070302-分析化学

分子识别，蛋白质分析，亲和分离，细胞分析

2004-09--2009-06   中国科学院化学研究所   博士学位
2000-09--2004-06   武汉大学   学士学位

   

2022-11~现在, 中国科学院化学研究所, 研究员
2017-02~2018-06,美国Texas A&M大学, 访问学者
2012-03~2022-11,中国科学院化学研究所, 副研究员
2009-07~2012-02,中国科学院化学研究所, 助理研究员
2004-09~2009-06,中国科学院化学研究所, 博士学位
2000-09~2004-06,武汉大学, 学士学位

2023-11-30-今,《分析测试学报》编委会, 青年编委
2023-09-27-今,北京理化分析测试技术学会色谱专业委员会, 常务理事
2022-12-01-2026-11-30,中国化学会色谱专业委员会, 委员
2019-04-30-今,《色谱》编委会, 青年编委
2016-09-16-今,《分析仪器》编委会, 编委

   

（1） 中国科学院化学研究所青年科学奖特别优秀奖, 特等奖, 研究所（学校）, 2022
（2） 中国科学院化学研究所青年科学奖特别优秀奖, 特等奖, 研究所（学校）, 2021
（3） 中国分析测试协会科学技术奖, 二等奖, 其他, 2016

（ 1 ） 一种分离富集循环肿瘤细胞的多肽功能化微纳界面材料及其制备方法和应用, 2022, 第 1 作者, 专利号: CN115404220A

（ 2 ） 一种分子印迹聚合物纳米材料的制备方法及在人血清中β受体阻滞剂检测中的应用, 2022, 第 5 作者, 专利号: CN115215957A

（ 3 ） 一种二价靶向多肽探针及其制备方法, 2021, 第 5 作者, 专利号: CN110456053B

（ 4 ） 一种检测人癌细胞的亲和肽及其应用, 2020, 第 3 作者, 专利号: CN108623658B

（ 5 ） 一种二价靶向多肽探针及其制备方法, 2019, 第 5 作者, 专利号: CN110456053A

（ 6 ） 缀合物及其制备方法和用途, 2019, 第 3 作者, 专利号: CN106334194B

（ 7 ） 一种检测人癌细胞的亲和肽及其应用, 2018, 第 3 作者, 专利号: CN108623658A

（ 8 ） 一种双靶向多肽-药物偶联物及其制备方法与抗肿瘤应用, 2018, 第 1 作者, 专利号: CN108578708A

（ 9 ） 人血清白蛋白特异性识别多肽及其应用, 2018, 第 1 作者, 专利号: CN108341853A

（ 10 ） 一种检测水样中铅离子的方法, 2013, 第 3 作者, 专利号: CN103185737A

（ 11 ） 双孔微米级聚甲基丙烯酸环氧丙酯-甲基丙烯酸乙二醇双酯交联微球及其制备方法, 2012, 第 3 作者, 专利号: CN102617804A

（ 12 ） 一种阵列式连续流动微流控芯片装置及其制作方法与应用, 2012, 第 3 作者, 专利号: CN102527306A

（ 13 ） 检测人癌细胞的多肽及其应用, 2010, 第 2 作者, 专利号: CN101781357A

   

