基本信息
刘宏伟  男  博导  中国科学院微生物研究所
电子邮件: liuhw@im.ac.cn
通信地址: 北辰西路一号院3号
邮政编码: 100101

研究领域

研究方向:珍稀食药用真菌活性次生代谢产物化学
   从事天然产物化学的研究工作。利用各种活性筛选方法结合现代色谱、光谱技术对我国多种特色天然药物资源(包括传统中药和民族药,海洋生物和食药用真菌)进行化学研究,获得了300余个天然产物(包括新结构的抗肿瘤先导化合物Lissoclibadins),为创新药物的研发提供了备选化合物,并为研究生物的互作和环境适应机制提供了化学分子探针。

近五年主要科研成果:
1:药用真菌鸟巢菌次级代谢产物的化学与生物活性研究

鸟巢菌中的若干种为药用真菌,可健脾止痛、消食化积、治胃病止胃痛(图1)。目前已完成了一株黑蛋巢菌(编号L38的非洲黑蛋巢菌)大米固体发酵产物的化学成分研究,分离得到38个鸟巢烷类二萜(图2),并开展了抗炎、抗菌和抗肿瘤活性成分研究(图3)。部分研究结果已发表在Fitoterapia,2013,84, 22-31。


2:
腐生、共生真菌新结构活性化合物

从西藏金耳共生的毛韧革菌获得19个新结构倍半萜,包括4个倍半萜杂合二聚体,4个多毛烷型倍半萜二聚体,2个三聚体,多靶点活性筛选发现化合物Sterhirsutins E-G具有较强的细胞毒活性;Sterhirsutin K具有自噬活性;Sterhirsutin G具有免疫抑制活性(Org. Lett. 2014, 16, 5092Org. Lett. 2015, 173098)。从高寒腐生粘褶菌获得3个具有细胞毒活性的新骨架甾体化合物 (Org. Lett. 2015, 172538)                                                                            

3:猴头菌降糖活性成分研究

从西藏猴头菌发现11个新结构的异吲哚琳酮化合物,部分化合物显示了较好的α-葡萄糖苷酶抑制活性(IC50, 5-25 μM)和PPARαγ受体激动活性(EC50, 0.06-2.17μM)(J. Nat. Prod.2015, 1, 146)。构效关系分析表明:苯环上的烷烃侧链和酚羟基是活性必须基团。


主要学习经历

2001-10--2004-09   东京海洋大学海洋环境学系   水产学博士学位
1998-09--2003-06   沈阳药科大学中药学院   药物化学博士学位
1993-09--1998-06   沈阳药科大学药学院   理学学士学位
科研经历
2011/6-至今,中科院微生物研究所,真菌学国家重点实验室,研究员,研究组长 2009/1-2011/5,中科院微生物研究所,真菌学国家重点实验室,副研究员,研究组长 2006/10-2008/12,首都医科大学,化学生物学与药学院,副教授 2004/10-2006/9,清华大学生物系博士后

专利成果

1.       刘宏伟、张小青、宝丽。一株中华隐孔菌及其固体培养方法与应用。授权专利号:ZL201010135110.0 

2.       刘宏伟,韩俊杰,陈玉惠,宝丽. 11-氧乙酰鸟巢烷三醇和15-氧乙酰鸟巢烷三醇的生产方法及其专用菌株。授权专利号:ZL20121 0352773.7. 

3.       刘宏伟、宝丽、王雅琪。来源于金针菇的倍半萜化合物的新用途。授权专利号:ZL201110051193.X. 

4.       刘宏伟、宝丽、王雅琪。一种降倍半萜类化合物及其制备方法与应用。授权专利号:ZL201110443960.1 

5.       刘宏伟、张立新、王全新、郭良栋。蛇孢菌素类二倍半萜化合物及其制备方法与应用。授权专利号:ZL201110431751.5 

6.       刘宏伟,王全新,宝丽,韩俊杰。Coicenal类二萜化合物及其制备方法和在制备抗炎药物中的应用。授权专利号:ZL 201310254586.X 

7.       刘宏伟,韩俊杰,宝丽. 一种鸟巢烷类二萜化合物在制备抗肿瘤药物中的应用。授权专利号:ZL 201210352484.7 

8.       刘宏伟,宝丽. 一种杏鲍菇功能性食品及其制备方法。授权专利号:ZL 201210380590.6 

9.       刘宏伟,马轲,韩俊杰,宝丽. 两种三联苯并二恶嗪衍生物及其应用. 授权专利号:ZL 201410056590.x. 

10.   刘宏伟,王全新,宝丽,陈吉龙。一种化合物、该化合物的制备方法以及化合物在制备抗肿瘤药物中的应用。授权专利号:ZL 201310093409.8

11.   刘宏伟,韩俊杰,赵烽,宝丽. 11-氧乙酰鸟巢烷三醇在制备预防和/或治疗胃溃疡药物中的应用,授权专利号:ZL 201410376678.X. 

