基本信息
方巧君  女  硕导  国家纳米科学中心
email: fangqj@nanoctr.cn
address: 中关村北一条11号科研楼305
postalCode: 100190

招生信息

   
招生专业
0701J3-生物信息学
0702J1-纳米科学与技术
招生方向
纳米尺度理论模拟,纳米生物学
纳米生物相互作用理论计算
蛋白组学,基因组学

教育背景

2000-06--2005-10   约翰霍普金斯大学医学院   博士
1996-09--1999-06   北京大学   硕士
1991-09--1996-06   北京大学   学士

工作经历

   
工作简历
2013-02~现在, 国家纳米科学中心, 研究员
2009-07~2013-01,Fred Hutchinson Cancer Research Center, 正式科研人员
2007-02~2009-06,Fred Hutchinson Cancer Research Center, 博士后
2005-10~2007-01,约翰霍普金斯大学医学院, 博士后
2000-06~2005-10,约翰霍普金斯大学医学院, 博士
1996-09~1999-06,北京大学, 硕士
1991-09~1996-06,北京大学, 学士
社会兼职
2017-11-01-2021-10-31,中国生物物理学纳米生物学分会理事, 理事

教授课程

纳米尺度理论与计算
Nanobiotechnology
纳米生物学概论
纳米生物学
纳米生物理论模拟

专利与奖励

   
奖励信息
(1) 研究生优秀课程, , 研究所(学校), 2021
专利成果
( 1 ) 一种小鼠原代肝脏枯否细胞的提取方法, 2021, 第 2 作者, 专利号: CN113604419A

