方巧君  女  博导  国家纳米科学中心
email: fangqj@nanoctr.cn
address: 中关村北一条11号新科研楼619
postalCode: 100190




2000-06--2005-10   约翰霍普金斯大学医学院   博士
1996-09--1999-06   北京大学   硕士
1991-09--1996-06   北京大学   学士


2013-02~现在, 国家纳米科学中心, 研究员
2009-07~2013-01,Fred Hutchinson Cancer Research Center, 正式科研人员
2007-02~2009-06,Fred Hutchinson Cancer Research Center, 博士后
2005-10~2007-01,约翰霍普金斯大学医学院, 博士后
2000-06~2005-10,约翰霍普金斯大学医学院, 博士
1996-09~1999-06,北京大学, 硕士
1991-09~1996-06,北京大学, 学士
2017-11-01-2021-10-31,中国生物物理学纳米生物学分会理事, 理事




(1) 优秀教师奖, 研究所(学校), 2022
(2) 研究生优秀课程, , 研究所(学校), 2021
( 1 ) 一种磁性纳米颗粒及其制备方法和应用, 2022, 第 2 作者, 专利号: 202210131909.5

( 2 ) 一种小鼠原代肝脏枯否细胞的提取方法, 2021, 第 2 作者, 专利号: CN113604419A

( 3 ) 双亲性靶向穿膜肽及其自组装的纳米探针、载药纳米颗粒, 2018, 第 2 作者, 专利号: CN108484733A

( 4 ) 特异性靶向HER2蛋白的多肽及其应用, 2016, 第 3 作者, 专利号: CN105693860A

( 5 ) 一种特异靶向EGFR蛋白的多肽及其应用, 2015, 第 2 作者, 专利号: CN105085632A

( 6 ) 一种特异靶向HER2蛋白的多肽及其应用, 2015, 第 2 作者, 专利号: CN105085631A

( 7 ) 一种特异靶向HER2蛋白的多肽, 2014, 第 2 作者, 专利号: CN104130315A


(1) Terminus-immobilization effect on peptide conformations and peptide-peptide interactions, NANO RESEARCH, 2023, 通讯作者
(2) Engineering magnetotactic bacteria MVs to synergize chemotherapy, ferroptosis and immunotherapy for augmented antitumor therapy, NANOSCALE HORIZONS, 2023, 通讯作者
(3) Advancing osmotic power generation by covalent organic framework monolayer, NATURE NANOTECHNOLOGY, 2022, 第11作者
(4) Heterochirality-Mediated Cross-Strand Nested Hydrophobic Interaction Effects Manifested in Surface-Bound Peptide Assembly Structures, JOURNAL OF PHYSICAL CHEMISTRY B, 2022, 第 6 作者
(5) A structure-preserving finite element discretization for the time-dependent Nernst-Planck equation, JOURNAL OF APPLIED MATHEMATICS AND COMPUTING, 2022, 第 3 作者
(6) Strategy for Avoiding Protein Corona Inhibition of Targeted Drug Delivery by Linking Recombinant Affibody Scaffold to Magnetosomes, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2022, 第 9 作者
(7) Self-Confirming Magnetosomes for Tumor-Targeted T-1/T-2 Dual-Mode MRI and MRI-Guided Photothermal Therapy, ADVANCED HEALTHCARE MATERIALS, 2022, 通讯作者
(8) Bacterial Magnetosomes Release Iron Ions and Induce Regulation of Iron Homeostasis in Endothelial Cells, Nanomaterials, 2022, 通讯作者
(9) CD151 enrichment in exosomes of luminal androgen receptor breast cancer cell line contributes to cell invasion, BIOCHIMIE, 2021, 通讯作者
(10) Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study, NANOMATERIALS, 2021, 通讯作者
(11) Siderophores for medical applications: Imaging, sensors, and therapeutics, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 通讯作者
(12) Protein biomarkers in breast cancer-derived extracellular vesicles for use in liquid biopsies, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2021, 通讯作者
(13) Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T, SCIENCE ADVANCES, 2020, 通讯作者
(14) Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery, NANOSCALE, 2020, 通讯作者
(15) A Protein Corona Adsorbed to a Bacterial Magnetosome Affects Its Cellular Uptake, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 
(16) A P4 Medicine Perspective of Gut Microbiota and Prediabetes: Systems Analysis and Personalized Intervention, JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE, 2020, 第 2 作者
(17) Switchable Ionic Rectifiers Based on Ferroelectric Nanopores, ACS APPLIED NANO MATERIALS, 2020, 第 7 作者
(18) Peptide conformation and oligomerization characteristics of surface-mediated assemblies revealed by molecular dynamics simulations and scanning tunneling microscopy, RSC ADVANCES, 2019, 通讯作者
(19) Peptosome Coadministration Improves Nanoparticle Delivery to Tumors through NRP1-Mediated Co-Endocytosis, BIOMOLECULES, 2019, 通讯作者
(20) Uncovering the Conduction Behavior of van der Waals Ambipolar Semiconductors, ADVANCED MATERIALS, 2019, 第 8 作者
(21) Proteomic profiling of RAW264.7 macrophage cells exposed to graphene oxide: insights into acute cellular responses, NANOTOXICOLOGY, 2019, 通讯作者
(22) Bilayer Adsorption of Porphyrin Molecules Substituted with Carboxylic Acid atop the NN4A Network Revealed by STM and DFT, LANGMUIR, 2019, 第 6 作者
(23) Efficient and Long-Lasting Current Rectification by Laminated Yet Separated, Oppositely Charged Monolayers, ACS APPLIED ELECTRONIC MATERIALS, 2019, 第 6 作者
(24) Switchable counterion gradients around charged metallic nanoparticles enable reception of radio waves, SCIENCE ADVANCES, 2018, 第 6 作者
(25) Conic shapes have higher sensitivity than cylindrical ones in nanopore DNA sequencing, SCIENTIFIC REPORTS, 2018, 通讯作者
(26) Quantitative proteomic analysis to the first commercialized liposomal paclitaxel nano-platform Lipusu revealed the molecular mechanism of the enhanced anti-tumor effect, ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 第 7 作者
(27) Peptide probes derived from pertuzumab by molecular dynamics modeling for HER2 positive tumor imaging, PLOS COMPUTATIONAL BIOLOGY, 2017, 通讯作者
(28) Polymer-klak peptide conjugates induce cancer cell death through synergistic effects of mitochondria damage and autophagy blockage, BIOCONJUGATE CHEMISTRY, 2017, 通讯作者
(29) Tumor detection using magnetosome nanoparticles functionalized with a newly screened EGFR/HER2 targeting peptide, BIOMATERIALS, 2017, 通讯作者
(30) Interaction of gold and silver nanoparticles with human plasma: analysis of protein corona reveals specific binding patterns, COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, 通讯作者
(31) Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp, PLOS ONE, 2015, 第 10 作者
(32) Rapid Screening of Peptide Probes through In Situ Single-Bead Sequencing Microarray, ANALYTICAL CHEMISTRY, 2014, 第11作者