12.   刘宏伟,韩俊杰. 二萜类化合物及其基于抗肿瘤的应用,授权专利号:ZL 201310556420.3. 

13.   刘宏伟,王波涛,马轲,齐秋月,韩俊杰. 苯甲酸衍生物及其制备与降糖应用. 授权专利号:ZL 201410111365.1. 14.   刘宏伟,马轲,韩俊杰,宝丽. 一种Sarcodon leucopus中降糖活性成分及其制备方法与应用. 授权专利号:ZL 201410056448.5. 

15.   刘宏伟,汪锴,宝丽,韩俊杰. 异吲哚类化合物及其应用. 授权专利号:ZL 201410394697.5

16.   刘宏伟,赵文华,宋晓红,夏颖,张英侠. 二聚体可水解鞣质衍生物用于制备治疗肥胖的药物和饮食添加剂的用途,2012,中国,授权专利号:ZL200710163924.3

17.   姚新生,刘宏伟,杨宝峰,吕延杰,戴毅.甾体化合物在制备治疗心脑血管疾病药物中的应用,2010,中国,授权专利号:ZL200710029721.5. 

18.   姚新生,刘宏伟,浪越通夫,小林久芳. 具有海星卵细胞细胞周期抑制作用的二萜类衍生物的制备及用途,2006,中国,授权专利号:ZX200410026676.4 


