,Min Guan*.Zinc Homeostasis in Bone: Zinc Transporters and Bone Diseases.Int J Mol Sci.2020 Feb 12;21(4). pii: E1236.IF 5.923     

• Xuekun Fu, Yunyan Li, Tongling Huang, Zhiwu Yu, Kun Ma,Meng Yang, Qingli Liu, Haobo Pan, Huaiyu Wang, Junfeng Wang*,Min Guan*. Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate containing-Bone Apatite Formation.Advanced Science.2018 Jan 28;5(4):1700755.IF 16.806            

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  Tongling Huang^#, Renzhong Liu^#, Xuekun Fu,Dongsheng Yao, Yang Lei, Meng Yang, Qingli Liu, William W. Lu,Chuanyue Wu, Min Guan*. Aging reduces an ERRα-directed mitochondrial glutaminase expression suppressing glutamine anaplerosis and osteogenic capacity of mesenchymal stem cells.Stem cells.2017 Feb;35(2):411-424.IF 6.277        

  
  

• Qingli Liu, Meng Yang, Renzhong Liu, Yang Lei, Xuekun Fu, Caijun Sun, Haobo Pan, Chi-Wai Wong,Min Guan*. Activation of farnesoid X receptor promotes triglycerides lowering by inhibiting Phospholipase A2 G12B inhyperlipidemicmice.Molecular and Cellular Endocrinology.2016 Nov 15;436:93-101.IF 4.102      

• Yao W*^#,Min Guan^#,Jia JJ, Dai WW, Lay YE, Amugongo S, Liu RW, Olivos D, Lam KS, Nolta J, Olvera D, Ritchie RO, Lane NE.Reversing bone loss by directing mesenchymal stem cell to the bone.Stem cells2013 Sep;31(9):2003-2014.    IF 6.277         

• Min Guan^#, Wei Yao^#*, Ruiwu Liu, Kit S Lam, Jan Nolta, Junjing Jia,Brian Panganiban, Liping Meng, Ping Zhou, Mohammad Shahnazari, Robert O Ritchie & Nancy E Lane. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass.Nature Medicine.2012 Feb 5; 18(3):456-62.  IF 53.44        

  Min Guan^#, Linbing Qu^#, Wenjuan Tan, Ling Chen*, ChiWai Wong*. Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A2 GXIIB.Hepatology. 2011 Feb; 53(2):458-66.IF 17.425          

  
  

  
  

  
  

  
  

• Other publications

• ZnL2-BPs Integrated Bone Scaffold under Sequential Photothermal Mediation: A Win-Win Strategy Delivering Antibacterial Therapy and Fostering Osteogenesis Thereafter．Yuzheng Wu , Qing Liao, Lie Wu, Yongxiang Luo, Wei Zhang, Min Guan, Haobo Pan, Liping Tong, Paul K Chu , Huaiyu Wang．ACS Nano2021 Oct 27doi: 10.1021/acsnano.1c06062.

• Lingxia Xie, Guomin Wang, Yuzheng Wu, Qing Liao, Shi Mo, Xiaoxue Ren, Liping Tong, Wei Zhang,Min Guan, Haobo Pan , Paul K Chu, Huaiyu Wang*. Programmed surface on poly(aryl-ether-ether-ketone) initiating immune mediation and fulfilling bone regeneration sequentially.Innovation(N Y). 2021 Aug 5;2(3):100148.

• Yanqun Li , Jianhui Yue, Yuan Liu, Jun Wu,Min Guan, Di Chen, Haobo Pan, Xiaoli Zhao*, William W Lu.Strontium regulates stem cell fate during osteogenic differentiation through asymmetric cell division.Acta Biomater2020 Oct 24;S1742-7061(20)30619-X.   citation: 0

• Jing Du, Chao Yuan, Weijie Wang, Zitong Yu, Rui Hao, Yi Zhang,Min Guan, Nan Li, Hui Yang*.Aptasensor-enabled quantitative analysis of nano-sized extracellular vesicles by flow cytometry.Analyst.2020 Nov 3.doi: 10.1039/d0an01652g.   