( 1 ) 纳米材料生物效益与安全性的组学研究, 负责人, 中国科学院计划, 2013-02--2016-12
( 2 ) 趋磁细菌纳米磁小体膜蛋白组学研究, 负责人, 地方任务, 2014-01--2016-12
( 3 ) 纳米生物效应与安全性系统研究, 参与, 中国科学院计划, 2015-01--2017-12
( 4 ) 单细胞精确操纵与基因组测序新方法在肿瘤防治中的应用研究, 参与, 国家任务, 2015-01--2018-12
( 5 ) 果蝇眼睛蛋白组研究, 负责人, 其他国际合作项目, 2017-01--2017-12
( 6 ) 磁小体作为新型天然MRI对比剂的生物相容性研究, 负责人, 地方任务, 2017-10--2020-10
( 7 ) 定量蛋白组测试分析, 负责人, 其他国际合作项目, 2018-06--2019-05
( 8 ) TMT定量蛋白组, 负责人, 其他国际合作项目, 2019-06--2022-12
( 9 ) 蛋白与磷脂结合模拟, 负责人, 其他国际合作项目, 2021-05--2021-12
( 10 ) 功能纳米系统的精准构筑原理与测量, 参与, 中国科学院计划, 2020-01--2024-12
( 11 ) 高内涵多肽纳米自组装体筛选和分析系统, 参与, 国家任务, 2021-01--2025-12
( 12 ) 癫痫/阿兹海默症的脑蛋白相互作用分析与计算模拟, 负责人, 境内委托项目, 2021-10--2021-12
( 13 ) 多肽-RNA 复合物中氨基酸和核苷酸的相互作用规律的理论 模拟研究, 负责人, 地方任务, 2023-10--2025-09
( 14 ) 中国人群尿路上皮癌精准诊疗关键技术及规范化临床体系建立, 参与, 国家任务, 2024-01--2028-12
(1)多肽及其自组装纳米体系 (peptosome)促进纳米载体递送的研究   019 中国生物物理学会纳米生物学分会学术年会 暨“创新纳米药物”雄安论坛   2019-04-24
(2)多肽介导的靶向肿瘤的纳米磁小体作为磁共振成像对比剂的研究   纳米科学技术分会第五届年会暨2018   2018-10-25
(3)Proteomics based study on the interactions of nanoparticles and biomolecules   2018中国生物物理学会纳米生物学分会学术年会暨“后基因组时代的纳米科技”科学与技术前沿论坛   2018-04-06
(4)磁小体的应用及其膜蛋白组的研究   2017年第七届“趋磁细菌研究及其应用”研讨会   2017-09-22
(5)Proteomics based study on the interactions of nanoparticles and biomolecules   2016福州纳米会议   2016-12-09
(6)Evaluating the accuracy of sub-cellular Proteomic-based prediction of extracellular and intracellular proteins   Qiaojun Fang   2009-05-29
(7)Evaluating Quantitative Proteomics Data of Tumor Cells and Plasma to Identify Markers of Therapy Response. NCI Nanotechnology Alliance Investigators Meeting   Qiaojun Fang?, Kian Kani?, Anjali Jain?, Vitor M. Faca?, Damon H. May?, Parag Mallick?§, Martin W. McIntosh   2008-09-12
(8)rotein Structure Prediction Using Fragment Ensembles with Highly Favorable Ramachandan / Rotamer Propensities   Qiaojun Fang and David Shortle   2002-12-01