出版信息

   
发表论文
[1] Jiyuan Liu, Huanqin Dai, Bo Wang, Hongwei Liu, Zhen Tian, Yalin Zhang. Exploring disordered loops in DprE1 provides a functional site to combat drug-resistance in Mycobacterium strains. European Journal of Medicinal Chemistry. 2022, 227: [2] Sun, Shanshan, Sun, Li, Wang, Kai, Qiao, Shanshan, Zhao, Xinyue, Hu, Xiaomin, Chen, Wei, Zhang, Shuyang, Li, Hantian, Dai, Huanqin, Liu, Hongwei. The gut commensal fungus, Candida parapsilosis, promotes high fat-diet induced obesity in mice. COMMUNICATIONS BIOLOGY[J]. 2021, 4(1): http://dx.doi.org/10.1038/s42003-021-02753-3.
[3] Ma, Ke, Zhang, Yuting, Guo, Cui, Yang, Yanlong, Han, Junjie, Yu, Bo, Yin, Wenbing, Liu, Hongwei. Reconstitution of biosynthetic pathway for mushroom-derived cyathane diterpenes in yeast and generation of new "non-natural" analogues. ACTA PHARMACEUTICA SINICA B[J]. 2021, 11(9): 2945-2956, http://dx.doi.org/10.1016/j.apsb.2021.04.014.
[4] ZHANG JinJin, CHEN BaoSong, DAI HuanQin, REN JinWei, ZHOU LiWei, WU ShengHua, LIU HongWei. Sesquiterpenes and polyphenols with glucose-uptake stimulatory and antioxidant activities from the medicinal mushroom Sanghuangporus sanghuang. CHINESE JOURNAL OF NATURAL MEDICINES[J]. 2021, 19(9): 693-699, http://dx.doi.org/10.1016/S1875-5364(21)60101-2.
[5] Sun, Li, Bao, Li, Phurbu, Dorji, Qiao, Shanshan, Sun, Shanshan, Perma, Yangzom, Liu, Hongwei. Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice. FOOD SCIENCE AND HUMAN WELLNESS[J]. 2021, 10(4): 442-451, https://doaj.org/article/62d4b08bbf2545a1bfd97415f961fca1.
[6] Zhang, Jinjin, Chen, Baosong, Liang, Jack, Han, Junjie, Zhou, Liwei, Zhao, Ruilin, Liu, Hongwei, Dai, Huanqin. Lanostane Triterpenoids with PTP1B Inhibitory and Glucose-Uptake Stimulatory Activities from Mushroom Fomitopsis pinicola Collected in North America. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2020, 68(37): 10036-10049, https://www.webofscience.com/wos/woscc/full-record/WOS:000573390100018.
[7] Qiao, Shanshan, Bao, Li, Wang, Kai, Sun, Shanshan, Liao, Mingfang, Liu, Chang, Zhou, Nan, Ma, Ke, Zhang, Yuwei, Chen, Yihua, Liu, ShuangJiang, Liu, Hongwei. Activation of a Specific Gut Bacteroides-Folate-Liver Axis Benefits for the Alleviation of Nonalcoholic Hepatic Steatosis. CELL REPORTS[J]. 2020, 32(6): https://doaj.org/article/3c0c6df27461447caf7c341d1077a6ea.
[8] Sun, Shanshan, Wang, Kai, Sun, Li, Cheng, Baosong, Qiao, Shanshan, Dai, Huanqin, Shi, Wenyu, Ma, Juncai, Liu, Hongwei. Therapeutic manipulation of gut microbiota by polysaccharides of Wolfiporia cocos reveals the contribution of the gut fungi-induced PGE(2) to alcoholic hepatic steatosis. GUT MICROBES[J]. 2020, 12(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7592601/.
[9] Chang Liu, Nan Zhou, MengXuan Du, YuTong Sun, Kai Wang, YuJing Wang, DanHua Li, HaiYing Yu, Yuqin Song, BingBing Bai, Yuhua Xin, Linhuan Wu, ChengYing Jiang, Jie Feng, Hua Xiang, Yuguang Zhou, Juncai Ma, Jun Wang, HongWei Liu, ShuangJiang Liu. The Mouse Gut Microbial Biobank expands the coverage of cultured bacteria. Nature Communications[J]. 2020, 11(1): 1-12, http://dx.doi.org/10.1038/s41467-019-13836-5.
[10] Chen, Baosong, Han, Junjie, Wang, Mengmeng, Dai, Huanqin, Zhang, Jinjin, Cai, Lei, Wei, Shenglong, Zhang, Xue, Liu, Hongwei. Amplisins A-E, chromone methide polymers with hypoglycemic activity from a new fungicolous fungus Amplistroma fungicola. ORGANIC CHEMISTRY FRONTIERS[J]. 2020, 7(18): 2761-2769, https://www.webofscience.com/wos/woscc/full-record/WOS:000569870300021.
[11] Basnet, Buddha Bahadur, Chen, Baosong, Suleimen, Yerlan Melsuly, Ma, Ke, Guo, Shouyu, Bao, Li, Huang, Ying, Liu, Hongwei. Cytotoxic Secondary Metabolites from the Endolichenic Fungus Hypoxylon fuscum. PLANTA MEDICA[J]. 2019, 85(13): 1088-1097, https://www.webofscience.com/wos/woscc/full-record/WOS:000481882000005.
