基本信息
李琳琳  女  硕导  纳米科学与技术学院
电子邮件: lilinlin@ucas.ac.cn
通信地址: 北京市怀柔区雁栖经济开发区杨雁东一路8号院
邮政编码:

招生信息

   
招生专业
0703J1-纳米科学与技术
071011-生物物理学
招生方向
纳米生物材料
纳米生物学

教育背景

2005-09--2008-07   中国科学院理化技术研究所   博士
2002-09--2005-07   北京师范大学   硕士
1998-09--2002-07   安徽大学   本科

工作经历

   
工作简历
2016-06~现在, 国家纳米科学中心, 青年研究员
2015-12~2016-05,国家纳米科学中心, 副研究员
2011-01~现在, 中国科学院理化技术研究所, 副研究员
2008-07~2010-12,中国科学院理化技术研究所, 助理研究员
2005-09~2008-07,中国科学院理化技术研究所, 博士
2002-09~2005-07,北京师范大学, 硕士
1998-09~2002-07,安徽大学, 本科

教授课程

微纳生物电子学与自驱动传感器

专利与奖励

   
奖励信息
(1) 万人计划青年拔尖人才, 特等奖, 国家级, 2020
(2) 2016年中科院青促会年会学术交叉奖, 院级, 2016
(3) 卢嘉锡青年人才奖, 院级, 2014
(4) 北京市科学技术奖, 三等奖, 省级, 2012
专利成果
( 1 ) 二硫化钼在干细胞增殖和/或分化中的应用及用于干细胞增殖/或分化的衬底及其应用, 2016, 第 2 作者, 专利号: 201610944176.1

( 2 ) 一种高效捕捉循环肿瘤细胞的微孔道装置和方法, 2016, 第 2 作者, 专利号: 201610596857.3

( 3 ) 一种具有磁共振成像与微波治疗肿瘤功能的微胶囊及其制备方法和应用, 2014, 第 5 作者, 专利号: 201410453005.X

( 4 ) 金壳包覆的中空介孔二氧化硅球及其制备方法和在肿瘤治疗方面的用途, 2008, 第 4 作者, 专利号: 200810224011.2

( 5 ) 负载了缓释细胞生长因子的具有内核的中空二氧化硅球的人体组织工程支架及其制法和用途, 2008, 第 3 作者, 专利号: 200810224013.1

