1. Decoding the genetic and epigenetic mechanisms of human aging

2. Stem cell-based disease mechanism research and precision medicine on human diseases

3. Development and application of new gene-editing methods and gene therapy technologies

1997-2002, B.S., Peking University Health Science Center

2002-2007, Ph.D., Institute of Biophysics, Chinese Academy of Sciences

2007-2009, Research associate, Dept. of Cell and Molecular Biology, The Scripps Research Institute

2009-2012, Research associate, Gene expression laboratory, The Salk Institute for Biological Studies

2012-2019, Professor, Institute of Biophysics, Chinese Academy of Sciences

2019-, Professor, Institute of Zoology, Chinese Academy of Sciences

2024, Chief scientist of Basic Science Center Program of NSFC

2024, Prize for Scientific and Technological Innovation of the Ho Leung Ho Lee Foundation

2024, Outstanding Contribution Scientist in Stem Cell Research

2023, Fellow of the International Union of Physiological Sciences (IUPS) Academy

2023, National Innovation Pioneer Medal

2023, Top 10 Science Advances in China

2023, Top 10 Scientific Advances in Life Sciences of China

2023, China Annuel Medical Innovation

2023, Most Cited Chinese Researchers (ELSEVIER)

2023, Second-class Beijing Science and Technology Award (first place)

2022, Fellow of the Academic Advisory Committee of the Chinese Academy of Medical Sciences

2022, Outstanding scientific, technological, and managerial talents with significant contributions in Beijing

2022, Most Cited Chinese Researchers (ELSEVIER)

2022, First prize for the Overseas Chinese Contribution Award

2022, China Medical Science and Technology Award

2021, XPLORER PRIZE

2021, Most Cited Chinese Researchers (ELSEVIER)

2021, Beijing Outstanding Youth Zhongguancun Award

2021, Most Picked Paper Award 2020 (Chinese Scientists with Cell Press)

2020, Most Cited Chinese Researchers (ELSEVIER)

2020, Top 10 Science Advances in China

2020, Top 10 Scientific Advances in Life Sciences of China

2020, Outstanding Science and Technology Achievement Prize of the Chinese Academy of Sciences

2020, Chief Scientist of National Key R&D Program

2019, China Youth Science and Technology Award (special prize)

2019, Chief scientist of Science Fund for Creative Research Groups of NSFC

2019, Gu Xiaocheng Lecture Award

2019, Stem Cell Research Innovation Award

2019, The VCANBIO Award for Innovation and Breakthroughs in Life Sciences and Medicine

2019, Wuxi AppTec Life Science and Chemistry Awards

2019, Promega Innovation Award

2018, Tan Jiazhen Prize in Life Sciences Innovation

2018, Top 10 Scientific Advances in Life Sciences of China

2017, Beijing Science and Technology Award

2017, Shulan Medical Youth Award

2017, Youth Scientist of Chinese Academy of Sciences

2017, CSCB Young Investigator

2017, Gerontology Outstanding Contribution Award

2016, Innovative Award of “the Capital of Ten Scientific and Technological Research and Management Plan”

2016, National Science Fund for Distinguished Young Scholars

2015, Chief scientist of the National Key Basic Research Program of China

2015, Bill and Melinda Gates Foundation Grand Challenges-Young Scientist

2015, CSSCR Stem Cell Young Investigator Award

2013, Bei Shi-Zhang Young Scientist Award in Biophysics

2012, National Science Fund for Excellent Young Scholars

Selected Publications:

1. Yang Y, Lu X, Liu N, Ma S, Zhang H, Zhang Z, Yang K, Jiang M, Zheng Z, Qiao Y, Hu Q, Huang Y, Zhang Y, Xiong M, Liu L, Jiang X, Reddy P, Dong X, Xu F, Wang Q, Zhao Q, Lei J, Sun S, Jing Y, Li J, Cai Y, Fan Y, Yan K, Jing Y, Haghani A, Xing M, Zhang X, Zhu G, Song W, Horvath S, Rodriguez Esteban C, Song M, Wang S, Zhao G, Li W, Izpisua Belmonte JC, Qu J*, Zhang W*, Liu GH*. Metformin decelerates aging clock in male monkeys. Cell. 2024. S0092-8674(24)00914-0. doi: 10.1016/j.cell.2024.08.021.

