基本信息
吴德成  男  博导  中国科学院化学研究所
电子邮件: dcwu@iccas.ac.cn
通信地址: 北京海淀中关村北一街2号
邮政编码: 100190

招生信息

   
招生专业
070305-高分子化学与物理
招生方向
生物医用高分子材料

教育背景

2002-01--2006-01   新加坡国立大学   研究生/博士
1998-09--2001-07   中国科学技术大学   研究生/硕士
1993-09--1998-07   中国科学技术大学   本科/学士

工作经历

   
工作简历
2015-03~现在, 中国科学院大学, 岗位教授
2011-01~现在, 中国科学院化学研究所, 研究员
2005-04~2010-12,新加坡材料研究与工程研究院, 研究工程师/高级研究工程师
2002-01~2006-01,新加坡国立大学, 研究生/博士
2001-07~2001-12,深圳桑夏高科技有限公司, 工程师
1998-09~2001-07,中国科学技术大学, 研究生/硕士
1993-09~1998-07,中国科学技术大学, 本科/学士
社会兼职
2017-08-20-2020-08-19,中国老年学和老年医学学会骨质疏松分会, 基础医学专家委员会副主任委员

教授课程

生物医用高分子

专利与奖励

   
奖励信息
(1) 教育部技术发明奖, 一等奖, 部委级, 2018
专利成果
( 1 ) 一种水分散叶面亲和型纳米农药缓释剂及其制备方法, 2017, 第 1 作者, 专利号: 201510578066.3

