071009-细胞生物学

蛋白折叠与聚集
神经退行性疾病的致病机理
蛋白质原子结构与功能研究

2002-09--2008-06   北京大学   博士学位
1998-09--2002-06   吉林大学   学士学位

   

2013-09~现在, 上海有机化学研究所, 研究员
2008-09~2013-07,美国加州大学洛杉矶分校, 博士后
2002-09~2008-06,北京大学, 博士学位
1998-09~2002-06,吉林大学, 学士学位

蛋白质导论

   

（ 1 ） 筛选和表征具有相分离能力蛋白的方法, 2023, 第 2 作者, 专利号: CN111175514B

（ 2 ） α-突触核蛋白C末端作为抗帕金森病药物的重要靶点, 2022, 第 1 作者, 专利号: CN115531543A

（ 3 ） 筛选和表征具有相分离能力蛋白的方法, 2020, 第 2 作者, 专利号: CN111175514A

（ 4 ） 一种蛋白质微小晶体冷冻样品的制备及结构解析的方法, 2019, 第 1 作者, 专利号: CN110095485A

   

（1） Creating an amyloid kaleidoscope' using short iodinated peptides, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 第 9 作者  通讯作者
（2） Graphene Quantum Dots Modulate Stress Granule Assembly and Prevent Abnormal Phase Transition of Fused in Sarcoma Protein, ACS NANO, 2023, 第 7 作者
（3） Conformational Dynamics of an ?-Synuclein Fibril upon Receptor Binding Revealed by Insensitive Nuclei Enhanced by Polarization Transfer-Based Solid-State Nuclear Magnetic Resonance and Cryo-Electron Microscopy, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2023, 第 9 作者  通讯作者
（4） Targeting amyloid proteins for clinical diagnosis of neurodegenerative diseases, FUNDAMENTAL RESEARCH, 2023, 第 5 作者  通讯作者
（5） Structural mechanism for specific binding of chemical compounds to amyloid fibrils, NATURE CHEMICAL BIOLOGY, 2023, 第 12 作者  通讯作者
（6） Intrastriatal injection of Parkinson's disease intestine and vagus lysates initiates alpha-synucleinopathy in rat brain, CELL DEATH & DISEASE, 2023, 第 9 作者
（7） Rational design of functional amyloid fibrillar assemblies, CHEMICAL SOCIETY REVIEWS, 2023, 第 9 作者  通讯作者
（8） beta(2)-Microglobulin coaggregates with A beta and contributes to amyloid pathology and cognitive deficits in Alzheimer's disease model mice, NATURE NEUROSCIENCE, 2023, 第 16 作者
（9） Identifying Heterozipper ?-Sheet in Twisted Amyloid Aggregation br, NANO LETTERS, 2022, 第 5 作者
（10） Non-ergodicity of a globular protein extending beyond its functional timescale, CHEMICAL SCIENCE, 2022, 第 5 作者
（11） Identifying Heterozipper ��-Sheet in Twisted Amyloid Aggregation, NANO LETTERS, 2022, 第 5 作者
（12） Conformational strains of pathogenic amyloid proteins in neurodegenerative diseases, NATURE REVIEWS NEUROSCIENCE, 2022, 第 2 作者  通讯作者
（13） Spatiotemporal dynamic regulation of membraneless organelles by chaperone networks, TRENDS IN CELL BIOLOGY, 2022, 第 2 作者  通讯作者
（14） Specific binding of Hsp27 and phosphorylated Tau mitigates abnormal Tau aggregation- induced pathology, ELIFE, 2022, 第 11 作者
（15） Hsp70 exhibits a liquid-liquid phase separation ability and chaperones condensed FUS against amyloid aggregation, ISCIENCE, 2022, 第 6 作者
（16） Generic amyloid fibrillation of TMEM106B in patient with Parkinson’s disease dementia and normal elders, Generic amyloid fibrillation of TMEM106B in patient with Parkinson's disease dementia and normal elders, CELL RESEARCH, 2022, 第 15 作者  通讯作者
（17） The mouse nicotinamide mononucleotide adenylyltransferase chaperones diverse pathological amyloid client proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, 2022, 第 6 作者
（18） Heparin induces alpha-synuclein to form new fibril polymorphs with attenuated neuropathology, NATURE COMMUNICATIONS, 2022, 第 11 作者  通讯作者
（19） Cryo-EM structure of an amyloid fibril formed by full-length human SOD1 reveals its conformational conversion, NATURE COMMUNICATIONS, 2022, 第 16 作者  通讯作者
（20） The hereditary mutation G51D unlocks a distinct fibril strain transmissible to wild-type alpha-synuclein, NATURE COMMUNICATIONS, 2021, 第 11 作者  通讯作者
（21） The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 第 17 作者  通讯作者
（22） Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation, Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation, CELL RESEARCH, 2021, 第 10 作者  通讯作者
（23） A novel partially-open state of SHP2 points to a "multiple gear" regulation mechanism, JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 第 23 作者  通讯作者
（24） Wild-type alpha-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 第 12 作者  通讯作者
（25） Proximal Single-Stranded RNA Destabilizes Human Telomerase RNA G-Quadruplex and Induces Its Distinct Conformers, JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2021, 第 9 作者
（26） Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, NATURE CHEMICAL BIOLOGY, 2021, 第 2 作者  通讯作者