2. Ma S, Ji Z, Zhang B, Geng L, Cai Y, Nie C, Li J, Zuo Y, Sun Y, Xu G, Liu B, Ai J, Liu F, Zhao L, Zhang J, Zhang H, Sun S, Huang H, Zhang Y, Ye Y, Fan Y, Zheng F, Hu J, Zhang B, Li J, Feng X, Zhang F, Zhuang Y, Li T, Yu Y, Bao Z, Pan S, Esteban CR, Liu Z, Deng H, Wen F, Song M, Wang S, Zhu G, Yang J, Jiang T, Song W, Belmonte JCI, Qu J*, Zhang W*, Gu Y*, Liu GH*. Spatial Transcriptomic Landscape Unveils Immunoglobin-associated Senescence as a Hallmark of Aging. Cell. 2024. in press.

3. Wang Q, Wang X, Liu B, Ma S, Zhang F, Sun S, Jing Y, Fan Y, Ding Y, Xiong M, Li J, Zhai Q, Zheng Y, Liu C, Xu G, Yang J, Wang S, Ye J, Belmonte JCI, Qu J*, Liu GH*, Zhang W*. Aging induces region-specific dysregulation of hormone synthesis in the primate adrenal gland. Nature Aging. 2024. 4(3):396-413.

4. Bi S, Jiang X, Ji Q, Wang Z, Ren J, Wang S, Yu Y, Wang R, Liu Z, Liu J, Hu J, Sun Q, Wu Z, Diao Z, Li J, Sun L, Belmonte JCI, Zhang W*, Liu GH*, Qu J*. The Sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA. Developmental Cell. 2024. S1534-5807(24)00107-2.

5. Li HY, Wang M, Jiang X, Jing Y, Wu Z, He Y, Yan K, Sun S, Ma S, Wang S, Belmonte JCI, Qu J*, Zhang W*, Wei T*, Liu GH*. CRISPR screening uncovers nucleolar RPL22 as a heterochromatin destabilizer and senescence driver. Nucleic Acids Research. 2024. doi: 10.1093/nar/gkae740. 

6. Sun S, Li J, Wang S, Li J, Ren J, Bao Z, Sun L, Ma X, Zheng F, Ma S, Sun L, Wang M, Yu Y, Ma M, Wang Q, Chen Z, Ma H, Wang X, Wu Z, Zhang H, Yan K, Yang Y, Zhang Y, Zhang S, Lei J, Teng ZQ, Liu CM, Bai G, Wang YJ, Li J, Wang X, Zhao G, Jiang T, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. CHIT1-positive microglia drive motor neuron aging in the primate spinal cord. Nature. 2023. 624(7992):611-620.

7. Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C,  Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. Resurrection of endogenous retroviruses during aging reinforces senescence. Cell. 2023. 186(2):287-304.

8. Jing Y, Jiang X, Ji Q, Wu Z, Wang W, Liu Z, Guillen-Garcia P, Eseban CR, Ready P, Horvath S, Li J, Geng L, Hu Q, Wang S, Belmonte JCI, Ren J*, Zhang W*, Qu J*, Liu GH*. Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation. Cell Stem Cell. 2023. 30(11):1452-1471.

9. Cai Y, Xiong M, Xin Z, Liu C, Jie R，Yang X, Lei J, Li W, Liu F, Chu Q, Yin J, Ye Y, Liu D, Fan Y, Sun S, Zhao Q, Zhao L, Che S, Zheng Y, Yan H, Ma S, Wang S, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Decoding aging-dependent regenerative decline across tissues at single-cell resolution. Cell Stem Cell. 2023. 30(12):1674-1691.e8.