( 2 ) 微纳米凝胶粒子及其可控制备方法与应用, 2017, 第 1 作者, 专利号: 201310159738.8

( 3 ) 基于可快速降解化学键的PEG水凝胶及其制备方法与应用, 2017, 第 1 作者, 专利号: 201710115545.0

( 4 ) 一种具有高强粘附性能的可注射生物胶水及其制备方法与应用, 2017, 第 1 作者, 专利号: 201710115561.X

( 5 ) 基于多面体低聚倍半硅氧烷改性聚乙二醇的生物胶水及其制备方法与应用, 2017, 第 1 作者, 专利号: 201710081407.5

( 6 ) 基于快速膜乳化法制备淀粉微囊与微球的方法, 2017, 第 1 作者, 专利号: 201410356279.7

( 7 ) 基于PEG和多糖的双网络水凝胶及其制备方法与应用, 2016, 第 1 作者, 专利号: 201610994581.4

( 8 ) 一种胶囊型复配农药制剂及其制备方法与应用, 2016, 第 1 作者, 专利号: 201610985307.0

( 9 ) 一种固态阿维菌素微粒制剂及其制备方法与应用, 2016, 第 1 作者, 专利号: 201610305485.4

( 10 ) 一种基于聚酯纳米粒子化学交联的杂化水凝胶及其制备方法与应用, 2016, 第 1 作者, 专利号: 201610274764.9

( 11 ) 一种负载药物的可生物降解聚合物及其制备方法和用途, 2016, 第 1 作者, 专利号: 201410200254.8

( 12 ) 树枝状聚缩酮及其制备方法和应用, 2016, 第 1 作者, 专利号: ZL 201410035950.8

( 13 ) 一种具有自恢复能力的高强化学-物理双网络水凝胶及其制备方法与应用, 2016, 第 1 作者, 专利号: 201610055595.X

( 14 ) 具有POSS基的树枝状聚合物及其制备方法, 2015, 第 1 作者, 专利号: ZL 201310538028.6

( 15 ) 一种微囊式超声造影剂及其制备方法, 2015, 第 1 作者, 专利号: ZL 201310378478.3

( 16 ) 一种氯虫苯甲酰胺微胶囊剂及其制备方法, 2015, 第 1 作者, 专利号: 201510555451.6

( 17 ) 一种复合材料及其制备方法与应用, 2015, 第 1 作者, 专利号: 201510004891.2

( 18 ) 一种仿天然血管中膜层结构与功能的组织工程支架, 2014, 第 2 作者, 专利号: ZL 201210363899.4

( 19 ) 一种多模成像造影剂及其制备方法和应用, 2014, 第 1 作者, 专利号: 201410608491.8

出版信息

   
发表论文
(1) POSS-based Supramolecular Amphiphilic Zwitterionic Complexes for Drug Delivery, Biomaterials Science, 2019, 通讯作者
(2) 基于双硫键交换可控构建的水凝胶及其动态交联机理研究, 高分子学报, 2019, 通讯作者
(3) Fabrication of Zwitterionic and pH-responsive Polyacetal Dendrimers for Anticancer Drug Delivery, Biomaterials Science, 2019, 通讯作者
(4) Tetra-PEG Based Hydrogel Sealants for In Vivo Visceral Hemostasis, Advanced Materials, 2019, 通讯作者
(5) Uniting aggregation-induced emission and stimuli-responsive aggregation-caused quenching, single molecule achieved multicolour luminescence, Journal of Materials Chemistry C, 2019, 通讯作者
(6) Fabrication of POSS-embedded Supramolecular Hyperbranched Polymers with Multi-responsive Morphology Transitions, Polym. Chem., 2018, 通讯作者
(7) Highly Elastic and Ultratough Hybrid Ionic–Covalent Hydrogels with Tunable Structures and Mechanics, Adv. Mater., 2018, 通讯作者
(8) Dynamic and Programmable Morphology and Size Evolution via a Living Hierarchical Self-assembly Strategy, Nat. Commun., 2018, 通讯作者
(9) Acetal-linked PEGylated paclitaxel prodrugs forming free-paclitaxel-loaded pH-responsive micelles with high drug loading capacity and improved drug delivery, Materials Science & Engineering C, 2018, 通讯作者
(10) Development of a Chlorantraniliprole Microcapsule Formulation with a High Loading Content and Controlled-Release Property, J. Agric. Food Chem., 2018, 通讯作者
(11) Construction of Versatile Multilayered Composite Nanoparticles from a Customized Nanogel Template, Bioactive Materials, 2018, 通讯作者
(12) POSS-embedded Supramolecular Hyperbranched Polymers Constructed From a 1→7 Branching Monomer with Controllable Morphology Transition, Sci. China. Chem., 2018, 通讯作者
(13) Controlled Cross-linking Strategy for Formation of Hydrogels, Microgels and Nanogels, Chin. J. Polym. Sci., 2018, 通讯作者
(14) Dopamine-assisted Fixation of Drug-loaded Polymeric Multilayers to the Osteoarticular Implants for Tuberculosis Therapy, Biomater. Sci., 2017, 通讯作者
(15) Ionic Colloidal Molding as a Biomimetic Scaffolding Strategy for Uniform Bone Tissue Regeneration, Adv. Mater., 2017, 通讯作者
(16) pH-Triggered Decomposition of Polymeric Fluorescent Vesicles to Induce Growth of Tetraphenylethylene Nanoparticles for Long-term Live Cell Imaging, Polymer, 2017, 通讯作者
(17) Influence of Surface Chemistry on Adhesion and Osteo/Odontogenic Differentiation of Dental Pulp Stem Cells, ACS Biomater. Sci. Eng., 2017, 第 5 作者
(18) Fabrication of Multi-Stimuli Responsive Supramolecular Hydrogels Based on Host–Guest Inclusion Complexation of a Tadpole-shaped Cyclodextrin Derivative with the Azobenzene Dimer, Polym. Chem., 2017, 通讯作者
(19) Effects of HAp and TCP in Constructing Tissue Engineering Scaffolds for Bone Repair, J. Mater. Chem. B, 2017, 通讯作者
(20) POSS-modified PEG Adhesives for Wound Closure, Chin. J. Polym. Sci., 2017, 通讯作者
(21) The Immobilization of Antibiotic-loaded Polymeric Coatings on Osteoarticular Ti Implants for the Prevention of Bone Infections, Biomater. Sci., 2017, 通讯作者
(22) Charge-reversible and pH-responsive Biodegradable Micelles and Vesicles from Linear-dendritic Supramolecular Amphiphiles for Anticancer Drug Delivery, Polym. Chem., 2017, 通讯作者
(23) Construction of Tough, in Situ Forming Double-Network Hydrogels with Good Biocompatibility, ACS Appl. Mater. Interfaces, 2017, 通讯作者