[12] Ma, Ke, Zhang, Peng, Tao, Qiaoqiao, Keller, Nancy P, Yang, Yanlong, Yin, WenBing, Liu, Hongwei. Characterization and Biosynthesis of a Rare Fungal Hopane-Type Triterpenoid Glycoside Involved in the Antistress Property of Aspergillus fumigatus. ORGANIC LETTERS[J]. 2019, 21(9): 3252-3256, [13] ShanShan SUN, Kai WANG, Ke MA, Li BAO, HongWei LIU. An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota. Chinese Journal of Natural Medicines[J]. 2019, 3-14, http://dx.doi.org/10.1016/S1875-5364(19)30003-2.
[14] Basnet, Buddha Bahadur, Liu, Li, Chen, Baosong, Suleimen, Yerlan Melsuly, Yu, Haiyang, Guo, Shouyu, Bao, Li, Ren, Jinwei, Liu, Hongwei. Four New Cytotoxic Arborinane-Type Triterpenes from the Endolichenic Fungus Myrothecium inundatum. PLANTA MEDICA[J]. 2019, 85(9-10): 701-707, https://www.webofscience.com/wos/woscc/full-record/WOS:000479174700003.
[15] Wang, Kai, Liao, Mingfang, Zhou, Nan, Bao, Li, Ma, Ke, Zheng, Zhongyong, Wang, Yujing, Liu, Chang, Wang, Wenzhao, Wang, Jun, Liu, ShuangJiang, Liu, Hongwei. Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids. CELL REPORTS[J]. 2019, 26(1): 222-+, http://dx.doi.org/10.1016/j.celrep.2018.12.028.
[16] Chen, Baosong, Zhang, Rjinjin, Han, Junjie, Zhao, Ruilin, Bao, Li, Huang, Ying, Liu, Hongwei. Lanostane Triterpenoids with Glucose-Uptake-Stimulatory Activity from Peels of the Cultivated Edible Mushroom Wolfiporia cocos. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2019, 67(26): 7348-7364, [17] Liu Li, Liu Ruixing, Basnet Buddha Bahadur, Bao Li, Han Junjie, Wang Long, Liu Hongwei. New phenolic bisabolane sesquiterpenoid derivatives with cytotoxicity from Aspergillus tennesseensis.. The Journal of antibiotics. 2018, [18] Sun, Shanshan, Ma, Ke, Tao, Qiaoqiao, Han, Junjie, Bao, Li, Liu, Li, Liu, Hongwei. Diketopiperazines and 2H-pyran-2-ones with antioxidant activity from the rice fermented with Aspergillus luchuensis. FITOTERAPIA[J]. 2018, 125: 266-272, http://dx.doi.org/10.1016/j.fitote.2018.01.016.
[19] Chen, Hongyu, Zhang, Jinjin, Ren, Jinwei, Wang, Wenzhao, Xiong, Weiping, Zhang, Yaodong, Bao, Li, Liu, Hongwei. Triterpenes and Meroterpenes with Neuroprotective Effects from Ganoderma leucocontextum. CHEMISTRY & BIODIVERSITY[J]. 2018, 15(5): https://www.webofscience.com/wos/woscc/full-record/WOS:000434072600005.
[20] Basnet, Buddha Bahadur, Liu, Hongwei, Liu, Li, Suleimen, Yerlan Melsuly. Diversity of Anticancer and Antimicrobial Compounds from Lichens and Lichen-derived Fungi: A Systematic Review (1985-2017). CURRENT ORGANIC CHEMISTRYnull. 2018, 22(25): 2487-2500, https://www.webofscience.com/wos/woscc/full-record/WOS:000454601800004.
[21] Liu, Ge, Wang, Kai, Kuang, Shan, Cao, Ruobing, Bao, Li, Liu, Rui, Liu, Hongwei, Sun, Chaomin. The natural compound GL22, isolated from Ganoderma mushrooms, suppresses tumor growth by altering lipid metabolism and triggering cell death. CELL DEATH & DISEASE[J]. 2018, 9(6): https://doaj.org/article/8b58295baab34818bbc9a9b171b15d55.
[22] Chen, Baosong, Li, Erwei, Liu, Li, Liao, Mingfang, Zhu, Zhaoxiang, Zhuang, Wenying, Bao, Li, Liu, Hongwei. Botryane Sesquiterpenoids, Cyclopentadepsipeptides, Xanthones, and Trichothecenes from Trichoderma oligosporum. PLANTA MEDICA[J]. 2018, 84(14): 1055-1063, https://www.webofscience.com/wos/woscc/full-record/WOS:000444454300008.
[23] Yang, Yanlong, Zhang, Yuting, Zhang, Shasha, Chen, Qingwen, Ma, Ke, Bao, Li, Tao, Yong, Yin, Wenbing, Wang, Guodong, Liu, Hongwei. Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis. JOURNAL OF NATURAL PRODUCTS[J]. 2018, 81(4): 1089-1092, https://www.webofscience.com/wos/woscc/full-record/WOS:000431165100047.
[24] Zhang, Jinjin, Ma, Ke, Han, Junjie, Wang, Kai, Chen, Hongyu, Bao, Li, Liu, Li, Xiong, Weiping, Zhang, Yaodong, Huang, Ying, Liu, Hongwei. Eight new triterpenoids with inhibitory activity against HMG-CoA reductase from the medical mushroom Ganoderma leucocontextum collected in Tibetan plateau. FITOTERAPIA[J]. 2018, 130: 79-88, http://dx.doi.org/10.1016/j.fitote.2018.08.009.