10. Ye Y, Yang K, Liu H, Yu Y, Song M, Huang D, Lei J, Zhang Y, Liu Z, Chu Q, Fan Y, Zhang S, Jing Y, Esteban CR, Wang S, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B. Nature Aging. 2023. 3(10):1269-1287. (Cover story)

11. Wu Z, Lu M, Liu D, Shi Y, Ren J, Wang S, Jing Y, Zhang S, Zhao Q, Li H, Yu Z, Liu Z, Bi S, Wei T, Yang Y, Xiao J, Belmonte JCI, Qu J*, Zhang W*, Ci W*, Liu GH*. M⁶A epitranscriptomic regulation of tissue homeostasis during primate aging. Nature Aging. 2023. 3(6):705-721. (Cover story)

12. Li J, Xiong M, Fu XH, Fan Y, Dong C, Sun X, Zheng F, Wang SW, Liu L, Xu M, Wang C, Ping J, Che S, Wang Q, Yang K, Zuo Y, Lu X, Zheng Z, Lan T, Wang S, Ma S, Sun S, Zhang B, Chen CS, Cheng KY, Ye J, Qu J, Xue Y, Yang YG*, Zhang F*, Zhang W*, Liu GH*. Determining a Multimodal Aging Clock in a Cohort of Chinese Women. Med. 2023. 4(11):825-848.e13. (Cover story)

13. Zhang H, Li J, Yu Y, Ren J, Liu Q, Bao Z, Sun S, Liu X, Ma S, Liu Z, Yan K, Wu Z,  Fan Y, Sun X, Zhang Y, Ji Q, Cheng F, Wei PH, Ma X, Zhang S, Xie Z, Niu Y, Wang WY, Han JD, Jiang T, Zhao G, Ji W, Belmonte JCI, Wang S*, Qu J*, Zhang W*, Liu GH*. Nuclear lamina erosion-induced resurrection of endogenous retroviruses underlies neuronal aging. Cell Reports. 2023. 42(6):112593.

14. Sun S, Ma S, Cai Y, Wang S, Ren J, Yang Y, Ping J, Wang X, Zhang Y, Yan H, Li W, Esteban CR, Yu Y, Liu F, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A Single-cell Transcriptomic Atlas of Exercise-induced Anti-inflammatory and Geroprotective Effects across the Body. Innovation. 2023. 4(1):100380.

15. Yan K, Ji Q, Zhao D, Li M, Sun X, Wang Z, Liu X, Liu Z, Li H, Ding Y, Wang S, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. SGF29 nuclear condensates reinforce cellular aging. Cell Discovery. 2023. 9(1):110.

16. Sun G, Zheng Y, Fu X, Zhang W, Ren J, Ma S, Sun S, He X, Wang Q, Ji Z, Cheng F, Yan K, Liu Z, Belmonte JCI, Qu J*, Wang S*, Chai R*, Liu GH*. Single-Cell Transcriptomic Atlas of Mouse Cochlear Aging. Protein Cell. 2023. 14(3):180-201. (Cover story)

17. Cheng F, Ji Q, Wang L, Wang CC, Liu GH*, Wang L*. Reducing oxidative protein folding alleviates senescence by minimizing ER-to-nucleus H₂O₂ release. EMBO Reports. 2023. 24(8):e56439. (Cover story)

18. Yang S, Liu C, Jiang M, Liu X, Geng L, Zhang Y, Sun S, Wang K, Yin J, Ma S, Wang S, Izpisua Belmonte JC, Zhang W*, Qu J*, Liu GH*. A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes. Protein Cell. 2023. 15(2):98-120.

19. Wang C, Yang K, Liu X, Wang S, Song M, Belmonte JCI, Qu J*, Liu GH*, Zhang W*. MAVS antagonizes human stem cell senescence as a mitochondrial stabilizer. Research. 2023. 6:0192.

20. Jing Y, Zuo Y, Sun L, Yu ZR, Ma S, Hu H, Zhao Q, Huang D, Zhang W, Belmonte JCI, Yu Y*, Qu J*, Liu GH*, Wang S*. SESN1 is a FOXO3 effector that counteracts skeletal muscle aging in primates. Cell Proliferation. 2023. 56(5):e13455.