（1） Advances in targeted tracking and detection of soluble amyloid-�� aggregates as a biomarker of Alzheimer's disease., Talanta, 2024, 第 3 作者  通讯作者
（2） Synthetic Peptides with Genetic-Codon-Tailored Affinity for Assembling Tetraspanin CD81 at Cell Interfaces and Inhibiting Cancer Metastasis., Angewandte Chemie International Edition, 2024, 第 6 作者  通讯作者
（3） Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence., Biosensors-Basel, 2023, 第 1 作者  通讯作者
（4） Molecularly Targeted Fluorescent Sensors for Visualizing and Tracking Cellular Senescence, BIOSENSORS-BASEL, 2023, 第 7 作者  通讯作者
（5） Tetraphenylethene-Based cis/trans Isomers for Targeted Fluorescence Sensing and Biomedical Applications., Chemistry – A European Journal, 2023, 第 1 作者
（6） Peptide-derived coordination frameworks for biomimetic and selective separation., Analytical and Bioanalytical Chemistry, 2023, 第 5 作者  通讯作者
（7） Tuning proapoptotic activity of a phosphoric-acid-tethered tetraphenylethene by visible-light- triggered isomerization and switchable protein interactions for cancer therapy., Angewandte Chemie International Edition, 2022, 第 1 作者
（8） Hydrazone bond-oriented molecularly imprinted nanocomposites for the selective separation of protein via the well-defined recognition sites., Microchimica Acta, 2022, 第 4 作者
（9） Tuning Proapoptotic Activity of a Phosphoric-Acid-Tethered Tetraphenylethene by Visible-Light-Triggered Isomerization and Switchable Protein Interactions for Cancer Therapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 第 1 作者
（10） Recent progress of exosome isolation and peptide recognition-guided strategies for exosome research., Frontiers in Chemistry, 2022, 第 4 作者
（11） Metal-organic framework-based nanoheater with photo-triggered cascade effects for on-demand suppression of cellular thermoresistance and synergistic cancer therapy., Advanced Healthcare Materials, 2022, 第 2 作者  通讯作者
（12） Metal���Organic Framework Accelerated One-Step Capture and Reduction of Palladium to Catalytically Active Nanoparticles., ACS Applied Materials & Interfaces, 2022, 第 7 作者  通讯作者
（13） Photosensitizer with High Efficiency Generated in Cells via Light-Induced Self-Oligomerization of 4,6-Dibromothieno[3,4-b]thiophene Compound Entailing a Triphenyl Phosphonium Group., Advanced Healthcare Materials, 2021, 第 2 作者
（14） Activity-Based Probe for Ratiometric Fluorescence Imaging of Caspase-3 in Living Cells, ANALYTICAL CHEMISTRY, 2021, 第 3 作者
（15） Metal-organic frameworks as advanced materials for sample preparation of bioactive peptides, ANALYTICAL METHODS, 2021, 第 3 作者  通讯作者
（16） 亲和分离在蛋白质泛素化修饰研究中的应用进展, Advances in the application of affinity separation for analyzing protein ubiquitination, 色谱, 2021, 第 2 作者
（17） Selective recognition of a cyclic peptide hormone in human plasma by hydrazone bond-oriented surface imprinted nanoparticles, ANALYTICA CHIMICA ACTA, 2021, 第 5 作者
（18） Engineering peptide-functionalized biomimetic nanointerfaces for synergetic capture of circulating tumor cells in an EpCAM-independent manner., Analytical Chemistry, 2021, 第 6 作者  通讯作者
（19） Activity-based probe for ratiometric fluorescence imaging of caspase-3 in living cells., Analytical Chemistry, 2021, 第 3 作者
（20） Metal-organic frameworks as advanced materials for sample preparation of bioactive peptides., Analytical Methods, 2021, 第 3 作者  通讯作者
（21） Pyridinium-substituted tetraphenylethylenes functionalized with alkyl chains as autophagy modulators for cancer therapy., Angewandte Chemie International Edition, 2020, 第 1 作者
（22） Aggregation-Induced Emission Luminogens for Mitochondria-Targeted Cancer Therapy, CHEMMEDCHEM, 2020, 第 1 作者  通讯作者