[25] 刘宏伟. Structural modification of natural product ganomycin I leading to discovery of a a-glucosidase and HMG-CoA reductase dual inhibitor improving obesity and metabolit dysfunction in vivo.. Journal of Medicinal Chemistry. 2018, [26] 刘宏伟. 2H-Pyranone and isocoumarin derivatives isolated from the plant pathogenic fungus Leptosphaena maculans.. Journal of Asian Natural Products Research. 2018, [27] 刘宏伟. Three new heptelidic derivatives from the culture of mushroom Lentinellus ursinus.. Natural Products and Bioprospecting. 2018, [28] Zhang Yuting, Liu Li, Bao Li, Yang Yanlong, Ma Ke, Liu Hongwei. Three new cyathane diterpenes with neurotrophic activity from the liquid cultures of Hericium erinaceus.. The Journal of antibiotics. 2018, http://kns.cnki.net/KCMS/detail/detail.aspx?QueryID=0&CurRec=1&recid=&FileName=SJPD9473F1A99D2EB10EAC0E541338554077&DbName=SJPD_06&DbCode=SJPD&yx=&pr=&URLID=&bsm=.
[29] 刘宏伟. New 1, 2-naphthoquinone-derived pigments from the mycobiont of lichen Trypethelium eluteriae Sprengel.. Natural Product Research. 2018, [30] 刘宏伟. Triterpenes and meroterpenes from Ganoderma lucidum with inhibitory activity against HMG-CoA reductase, aldose reductase and α-glucosidase. Fitoterapia. 2017, [31] Buddha Bahadur Basnet, Li Liu, Li Bao, Hongwei Liu. Current and future perspective on antimicrobial and anti-parasitic activities of Ganoderma sp.: an update. Mycology[J]. 2017, 8(2): 111-124, https://doaj.org/article/c28a9948f94941fe80a99d83f4012878.
[32] Kai Wang, Li Bao, Ke Ma, Jinjin Zhang, Baosong Chen, Junjie Han, Jinwei Ren, Huajun Luo, Hongwei Liu. A novel class of α-glucosidase and HMG-CoA reductase inhibitors from Ganoderma leucocontextum and the anti-diabetic properties of ganomycin I in KK-Ay mice. European Journal of Medicinal Chemistry. 2017, 127: 1035-1046, http://dx.doi.org/10.1016/j.ejmech.2016.11.015.
[33] Liu, Li, Liu, Ruixing, Basnet, Buddha Bahadur, Bao, Li, Han, Junjie, Ren, Jinwei, Zeng, Zhaoqing, Zhuang, Wenying, Liu, Hongwei. A new seco-pimarane diterpene and four new beta-resorcylic acid lactones from a fungicolous Hypomyces subiculosus. RSC ADVANCES[J]. 2017, 7(82): 51986-51992, https://www.webofscience.com/wos/woscc/full-record/WOS:000415116800031.
[34] Zhang, Jinjin, Ma, Ke, Chen, Hongyu, Wang, Kai, Xiong, Weiping, Bao, Li, Liu, Hongwei. A novel polycyclic meroterpenoid with aldose reductase inhibitory activity from medicinal mushroom Ganoderma leucocontextum. JOURNAL OF ANTIBIOTICS[J]. 2017, 70(8): 915-917, https://www.webofscience.com/wos/woscc/full-record/WOS:000406255800007.
[35] 刘宏伟. Discovery and characterization of the UbiA proteins as a new family of diterpene cyclases in bacteria and fungi. Angew. Chem. Int. Ed.. 2017, [36] 刘宏伟. New Decalin-Containing Tetramic acids and 4-hydroxy-2-pyridones with Antimicrobial and Cytotoxic Activity from the Fungus Coniochaeta cephalothecoides Collected in Tibetan Plateau (Medog). The Journal of Organic Chemistry. 2017, [37] Liu Li, Wang Long, Bao Li, Ren Jinwei, Basnet Buddha Bahadur, Liu Ruixing, He Luwei, Han Junjie, Yin WenBing, Liu Hongwei. Correction to Versicoamides F-H, Prenylated Indole Alkaloids from Aspergillus tennesseensis.. Organic letters. 2017, [38] 刘宏伟. 23) Li Liu(#); Li Bao(#); Long Wang(#); Ke Ma; Junjie Han; Yanlong Yang; Ruixing Liu; Jinwei Ren; Wenbing Yin; Wenzhao Wang; Hongwei Liu(*), Asperorydines A−M: Prenylated Tryptophan-derived Alkaloids with Diverse Skeletons and Neurotrophic Effects from Aspergillus oryzae.. The Journal of Organic Chemistry. 2017, [39] 刘宏伟. Sesquiterpenoids with PTP1-B inhibitory activity and cytotoxicity from the edible mushroom Pleurotus citrinopoleatus. Planta Medica. 2016, [40] 3-Anhydro-6-hydroxy-ophiobolin A displays high in vitro and in vivo efficacy against influenza A virus infection. 蛋白质与细胞:英文版. 2016, 7(11): 839-843, http://lib.cqvip.com/Qikan/Article/Detail?id=670753021.
[41] Wang, Kai, Bao, Li, Ma, Ke, Qi, Wei, Song, Fuhang, Yao, Yijian, Yin, Wenbing, Zhang, Lixin, Huang, Ying, Han, Junjie, Liu, Hongwei. Bioactive Spirobisnaphthalenes and Lactones from a Cup Fungus Plectania sp Collected in the Tibet Plateau Region. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY[J]. 2016, 2016(25): 4338-4346, http://www.corc.org.cn/handle/1471x/2376168.