21. Ma S, Wang S, Ye Y, Ren J, Chen R, Li W, Li J, Zhao L, Zhao Q, Sun G, Jing Y, Zuo Y, Xiong M, Yang Y, Wang Q, Lei J, Sun S, Long X, Song M, Yu S, Chan P, Wang J, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Heterochronic parabiosis induces systemic rejuvenation and stem cell revitalization across aged tissues. Cell Stem Cell. 2022. 29(6):990-1005.

22. Liu Z, Ji Q, Ren J, Yan P, Wu Z, Wang S, Sun L, Wang Z, Li J, Sun G, Liang C, Sun R, Jiang X, Hu J, Ding Y, Wang Q, Bi S, Wei G, Cao G, Zhao G, Wang H, Zhou Q, Belmonte JCI, Qu J*, Zhang W*, Liu GH*. Large-Scale Chromatin Reorganization Reactivates Placenta-Specific Genes that Drive Cellular Aging. Developmental Cell. 2022. 57(11):1347-1368.

23. Zhao H, Ji Q, Wu Z, Wang S, Ren J, Yan K, Wang Z, Hu J, Chu Q, Hu H, Cai Y, Wang Q, Huang D, Ji Z, Li J, Belmonte JCI, Song M*, Zhang W*, Qu J*, Liu GH*. Destabilizing heterochromatin by APOE mediates senescence. Nature Aging. 2022. 2(4):303-316.

24. Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, Wang Z, Chen H, Xia K, Lai X, Wang Q, Yang K, Li W, Wu Z, Wang C, Yan H, Jiang X, Ji Z, Ma M, Long X, Wang S, Wang H, Sun H, Belmonte JCI, Qu J*, Xiang AP*, Liu GH*. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Research. 2022. 50(6):3323-3347.

25. Kang W, Jin T, Zhang T, Ma S, Yan H, Liu Z, Ji Z, Cai Y, Wang S, Song M, Ren J, Hu B, Zhou Q, Zhang W*, Qu J*, Bao Y*, Liu GH*. Regeneration Roadmap: database resources for regenerative biology. Nucleic Acids Research. 2022. 50(D1):D1085-D1090.

26. Yan H, Wang R, Ma S, Huang D, Wang S, Ren J, Lu C, Chen X, Zhang W*, Qu J*, Zhou Y*, Liu GH*. Lineage Landscape: A comprehensive database that records lineage commitment across species. Nucleic Acids Research. 2022.51(D1):D1061-D1066.

27. Liu ZP, Li W, Geng L, Sun L, Wang Q, Yu Y, Yan P, Liang C, Ren J, Song M, Zhao Q, Lei J, Cai Y, Li J, Yan K, Wu Z, Chu Q, Li J, Wang S, Li C, Han JD, Hernandez-Benitez R, Shyh-Chang Ng, Izpisua Belmonte JC, Zhang WQ*, Qu J*, Liu GH*. Cross-species metabolomic analysis identifies uridine as a potent regeneration promoting factor. Cell Discovery. 2022. 1;8(1):6.

28. Shan H, Geng L, Jiang X, Song M, Wang J, Liu Z, Zhuo X, Wu Z, Ji Z, Wang S, Chan P, Qu J*, Zhang W*, Liu GH*. Large-Scale Chemical Screen Identifies Gallic Acid as a Geroprotector for Human Stem Cells. Protein Cell. 2022. 13(7):532-539.

29. Jing Y, Zuo Y, Yu Y, Sun L, Yu ZR, Ma S, Zhao Q, Hu H, Li J, Liu L, Sun G, Li J, Belmonte JCI, Zhang W*, Wang S*, Qu J*, Liu GH*. Single-nucleus Profiling Unveils a Geroprotective Role of the FOXO3 in Primate Skeletal Muscle Aging. Protein Cell. 2022.14(7):497-512.

30. Yuan B, Zhou X, Suzuki K, Ramos-Mandujano G, Wang M, Tehseen M, Cortés-Medina LV, Moresco JJ, Dunn S, Hernandez-Benitez R, Hishida T, Kim NY, Andijani MM, Bi C, Ku M, Takahashi Y, Xu J, Qiu J, Huang L, Benner C, Aizawa E, Qu J, Liu GH, Li Z, Yi F, Ghosheh Y, Shao C, Shokhirev M, Comoli P, Frassoni F, Yates JR 3rd, Fu XD, Esteban CR, Hamdan S, Li M, Izpisua Belmonte JC. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing. Nature Communications. 2022. 13(1):3646.