(24) A Universal Soaking Strategy to Convert Composite Hydrogels into Extremely Tough and Rapidly Recoverable Double-Network Hydrogels, Adv. Mater., 2016, 通讯作者
(25) Fabrication of pH-Responsive Nanoparticles with an AIE Feature for Imaging Intracellular Drug Delivery, Biomacromolecules, 2016, 通讯作者
(26) Bioreducible Gene Delivery Vector Capable of Self-Scavenging the Intracellular-Generated ROS Exhibiting High Gene Transfection, ACS Appl. Mater. Interfaces, 2016, 通讯作者
(27) Synthesis and Characterization of PLGA Nanoparticle/4-arm-PEG Hybrid Hydrogels with Controlled Porous Structures, RSC Advances, 2016, 通讯作者
(28) Synthesis and Properties of Hemostatic and Bacteria-Responsive in Situ Hydrogels for Emergency Treatment in Critical Situations, ACS Appl. Mater. Interfaces, 2016, 通讯作者
(29) Construction of a Controlled-Release Delivery System for Pesticides using Biodegradable PLA-based Microcapsules, Colloids Surf. B., 2016, 通讯作者
(30) Facile Creation of FRET Systems from a pH-Responsive AIE Fluorescent Vesicle, Chem. Commun., 2016, 通讯作者
(31) UV-Triggered Thiol-disulfide Exchange Reaction towards Tailored Biodegradable Hydrogels, Polym. Chem., 2016, 通讯作者
(32) Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(β-hydroxyl amine) for Drug Delivery, Biomacromolecules, 2016, 通讯作者
(33) Preparation of Uniform Starch Microcapsules by Premix Membrane Emulsion for Controlled Release of Avermectin, Carbohyd. Polym., 2016, 通讯作者
(34) High DNA-Binding Affinity and Gene-Transfection Efficacy of Bioreducible Cationic Nanomicelles with a Fluorinated Core, Angew. Chem. Int. Ed., 2016, 第 2 作者
(35) Effect of Topological Structures on the Self-Assembly Behavior of Supramolecular Amphiphiles, Langmuir, 2015, 通讯作者
(36) Synthesis, Self-Assembly, and Photoresponsive Behavior of Tadpole-, ACS Macro Lett., 2015, 通讯作者
(37) Uniform PEGylated PLGA Microcapsules with Embedded Fe3O4 Nanoparticles for US/MR Dual-Modality Imaging, ACS Appl. Mater. Interfaces, 2015, 通讯作者
(38) Acid-Labile Poly(glycidyl methacrylate)-Based Star Gene Vectors, ACS Appl. Mater. Interfaces, 2015, 通讯作者
(39) Syntheses of Sequence-Controlled Polymers via Consecutive Multicomponent Reactions, Macromolecules, 2015, 第 3 作者
(40) A Biomimetic 3D Microtubule-orientated Poly(lactide-co-glycolide) Scaffold with Interconnected pores for Tissue Engineering, J. Mater. Chem. B., 2015, 通讯作者
(41) Mesenchymal Stem Cells Attenuated PLGA-induced Inflamatory Responses by Inhibiting Host DC Maturation and Function, Biomaterials, 2015, 通讯作者
(42) Isoniazid Conjugated Poly(lactide-co-glycolide): Long-term Controlled Drug Release and Tissue Regeneration for Bone Tuberculosis Therapy, Biomaterials, 2015, 通讯作者
(43) Synthesis and Self-assembly Behavior of POSS-embedded Hyperbranched Polymers, Chem. Commun., 2015, 通讯作者
(44) POSS Dendrimers Constructed from a 1→7 Branching Monomer, Chem. Commun., 2015, 通讯作者
(45) Self-Assembly Behavior of a Linear-Star Supramolecular Amphiphile Based on Host-Guest Complexation, Langmuir, 2014, 通讯作者
(46) Bioreducible POSS-Cored Star-Shaped Polycation for Efficient Gene Delivery, ACS Appl. Mater. Interfaces, 2014, 通讯作者
(47) Modified Composite Microspheres of Hydroxyapatite and Poly(lactide-co-glycolide) as an Injectable Scaffold, Appl. Surf. Sci., 2014, 通讯作者
(48) Fabrication of Uniform Sized Polylactone Microcapsules by Premix Membrane Emulsification for Ultrasound Imaging, Polym. Chem., 2014, 通讯作者
(49) Synthesis of Sequence-ordered Polymers via Sequential Addition of Monomers in One Pot, Chem. Commun., 2013, 第 3 作者
(50) Peptide Hydrogels Assembled from Nonionic Alkyl-polypeptide Amphiphiles Prepared by Ring-Opening Polymerization, Biomacromolecules, 2013, 第 2 作者
(51) Controlled cross-linking strategy: from hybrid hydrogels to nanoparticle macroscopic aggregates, Polym. Chem., 2013, 通讯作者
(52) Redox-Responsive Hyperbranched Poly(amido amine)s with Tertiary Amino Cores for Gene Delivery, Biomacromolecules, 2013, 第 2 作者
(53) Controlled Formation of Microgels/Nanogels from a Disulfide-Linked Core/Shell Hyperbranched Polymer, ACS Macro Lett., 2012, 通讯作者
(54) 

科研活动

   
科研项目
( 1 ) 叶面亲和型与多功能纳米载药系统构建, 负责人, 国家任务, 2014-01--2018-08
( 2 ) 树枝状聚缩酮的合成、自组装及应用, 负责人, 国家任务, 2015-01--2018-12
( 3 ) 智能微纳米凝胶的可控制备及应用, 负责人, 国家任务, 2012-01--2015-12
( 4 ) 水凝胶的化学结构研究, 负责人, 企业委托, 2015-02--2015-07
( 5 ) 生物医用高分子, 负责人, 国家任务, 2018-01--2022-12
( 6 ) 高性能双交联网络水凝胶的可控构筑, 负责人, 国家任务, 2017-01--2020-12
( 7 ) 透明质酸水凝胶的化学结构研究, 负责人, 企业委托, 2016-10--2017-04
( 8 ) 可吸收硬脑膜封合医用胶的化学结构研究, 负责人, 企业委托, 2017-03--2017-07