基本信息
邓涛  女  博导  中国科学院微生物研究所
email: dengt@im.ac.cn
address: 北京市朝阳区北辰西路1号院3号
postalCode:

招生信息

   
招生专业
100103-病原生物学
招生方向
流感病毒复制分子机制, 抗病毒策略与疫苗研发
流感病毒RNA特征,结构及其功能研究

教育背景

2002-11--2006-03   英国牛津大学邓肯病理学院   博士
1988-08--1992-06   兰州大学生物系   学士

工作经历

   
工作简历
2020-03~现在, 中国科学院微生物研究所, 课题组长
2009-10~2020-03,中国医学科学院病原生物学研究所, 课题组长
2009-01~2009-09,英国国家生物制品标准与控制研究院, Senior Scientist,减毒活疫苗室主任
2006-03~2008-12,英国牛津大学邓肯病理学院, 博士后
2002-11~2006-03,英国牛津大学邓肯病理学院, 博士
2001-11~2006-03,英国牛津大学邓肯病理学院, Research Assistant
2001-04~2001-11,英国牛津大学邓肯病理学院, 访问学者
1992-06~2000-08,原卫生部兰州生物制品研究所, 助理工程师
1988-08~1992-06,兰州大学生物系, 学士

教授课程

医学分子病毒学

专利与奖励

   
奖励信息
(1) 中国医学科学院 北京协和医学院 协和学者特聘教授, 院级, 2015
(2) 获得盖茨基金会 科技部“大挑战 2015· 青年科学家”奖, 部委级, 2015
专利成果
( 1 ) 甲型流感病毒亚型基因型定型的方法, 2017, 第 1 作者, 专利号: ZL 2014 1 0354092.3