31. Hishida T, Yamamoto M, Hishida-Nozaki Y, Shao C, Huang L, Wang C, Shojima K, Xue Y, Hang Y, Shokhirev M, Memczak S, Sahu SK, Hatanaka F, Ros RR, Maxwell MB, Chavez J, Shao Y, Liao HK, Martinez-Redondo P, Guillen-Guillen I, Hernandez-Benitez R, Esteban CR, Qu J, Holmes MC, Yi F, Hickey RD, Garcia PG, Delicado EN, Castells A, Campistol JM, Yu Y, Hargreaves DC, Asai A, Reddy P, Liu GH, Izpisua Belmonte JC. In vivo partial cellular reprogramming enhances liver plasticity and regeneration. Cell Reports. 2022. 39(4):110730.

32. Wang W, Zheng Y, Sun S, Li W, Song M, Ji Q, Wu Z, Liu Z, Fan Y, Liu F, Li J, Esteban CR, Wang S, Zhou Q, Belmonte JCI, Zhang W*, Qu J*, Tang F*, Liu GH*. A Genome-wide CRISPR-Based Screen Identifies KAT7 as a Senescence Driver. Science Translational Medicine. 2021.13, Jan 6;13(575):eabd2655.

33. Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S, Wang S, He Y, Esteban CR, Huang J, Yu N, Chan P, Belmonte JCI, Zhang W*, Qu J*, Liu GH*. A single-cell transcriptomic atlas of human skin aging. Developmental Cell. 2021. 56(3):383-397 (Cover story)

34. Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W*, Qu J*, Liu GH*. Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2021. 31(2):187-205.

35. Wang S, Yao X, Ma S, Ping Y, Fan Y, Sun S, He Z, Shi Y, Sun L, Xiao S, Song M, Cai J, Li J, Tang R, Zhao L, Wang C, Wang Q, Zhao L, Hu H, Liu X, Sun G, Chen L, Pan G, Chen H, Li Q, Zhang P, Xu Y, Feng H, Zhao GG, Wen T, Yang Y, Huang X, Li W, Liu Z, Wang H, Wu H, Hu B, Ren Y, Zhou Q, Qu J*, Zhang W*, Liu GH*, Bian XW*. A Single-cell Transcriptomic Landscape of the Human COVID-19 Lung. Nature Cell Biology. 2021. 23(12):1314-1328 (Leading contact)

36. Zhang H, Li J, Ren J, Sun S, Ma S, Zhang W, Yu Y, Cai Y, Yan K, Li W, Hu B, Chan P, Zhao GG, Belmonte JCI, Zhou Q, Qu J*, Wang S*, Liu GH*. Single-nucleus transcriptomic landscape of primate hippocampal aging. Protein Cell. 2021. 12(9):695-716. (Cover story)

37. Aging Atlas Consortium, Zhang W*, Jing Qu*, Bao Y*, Liu GH*. Aging Atlas: a multi-omics database for aging biology. Nucleic Acids Research. 2021. 8;49(D1):D825-D830.

38. Li H, Wei X, Zhou L, Zhang W, Wang C, Guo Y, Li D, Chen J, Liu T, Zhang Y, Ma S, Wang C, Tan F, Xu J, Liu Y, Yuan Y, Chen L, Wang Q, Qu J, Shen Y, Liu S, Fan G, Liu L, Liu X, Hou Y, Liu GH*, Gu Y*, Xu X*. Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis. Protein Cell.  2021. 12(1):57-66.

39. Li CJ, Xiao Y, Sun YC, He WZ, Liu L, Huang M, He C, Huang M, Chen KC, Hou J, Feng X, Su T, Guo Q, Huang Y, Peng H, Yang M, Liu GH, Luo XH. Senescent immune cells release Grancalcin to promote skeletal aging. Cell Metabolism. 2021.33(10):1957-1973.

40. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Izpisua Belmonte JC*, Jing Qu*, Tang F*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180(3):585-600. (Cover story)

41. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JCI*, Zhang W*, Qu J*, Liu GH*. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020. 180(5):984-1001.

42. Ma S, Sun S, Li J, Fan Y, Qu J, Sun L, Wang S, Zhang Y, Yang S, Liu Z, Wu Z, Zhang S, Wang Q, Zheng A, Duo S, Yu Y, Belmonte JCI, Chan P, Zhou Q, Song M*, Zhang W*, Liu GH*. Single-Cell Transcriptomic Atlas of Primate Cardiopulmonary Aging. Cell Research. 2020. 10;1-18.

43. Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W*, Sun Q*, Qu J*, Liu GH*. Genome-wide R-loop landscapes during cell differentiation and reprogramming. Cell Reports. 2020. 32(1):107870

44. Wang F, Zhang W, Yang Q, Kang Y, Fan Y, Wei J, Liu Z, Dai S, Li H, Li Z, Xu L, Chu C, Qu J, Si C, Ji W*, Liu GH*, Long C*, Niu Y*. Generation of a Hutchinson-Gilford progeria syndrome monkey model by base editing. Protein Cell. 2020. 11(11):809-824. (Cover story)

45. Zheng Y, Liu X, Le W, Xie L, Li H, Wen W, Wang S, Ma S, Huang Z, Ye J, Shi W, Ye Y, Liu Z, Song M, Zhang W, Belmonte JCI, Xiao C, Qu J*, Wang H*, Liu GH*, Su W*. A human circulating immune cell landscape in aging and COVID-19. Protein Cell. 2020. 192:111357.

46. Wang S, Min Z, Ji Q, Geng L, Su Y, Liu Z, Hu H, Wang L, Zhang W, Suzuiki K, Huang Y，Zhang P, Tang T, Qu J*, Yu Y*, Liu GH*, Qiao J*. Rescue of Premature Aging Defects in Cockayne Syndrome Stem Cells by CRISPR/Cas9-Mediated Gene Correction. Protein Cell. 2020. 11(1):1-22.

47. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Izpisua Belmonte JC, Qu J*, Tang F*, Liu GH*. FOXO3-Engineered Human ESC-Derived Vascular Cells Promote Vascular Protection and Regeneration. Cell Stem Cell. 2019. 24(3), 447-461. (Cover story)

48. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Izpisua Belmonte JC, Chan P, Qu J*, Liu GH*. Stabilizing Heterochromatin by DGCR8 Alleviates Senescence and Osteoarthritis. Nature Communications. 2019.10(1):3329.

49. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Izpisua Belmonte JC, Chan P, Qu J*, Tang F*, Liu GH*. Upregulation of FOXD1 by YAP Alleviates Senescence and Osteoarthritis. PLoS Biology. 2019. 17(4):e3000201.

50. Ling C, Liu Z, Song M, Zhang W, Wang S, Liu X, Ma S, Sun S, Fu L, Chu Q, Izpisua Belmonte JC, Wang Z, Qu J*, Yuan Y*, Liu GH*. Modeling CADASIL Vascular Pathologies with Patient-Derived Induced Pluripotent Stem Cells. Protein Cell. 2019. 10(4):249-271.

51. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J*, Tang F*, Liu GH*. Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis. Cell Reports. 2019. 26(13):3643-3656.

52. Geng L, Liu Z, Zhang W*, Li W, Wu Z, Wang W, Ren R, Su Y, Wang P, Ju Z, Chan P, Song M*, Qu J*, Liu GH*. Chemical Screen Identifies a Geroprotective Role of Quercetin in Premature Aging. Protein Cell. 2019. 10(6):417-435.

