2000-09--2003-06   中国药科大学   博士
1997-09--2000-06   中国药科大学   硕士学位
1992-09--1997-06   中国药科大学   学士学位

   

2011-03~现在, 上海药物研究所, 研究员，课题组长
2008-05~2011-03,美国诺华生物医学研究所, 实验室主管
2007-11~现在, 美国诺华生物医学研究所, 研究员
2004-01~2007-10,美国明尼苏达大学药学院药学系, 博士后
2000-09~2003-06,中国药科大学, 博士
1997-09~2000-06,中国药科大学, 硕士学位
1992-09~1997-06,中国药科大学, 学士学位

2017-11-01-今,中国细胞生物学学会细胞治疗研究与应用分会, 常务委员
2017-09-01-今,中国药理学会药代青委会副主任, 副主任
2015-05-12-今,上海市药物代谢委员会专业委员, 专业委员

高等药理学
高等药理学（定量毒理学）

   

（ 1 ） 丹参乙酸镁或含有丹参乙酸镁的药物组合物对于肝脏缺血再灌注的保护作用及应用, [[[", 第 2 作者, 专利号: [[[CN111686103A]]]

（ 2 ） 抗肺纤维化药物筛选模型的构建方法及由其构建的抗肺纤维化药物筛选模型及其应用, 2022, 第 1 作者, 专利号: CN114107168A

（ 3 ） 丹参乙酸镁在制备抗肺纤维化药物中的用途, 2022, 第 2 作者, 专利号: CN114081877A

（ 4 ） 9,10-二氢菲类化合物及其用于肝损伤治疗的用途, 2021, 第 2 作者, 专利号: CN113244203A

（ 5 ） 含小檗碱和知母皂苷的组合物及其应用, 2017, 第 6 作者, 专利号: CN107184590A

（ 6 ） 含有螺甾烷化合物的组合物及其用途, 2017, 第 6 作者, 专利号: CN106551943A

（ 7 ） 体外培养肝样细胞的方法及采用该方法培养的优化后肝样细胞, 2015, 第 1 作者, 专利号: CN104694456A

   