（27） O-Glycosylation Induces Amyloid-beta To Form New Fibril Polymorphs Vulnerable for Degradation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2021, 第 13 作者  通讯作者
（28） Liquid-liquid phase separation in biology: mechanisms,physiological functions and human diseases, Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases, SCIENCE CHINA-LIFE SCIENCES, 2020, 第 4 作者  通讯作者
（29） The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, NATURE COMMUNICATIONS, 2020, 第 12 作者  通讯作者
（30） Structural Diversity of Amyloid Fibrils and Advances in Their Structure Determination, BIOCHEMISTRY, 2020, 第 2 作者  通讯作者
（31） Different regions of synaptic vesicle membrane regulate VAMP2 conformation for the SNARE assembly, NATURE COMMUNICATIONS, 2020, 第 16 作者  通讯作者
（32） Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2020, 第 15 作者  通讯作者
（33） Cryo-EM structure of full-length alpha-synuclein amyloid fibril with Parkinson's disease familial A53T mutation, CELL RESEARCH, 2020, 第 10 作者  通讯作者
（34） Structural basis of the interplay between ��-synuclein and Tau in regulating pathological amyloid aggregation, JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 第 7 作者  通讯作者
（35） Nicotinamide mononucleotide adenylyltransferase uses its NAD + substrate-binding site to chaperone phosphorylated Tau, ELIFE, 2020, 第 20 作者  通讯作者
（36） Investigation of structure and dynamics of alpha-synuclein on membrane by quenchers-in-a-liposome fluorescence resonance energy transfer method, ACTA PHYSICA SINICA, 2020, 第 9 作者
（37） Phase separation of disease-associated SHP2 mutants underlies MAPK hyperactivation, CELL, 2020, 第 23 作者
（38） Stress Induces Dynamic, Cytotoxicity-Antagonizing TDP-43 Nuclear Bodies via Paraspeckle LncRNA NEAT1-Mediated Liquid-Liquid Phase Separation, MOLECULAR CELL, 2020, 第 12 作者  通讯作者
（39） Structural basis of the interplay between alpha-synuclein and Tau in regulating pathological amyloid aggregation, J Biol Chem, 2020, 第 1 作者  通讯作者
（40） 脂质体包裹荧光受体方法研究α-突触核蛋白在磷脂膜上的结构和动态特征, Investigation of structure and dynamics of ��-synuclein on membrane by quenchers-in-a-liposome fluorescence resonance energy transfer method, 物理学报, 2020, 第 9 作者
（41） Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 11 作者  通讯作者
（42） Parkinson's disease associated mutation E46K of alpha-synuclein triggers the formation of a distinct fibril structure, NATURE COMMUNICATIONS, 2020, 第 12 作者  通讯作者
（43） Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 第 12 作者  通讯作者
（44） Cryo-EM structure of an amyloid fibril formed by full-length human prion protein, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2020, 第 14 作者  通讯作者
（45） Heat shock protein 104 (HSP104) chaperones soluble Tau via a mechanism distinct from its disaggregase activity, JOURNAL OF BIOLOGICAL CHEMISTRY, 2019, 第 9 作者  通讯作者
（46） New insights of poly(ADP-ribosylation) in neurodegenerative diseases: A focus on protein phase separation and pathologic aggregation., BIOCHEMICAL PHARMACOLOGY, 2019, 第 1 作者  通讯作者
（47） Exploiting mammalian low-complexity domains for liquid-liquid phase separation���driven underwater adhesive coatings, SCIENCE ADVANCES, 2019, 第 10 作者
（48） Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules, ANALYTICAL CHEMISTRY, 2019, 第 5 作者  通讯作者
（49） Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, NATURE COMMUNICATIONS, 2019, 第 18 作者  通讯作者
（50） PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins, CELL RESEARCH, 2019, 第 15 作者  通讯作者
（51） Detecting Single-Molecule Dynamics on Lipid Membranes with Quenchers-in-a-Liposome FRET, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 10 作者  通讯作者
（52） PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins, PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins, 细胞研究:英文版, 2019, 第 15 作者  通讯作者
（53） Second messenger Ap(4)A polymerizes target protein HINT1 to transduce signals in Fc epsilon RI-activated mast cells, NATURE COMMUNICATIONS, 2019, 第 11 作者
（54） Second messenger Ap 4 A polymerizes target protein HINT1 to transduce signals in Fc��RI-activated mast cells, NATURE COMMUNICATIONS, 2019, 第 11 作者
（55） Modular genetic design of multi-domain functional amyloids: insights into self-assembly and functional properties, CHEMICAL SCIENCE, 2019, 第 13 作者