（23） Pyridinium-Substituted Tetraphenylethylenes Functionalized with Alkyl Chains as Autophagy Modulators for Cancer Therapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2020, 第 1 作者
（24） 超高效液相色谱-质谱联用法监测人心房钠尿肽的化学合成, Monitoring chemical synthesis of human atrialnatriuretic peptide by ultra high performanceliquid chromatography-mass spectrometry analysis, 色谱, 2020, 第 3 作者
（25） Aggregation-induced emission luminogens for mitochondria-targeted cancer therapy., ChemMedChem, 2020, 第 1 作者  通讯作者
（26） Temperature-controlled ionic liquid dispersive liquid-liquid microextraction combined with fluorescence detection of ultra-trace Hg2+ in water, ANALYTICAL METHODS, 2019, 第 8 作者
（27） Biomimetic Sensing System for Tracing Pb2+ Distribution in Living Cells Based on the Metal-Peptide Supramolecular Assembly, ACS APPLIED MATERIALS & INTERFACES, 2019, 第 2 作者  通讯作者
（28） Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging, MOLECULES, 2019, 第 3 作者  通讯作者
（29） Peptide-Guided System with Programmable Subcellular Translocation for Targeted Therapy and Bypassing Multidrug Resistance, ANALYTICAL CHEMISTRY, 2019, 第 2 作者  通讯作者
（30） 基于血脑屏障靶向多肽的脑神经分析化学研究进展, Targeted Analysis of Central Nervous System Using Blood-Brain Barrier Shuttle Peptides, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2019, 第 1 作者
（31） Toward the Identification of Intensified Reaction Conditions Using Response Surface Methodology: A Case Study on 3-Methylpyridine N-Oxide Synthesis, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2019, 第 2 作者
（32） Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging., Molecules, 2019, 第 3 作者  通讯作者
（33） Peptide-Guided System with Programmable Subcellular Translocation for Targeted Therapy and Bypassing Multidrug Resistance., Analytical Chemistry, 2019, 第 2 作者  通讯作者
（34） Biomimetic sensing system for tracing Pb2+ distribution in living cells based on the metal���peptide supramolecular assembly., ACS Applied Materials & Interfaces, 2019, 第 2 作者  通讯作者
（35） Bioinspired Peptide for Imaging Hg2+ Distribution in Living Cells and Zebrafish Based on Coordination-Mediated Supramolecular Assembling, ANALYTICAL CHEMISTRY, 2018, 第 2 作者  通讯作者
（36） Investigating Subcellular Compartment Targeting Effect of Porous Coordination Cages for Enhancing Cancer Nanotherapy, SMALL, 2018, 第 3 作者
（37） Enzyme-MOF Nanoreactor Activates Nontoxic Paracetamol for Cancer Therapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2018, 第 2 作者
（38） Bioinspired Peptide for Imaging Hg2+ Distribution in Living Cells and Zebrafish Based on Coordination-Mediated Supramolecular Assembling., Analytical Chemistry, 2018, 第 2 作者  通讯作者
（39） Dual-targeting peptide probe for sequence- and structure-sensitive sensing of serum albumin, BIOSENSORS & BIOELECTRONICS, 2017, 第 2 作者  通讯作者
（40） Surface-imprinted magnetic nanoparticles for the selective enrichment and fast separation of fluoroquinolones in human serum, JOURNAL OF SEPARATION SCIENCE, 2017, 第 3 作者
（41） Probing the Dynamic Interaction between Damaged DNA and a Cellular Responsive Protein Using a Piezoelectric Mass Biosensor, ACS APPLIED MATERIALS & INTERFACES, 2017, 第 4 作者  通讯作者
（42） Rapid, sensitive, and in-solution screening of peptide probes for targeted imaging of live cancer cells based on peptide recognition-induced emission, CHEMICAL COMMUNICATIONS, 2017, 第 3 作者  通讯作者
（43） Well-defined magnetic surface imprinted nanoparticles for selective enrichment of 2,4-dichlorophenoxyacetic acid in real samples, TALANTA, 2017, 第 4 作者