（1） FEK self-assembled peptide hydrogels facilitate primary hepatocytes culture and pharmacokinetics screening, JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2022, 第 11 作者
（2） MSCs cell fates in murine acute liver injury and chronic liver fibrosis induced by carbon tetrachloride., DRUG METABOLISM AND DISPOSITION, 2022, 第 11 作者
（3） Functional Proliferating Human Hepatocytes: In Vitro Hepatocyte Model for Drug Metabolism, Excretion, and Toxicity, DRUG METABOLISM AND DISPOSITION, 2021, 第 11 作者
（4） Anti-Fibrosis Effects of Magnesium Lithospermate B in Experimental Pulmonary Fibrosis: By Inhibiting TGF-beta RI/Smad Signaling, MOLECULES, 2021, 第 11 作者
（5） Define Mesenchymal Stem Cell from Its Fate: Biodisposition of Human Mesenchymal Stem Cells in Normal and Concanavalin A-Induced Liver Injury Mice, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 第 12 作者
（6） Single cell Raman spectroscopy to identify different stages of proliferating human hepatocytes for cell therapy, STEM CELL RESEARCH & THERAPY, 2021, 第 11 作者
（7） A novel bile acid analog, A17, ameliorated non-alcoholic steatohepatitis in high-fat diet-fed hamsters, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 第 11 作者
（8） Gigantol ameliorates CCl4-induced liver injury via preventing activation of JNK/cPLA2/12-LOX inflammatory pathway, SCIENTIFIC REPORTS, 2020, 第 11 作者
（9） Large-scale Generation of Functional and Transplantable Hepatocytes and Cholangiocytes from Human Endoderm Stem Cells, CELL REPORTS, 2020, 第 21 作者
（10） Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2, Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2, ACTA PHARMACOLOGICA SINICA, 2020, 第 11 作者
（11） Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia, CANCER CELL, 2019, 第 19 作者
（12） Roles of Hepatic Drug Transporters in Drug Disposition and Liver Toxicity, DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY, 2019, 第 11 作者
（13） An Adaption of Human-Induced Hepatocytes to In Vitro Genetic Toxicity Tests, MUTAGENESIS, 2019, 第 8 作者
（14） Intestinal Transporter-Associated Drug Absorption and Toxicity, DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY, 2019, 第 11 作者
（15） Modelling liver cancer initiation with organoids derived from directly reprogrammed human hepatocytes, NATURE CELL BIOLOGY, 2019, 第 15 作者
（16） Different structures of berberine and five other protoberberine alkaloids that affect P-glycoprotein-mediated efflux capacity, differentstructuresofberberineandfiveotherprotoberberinealkaloidsthataffectpglycoproteinmediatedeffluxcapacity, ACTA PHARMACOLOGICA SINICA, 2019, 第 11 作者
（17） Enhanced Anti-diabetic Effect of Berberine Combined With Timosaponin B2 in Goto-Kakizaki Rats, Associated With Increased Variety and Exposure of Effective Substances Through Intestinal Absorption, FRONTIERS IN PHARMACOLOGY, 2019, 第 11 作者
（18） The Protective Effect of Magnesium Lithospermate B on Hepatic Ischemia/Reperfusion via Inhibiting the Jak2/Stat3 Signaling Pathway, FRONTIERS IN PHARMACOLOGY, 2019, 第 11 作者
（19） Drug Transporters in Drug Disposition, Effects and Toxicity Preface, DRUG TRANSPORTERS IN DRUG DISPOSITION, EFFECTS AND TOXICITY, 2019, 第 2 作者
（20） 生物人工肝的研究进展, Advances in Bioartificial Liver System, 中国细胞生物学学报, 2019, 第 4 作者
（21） Exploration of the hepatoprotective chemical base of an orally administered herbal formulation (YCHT) in normal and CCl4-intoxicated liver injury rats. Part 2: Hepatic disposition in vivo and hepatoprotective activity in vitro, JOURNAL OF ETHNOPHARMACOLOGY, 2019, 第 11 作者
（22） Multifunctional zinc-based hollow nanoplatforms as a smart pH-responsive drug delivery system to enhance in vivo tumor-inhibition efficacy, MATERIALS & DESIGN, 2018, 第 10 作者
（23） Enhanced doxorubicin delivery to hepatocellular carcinoma cells via CD147 antibody-conjugated immunoliposomes, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2018, 第 3 作者
（24） 肝样细胞模型在药物肝脏代谢和毒性研究中的进展, Progress of Hepatocyte-like Cell Models in the Research of Hepatic Metabolism and Toxicity of Drugs, 药学进展, 2018, 第 2 作者
（25） 细胞的命运：间充质干细胞的药代动力学, The Fate of Cells: Pharmacokinetics of MSC, 中国细胞生物学学报, 2018, 第 3 作者
（26） The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine, XENOBIOTICA, 2018, 第 11 作者
