Doctoral Supervisor,Shenzhen Institutes of Advanced Technology Chinese Academy of Science;B class talent of Shenzhen Peacock Plan; Director of the seventh branch of China Democratic National Construction Association, Luohu District, Shenzhen; Supervisor of non - public medical institutions association, shenzhen;member of Private Hospital Management Branch, China non - public medical institutions association;executive director of Shenzhen Biomedical Association; Based society member of Society of international Orthopaedic and trauma ( SICOT );Basic professional committee member of Orthopedic branch, China Association of Promoting Traditional Medicine;Honorary research fellow, Institute of Economics and Public Policy Center,China Academy of Social Sciences;Director of Bioactive materials Engineering Center for Biomedical, Guangdong Province;member of the ninth council, Shenzhen Association of Young scientific talent;Deputy of the 6th congress of China Democratic National Construction Association; Organizing Committee of overseas returnee training class, The first term of the Party School,2015; Class council member of united front theory seminar, Shenzhen, 2015; Organizing Committee of  the  31th democratic Party training courses, 2016;New Professionals Federation member, Luohu district, shenzhen;Deputy Director of Qing Chun Charitable Fund.

Tel: 15989501432


Research Areas

1、RA inflammatory disease pathogenesis and new applications of old drugs

2、Complex disease states and mechanisms of fracture healing mode

3、Bone-cartilage tissue engineering research


2005 / 09-2008 / 07, Shanghai Jiao Tong University School of Medicine, PhD (Clinical Medicine);

2002 / 09-2005 / 07, Department of Orthopedics, Shandong University of Traditional Chinese Medicine, Master (Clinical Medicine);

1997 / 09-2002 / 07, Department of Orthopedics, Shandong University of Traditional Chinese Medicine, Bachelor (Clinical Medicine)


Work Experience

2013/12-Now​,Professor, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Institute of Translation and Medical Research and Development Center;

2011 / 09- 2013/12, associate researcher, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Center for Translational Medicine Research and Development;

2010 / 03- 2011/08, assistant researcher, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Center for Translational Medicine Research and Development;

2009 / 05-2010 / 02, research associate, Department of Bone Traumatology, The Chinese University of Hong Kong;

2008 / 08-2009 / 03, Postdoctoral, Department of Orthopedics, Second Affiliated Hospital of Zhejiang University;

Teaching Experience




(1) Down-regulation of hypoxia-inducible factor-1α by RNA interference alleviates the development of collagen-induced arthritis in rats, Molecular Therapy-Nucleic Acids, 2020-01
(2) Genistein inhibits angiogenesis developed during rheumatoid arthritis through the IL-6/JAK2/STAT3/VEGF signalling pathway, Journal of Orthopaedic Translation, 2019-08
(3) A 1064 nm excitable semiconducting polymer nanoparticle for photoacoustic imaging of gliomas, Nanoscale, 2019
(4) Fracture Healing in a Collagen-Induced Arthritis Rat Model: Radiology and Histology Evidence, Journal of Orthopaedic Research, 2018
(5) Relationship between heterotopic ossification and traumatic brain injury Why severe traumatic brain injury increases the risk of heterotopic ossification, Journal of Orthopaedic Translation, 2017
(6) Study in Treatment of Collagen-Induced Arthritis in DBA/1 Mice Model by Genistein, Current Pharmaceutical Design, 2016
(7) Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-κB pathways., Int Immunopharmacol, 2015
(8) GTS-21 attenuates lipopolysaccharide-induced inflammatory cytokine production in vitro by modulating the Akt and NF-κB signaling pathway through the α7 nicotinic acetylcholine receptor, Int Immunopharmacol, 2015
(9) Attenuation of Collagen-Induced Arthritis in rat by nicotinic alpha7 receptor partial agonist GTS-21., Biomed Res Int., 2014
(10) Genistein suppresses tumor necrosis factor α-induced inflammation via modulating reactive oxygen species/Akt/nuclear factor κB and adenosine monophosphate-activated protein kinase signal pathways in human synoviocyte MH7A cells., Drug Des Devel Ther., 2014
(11) Genistein:the potential for efficacy in rheumatoid arthritis., Clinical Rheumatology, 2013
(12) Advances in research on animal models of rheumatoid arthritis., Clinical rheumatology., 2013
(13)  Hypoxia-inducible factor: a potential therapeutic target for rheumatoid arthritis. , Curr Drug Targets., 2013
(14) Hypoxia-Inducible Factor: A Potential Therapeutic Target for Rheumatoid Arthritis., Current Drug Targets, 2013
(15) Berberine inhibits lipopolysaccharide and polyethylene particle-induced mouse calvarial osteolysis in vivo ., Journal of Surgery research., 2012
(16) Effects of tetracyclines on bone: an ambiguous question needs to be clarified, Pharmazie, 2012
(17) FGFReceptor-mediated Gene Delivery Using Ligands Coupled to PEI-?-CyD, Journal of Biomedicine and Biotechnology, 2012

( 1 ) 一种治疗类风湿性关节炎的药物组合物、制备方法及其贴剂, 实用新型, 2014, 第 1 作者, 专利号: 201410758729.5
( 2 ) 一种炎症伴发骨折复合疾病模型的制备方法, 实用新型, 2014, 第 1 作者, 专利号: 201410837178.1
( 3 ) 葫芦素E在制备治疗血管新生不足相关疾病 药物或生物医用材料中的用途和应用其的产品, 发明, 2018, 第 2 作者, 专利号: 201811013796 .9
( 4 ) 吡非尼酮在制备防治类风湿性关节炎的药物中的应用, 发明, 2019, 第 1 作者, 专利号: 201910917004.9
( 5 ) 吡非尼酮在制备促血管生成药物中的应用, 发明, 2019, 第 1 作者, 专利号: 201911287236.7



成文翔  博士研究生  071010-生物化学与分子生物学  

黄欢  硕士研究生  071010-生物化学与分子生物学  

陈敬钦  博士研究生  071010-生物化学与分子生物学  

陈建海  博士研究生  071010-生物化学与分子生物学  

林结桃  硕士研究生  071010-生物化学与分子生物学  


李健  博士研究生  071010-生物化学与分子生物学