（56） Fibril Self-Assembly of Amyloid-Spider Silk Block Polypeptides, BIOMACROMOLECULES, 2019, 第 4 作者
（57） Amyloid fibril structure of α-synuclein determined by cryo- electron microscopy, Amyloid fibril structure of ��-synuclein determined by cryo- electron microscopy, 细胞研究：英文版, 2018, 第 9 作者
（58） Amyloid fibril structure of α-synuclein determined by cryo- electron microscopy, Amyloid fibril structure of ��-synuclein determined by cryo- electron microscopy, 细胞研究：英文版, 2018, 第 9 作者
（59） Atomic structures of FUS LC domain segments reveal bases for reversible amyloid fibril formation, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2018, 第 10 作者  通讯作者
（60） Mechanistic insights into the switch of alpha B-crystallin chaperone activity and self-multimerization, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 第 8 作者  通讯作者
（61） In-Cell NMR Study of Tau and MARK2 Phosphorylated Tau, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 第 8 作者
（62） Amyloid fibril structure of alpha-synuclein determined by cryoelectron microscopy, CELL RESEARCH, 2018, 第 9 作者  通讯作者
（63） Mechanistic Basis for Client Recognition and Amyloid Inhibition of NMNAT, BIOPHYSICAL JOURNAL, 2018, 第 4 作者
（64） Better Together: A Hybrid Amyloid Signals Necroptosis, CELL, 2018, 第 2 作者  通讯作者
（65） A Structural View of alpha B-crystallin Assembly and Amyloid Aggregation, PROTEIN AND PEPTIDE LETTERS, 2017, 第 4 作者  通讯作者
（66） Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment, JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 10 作者  通讯作者
（67） N-Terminal Acetylation Preserves alpha-Synuclein from Oligomerization by Blocking Intermolecular Hydrogen Bonds, ACS CHEMICAL NEUROSCIENCE, 2017, 第 10 作者
（68） Diverse Supramolecular Nanofiber Networks Assembled by Functional Low-Complexity Domains, ACS NANO, 2017, 第 14 作者
（69） Precise and Reversible Protein-Microtubule-Like Structure with Helicity Driven by Dual Supramolecular Interactions, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 第 11 作者
（70） Versatile Structures of alpha-Synuclein, FRONTIERS IN MOLECULAR NEUROSCIENCE, 2016, 第 7 作者  通讯作者
（71） Tunable assembly of amyloid-forming peptides into nanosheets as a retrovirus carrier, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 第 12 作者
（72） Tunable assembly of amyloid-forming prptides into nanosheets as a retrovirus carrier, Proc Natl Acad Sci U S A, 2015, 第 1 作者  通讯作者
（73） The electronic effects of ligands on metal-coordination geometry: a key role in the visual discrimination of dimethylaminopyridine and its application towards chemo-switch, CHEMICAL COMMUNICATIONS, 2015, 第 2 作者
（74） Antiparallel Triple-strand Architecture for Prefibrillar A��42 Oligomers, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 第 2 作者
（75） Designed amyloid fibers as materials for selective carbon dioxide capture, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 第 4 作者
（76） Structure-Based Design of Functional Amyloid Materials, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 第 10 作者
（77） Antiparallel Triple-strand Architecture for Prefibrillar A beta 42 Oligomers, JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 第 2 作者
（78） Antiparalle triple-strand architecture for prefibrillar Abeta42 oligomer, J Biol Chem, 2014, 第 1 作者
（79） The structured core domain of aB-crystallin can prevent amyloid fibrillation and associated toxicity., 2014, 第 1 作者
（80） Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta, ELIFE SCIENCES PUBLICATIONS, LTD, 2013, 
（81） Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta, ELIFE, 2013, 第 2 作者
（82） Toxic fibrillar oligomers of amyloid-�� have cross-�� structure, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 第 2 作者
（83） Atomic View of a Toxic Amyloid Small Oligomer, SCIENCE, 2012, 第 2 作者
（84） Out-of-register ��-sheets suggest a pathway to toxicamyloid aggregations., Proc. Nat. Acad. Sci. USA.,, 2012, 第 1 作者
（85） Amyloid ��-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity., 2012, 第 1 作者
（86） Characteristics of amyloid-related oligomers revealed by crystal structures of macrocyclic ��-sheet mimics, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 第 1 作者
（87） ��2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages., Nat. Struct. Mol. Biol.,, 2011, 第 1 作者