（27） Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance-Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator-Activated Receptor �� Activation., Mol Pharmacol, 2018, 第 11 作者
（28） Preparation, characterization, biotoxicity, and biodistribution of thermo-responsive magnetic complex micelles formed by Mn0.6Zn0.4Fe2O4 and a PCL/PEG analogue copolymer for controlled drug delivery, JOURNAL OF MATERIALS CHEMISTRY B, 2017, 第 4 作者
（29） Fabrication of stable galactosylated alginate microcapsules via covalent coupling onto hydroxyl groups for hepatocytes applications, CARBOHYDRATE POLYMERS, 2017, 第 8 作者
（30） Distinct Gene Expression and Epigenetic Signatures in Hepatocyte-like Cells Produced by Different Strategies from the Same Donor, STEM CELL REPORTS, 2017, 第 15 作者
（31） An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT), CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY, 2017, 第 11 作者
（32） Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes, CELL RESEARCH, 2016, 第 11 作者
（33） Altered Expression of Transporters, its Potential Mechanisms and Influences in the Liver of Rodent Models Associated with Diabetes Mellitus and Obesity, EUROPEANJOURNALOFDRUGMETABOLISMANDPHARMACOKINETICS, 2016, 第 11 作者
（34） Functional human induced hepatocytes (hiHeps) with bile acid synthesis and transport capacities: A novel in vitro cholestatic model, SCIENTIFIC REPORTS, 2016, 第 11 作者
（35） Leflunomide-induced hepatotoxicity is attenuated by cytochrome P450-dependent metabolism and increased by inhibition of sodium taurocholate co-transporting polypeptide., Acta Pharmacol Sin., 2016, 第 11 作者
（36） Hepatocellular Carcinoma Repression by TNF alpha-Mediated Synergistic Lethal Effect of Mitosis Defect-Induced Senescence and Cell Death Sensitization, HEPATOLOGY, 2016, 第 13 作者
（37） 大分子药物的吸收分布代谢排泄和毒性特征及药代模型的应用, 药学学报, 2016, 第 3 作者
（38） Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity, ACTA PHARMACOLOGICA SINICA, 2016, 第 11 作者
（39） Systematic and comprehensive strategy for metabolite profiling in bioanalysis using software-assisted HPLC-Q-TOF: magnoflorine as an example, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2016, 第 11 作者
（40） Optimized Hepatocyte-Like Cells with Functional Drug Transporters Directly-Reprogrammed from Mouse Fibroblasts and their Potential in Drug Disposition and Toxicology, CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2016, 第 11 作者
（41） The Hepatobiliary Disposition of Timosaponin B2 Is Highly Dependent on Influx/Efflux Transporters but Not Metabolism, DRUG METABOLISM AND DISPOSITION, 2015, 第 11 作者
（42） Simultaneous determination of gypenoside LVI, gypenoside XLVI, 2��-OH-protopanaxadiol and their two metabolites in rat plasma by LC���MS/MS and its application to pharmacokinetic studies, JOURNAL OF CHROMATOGRAPHY B, 2015, 第 5 作者
（43） HDAC inhibitor-induced drug resistance involving ATP-binding cassette transporters, ONCOLOGY LETTERS, 2015, 第 11 作者
（44） Improving the dissolution and bioavailability of 6-mercaptopurine via co-crystallization with isonicotinamide, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2015, 第 11 作者
（45） Organic anion-transporting polypeptides contribute to the hepatic uptake of berberine, XENOBIOTICA, 2015, 第 9 作者
（46） Simultaneous determination of gypenoside LVI, gypenoside XLVI, 2 alpha-OH-protopanaxadiol and their two metabolites in rat plasma by LC MS/MS and its application to pharmacokinetic studies, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2015, 第 5 作者
（47） 新型肝样细胞在预测药物胆汁分泌风险中的应用, 2015, 第 6 作者
（48） The Hepatobiliary disposition of timosaponin B2 is highly dependent on influx/efflux transporters but not metabolism., Drug Metab Dispos, 2014, 第 11 作者
（49） Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters, Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters, 中国药理学报：英文版, 2014, 第 8 作者
（50） Study on the PK profiles of magnoflorine and its potential interaction in Cortex phellodendri decoction by LC-MS/MS, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2014, 第 11 作者
（51） Direct Reprogramming of Human Fibroblasts to Functional and Expandable Hepatocytes, CELL STEM CELL, 2014, 第 17 作者
（52） Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters, ACTA PHARMACOLOGICA SINICA, 2014, 第 8 作者