• Gao A, Liao Q, Xie L, Wang G, Zhang W, Wu Y, Li P,Guan M, Pan H, Tong L, Chu PK, Wang H*.Tuning the surface immunomodulatory functions of polyetheretherketone for enhanced osseointegration.Biomaterials.2020 Feb;230:119642.              

• Chen L, Wu M, Zhang S, Tan W,Guan M, Feng L, Chen C, Tao J, Chen L*, Qu L*.Estrogen-related receptor γ regulates hepatic triglyceride metabolism through phospholipase A2 G12B.FASEB J.2019 Jul;33(7):7942-7952.      

• Tong L, Liao Q, Zhao Y, Huang H, Gao A, Zhang W, Gao X, Wei W,Guan M, Chu PK, Wang H*.Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant.Biomaterials.2019 Feb;193:1-11.    

• Pingchao Li, Fengling Feng, Enxiang Pan, Xiaozhen Fan, Qing Yang,Min Guan, Ling Chen⁎, Caijun Sun*.Scavenger receptor-mediated Ad5 entry and acLDL accumulation in monocytes/macrophages synergistically trigger innate responses against viral infection.Virology.2018 Jun;519:86-98. doi: 10.1016/j.virol.2018.04.005.     

• Zhao, Yuetao; Tong, Liping; Li, Yong; Pan, Haobo; Zhang, Wei;Guan, Min; Li, Weihao; Chen, Yixin; Li, Qing; Li, Zhongjun; Wang, Huaiyu*; Yu, Xuefeng*; Chu, Paul*.Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer.ACSApplied Materials & Interfaces.2016 Mar 9;8(9):5813-20.  citation: 18

• Yan Chen, Ting Wang,Min Guan, FKL Leung, Cao Xu, Wang Ting, Weiwei Zhao, Xiaohua Pan, and W W Lu*. Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis.Osteoarthritis and Cartilage.2015 Dec;23(12):2174-83.  citation: 32

• Zhendong Zhong, Cassandra R. Zylstra-Diegel, Cassie A. Schumacher, Jacob J. Baker, April C. Carpenter, Sujata Rao, Wei Yao,Min Guan, Jill A. Helms, Nancy E. Lane, Richard A. Lang, Bart O. Williams*. Wntless functions in mature osteoblasts to regulate bone mass.Proc Natl Acad Sci USA.2012 Aug 14;109 (33):E2197-204.      

• Junjing Jia^#, Wei Yao^#,Min Guan, Weiwei Dai, Mohammad Shahnazari, Rekha Kar, Lynda Bonewald, Jean X. Jiang and Nancy E. Lane*. Glucocorticoid Dose Determines Osteocyte Cell Fate.FASEB J.2011 Oct;25(10):3366-76.   

• Wei Yao*, Weiwei Dai, Mohammad Shahnazari, Aaron Pham, Zhiqiang Chen, Haiyan Chen,Min Guan, Nancy E. Lane. Inhibition oftheProgesteroneNuclearReceptorduringtheBoneLinearGrowthPhaseIncreases Peak Bone Mass in Female Mice.Plos one2010;7(5):e11410.          

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Using cellular systems, pharmacological approaches and animal genetics to study the hormonal and pathophysiological regulations contributing to metabolic diseases such as osteoporosis, fatty liver, diabetes and obesity.

已指导学生

钟丽红  硕士研究生  071010-生物化学与分子生物学  

杨萌  博士研究生  071010-生物化学与分子生物学  

现指导学生

黄童龄  博士研究生  071010-生物化学与分子生物学  

高璐  博士研究生  071010-生物化学与分子生物学  

王紫辉  硕士研究生  086000-生物与医药  

             2011   The American Society of Bone and Mineral Research (ASBMR) Travel Award

2011   Alice L. Jee Memorial Young Investigator Award

2011   ASBMR Young Investigator Award

2011   UC Davis Medical Center Postdoctoral Scholar Award

2014   Overseas High-Caliber Personnel (Level B) in Shenzhen.

2015   Youth Innovation Promotion Association, Chinese Academy of Sciences

2017   Youth innovation talent of Guangdong Special Support Program