( 2 ) 一种提高流感病毒疫苗株产量的方法, 2015, 第 1 作者, 专利号: ZL 2012 1 0299497.2

出版信息

   
发表论文
(1) Mapping of the influenza A virus genome RNA structure and interactions reveals essential elements of viral replication, Cell Reports, 2024, 
(2) Twenty natural amino acid substitution screening at the last residue 121 of influenza A virus NS2 protein reveals the critical role of NS2 in promoting virus genome replication by coordinating with viral polymerase, Journal of Virology, 2024, 
(3) Fine Regulation of Influenza Virus RNA Transcription and Replication by Stoichiometric Changes in Viral NS1 and NS2 Proteins., Journal of Virology, 2023, 第 6 作者  通讯作者
(4) The Hierarchical Sequence Requirements of the H1 SubtypeSpecific Noncoding Regions of Influenza A Virus, MICROBIOLOGY SPECTRUM, 2022, 第 7 作者  通讯作者
(5) Anti-inflammatory effects of Chaishi Tuire Granules on influenza A treatment by mediating TRAF6/MAPK14 axis, FRONTIERS IN MEDICINE, 2022, 第 15 作者  通讯作者
(6) Apolipoprotein E mediates cell resistance to influenza virus infection, SCIENCE ADVANCES, 2022, 第 17 作者
(7) An anti-influenza A virus microbial metabolite acts by degrading viral endonuclease PA, NATURECOMMUNICATIONS, 2022, 第 15 作者
(8) Synergistic Effect between 3 '-Terminal Noncoding and Adjacent Coding Regions of the Influenza A Virus Hemagglutinin Segment on Template Preference, JOURNAL OF VIROLOGY, 2021, 第 8 作者  通讯作者
(9) Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection, Sensing of cytoplasmic chromatin by cGAS activates innate immune response in SARS-CoV-2 infection, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 第 15 作者
(10) Structural insight into RNA synthesis by influenza D polymerase, NATURE MICROBIOLOGY, 2019, 第 15 作者
(11) Identification of a Type-Specific Promoter Element That Differentiates between Influenza A and B Viruses, JOURNAL OF VIROLOGY, 2019, 第 7 作者  通讯作者
(12) Influenza Virus Exploits an Interferon-Independent lncRNA to Preserve Viral RNA Synthesis through Stabilizing Viral RNA Polymerase PB1, CELL REPORTS, 2019, 第 10 作者
(13) Screening for Novel Small-Molecule Inhibitors Targeting the Assembly of Influenza Virus Polymerase Complex by a Bimolecular Luminescence Complementation-Based Reporter System, JOURNAL OF VIROLOGY, 2017, 第 7 作者
(14) Dual Roles of the Hemagglutinin Segment-Specific Noncoding Nucleotides in the Extended Duplex Region of the Influenza A Virus RNA Promoter, JOURNAL OF VIROLOGY, 2017, 第 11 作者
(15) 重组H9N2禽流感病毒的构建及其在不同细胞中的复制特性, Generation of an H9N2 avian influenza virus and characterization of its replication properties in different cells, 基础医学与临床, 2015, 
(16) Influenza A virus utilizes a suboptimal Kozak sequence to fine-tune virus replication and host response., JOURNAL OF GENERAL VIROLOGY, 2015, 第 6 作者  通讯作者
(17) DnaJA1/Hsp40 Is Co-Opted by Influenza A Virus To Enhance Its Viral RNA Polymerase Activity, JOURNAL OF VIROLOGY, 2014, 第 11 作者
(18) Integrating computational modeling and functional assays to decipher the structure-function relationship of influenza virus PB1 protein, SCIENTIFIC REPORTS, 2014, 第 13 作者
(19) The N-Terminal Domain of PA from Bat-Derived Influenza-Like Virus H17N10 Has Endonuclease Activity, JOURNAL OF VIROLOGY, 2014, 第 6 作者
(20) Fragile X mental retardation protein stimulates ribonucleoprotein assembly of influenza A virus, NATURE COMMUNICATIONS, 2014, 第 15 作者  通讯作者
(21) New Insights into the Nonconserved Noncoding Region of the Subtype-Determinant Hemagglutinin and Neuraminidase Segments of Influenza A Viruses, JOURNAL OF VIROLOGY, 2014, 第 8 作者  通讯作者
(22) A peptide derived from the C-terminus of PB1 inhibits influenza virus replication by interfering with viral polymerase assembly, FEBS JOURNAL, 2013, 第 5 作者  通讯作者
(23) Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site, NATURE, 2009, 第 10 作者
(24) The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) regulates promoter binding, PLos One, 2009, 第 1 作者
(25) Hsp90 inhibitors reduce influenza virus replication in cell culture, VIROLOGY, 2008, 第 2 作者
(26) Different De Novo Initiation Strategies Are Used by Influenza Virus RNA Polymerase on Its cRNA and Viral RNA Promoters during Viral RNA Replication, JOURNAL OF VIROLOGY, 2006, 
(27) Role of the influenza virus heterotrimeric RNA polymerase complex in the initiation of replication, JOURNAL OF GENERAL VIROLOGY, 2006, 第 1 作者
(28) The role of Ran binding protein 5 (RanBP5) in the nuclear import and assembly of the influenza virus RNA polymerase complex, Journal of Virology, 2006, 第 1 作者
(29) In Vitro Assembly of PB2 with a PB1-PA Dimer Supports a New Model of Assembly of Influenza A Virus Polymerase Subunits into a Functional Trimeric Complex, JOURNAL OF VIROLOGY, 2005, 
(30) Mutational Analysis of the Influenza Virus cRNA Promoter and Identification of Nucleotides Critical for Replication, JOURNAL OF VIROLOGY, 2004, 
(31) A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Promotes the Generation of Defective Interfering RNAs, JOURNAL OF VIROLOGY, 2003, 
(32) A Single Amino Acid Mutation in the PA Subunit of the Influenza Virus RNA Polymerase Inhibits Endonucleolytic Cleavage of Capped RNAs, JOURNAL OF VIROLOGY, 2002, 

科研活动

   
科研项目
( 1 ) 病毒基因组未来变异演化预测与预警技术研发, 负责人, 国家任务, 2022-11--2025-10
( 2 ) 以流感病毒活疫苗为载体的新型SARS-CoV-2疫苗的开发研究, 负责人, 地方任务, 2022-01--2023-12
( 3 ) 新发突发病毒复制蛋白机器与广谱药物靶点, 参与, 国家任务, 2021-12--2024-11
( 4 ) hnRNPM调控甲型流感病毒复制及宿主特异性的分子机制研究, 负责人, 国家任务, 2021-01--2024-12
( 5 ) PABPC1影响甲型流感病毒复制的分子机制研究, 负责人, 国家任务, 2019-01--2022-12
( 6 ) 我国周边地区重要传染病防控及处置能力提升研究, 负责人, 国家任务, 2018-01--2021-04
( 7 ) 重要新发突发传染病生物安全基础与防控技术研究, 参与, 其他国际合作项目, 2016-01--2020-12