[42] Tao, Qiaoqiao, Ma, Ke, Yang, Yanlong, Wang, Kai, Chen, Baosong, Huang, Ying, Han, Junjie, Bao, Li, Liu, XiaoBin, Yang, Zhuliang, Yin, WenBing, Liu, Hongwei. Bioactive Sesquiterpenes from the Edible Mushroom Flammulina velutipes and Their Biosynthetic Pathway Confirmed by Genome Analysis and Chemical Evidence. JOURNAL OF ORGANIC CHEMISTRY[J]. 2016, 81(20): 9867-9877, http://ir.kib.ac.cn/handle/151853/33647.
[43] Tian, Jin, Han, JunJie, Zhang, Xue, He, LuWei, Zhang, YongJie, Bao, Li, Liu, HongWei. New Cyclohexadepsipeptides from an Entomogenous Fungus Fusarium proliferatum and Their Cytotoxicity and Autophagy-Inducing Activity. CHEMISTRY & BIODIVERSITY[J]. 2016, 13(7): 852-860, https://www.webofscience.com/wos/woscc/full-record/WOS:000383393100006.
[44] Jin, Xin, Han, Junjie, Yang, Shuxian, Hu, Yuan, Liu, Hongwei, Zhao, Feng. 11-O-acetylcyathatriol inhibits MAPK/p38-mediated inflammation in LPS-activated RAW 264.7 macrophages and has a protective effect on ethanol-induced gastric injury. MOLECULAR MEDICINE REPORTS[J]. 2016, 14(1): 874-880, https://www.webofscience.com/wos/woscc/full-record/WOS:000379551700117.
[45] He, Luwei, Han, Junjie, Li, Baowei, Huang, Li, Ma, Ke, Chen, Quan, Liu, Xinzhong, Bao, Li, Liu, Hongwei. Identification of a new cyathane diterpene that induces mitochondrial and autophagy-dependent apoptosis and shows a potent in vivo anti-colorectal cancer activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY[J]. 2016, 111: 183-192, http://dx.doi.org/10.1016/j.ejmech.2016.01.056.
[46] 刘宏伟. New sesquiterpenoid from the edible mushroom Pleurotus cystidiosus and their inhibitory activity against a-glucosidase and PTP1B. Fitoterapia. 2016, [47] 刘宏伟. Erinacerins C-L, Isoindolini-1-ones with a-glucosidase inhibitory activity form cultures of the medicinal mushroom Hericium erinaceus.. 2015, [48] Qi, QiuYue, Li, ErWei, Han, JunJie, Pei, YunFei, Ma, Ke, Bao, Li, Huang, Ying, Zhao, Feng, Liu, HongWei. New ambuic acid derivatives from the solid culture of Pestalotiopsis neglecta and their nitric oxide inhibitory activity. SCIENTIFIC REPORTS[J]. 2015, 5: http://www.corc.org.cn/handle/1471x/2376577.
[49] Han, JunJie, Bao, Li, Tao, QiaoQiao, Yao, YiJian, Liu, XingZhong, Yin, WenBing, Liu, HongWei. Gloeophyllins A-J, Cytotoxic Ergosteroids with Various Skeletons from a Chinese Tibet Fungus Gloeophyllum abietinum. ORGANIC LETTERS[J]. 2015, 17(10): 2538-2541, https://www.webofscience.com/wos/woscc/full-record/WOS:000354908300063.
[50] 刘宏伟. Eight new alkaloids with PTP1B and a-glucosidase inhibitory activity from the medicinal mushroom Hericium erinaceus.. Tetrahedron. 2015, [51] Han, JunJie, Zhang, Lei, Xu, JieKun, Bao, Li, Zhao, Feng, Chen, YuHui, Zhang, WeiKu, Liu, HongWei. Three new cyathane diterpenoids from the medicinal fungus Cyathus africanus. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH[J]. 2015, 17(5): 541-549, https://www.webofscience.com/wos/woscc/full-record/WOS:000357942400016.
[52] 刘宏伟. Lanostane triterpenes from the Tibetan Medicinal Mushroom Ganoderma leucocontextum and their inhibitory effects on HMG-CoA reductase and a-glucosidase.. Journal of Natural Products.. 2015, [53] Huang, Li, Han, Junjie, BenHail, Danya, He, Luwei, Li, Baowei, Chen, Ziheng, Wang, Yueying, Yang, Yanlei, Liu, Lei, Zhu, Yushan, ShoshanBarmatz, Varda, Liu, Hongwei, Chen, Quan. A New Fungal Diterpene Induces VDAC1-dependent Apoptosis in Bax/Bak-deficient Cells. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2015, 290(39): 23563-23578, http://dx.doi.org/10.1074/jbc.M115.648774.
[54] Ma, Ke, Li, Li, Bao, Li, He, Luwei, Sun, Chen, Zhou, Bing, Si, Shuyi, Liu, Hongwei. Six new 3,4-seco-27-norlanostane triterpenes from the medicinal mushroom Ganoderma boninense and their antiplasmodial activity and agonistic activity to LXR beta. TETRAHEDRON[J]. 2015, 71(12): 1808-1814, https://www.webofscience.com/wos/woscc/full-record/WOS:000350835800005.
[55] Qi, QiuYue, Ren, JinWei, Sun, LiWei, He, LuWei, Bao, Li, Yue, Wei, Sun, QinMiao, Yao, YiJian, Yin, WenBing, Liu, HongWei. Stucturally Diverse Sesquiterpenes Produced by a Chinese Tibet Fungus Stereum hirsutum and Their Cytotoxic and Immunosuppressant Activities. ORGANIC LETTERS[J]. 2015, 17(12): 3098-3101, https://www.webofscience.com/wos/woscc/full-record/WOS:000356845000060.