（53） Opposite regulation of hepatic breast cancer resistance protein in type 1 and 2 diabetes mellitus, EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 第 10 作者
（54） Evaluation and optimization of high-performance liquid chromatography coupled with high-resolution mass spectrometry for phospholipid quantitation, RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2014, 第 4 作者
（55） Alpha-naphthylisothiocyanate modulates hepatobiliary transporters in sandwich-cultured rat hepatocytes, TOXICOLOGY LETTERS, 2014, 第 11 作者
（56） d-Penicillamine2，5-enkephalin作为底物考察三明治大鼠原代肝细胞的转运体功能研究, 中国临床药理学与治疗学, 2013, 第 4 作者
（57） 人源化小鼠模型在药物代谢和毒性研究中的应用, 中国药学杂志, 2013, 第 3 作者
（58） Design, synthesis and biological evaluation of a novel class of potent TGR5 agonists based on a 4-phenyl pyridine scaffold, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 第 5 作者
（59） 葡萄糖和胰岛素调节三明治肝细胞中胆酸相关转运体表达及功能, 中国临床药理学与治疗学, 2013, 第 5 作者
（60） Metabolism and Pharmacokinetics of Mangiferin in Conventional Rats, Pseudo-Germ-Free Rats, and Streptozotocin-Induced Diabetic Rats, DRUG METABOLISM AND DISPOSITION, 2012, 第 3 作者
（61） Assessment of Biliary Clearance in Early Drug Discovery using Sandwich-cultured Hepatocyte Model, JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 第 11 作者
（62） Induction of cytochromes P450 1A1 and 1A2 by tanshinones in human HepG2 hepatoma cell line, TOXICOLOGY AND APPLIED PHARMACOLOGY, 2011, 第 5 作者
（63） Inhibition of Renal NQO1 Activity by Dicoumarol Suppresses Nitroreduction of Aristolochic Acid I and Attenuates its Nephrotoxicity, TOXICOLOGICAL SCIENCES, 2011, 第 0 作者
（64） Organic cation uptake is enhanced in bcrp1-transfected MDCKII cells, MOLECULAR PHARMACEUTICS, 2010, 第 1 作者
（65） Interactions of pluronic block copolymers on P���gp efflux activity: Experience with HIV���1 protease inhibitors, JOURNAL OF PHARMACEUTICAL SCIENCES, 2008, 第 2 作者
（66） Investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) on pharmacokinetics and central nervous system penetration of abacavir and zidovudine in the mouse, DRUG METABOLISM AND DISPOSITION, 2008, 第 3 作者
（67） glycoprotein-mediated active efflux of the anti-HIV1 nucleoside abacavir limits cellular accumulation and brain distribution., Drug Metab Dispos., 2007, 第 1 作者
（68） Mitoxantrone permeability in MDCKII cells is influenced by active influx transport, MOLECULAR PHARMACEUTICS, 2007, 第 1 作者
（69） Abcg2/Bcrp1 mediates the polarized transport of anti-retroviral nucleosides Abacavir and Zidovudine (AZT)., Drug Metabolism and Disposition,, 2007, 第 1 作者
（70） Development and validation of a sensitive quantification method for hematoporphyrin monomethyl ether in plasma using high-performance liquid chromatography with fluorescence detection, BIOMEDICAL CHROMATOGRAPHY, 2006, 第 4 作者
（71） 犬血浆中洛伐他汀的LC—MS法快速测定及药代动力学研究, Rapid LC- MS determination and pharmacokinetic research of lovastatin in dog plasma, 药物分析杂志, 2006, 第 7 作者
（72） Simultaneous rapid quantification of ginsenoside Rg 1 and its secondary glycoside Rh 1 and aglycone protopanaxatriol in rat plasma by liquid chromatography���mass spectrometry after solid-phase extraction, JOURNALOFPHARMACEUTICALANDBIOMEDICALANALYSIS, 2005, 
（73） 光动力药物血卟啉单甲醚HPLC-荧光检测法的建立及其药代动力学研究, Determination of Hematoporphyrin Monomethyl Ether in Dogs Plasma by HPLC Using Fluorescence Detection, 中国激光医学杂志, 2005, 第 7 作者
（74） Transport and bioavailability studies of astragaloside IV, an active ingredient in Radix Astragali, BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2004, 
（75） 小檗碱对葡萄糖吸收的抑制作用, Inhibitory action of berberine on glucose absorption, 药学学报, 2003, 第 1 作者
（76） The antihyperglycaemic activity of berberine arises from its decreasing of glucose absorption., Planta Medica., 2003, 第 1 作者
（77） Cyclosporine A enhanced protection of nimodipine against brain damage induced by hypoxia-ischemia in mice and rats., Acta Pharmacol Sin, 2002, 第 1 作者
（78） Intracarotid infusion of hypertonic mannitol changes permeability of blood-brain barrier to methotrexate in rats., Acta Pharmcol Sin, 2002, 第 1 作者
（79） 环胞素A加强尼莫地平对脑损伤保护作用, 中国药理学报：英文版, 2002, 第 2 作者
（80） The involvement of P-glycoprotein in berberine absorption, PHARMACOLOGY & TOXICOLOGY, 2002, 
（81） 动脉内输注高渗性甘露醇改变大鼠血脑屏障对甲氨喋呤的通透性, 中国药理学报, 2000, 第 2 作者
（82） 中药复方药物动力学研究的方法及展望, 中草药, 1998, 第 1 作者