53. Zhang W, Wan H, Feng G, Qu J, Wang J, Jing Y, Ren R, Liu Z, Zhang L, Chen Z, Wang S, Zhao Y, Wang Z, Yuan Y, Zhou Q, Li W*, Liu GH*, Hu B*. SIRT6 Deficiency Results in Developmental Retardation in Cynomolgus Monkeys. Nature. 2018. 560(7720):661-665 (Leading contact)

54. Wang S, Hu B, Ding Z, Dang Y, Wu J, Li D, Liu X, Xiao B, Zhang W, Ren R, Lei J, Hu H, Chen C, Chan P, Li D, Qu J*, Tang F*, Liu GH*. ATF6 Safeguards Organelle Homeostasis and Cellular Aging in Human Mesenchymal Stem Cells. Cell Discovery. 2018. Jan 5;4:2. 

55. Fang J, Yang J, Wu X, Zhang G, Li T, Zhang H, Wang CC, Liu GH*, Wang L*. Metformin Alleviates Human Cellular Aging by Upregulating the ER Peroxidase GPx7. Aging Cell. 2018.17(4):e12765.

56. Wu Z, Zhang W, Song M, Wang W, Wei G, Li W, Lei J, Huang Y, Sang Y, Chan P, Chen C, Qu J*, Suzuki K*, Izpisua Belmonte JC*, Liu GH*. Differential Stem Cell Aging Kinetics in Hutchinson–Gilford Progeria Syndrome and Werner Syndrome. Protein Cell. 2018. 9(4):333-350. (Cover story)

57. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T*, Qu J*, Liu GH*. Visualization of Aging-associated Chromatin Alterations with an Engineered Tale System. Cell Research. 2017. 27(4):483-504. (Cover story)

58. Yang J, Li J, Suzuki K, Liu X, Wu J, Zhang W, Ren R, Zhang W, Chan P, Izpisua Belmonte JC, Qu J*, Tang F*, Liu GH*. Genetic Enhancement in Cultured Human Adult Stem Cells Conferred by a Single Nucleotide Recoding. Cell Research. 2017. 27(9):1178-1181.

59. Wang L, Yi F, Fu L, Yang J, Wang S, Wang Z, Suzuki K, Sun L, Xu X, Yu Y, Qiao J, Izpisua Belmonte JC, Yang Z, Yuan Y*, Qu J*, Liu GH*. CRISPR/Cas9-Mediated Targeted Gene Correction in Amyotrophic Lateral Sclerosis Patient iPSCs. Protein Cell. 2017. 8(5):365-378. (Cover story) 

60. Kubben N, Zhang W, Wang L, Voss T, Yang J, Qu J, Liu GH*, Misteli T*, Repression of the Antioxidant NRF2 Pathway in Premature Aging. Cell. 2016. 165(6):1361-1374.

61. Pan H, Guan D, Liu X, Li J, Wang L, Wu J, Zhou J, Zhang W, Ren R, Zhang W, Li Y, Yang J, Hao Y, Yuan T, Yuan G, Wang H, Ju Z, Mao Z, Li J, Qu J*, Tang F*, Liu GH*. SIRT6 Safeguards Human Mesenchymal Stem Cells From Oxidative Stress by Coactivating NRF2. Cell Research. 2016. 26(2):190-205.

62. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nuñez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Izpisua Belmonte JC. In Vivo Genome Editing via CRISPR/Cas9 Mediated Homology-Independent Targeted Integration. Nature. 2016. 540(7631):144-149.

63. Fu L, XX, Ren R, Wu J, Zhang W, Yang J, Ren X, Wang S, Zhao Y, Sun L, Yu Y, Wang Z, Yang Z, Yuan Y, Qiao J, Izpisua Belmonte JC*, Qu J*, Liu GH*. Modeling Xeroderma Pigmentosum Associated Neurological Pathologies with Patients-Derived iPSCs. Protein Cell. 2016.7(3):210-221.

64. Wang H, Diao D, Shi Z, Zhu X, Gao Y, Gao S, Liu X, Wu Y, Rudolph KL, Liu GH, Li T, Ju Z. SIRT6 Controls Hematopoietic Stem Cell Homeostasis through Epigenetic Regulation of Wnt Signaling. Cell Stem Cell. 2016. 7;18(4):495-507.