[56] Xue Danfeng, QuanXin Wang, Chen Ziheng, Lei Cai, Li Bao, QiuYue Qi, Liu Lei, Wang Xiaohui, Jin Haijing, Wang Jun, Wu Hao, Liu Hongwei, Chen Quan. 3-Anhydro-6-Hydroxy-Ophiobolin A, A Fungal Sesterterpene from Bipolaris oryzae Induced Autophagy and Promoted the Degradation of α-Synuclein in PC12 Cells. Bioorganic & Medicinal Chemistry Letters[J]. 2015, 25(7): 1464-1470, http://dx.doi.org/10.1016/j.bmcl.2015.02.030.
[57] Wang, Kangji, Zhang, Zhenying, Chen, Xi, Sun, Xianyun, Jin, Cheng, Liu, Hongwei, Li, Shaojie. Transcription Factor ADS-4 Regulates Adaptive Responses and Resistance to Antifungal Azole Stress. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY[J]. 2015, 59(9): 5396-5404, http://dx.doi.org/10.1128/AAC.00542-15.
[58] Ma, Ke, Bao, Li, Han, Junjie, Jin, Tao, Yang, Xiaoli, Zhao, Feng, Li, Shaifei, Song, Fuhang, Liu, Miaomiao, Liu, Hongwei. New benzoate derivatives and hirsutane type sesquiterpenoids with antimicrobial activity and cytotoxicity from the solid-state fermented rice by the medicinal mushroom Stereum hirsutum. FOOD CHEMISTRY[J]. 2014, 143: 239-245, http://dx.doi.org/10.1016/j.foodchem.2013.07.124.
[59] Qi, QiuYue, Huang, Li, He, LuWei, Han, JunJie, Chen, Quan, Cai, Lei, Liu, HongWei. Cochlioquinone Derivatives with Apoptosis-Inducing Effects on HCT116 Colon Cancer Cells from the Phytopathogenic Fungus Bipolaris luttrellii L439. CHEMISTRY & BIODIVERSITY[J]. 2014, 11(12): 1892-1899, https://www.webofscience.com/wos/woscc/full-record/WOS:000346096400002.
[60] Qi, QiuYue, Bao, Li, Ren, JinWei, Han, JunJie, Zhang, ZongYao, Li, Yi, Yao, YiJian, Cao, Rui, Liu, HongWei. Sterhirsutins A and B, Two New Heterodimeric Sesquiterpenes with a New Skeleton from the Culture of Stereum hirsutum Collected in Tibet Plateau. ORGANIC LETTERS[J]. 2014, 16(19): 5092-5095, https://www.webofscience.com/wos/woscc/full-record/WOS:000342719500032.
[61] 刘宏伟. New α-Glucosidase inhibitors with p-terphenyl skeleton from the mushroom Hydnellum concrescens.. 2014, [62] 刘宏伟. Two sarcoviolins with antioxidative and α-Glucosidase inhibitory activity from the edible mushroom Sarcodon leucopus collected in Tibet.. Journal of Natural Products. 2014, [63] 刘宏伟. Depside α-Glucosidase inhibitiors from a culture of the mushroom Stereum hirsutum.. 2014, [64] Wang, Botao, Han, Junjie, Xu, Wei, Chen, Yuhui, Liu, Hongwei. Production of bioactive cyathane diterpenes by a bird's nest fungus Cyathus gansuensis growing on cooked rice. FOOD CHEMISTRY[J]. 2014, 152: 169-176, http://dx.doi.org/10.1016/j.foodchem.2013.11.137.
[65] Ma, Ke, Ren, Jinwei, Han, Junjie, Bao, Li, Li, Li, Yao, Yijian, Sun, Chen, Zhou, Bing, Liu, Hongwei. Ganoboninketals A-C, Antiplasmodial 3,4-seco-27-Norlanostane Triterpenes from Ganoderma boninense Pat.. JOURNAL OF NATURAL PRODUCTS[J]. 2014, 77(8): 1847-1852, https://www.webofscience.com/wos/woscc/full-record/WOS:000340861800012.
[66] Zhao, Feng, Hu, Yuan, Chong, Chuanke, Lu, Minghui, Chen, Liping, Kan, Weijuan, Chen, Lei, Liu, Hongwei. Ardisiphenol D, a resorcinol derivative identified from Ardisia brevicaulis, exerts antitumor effect through inducing apoptosis in human non-small-cell lung cancer A549 cells. PHARMACEUTICAL BIOLOGY[J]. 2014, 52(7): 797-803, https://www.webofscience.com/wos/woscc/full-record/WOS:000337089900001.
[67] Li, Yongxia, Bao, Li, Song, Bin, Han, Junjie, Li, Heran, Zhao, Feng, Liu, Hongwei. A new benzoquinone and a new benzofuran from the edible mushroom Neolentinus lepideus and their inhibitory activity in NO production inhibition assay. FOOD CHEMISTRY[J]. 2013, 141(3): 1614-1618, http://dx.doi.org/10.1016/j.foodchem.2013.04.133.