   

（ 1 ） 东方英才计划领军项目, 负责人, 地方任务, 2023-12--2028-12
（ 2 ） 化学合成的极限, 参与, 中国科学院计划, 2023-07--2028-07
（ 3 ） 帕金森病关键蛋白病理聚集的分子机制与化学干预研究, 负责人, 中国科学院计划, 2023-01--2025-12
（ 4 ） 基于肠脑轴的帕金森病致病机制研究, 参与, 地方任务, 2022-10--2025-09
（ 5 ） 神经系统疾病致病机理的研究和干预, 参与, 国家任务, 2022-06--2026-12
（ 6 ） 《alpha-突触核蛋白在突触前的保护机制研究》, 负责人, 国家任务, 2020-11--2023-11
（ 7 ） 《蛋白相分离的紊乱与神经退行性疾病》, 负责人, 地方任务, 2020-10--2023-09
（ 8 ） 《细胞程序死亡过程中重要蛋白质复合体的动态调控机制与结构生物学基础》, 负责人, 地方任务, 2018-12--2021-11
（ 9 ） 神经退行性疾病中 细胞死亡机理和干预的研究, 参与, 国家任务, 2016-08--2021-07
（ 10 ） 蛋白质超微晶体结构研究方法的建立及其在人类重要蛋白结构研究中的应用, 负责人, 国家任务, 2015-01--2017-12
（ 11 ） 热休克蛋白解聚致病淀粉样纤维的结构与分子机理研究, 负责人, 国家任务, 2015-01--2018-12
（ 12 ） 青年****, 负责人, 国家任务, 2014-10--2017-09