（ 1 ） 药物转运体在药物分布、药效和毒理方面的作用, Drug Transporters in Drug Disposition, Effects and Toxicity, Springer, 2019-10, 第 2 作者

   

（ 1 ） 肝纤维化逆向扰动MSC外泌体肝细胞群药代动力学特征的机制研究, 负责人, 国家任务, 2022-01--2025-12
（ 2 ） 天然9,10-二氢菲类化合物抗肝纤维化活性的发现与候选新药研究, 参与, 研究所自主部署, 2021-11--2023-10
（ 3 ） AhR对于间充质干细胞体内动力学的影响及其机制研究, 负责人, 国家任务, 2019-01--2022-12
（ 4 ） 基于名贵中药石斛传统功效活性成分的抗炎保肝创新药物研发, 负责人, 中国科学院计划, 2018-11--2020-11
（ 5 ） 靶向肿瘤的个性化药物的毒性特征和关键技术, 参与, 中国科学院计划, 2018-01--2020-09
（ 6 ） 人造肝脏类器官的功能和安全性评价, 负责人, 中国科学院计划, 2017-12--2022-11
（ 7 ） 有关类风湿关节炎状态下药物相互作用机制, 负责人, 国家任务, 2016-01--2017-12
（ 8 ） 治疗2型糖尿病1.5类化学复方候选新药ZH-063的临床前个性化特征研究, 参与, 中国科学院计划, 2016-01--2018-12
（ 9 ） 实现转让的临床前研究候选新药ZH-063, 负责人, 境内委托项目, 2015-03--2020-10
（ 10 ） ****（A类**）, 负责人, 中国科学院计划, 2014-05--2017-05
（ 11 ） 肝癌靶向治疗的新型纳米载药系统的构建及其应用研究, 负责人, 国家任务, 2014-01--2016-10
（ 12 ） 构建新型肝样细胞模型用于药物代谢和安全性评价, 负责人, 国家任务, 2013-10--2016-10
（ 13 ） 生物人工肝的研发, 负责人, 中国科学院计划, 2013-03--2015-03
（ 14 ） 新型纳米载药与治疗技术研究与应用, 参与, 国家任务, 2013-01--2016-12
（ 15 ） 建立符合国际GLP标准要求，以毒性病理学为优势的药物安全评价技术平台, 负责人, 国家任务, 2012-01--2015-04
（ 16 ） 基于人源化动物模型和肝脏生物功能网络的药物肝毒性预测关键新技术, 负责人, 国家任务, 2012-01--2015-04
（ 17 ） 新型体外模型研究糖尿病中肝脏胆酸药物转运体功能变化, 负责人, 国家任务, 2012-01--2012-12
（ 18 ） 项目****, 负责人, 中国科学院计划, 2011-05--2014-05