[68] 刘宏伟. Phaeolschidins A-E, five hispidin derivatives with antioxidant activity from the fruiting body of Phaeolus schweinitzii collected in Tibetan plateau.. Journal of Natural Products. 2013, [69] 刘宏伟. Isolation, identification and bioactivity of monoterpenoids and sesquiterpenoids from the mycelia of the edible mushroom Pleurotus cornucopiae.. Journal of Agricultural Food and Chemistry. 2013, [70] Wang, QuanXin, Bao, Li, Yang, XiaoLi, Guo, Hui, Ren, Biao, Guo, LiangDong, Song, FuHang, Wang, WenZhao, Liu, HongWei, Zhang, LiXin. Tricycloalternarenes F-H: Three new mixed terpenoids produced by an endolichenic fungus Ulocladium sp using OSMAC method. FITOTERAPIA[J]. 2013, 85: 8-13, https://www.webofscience.com/wos/woscc/full-record/WOS:000317172000002.
[71] Wang, QuanXin, Bao, Li, Yang, XiaoLi, Liu, DaiLin, Guo, Hui, Dai, HuanQin, Song, FuHang, Zhang, LiXin, Guo, LiangDong, Li, ShaoJie, Liu, HongWei. Ophiobolins P-T, five new cytotoxic and antibacterial sesterterpenes from the endolichenic fungus Ulocladium sp.. FITOTERAPIA[J]. 2013, 90: 220-227, https://www.webofscience.com/wos/woscc/full-record/WOS:000326427600027.
[72] Han, JunJie, Chen, YuHui, Bao, Li, Yang, XiaoLi, Liu, Dailin, Li, ShaoJie, Zhao, Feng, Liu, Hongwei. Anti-inflammatory and cytotoxic cyathane diterpenoids from the medicinal fungus Cyathus africanus. FITOTERAPIA[J]. 2013, 84: 22-31, https://www.webofscience.com/wos/woscc/full-record/WOS:000316531400005.
[73] Wen Wu, Feng Zhao, Rong Ding, Li Bao, Hao Gao, JinCai Lu, XinSheng Yao, XiaoQing Zhang, HongWei Liu. Four New Cryptoporic Acid Derivatives from the Fruiting Bodies of Cryptoporus sinensis, and Their Inhibitory Effects on Nitric Oxide Production. 2011, [74] Yan, Sha, Li, Saifei, Wu, Wen, Zhao, Feng, Bao, Li, Ding, Rong, Gao, Hao, Wen, HuaAn, Song, Fuhang, Liu, HongWei. Terpenoid and Phenolic Metabolites from the Fungus Xylaria sp Associated with Termite Nests. CHEMISTRY & BIODIVERSITY[J]. 2011, 8(9): 1689-1700, https://www.webofscience.com/wos/woscc/full-record/WOS:000295257200005.
[75] Wu, Wen, Dai, Huanqin, Bao, Li, Ren, Biao, Lu, Jingcai, Luo, Yuanming, Guo, Liangdong, Zhang, Lixin, Liu, Hongwei. Isolation and Structural Elucidation of Proline-Containing Cyclopentapeptides from an Endolichenic Xylaria sp.. JOURNAL OF NATURAL PRODUCTS[J]. 2011, 74(5): 1303-1308, http://124.16.144.217/handle/311023/1568.
[76] 刘宏伟. Two new resveratrol tetramers isolated from Cayratia japonica (Thunb.) Gagn. with strong inhibitory activity on fatty acid synthase and anti-oxidative activity. Chemistry and Biodiversity. 2010, [77] Liu, Hongwei, Zhao, Feng, Yang, Ruiyun, Wang, Manyuan, Zheng, Meiqing, Zhao, Yisong, Zhang, Xue, Qiu, Feng, Wang, Hengshan. Dimeric 1,4-benzoquinone derivatives and a resorcinol derivative from Ardisia gigantifolia. PHYTOCHEMISTRY[J]. 2009, 70(6): 773-778, http://dx.doi.org/10.1016/j.phytochem.2009.04.004.
[78] Zhang, Yonggang, Liu, Shunchun, Liu, Hongwei, Liu, Xingzhong, Che, Yongsheng. Cycloaspeptides F and G, Cyclic Pentapeptides from a Cordyceps-Colonizing Isolate of Isaria farinosa. JOURNAL OF NATURAL PRODUCTS[J]. 2009, 72(7): 1364-1367, http://124.16.144.217/handle/311023/1552.
[79] Liu, Hongwei, Li, Jiankuan, Zhao, Wenhua, Bao, Li, Song, Xiaohong, Xia, Ying, Wang, Xue, Zhang, Chao, Wang, Xiaozhu, Yao, Xinsheng, Li, Ming. Fatty Acid Synthase Inhibitors from Geum japonicum THUNB. var. chinense. CHEMISTRY & BIODIVERSITY[J]. 2009, 6(3): 402-410, http://124.16.144.217/handle/311023/2286.
[80] 刘宏伟. Characterization and online detection of aromatic alkaloids in the ascidian Lissoclinum cf. badium by liquid hromatography/UV detection mass spectrometry.. Rapid Communications in Mass Spectrometry. 2007, [81] Liu, HW, Fujiwara, T, Nishikawa, T, Mishima, Y, Nagai, H, Shida, T, Tachibana, K, Kobayashi, H, Mangindaan, REP, Namikoshi, M. Lissoclibadins 1-3, three new polysulfur alkaloids, from the ascidian Lissoclinum cf. badium. TETRAHEDRON[J]. 2005, 61(36): 8611-8615, http://dx.doi.org/10.1016/j.tet.2005.07.002.
[82] 刘宏伟. Isolation and Characterization of Polybrominated Diphenyl Ethers as Inhibitors of Tubulin Polymerization from Palau Sponge Phyllospongia dendyi.. 2004, 
发表著作
( 1 ) 传统草药研究方法, Traditional herbal medicine research methods, a John and Sons, Inc, 2011-03, 第 4 作者

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