( 6 ) 可缓控释治疗性药物的高分子复合纤维手术缝合线及其制备方法, 2008, 第 3 作者, 专利号: 200810224012.7

( 7 ) 双壳层药物缓控释载体材料及其制备方法和用途, 2006, 第 2 作者, 专利号: 200610113976.5

( 8 ) 具有内核的中空二氧化硅亚微米球及其制备方法和用途, 2006, 第 3 作者, 专利号: 200610089184.9

( 9 ) 磁靶向药物缓控释载体材料及其制备方法和用途, 2006, 第 3 作者, 专利号: 200610081252.7

出版信息

   
发表论文
(1) Piezoelectric Nanotopography Induced Neuron-Like Differentiation of Stem Cells., Adv. Funct. Mater., 2019, 通讯作者
(2) Transparent and Stretchable Triboelectric Nanogenerator for Self-Powered Tactile Sensing, Nano Energy, 2019, 通讯作者
(3) Self-powered Intracellular Drug Delivery by a Biomechanical Energy-Driven Triboelectric Nanogenerator, Adv. Mater., 2019, 通讯作者
(4) Piezoelectric Effect Enhanced Full-Spectrum Photoelectrocatalysis in p-n Heterojunction, Adv. Funct. Mater., 2019, 通讯作者
(5) Regulation of Ca2+ Signaling for Drug-Resistant Breast Cancer Therapy with Mesoporous Silica Nanocapsules Encapsulated Doxorubicin/siRNA Cocktail, ACS Nano, 2019, 通讯作者
(6) Self-Assembled Copper-Amino Acid Nanoparticles for In Situ Glutathione “AND” H2O2 Sequentially Triggered Chemodynamic Therapy, J. Am. Chem. Soc., 2019, 通讯作者
(7) Piezoelectric polyacrylonitrile nanofiber film based dual-function self-powered flexible sensor., ACS Appl. Mater. Inter., 2018, 通讯作者
(8) Killing two birds with one stone: to eliminate the toxicity and enhance the photocatalytic property of CdS nanobelts by assembling ultrafine TiO2 nanowires on them, Sol. Energ. Mat. Sol. C., 2018, 通讯作者
(9) Heterostructured Nanorod Array with Piezophototronic and Plasmonic Effect for Photodynamic Bacteria Killing and Wound Healing., Nano Energy, 2018, 通讯作者
(10) Nanostructured molybdenum disulfide biointerface for adhesion and osteogenic differentiation of mesenchymal stem cells., Appl. Mater Today, 2018, 通讯作者
(11) Photothermally Tunable Biodegradation of Implantable Triboelectric Nanogenerators for Tissue Repairing, Nano Energy, 2018, 通讯作者
(12) High-Performance Wearable Supercapacitors Fabricated with Surface Activated Continuous Filament Graphite Fibers, Journal of Power Sources, 2017, 通讯作者
(13) Nanostructured molybdenum disulfide film for promoting neural stem cell neuronal differentiation: towards nerve tissue-engineered 3D scaffold., Advanced Biosystems, 2017, 通讯作者
(14) Structural Effect of Fe3O4 Nanoparticles on Peroxidase-Like Activity for Cancer Therapy, Colloid. Surface. B, 2017, 通讯作者
(15) Hierarchical Porous Carbon with Ordered Striaight Micro-Channels Templated by Continuous Filament Glass Fiber Array for High Performance Supercapacitor., J. Mater. Chem. A, 2017, 通讯作者
(16) One-Step Synthesis of Ultrathin Nanobelts-Assembled Urchin-Like Anatase TiO2 Nanostructures for Highly Efficient Photocatalysis, CrystEngComm, 2017, 通讯作者
(17) Biodegradable inorganic nanoparticles: an opportunity for improved cancer therapy?, Nanomedicine-UK, 2017, 通讯作者
(18) TiO2 Nanorod Array as Highly Affinitive Nano-Bio Interface of Microfluidic Device for Efficient Capture of Circulating Tumor Cells, Nano Research, 2017, 通讯作者
(19) Application of bacterial magnetic nanoparticles in nanobiotechnology., J. Nanosci. Nanotechnol., 2016, 通讯作者
(20) Size Effect of Mesoporous and Hollow Silica nanoparticles on Solid Tumor Targeting and Penetration., J. Nanosci. Nanotechnol., 2016, 通讯作者
(21) High-yield preparation of robust gold nanoshells on silica nanorattles with good biocompatibility., Sci. Bull., 2016, 通讯作者
(22) Rutile nanorod/anatase nanowire junction array as both sensor and power supplier for high performance wireless UV photodetector., Small, 2016, 通讯作者
(23) Self-powered electrical stimulation for enhancing neural differentiation of MSCs on graphene-PEDOT hybrid microfibers., ACS Nano, 2016, 通讯作者
(24) Multifunctional Carbon-Silica Nanocapsules with Gold Core for Synergistic Photothermal and Chemo- Cancer Therapy under the Guidance of Bimodal Imaging., Adv. Funct. Mater., 2016, 通讯作者
(25) Microenvironment-Driven Bioelimination of Magnetoplasmonic Nanoassemblies and Their Multimodal Imaging Guided Tumor Photothermal Therapy., ACS Nano, 2016, 通讯作者
(26) Bacterial magnetic nanoparticles for photothermal therapy of cancer under the guidance of MR imaging, Biomaterials, 2016, 通讯作者
(27) Biosynthesis of fluorescent gold nanoclusters for in vitro and in vivo tumor imaging., Opt. Commun., 2015, 通讯作者
(28) Biodistribution, excretion, and toxicity of mesoporous silica nanoparticles after oral administration depend on their shape., Nanomed-Nanotechnol., 2015, 通讯作者
(29) Fluorescence switching method for cascade detection of salicylaldehyde and Zinc(II) ion using protein protected gold nanoclusters., Biosens. Bioelectron., 2015, 通讯作者
(30) Multifuntional silica-based nanocomposites for cancer nanotheranostics., J. Biomed. Nanotechnol., 2014, 第 1 作者
(31) Overcoming Multidrug Resistance with Mesoporous Silica Nanorods as Nanocarrier of Doxorubicin, Jounal of Nanoscience and Nanotechnology , 2012, 第 1 作者
(32) Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior, Chinese Science Bulletin., 2012, 第 1 作者
(33) Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery, Advanced Materials, 2012, 第 2 作者
(34) Doxorubicin loaded silica nanorattle actively homing to tumor with improved anti-tumor effect., Nanoscale, 2012, 第 2 作者
(35)  The shape effect of PEGylated mesoporous silica nanoparticles on cellular uptake pathway in Hela cells., Micropor. Mesopor. Mat. , 2012, 第 2 作者
(36) The Shape Effect of Mesoporous Silica Nanoparticles on Biodistribution, Clearance and Biocompatibility in vivo, ACS Nano, 2011, 第 1 作者
(37) Silica Nanorattle_Doxorubicin-Anchored Mesenchymal Stem Cells for Tumor-Tropic Therapy, ACS Nano, 2011, 第 1 作者
(38) Single and Repeated Dose Toxicity of Mesoporous Hollow Silica Nanoparticles in Intravenously Exposed Mice., Biomaterials, 2011, 第 2 作者
(39) In Vivo Delivery of Silica Nanorattle Encapsulated Docetaxel for Liver Cancer Therapy with Low Toxicity and High Efficacy, ACS Nano, 2010, 第 1 作者
(40) Facile and Scalable Synthesis of Tailored Silica “Nanorattle” Structures. , Advanced Materials, 2009, 第 1 作者
(41) Preparation and Characterization of Quantum Dots Coated Magnetic Hollow Spheres for Magnetic Fluorescent Multimodal Imaging and Drug Delivery, Jounal of Nanoscience and Nanotechnology, 2009, 第 1 作者
发表著作
Multifunctional Mesoporous/Hollow Silica for Cancer Nanotheranostics, Advances in Nanotheranostics II, Springer Verlag, 2015-09, 第 2 作者
Gold Nanoparticles and Their Bioapplications, John Wiley and Sons Ltd., 2018-03, 第 3 作者
Hybrid Nanocapsules for Imaging-Guided Synergistic Theranostics, Elsevier, 2019-03, 第 3 作者