65. Li Y, Zhang W, Chang L, Han Y, Sun L, Guo X, Tang H, Liu Z, Deng H, Ye Y, Ren R, Wang Y, Li J, Qiao J, Qu J*, Zhang W*, Liu GH*. Vitamin C Alleviates Aging Defects in a Stem Cell Model for Werner Syndrome. Protein Cell. 2016. 7(7):478-488. (Cover story)

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Reviews or Views:

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2.     Roles of chromatin and genomic instabilities in cellular senescence and their relevance to ageing and related diseases. Nature Reviews Molecular Cell Biology. 2024. doi:10.1038/s41580-024-00775-3.

3.     Stress, epigenetics, and aging: unraveling the intricate crosstalk. Molecular Cell. 2024. 84(1):34-54.

4.     Targeting aging and age-related diseases with vaccines. Nature Aging. 2024.4(4):464-482.

5.     Exploring the heterogeneous targets of metabolic aging at single-cell resolution. Trends in Endocrinology & Metabolism. 2024. doi:10.1016/j.tem.2024.07.009.

6.     Emerging epigenetic insights into aging mechanisms and interventions. Trends in Pharmacological Sciences. 2024. 45(2):157-172.

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8.     The Aging Biomarker Consortium represents a new era for aging research in China. Nature Medicine. 2023. 29(9):2162-2165.

9.     Endogenous retroviruses in mammalian development and health. Trends in Microbiology. 2023. S0966-842X(23)00267-6.

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11.  Decoding Aging Hallmarks at the Single-Cell Level. Annual Review of Biomedical Data Science. 2023. 10:6:129-152.

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16.  Hepatocyte reprogramming in liver regeneration: biological mechanisms and applications. The FEBS Journal. 2023. 290(24):5674-5688.

17.  Glutathione restoration: a sword to combat skeletal muscle stem cell aging. Life Metabolism. 2023. 2(3):load012.

18.  A narrative review of organoids for investigating organ aging: opportunities and challenges. Journal of Bio-X Research. 2023. 6(1):p 3-14. (Cover story)

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20.  Longevity secret - a pluripotent superpower. Cell Metabolism. 2022. 34(6):803-804.

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22.  A Stem Cell Aging Framework, from Mechanisms to Interventions. Cell Reports. 2022. 41(3):111451.

23.  The landscape of aging. Science China Life Science. 2022 2:1-101.

24.  Opening up the black box of human cell plasticity. Innovation. 2022 3(5):100276.

25.  Epigenetic regulation of aging: implications for interventions of aging and diseases. Signal Transduction and Targeted Therapy. 2022. 7(1):374.

26.  Genetic Enhancement: an Avenue to Combat Aging-related Diseases. Life Medicine. 2022.1(3): 307–318.

27.  Emerging role of RNA m⁶A modification in aging regulation. Current Medicine. 2022. 1(8).

28.  Potential Approaches for Intervening Aging. National Science Open. 2022.1(2): 20220021.

29.  Deciphering aging at three-dimensional genomic resolution. Cell Insight. 2022. 1(3):100034.

30.  Rejuvenation of Tissue Stem Cells by Intrinsic and Extrinsic Factors. Stem Cells Translational Medicine.2022. 11(3):231-238.

31.  Mitochondrial sirtuins, metabolism, and aging. J Genet Genomics. 2022. 49(4):287-298.

32.  The Aging Epigenome and its Rejuvenation. Nature Reviews Molecular Cell Biology. 2020. 21(3):137-150.

33.  Engineering Tissues and Organs: The Road to the Clinic. Cell. 2020. 181(1):22-23. (Leading Edge Voices)

34.  Single-Cell “OMICS” in Aging: A Young Growing Field. Nature Metabolism. 2020. 2(4): 293-302.

35.  A Beta-Galactosidase Kiss of Death for Senescent Cells. Cell Research. 2020. 30(7):556-557.

36.  Treating Osteoarthritis via Gene Therapy with Rejuvenation Factors. Gene Therapy. 2020. 27(7-8):309-311. 

37.  Protein Quality Control of Cell Stemness. Cell Regeneration. 2020. 12;9(1):22.

38.  Age-Related Cardiopathies Gene Editing. Aging. 2019. 11(5):1327-1328.

39.  Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018. 123(7):773-786.

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