( 2 ) 双亲性靶向穿膜肽及其自组装的纳米探针、载药纳米颗粒, 2021, 第 2 作者, 专利号: CN108484733B

( 3 ) 特异性靶向HER2蛋白的多肽及其应用, 2019, 第 3 作者, 专利号: CN105693860B

( 4 ) 一种特异靶向EGFR蛋白的多肽及其应用, 2019, 第 2 作者, 专利号: CN105085632B

( 5 ) 一种特异靶向HER2蛋白的多肽及其应用, 2019, 第 2 作者, 专利号: CN105085631B

( 6 ) 一种特异靶向HER2蛋白的多肽, 2014, 第 2 作者, 专利号: CN104130315A

出版信息

   
发表论文
(1) A comprehensive assessment of the biocompatibility of Magnetospirillum gryphiswaldense MSR-1 bacterial magnetosomes in vitro and in vivo, TOXICOLOGY, 2021, 通讯作者
(2) CD151 enrichment in exosomes of luminal androgen receptor breast cancer cell line contributes to cell invasion, BIOCHIMIE, 2021, 通讯作者
(3) Biocompatibility of Bacterial Magnetosomes as MRI Contrast Agent: A Long-Term In Vivo Follow-Up Study, NANOMATERIALS, 2021, 通讯作者
(4) Siderophores for medical applications: Imaging, sensors, and therapeutics, INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 通讯作者
(5) Protein biomarkers in breast cancer-derived extracellular vesicles for use in liquid biopsies, AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 2021, 通讯作者
(6) Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T, SCIENCE ADVANCES, 2020, 通讯作者
(7) Drug-internalized bacterial swimmers for magnetically manipulable tumor-targeted drug delivery, NANOSCALE, 2020, 通讯作者
(8) A Protein Corona Adsorbed to a Bacterial Magnetosome Affects Its Cellular Uptake, INTERNATIONAL JOURNAL OF NANOMEDICINE, 2020, 
(9) A P4 Medicine Perspective of Gut Microbiota and Prediabetes: Systems Analysis and Personalized Intervention, JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE, 2020, 第 2 作者
(10) Switchable Ionic Rectifiers Based on Ferroelectric Nanopores, ACS APPLIED NANO MATERIALS, 2020, 第 7 作者
(11) Peptide conformation and oligomerization characteristics of surface-mediated assemblies revealed by molecular dynamics simulations and scanning tunneling microscopy, RSC ADVANCES, 2019, 通讯作者
(12) Peptosome Coadministration Improves Nanoparticle Delivery to Tumors through NRP1-Mediated Co-Endocytosis, BIOMOLECULES, 2019, 通讯作者
(13) Uncovering the Conduction Behavior of van der Waals Ambipolar Semiconductors, ADVANCED MATERIALS, 2019, 第 8 作者
(14) Design of a Simple and Practical Nanosystem Coordinates Tumor Targeting and Penetration for Improved Theranostics, ADVANCED THERAPEUTICS, 2019, 通讯作者
(15) Proteomic profiling of RAW264.7 macrophage cells exposed to graphene oxide: insights into acute cellular responses, NANOTOXICOLOGY, 2019, 通讯作者
(16) Bilayer Adsorption of Porphyrin Molecules Substituted with Carboxylic Acid atop the NN4A Network Revealed by STM and DFT, LANGMUIR, 2019, 第 6 作者
(17) Efficient and Long-Lasting Current Rectification by Laminated Yet Separated, Oppositely Charged Monolayers, ACS APPLIED ELECTRONIC MATERIALS, 2019, 第 6 作者
(18) Switchable counterion gradients around charged metallic nanoparticles enable reception of radio waves, SCIENCE ADVANCES, 2018, 第 6 作者
(19) Conic shapes have higher sensitivity than cylindrical ones in nanopore DNA sequencing, SCIENTIFIC REPORTS, 2018, 通讯作者
(20) Quantitative proteomic analysis to the first commercialized liposomal paclitaxel nano-platform Lipusu revealed the molecular mechanism of the enhanced anti-tumor effect, ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 第 7 作者
(21) Peptide probes derived from pertuzumab by molecular dynamics modeling for HER2 positive tumor imaging, PLOS COMPUTATIONAL BIOLOGY, 2017, 通讯作者
(22) Polymer-klak peptide conjugates induce cancer cell death through synergistic effects of mitochondria damage and autophagy blockage, BIOCONJUGATE CHEMISTRY, 2017, 通讯作者
(23) Tumor detection using magnetosome nanoparticles functionalized with a newly screened EGFR/HER2 targeting peptide, BIOMATERIALS, 2017, 通讯作者
(24) Nanoparticle abraxane possesses impaired proliferation in A549 cells due to the underexpression of glucosamine 6-phosphate N-acetyltransferase 1 (GNPNAT1, International Journal of Nanomedicine, 2017, 第 6 作者
(25) Polymer– KLAK Peptide Conjugates Induce Cancer Cell Death through Synergistic Effects of Mitochondria Damage and Autophagy Blockage, Bioconjugate Chemistry, 2017, 第 8 作者
(26) Chiral Nanoparticle as a New Efficient Antimicrobial Nanoagent, ADVANCED HEALTHCARE MATERIALS, 2017, 通讯作者
(27) Interaction of gold and silver nanoparticles with human plasma: analysis of protein corona reveals specific binding patterns, COLLOIDS AND SURFACES B-BIOINTERFACES, 2017, 通讯作者
(28) An Evaluation of Blood Compatibility of Silver Nanoparticles, SCIENTIFIC REPORTS, 2016, 通讯作者
(29) HER2 Targeting Peptides Screening and Applications in Tumor Imaging and Drug Delivery, THERANOSTICS, 2016, 通讯作者
(30) High-Throughput Peptide Screening on a Bimodal Imprinting Chip Through MS-SPRi Integration, Methods Mol Biol, 2016, 
(31) Temperature-Triggered Chiral Self-Assembly of Achiral Molecules at the Liquid-Solid Interface, ACS Applied Materials & Interfaces, 2016, 第 5 作者
(32) Quantitative proteomic analysis of cellular resistance to the nanoparticle abraxane, ACS NANO, 2015, 第 5 作者
(33) Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp, PLOS ONE, 2015, 第 10 作者
(34) Structure-based Design of Peptides with High Affinity and Specificity to HER2 Positive Tumors, THERANOSTICS, 2015, 通讯作者
(35) Rapid Screening of Peptide Probes through In Situ Single-Bead Sequencing Microarray, ANALYTICAL CHEMISTRY, 2014, 第11作者
(36) Bimodal Imprint Chips for Peptide Screening: Integration of High-Throughput Sequencing by MS and Affinity Analyses by Surface Plasmon Resonance Imaging, ANALYTICAL CHEMISTRY, 2014, 第 13 作者
(37) Impact of Protein Stability, Cellular Localization, and Abundance on Proteomic Detection of Tumor-Derived Proteins in Plasma, PLOS ONE, 2011, 通讯作者
(38) Brain specific proteins decline in the cerebrospinal fluid of humans with Huntingtons Disease, Molecular and Cellular Proteomics, 2009, 第 1 作者
(39) A software platform for rapidly creating computational tools for mass spectrometry-based proteomics, Journal of proteome research, 2009, 第 4 作者
(40) Protein Refolding in Silico with Atom-based Statistical Potentials and Conformational Search Using a Simple Genetic Algorithm, JOURNAL OF MOLECULAR BIOLOGY, 2006, 第 1 作者
(41) A consistent set of statistical potentials for quantifying local side-chain and backbone interactions, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 
(42) Enhanced sampling near the native conformation using statistical potentials for local side-chain and backbone interactions, PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2005, 
(43) Prediction of protein structure by emphasizing local side-chain/backbone interactions in ensembles of turn fragments, PROTEINS-STRUCTURE FUNCTION AND GENETICS, 2003, 
(44) A histone fold TAF octamer within the yeast TFIID transcriptional coactivator, NATURE STRUCTURAL BIOLOGY, 2001, 