科研活动

   
科研项目
( 1 ) 间充质干细胞携带药物控释纳米颗粒靶向治疗脑胶质瘤的原理研究, 负责人, 国家任务, 2010-01--2012-12
( 2 ) 诊疗一体化多级纳米超分子组装体的构建及提高肿瘤靶向输送的研究, 负责人, 国家任务, 2015-01--2018-12
( 3 ) 间充质干细胞靶向协同纳米金壳夹心二氧化硅增敏热化疗治疗恶性肿瘤的研究, 负责人, 国家任务, 2013-01--2016-12
( 4 ) 磁性荧光夹心二氧化硅复合颗粒药物靶向输送联合MRI影像/荧光双重影像治疗恶性肿瘤的研究, 负责人, 研究所自选, 2013-07--2015-06
( 5 ) 青年促进会, 负责人, 中国科学院计划, 2015-01--2018-12
( 6 ) 具有纳米结构和压电性能的生物支架调控干细胞神经分化用于神经缺损修复, 负责人, 地方任务, 2017-01--2019-12
( 7 ) 具有化学动力学和钙信号调控协同效应的纳米药物构建及抗肿瘤研究, 负责人, 国家任务, 2020-01--2022-12
( 8 ) 万人计划青年拔尖人才计划, 负责人, 国家任务, 2020-01--2023-12
参与会议
(1)Size Effect of Mesoporous and Hollow Silica nanoparticles on Tumor Targeting and Penetration   2014-04-13
(2) Different Mesoporous Silica Drug Delivery System and their Biological Effect.   Linlin Li   2010-06-21