（44） Dual-targeting peptide probe for sequence- and structure-sensitive sensing of serum albumin, BIOSENSORS & BIOELECTRONICS, 2017, 第 2 作者  通讯作者
（45） 脑啡肽的固相合成与LC-MS/MS分离鉴定, Separation and Characterization of Solid Phase Synthesized Enkephalins by LC-MS/MS, 分析测试学报, 2017, 第 3 作者
（46） Recent applications of surface molecularly imprinting materials land techniques for separation and analysis, CHINESE JOURNAL OF CHROMATOGRAPHY, 2016, 第 3 作者
（47） Emissive nanoparticles from pyridinium-substituted tetraphenylethylene salts: imaging and selective cytotoxicity towards cancer cells in vitro and in vivo by varying counter anions, CHEMICAL SCIENCE, 2016, 第 1 作者
（48） Self-Assembled Nanostructures Based on Activatable Red Fluorescent Dye for Site-Specific Protein Probing and Conformational Transition Detection, ANALYTICAL CHEMISTRY, 2016, 第 2 作者  通讯作者
（49） 表面分子印迹材料和技术在分离分析中的应用进展, Recent applications of surface molecularly imprinting materials and techniques for separation and analysis, 色谱, 2016, 第 3 作者
（50） Rational design and functional evolution of targeted peptides for bioanalytical applications, SCIENCE CHINA-CHEMISTRY, 2016, 第 1 作者
（51） A New Fluorometric Turn-on Assay for Carboxylesterase and Inhibitor Screening Based on Aggregation Induced Emission Behavior of Tetraphenylethylene Molecules, ACTA CHIMICA SINICA, 2016, 第 2 作者
（52） 新型四苯乙烯衍生物的设计合成及其在羧酸酯酶活性分析中的应用, A New Fluorometric Turn-on Assay for Carboxylesterase and Inhibitor Screening Based on Aggregation Induced Emission Behavior of Tetraphenylethylene Molecules, 化学学报, 2016, 第 2 作者
（53） A peptide-based pH-sensitive drug delivery system for targeted ablation of cancer cells, CHEMICAL COMMUNICATIONS, 2015, 第 2 作者  通讯作者
（54） A continuous-flow mass biosensor for the real-time dynamic analysis of protease inhibition, CHEMICAL COMMUNICATIONS, 2015, 第 1 作者
（55） Fluorescence Turn-On Chemosensor for Highly Selective and Sensitive Detection and Bioimaging of Al3+ in Living Cells Based on Ion-Induced Aggregation, ANALYTICAL CHEMISTRY, 2015, 第 2 作者
（56） 靶向多肽识别与高选择性分离分析, 色谱, 2015, 第 1 作者
（57） A highly selective fluorescence turn-on detection of hydrogen peroxide and d-glucose based on the aggregation/deaggregation of a modified tetraphenylethylene, TETRAHEDRON LETTERS, 2014, 第 2 作者
（58） Highly selective piezoelectric sensor for lead(II) based on the lead-catalyzed release of gold nanoparticles from a self-assembled nanosurface, MICROCHIMICA ACTA, 2014, 第 3 作者
（59） Well-defined nanostructured surface-imprinted polymers for highly selective magnetic separation of fluoroquinolones in human urine, ACS APPLIED MATERIALS & INTERFACES, 2014, 第 2 作者  通讯作者
（60） Tetraphenylethylene conjugated with a specific peptide as a fluorescence turn-on bioprobe for the highly specific detection and tracing of tumor markers in live cancer cells, CHEMISTRYAEUROPEANJOURNAL, 2014, 第 1 作者
（61） Preparation of monodispersed macroporous core���shell molecularly imprinted particles and their application in the determination of 2,4-dichlorophenoxyacetic acid, JOURNAL OF CHROMATOGRAPHY A, 2014, 第 4 作者
（62） A tetra-layer microfluidic system for peptide affinity screening through integrated sample injection, ANALYST, 2013, 第 2 作者
（63） Gold nanoparticle-sensitized quartz crystal microbalance sensor for rapid and highly selective determination of Cu(II) ions, ANALYST, 2013, 第 2 作者  通讯作者
（64） 高亲水性强阳离子交换色谱填料的制备及其在蛋白质分析中的应用, Preparation of highly hydrophilic strong cation exchangers and their applications in protein analysis, 色谱, 2013, 第 2 作者
（65） Highly selective analysis of proteins based on targetable peptide probes, 分析测试学报, 2012, 第 1 作者