科研活动

   
科研项目
( 1 ) 纳米材料生物效益与安全性的组学研究, 负责人, 中国科学院计划, 2013-02--2016-12
( 2 ) 趋磁细菌纳米磁小体膜蛋白组学研究, 负责人, 地方任务, 2014-01--2016-12
( 3 ) 纳米生物效应与安全性系统研究, 参与, 中国科学院计划, 2015-01--2017-12
( 4 ) 单细胞精确操纵与基因组测序新方法在肿瘤防治中的应用研究, 参与, 国家任务, 2015-01--2018-12
( 5 ) 果蝇眼睛蛋白组研究, 负责人, 其他任务, 2017-01--2017-12
( 6 ) 磁小体作为新型天然MRI对比剂的生物相容性研究, 负责人, 地方任务, 2017-10--2020-10
( 7 ) 定量蛋白组测试分析, 负责人, 其他任务, 2018-06--2019-05
( 8 ) TMT定量蛋白组, 负责人, 其他任务, 2019-06--2022-12
( 9 ) 蛋白与磷脂结合模拟, 负责人, 其他任务, 2021-05--2021-12
( 10 ) 功能纳米系统的精准构筑原理与测量, 参与, 中国科学院计划, 2020-01--2024-12
( 11 ) 高内涵多肽纳米自组装体筛选和分析系统, 参与, 国家任务, 2021-01--2025-12
参与会议
(1)多肽及其自组装纳米体系 (peptosome)促进纳米载体递送的研究   019 中国生物物理学会纳米生物学分会学术年会 暨“创新纳米药物”雄安论坛   2019-04-24
(2)多肽介导的靶向肿瘤的纳米磁小体作为磁共振成像对比剂的研究   纳米科学技术分会第五届年会暨2018   2018-10-25
(3)Proteomics based study on the interactions of nanoparticles and biomolecules   2018中国生物物理学会纳米生物学分会学术年会暨“后基因组时代的纳米科技”科学与技术前沿论坛   2018-04-06
(4)磁小体的应用及其膜蛋白组的研究   2017年第七届“趋磁细菌研究及其应用”研讨会   2017-09-22
(5)Proteomics based study on the interactions of nanoparticles and biomolecules   2016福州纳米会议   2016-12-09
(6)Evaluating the accuracy of sub-cellular Proteomic-based prediction of extracellular and intracellular proteins   Qiaojun Fang   2009-05-29
(7)Evaluating Quantitative Proteomics Data of Tumor Cells and Plasma to Identify Markers of Therapy Response. NCI Nanotechnology Alliance Investigators Meeting   Qiaojun Fang?, Kian Kani?, Anjali Jain?, Vitor M. Faca?, Damon H. May?, Parag Mallick?§, Martin W. McIntosh   2008-09-12
(8)rotein Structure Prediction Using Fragment Ensembles with Highly Favorable Ramachandan / Rotamer Propensities   Qiaojun Fang and David Shortle   2002-12-01