（66） Discovery, Synthesis, and Evaluation of Small-Molecule Signal Transducer and Activator of Transcription 3 Inhibitors, CHEMICAL AND PHARMACEUTICAL BULLETIN, 2012, 第 3 作者
（67） Highly selective analysis of proteins based on targetable peptide probes, 分析测试学报, 2012, 第 1 作者
（68） Superparamagnetic surface molecularly imprinted nanoparticles for water-soluble pefloxacin mesylate prepared via surface initiated atom transfer radical polymerization and its application in egg sample analysis, JOURNAL OF CHROMATOGRAPHY A, 2012, 第 2 作者
（69） Cyclic interconversion of methionine containing peptide between oxidized and reduced phases monitored by reversed-phase HPLC and ESI-MS/MS, TALANTA, 2012, 第 2 作者  通讯作者
（70） Discovery, Synthesis, and Evaluation of Small-Molecule Signal Transducer and Activator of Transcription 3 Inhibitors, CHEMICAL & PHARMACEUTICAL BULLETIN, 2012, 第 3 作者
（71） Highly Specific Targeting and Imaging of Live Cancer Cells by Using a Peptide Probe Developed from Rationally Designed Peptides, CHEMBIOCHEM, 2011, 第 1 作者
（72） A rapid and highly selective colorimetric method for direct detection of tryptophan in proteins via DMSO acceleration, CHEMICAL COMMUNICATIONS, 2011, 第 1 作者
（73） Dynamic interaction between melamine and cyanuric acid in artificial urine investigated by quartz crystal microbalance, ANALYST, 2011, 第 2 作者
（74） A novel polychloromethylstyrene coated superparamagnetic surface molecularly imprinted core-shell nanoparticle for bisphenol A, JOURNAL OF MATERIALS CHEMISTRY, 2011, 第 4 作者
（75） Integrated SPPS on continuous-flow radial microfluidic chip, LAB ON A CHIP, 2011, 第 2 作者
（76） Multistimuli Responsive Organogels Based on a New Gelator Featuring Tetrathiafulvalene and Azobenzene Groups: Reversible Tuning of the Gel-Sol Transition by Redox Reactions and Light Irradiation, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2010, 第 6 作者
（77） 多肽型QCM生物传感器的构建及应用, 分析化学, 2009, 第 1 作者
（78） Determination of methotrexate in human serum by high-performance liquid chromatography combined with pseudo template molecularly iniprinted polymer, JOURNAL OF CHROMATOGRAPHY A, 2009, 第 3 作者
（79） Design, synthesis and screening of antisense peptide based combinatorial peptide libraries towards an aromatic region of SARS-CoV, JOURNAL OF MOLECULAR RECOGNITION, 2008, 第 1 作者
（80） In situ growth of nanogold on quartz crystal microbalance and its application in the interaction between heparin and antithrombin III, JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2008, 第 2 作者
（81） Determining binding sites of drugs on human serum albumin using FIA-QCM, BIOSENSORS & BIOELECTRONICS, 2008, 第 2 作者
（82） Study on peptide-peptide interaction using high-performance affinity chromatography and quartz crystal microbalance biosensor, CHINESE SCIENCE BULLETIN, 2007, 第 2 作者
（83） Quartz crystal microbalance biosensor for recombinant human interferon-beta detection based on antisense peptide approach, ANALYTICA CHIMICA ACTA, 2007, 第 3 作者
（84） New heterocyclic tetrathiafulvalene compounds with an azobenzene moiety: Photomodulation of the electron-donating ability of the tetrathiafulvalene moiety, JOURNAL OF ORGANIC CHEMISTRY, 2007, 第 3 作者
（85） 含双蒽基团酰胺受体分子的合成及阴离子识别研究, Studies on Synthesis and Anion Recognition of a Novel Amide Receptor Bearing Two Anthracene Substituents, 高等学校化学学报, 2003, 第 5 作者

Chapter 17: "Red-Emissive AIEgens Based on Tetraphenylethylene for Biological Applications" in the Handbook of Aggregation-Induced Emission., John Wiley & Sons Ltd., 2022-04, 第 1 作者

   

（ 1 ） 多蛋白靶标与膜曲率协同识别的凋亡囊泡亲和分离分析新方法, 负责人, 国家任务, 2024-01--2027-12
（ 2 ） 蛋白质高选择性分析, 负责人, 国家任务, 2021-01--2024-12